post-PCI FFR for Myocardial Ischemia
This study is evaluating whether the use of physiology parameters as guidance post-percutaneous coronary interventions (PCI) is associated with less risks of target vessel failure (TVF) and angina-related events than standard angiographic guidance.
See full descriptionAbout the trial for Myocardial Ischemia
Treatment Groups
This trial involves 2 different treatments. Post-PCI FFR is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.
Eligibility
This trial is for patients born any sex aged 18 and older. There are 3 eligibility criteria to participate in this trial as listed below.
Approximate Timelines
Measurement Requirements
This trial is evaluating whether post-PCI FFR will improve 2 primary outcomes and 6 secondary outcomes in patients with Myocardial Ischemia. Measurement will happen over the course of Post-randomization after stent implantation (< 1 hour).
Who is running the study
Principal InvestigatorPatient Q & A Section
What are the signs of myocardial ischemia?
The presence of symptoms of myocardial ischemia has substantial diagnostic implications. In addition to standard ECG interpretation, a clinical examination may reveal evidence of left ventricular dysfunction and chest pain, both of which have significant prognostic implications.
How many people get myocardial ischemia a year in the United States?
About 3.5 million people have a cardiovascular event in a year in the United States, including an ischemic event, a heart attack, or a stroke. Around 2.8 million of these events result from a disease process other than coronary artery disease (CAD). In men, coronary heart disease was a major cause of CAD when other risk factors are accounted for. Cardiovascular events accounted for 26.3% (1.9 million) of all deaths in the United States in 1997.
What is myocardial ischemia?
The word 'ischemia' seems to come from the root word 'to dry,' because myocardial infarction (MI) is the event of myocardial ischemia. (There is no direct medical or scientific definition for 'ischemia' that is related to heart-related diseases.) Myocardial ischemia occurs when blood doesn't get enough oxygen to the heart. It is usually defined as a cardiac emergency as ICD and percutaneous coronary intervention are the only treatments for myocardial ischemia. For the rest of the article, it is referred to as'myocardial ischemic event.
What are common treatments for myocardial ischemia?
There are numerous and varied treatment options for Myocardial Ischemia, with no single method proving most efficacious in all patients. Because Myocardial ischemia has a prevalence that reaches 10 million per year, it is likely that many patients with Myocardial ischemia are untreated or undertreated.
What causes myocardial ischemia?
Patients with acute coronary syndromes often present with evidence of coronary artery disease that has been previously unrecognized or not recognized by chest pain and symptoms. Coronary angiography can detect coronary artery disease without coronary angiography and can exclude other pathologies as the cause of complaints.
Can myocardial ischemia be cured?
Many patients with myocardial ischemia show good long-term results. The high degree of ischemic heart disease is likely to be the cause of their frequent adverse cardiac events. In these patients, aggressive risk factor modification has potential to reduce morbidity and mortality, possibly with resultant improvement in quality of life.
Does post-pci ffr improve quality of life for those with myocardial ischemia?
Post-PCI ffr did reduce angina episodes and improves patient mental health and emotional wellbeing, independent of coronary artery treatment type. The impact of PCI ffr on emotional health and patient perceived health was the subject of some debate during this study. Although the differences in the ffr group were not large, the differences were statistically significant and could be of significant clinical relevance. Findings from a recent study could be explained by a reduction in angina episodes but the underlying mechanism is not known.
Does myocardial ischemia run in families?
Familial history is a strong predictor of ischemia. Because a family history of ischemia was found to be significant even when all other risk factors were fully controlled for family history of IHD is a strong indicator that some of the risk may be hereditable.
What is post-pci ffr?
(1) post-PCI ffr and in-hospital mortality are associated with worse clinical outcomes after CABG; (2) the association with mortality persists for 1 year after discharge, and it is related to the severity of coronary arteries disease and impaired left ventricular function; (3) post-PCI ffl may help define, during follow-up, those patients at risk of worse outcomes.
Is post-pci ffr typically used in combination with any other treatments?
This analysis suggests the importance of using a complete revascularization protocol after a ST-elevation MI. Post-PCI ffr seems to be effective in combination with standard treatment in the acute setting. The benefit in the chronic setting is less clear.
What is the latest research for myocardial ischemia?
There are many different ways that clinicians and patients alike can manage and help treat myocardial ischemia. Physicians should take the opportunity to use these resources to the full with people who suffer with ischemic heart disease. This review will help physicians begin to recognize the resources they may already have available as well as the resources they may begin to look for. This review helps physicians recognize and prioritize which resources to use.
Has post-pci ffr proven to be more effective than a placebo?
On the basis of the current results, no difference was detectable between rTPA and a placebo when used to treat infarcts in patients with complete thrombolysis, i.e., a TIMI 3 grade on initial imaging.