Polymyxin B Sulfate

Q: What is polymyxin B sulfate drops used for?

<p>This medicine is a combination of two <a href="https://www.withpower.com/clinical-trials/antibiotics">antibiotics</a>, polymyxin B and trimethoprim, and is used to treat eye infections, including acute bacterial conjunctivitis and blepharoconjunctivitis. This medicine works by killing the bacteria or preventing their growth.</p>

Pseudomonas Infections, Otitis Externa, Klebsiella + 15 more

Treatment

9 FDA approvals

15 Active Studies for Polymyxin B Sulfate

Treatment for

Pseudomonas Infections

What is Polymyxin B Sulfate

Polymyxin BThe Generic name of this drug

Treatment SummaryTrimethoprim is an antibiotic used to treat urinary tract infections. It works by blocking a bacterial enzyme that helps the bacteria produce DNA, which leads to the bacteria's death. Trimethoprim is often used in combination with sulfamethoxazole, but can also be used on its own. It is structurally similar to pyrimethamine, another antibiotic used to treat infections caused by parasites.

Polysporinis the brand name

image of different drug pills on a surface

Polymyxin B Sulfate Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Polysporin

Polymyxin B

1951

279

Approved as Treatment by the FDA

Polymyxin B, commonly known as Polysporin, is approved by the FDA for 9 uses like Meningitis, Bacterial and Conjunctivitis .

Meningitis, Bacterial

Conjunctivitis

Used to treat Ocular Inflammation in combination with Dexamethasone

Ocular Inflammation

Used to treat Ocular Inflammation in combination with Dexamethasone

Bacterial Infections

Urinary Tract Infections

ocular bacterial infections

Used to treat ocular bacterial infections in combination with Bacitracin

Bacteremia caused by Enterobacter aerogenes

Pseudomonas Infections

Urinary Tract Infection (UTI)

Effectiveness

How Polymyxin B Sulfate Affects PatientsTrimethoprim helps fight bacterial infections by blocking an essential step in the creation of bacterial proteins and nucleic acids. It is effective against some gram-negative bacteria and certain types of _Staphylococcus_. Sometimes bacteria can become resistant to trimethoprim, either by changing their cell wall, overproducing an enzyme, or making a resistant form of the enzyme. Taking trimethoprim can very rarely cause blood disorders like low platelet count or low white blood cell count. Signs like fever, sore throat, and pale skin may happen before the blood disorder develops. To make sure this drug will work, local antibiotic

How Polymyxin B Sulfate works in the bodyTrimethoprim works to kill bacteria by stopping them from making the proteins and nucleic acids they need to survive. It does this by blocking an enzyme in the process of making these molecules. When used alone, trimethoprim can only stop bacteria from reproducing, but when combined with sulfamethoxazole, the two work together to actually kill the bacteria. This combination blocks two steps in the process of making proteins and nucleic acids, making it much more effective than trimethoprim alone.

When to interrupt dosage

The proposed measure of Polymyxin B Sulfate is contingent upon the determined condition, for example Urinary tract infection, Immunocompromised and Pneumocystis Jirovecii Pneumonia. The dosage also varies as indicated by the delivery approach (e.g. Tablet - Oral or Tablet) listed in the table following.

Condition

Dosage

Administration

Klebsiella

, 100000.0 [USP'U]/mL, 5.0 [USP'U]/mg, 10.0 [USP'U]/mg, 10.0 [iU]/mg, 5.0 [iU]/mg, 200000.0 [USP'U]/mL, 10000.0 [USP'U]/mL, 1.0 [USP'U]/mg, 10000.0 units/mL, 10000.0 mL/mL, 10.0 mg/mg, 10000.0 mg/mL, 500000.0 [iU], 500000.0 [USP'U], 10.0 units/mg, 5000.0 [USP'U], 5.0 units/mg, 5.3228 [iU]/mg, 10000.0 [iU]/mL, 200000.0 [iU]/mL, 0.5 units/mg, 0.0052 mg/mg, 1.0 [iU]/mg, 16250.0 units/mL, 1500.0 units, 50.0 [iU]/mg, 0.01 mg/mg, 0.1 [USP'U]/mg, 10000.0 mg/mg, 50.0 mg, 500000.0 units, 0.77 mg/mL, 5000.0 units/mL, 15.0 [USP'U]/mg, 0.006 mg/mg, 6.0 units/mg, 6000.0 units/mL, 200000.0 units/mL, 1.0 units/mg

Ophthalmic, , Solution / drops - Ophthalmic, Topical, Ointment - Topical, Cream - Topical, Ointment - Ophthalmic, Irrigant - Irrigation, Irrigation, Suspension / drops - Auricular (otic), Auricular (otic), Solution / drops - Auricular (otic), Suspension / drops - Ophthalmic, Suspension - Ophthalmic, Solution - Ophthalmic, Intramuscular; Intrathecal; Intravenous; Ophthalmic, Injection, powder, for solution - Intramuscular; Intrathecal; Intravenous; Ophthalmic, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intrathecal; Intravenous; Ophthalmic, Intramuscular; Intravenous, Solution - Irrigation, Stick - Topical, Suspension - Auricular (otic), Powder - Topical, Solution - Auricular (otic), Liquid - Auricular (otic), Cream, Kit, Injection, solution - Intramuscular; Intrathecal; Intravenous; Ophthalmic, Intramuscular; Intrathecal; Intravenous, Intramuscular; Intrathecal; Intravenous; Respiratory (inhalation); Topical, Powder, Ointment, Injection, Solution / drops, Suspension, Kit - Topical, Injection, powder, for solution, Lozenge - Oral, Suspension / drops, Liquid - Ophthalmic, Solution, Lozenge, Gel - Topical, Oral, Solution - Auricular (otic); Ophthalmic, Stick, Liquid, Buccal, Auricular (otic); Ophthalmic, Ointment - Ophthalmic; Topical, Lozenge - Buccal, Ophthalmic; Topical, Injection - Intramuscular; Intrathecal; Intravenous, Solution / drops - Auricular (otic); Ophthalmic, Powder, for solution, Injection, powder, lyophilized, for solution, Ointment; Swab - Topical, Injection, solution, Powder, for solution - Intramuscular; Intrathecal; Intravenous; Respiratory (inhalation); Topical, Gel, Kit - Oral; Topical, Swab - Topical, Ointment; Swab, Suspension - Topical, Oral; Topical, Liquid - Auricular (otic); Ophthalmic, Powder, for solution - Intramuscular; Intrathecal; Intravenous; Ophthalmic, Irrigant, Swab, Solution - Urethral, Urethral, Injection, powder, lyophilized, for solution - Intramuscular; Intrathecal; Intravenous, Irrigation; Ophthalmic; Topical, Kit - Irrigation; Ophthalmic; Respiratory (inhalation); Topical, Irrigation; Ophthalmic; Respiratory (inhalation); Topical, Kit - Irrigation; Ophthalmic; Topical, Kit - Ophthalmic, Kit - Ophthalmic; Topical, Ophthalmic; Respiratory (inhalation); Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Electro-osmosis, Kit - Ophthalmic; Respiratory (inhalation); Topical, Kit - Electro-osmosis, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Irrigation; Ophthalmic; Oral; Respiratory (inhalation); Topical, Irrigation; Oral; Respiratory (inhalation); Topical, Kit - Irrigation; Oral; Respiratory (inhalation); Topical, Irrigation; Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Ophthalmic; Oral; Topical, Ophthalmic; Oral; Topical, Kit - Respiratory (inhalation); Topical, Respiratory (inhalation); Topical, Oral; Respiratory (inhalation); Topical, Kit - Oral; Respiratory (inhalation); Topical, Suspension / drops - Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated

Otorrhoea

Meningitis caused by Haemophilus influenzae

ocular bacterial infections

Urinary Tract Infection (UTI)

Conjunctivitis, Bacterial

Otitis Externa

Ear Inflammation

Conjunctivitis

Otitis

Bacteria

Meningitis, Bacterial

Communicable Diseases

Conjunctivitis

Urinary Tract Infections

Bacteremia caused by Enterobacter aerogenes

Pseudomonas Infections

Urinary tract infection

Warnings

Polymyxin B Sulfate has eight contraindications and should not be combined with any of the situations outlined in the table below.Polymyxin B Sulfate Contraindications

Condition

Risk Level

Notes

conjunctiva

Do Not Combine

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Polymyxin B Sulfate.

Common Polymyxin B Sulfate Drug Interactions

Drug Name

Risk Level

Description

Vibrio cholerae CVD 103-HgR strain live antigen

Major

The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Polymyxin B.

Naxitamab

Minor

Polymyxin B may increase the neurotoxic activities of Naxitamab.

Typhoid vaccine

Minor

The therapeutic efficacy of Typhoid vaccine can be decreased when used in combination with Polymyxin B.

(R)-warfarin

Moderate

The risk or severity of bleeding can be increased when Polymyxin B is combined with (R)-warfarin.

(S)-Warfarin

Moderate

The risk or severity of bleeding can be increased when Polymyxin B is combined with (S)-Warfarin.

Polymyxin B Sulfate Toxicity & Overdose RiskIn mice and rats, the lowest toxic dose of trimethoprim is 2764 mg/kg and greater than 5300 mg/kg, respectively. If someone takes a higher dose than 1 gram, they may feel nausea, vomiting, dizziness, headaches, mental depression, confusion, or bone marrow issues. To treat this, supportive care and stomach pumping should be given. Increasing the acidity of the urine may help rid the body of the drug and hemodialysis can also be used, though it is not very effective.

Polymyxin B Sulfate Novel Uses: Which Conditions Have a Clinical Trial Featuring Polymyxin B Sulfate?

8 active clinical trials are currently underway to assess the utility of Polymyxin B Sulfate in treating Shigella flexneri-induced Enteritis, Bacterial-induced Blepharoconjunctivitis and Diarrhea.

Condition

Clinical Trials

Trial Phases

Otitis

2 Actively Recruiting

Not Applicable

Urinary Tract Infections

4 Actively Recruiting

Not Applicable, Phase 4

Urinary Tract Infection (UTI)

9 Actively Recruiting

Phase 1, Phase 3, Phase 4, Not Applicable

Bacteria

0 Actively Recruiting

Communicable Diseases

0 Actively Recruiting

Meningitis, Bacterial

0 Actively Recruiting

Otitis Externa

0 Actively Recruiting

Pseudomonas Infections

0 Actively Recruiting

ocular bacterial infections

0 Actively Recruiting

Urinary tract infection

0 Actively Recruiting

Conjunctivitis, Bacterial

0 Actively Recruiting

Conjunctivitis

0 Actively Recruiting

Klebsiella

0 Actively Recruiting

Ear Inflammation

0 Actively Recruiting

Meningitis caused by Haemophilus influenzae

0 Actively Recruiting

Conjunctivitis

0 Actively Recruiting

Otorrhoea

0 Actively Recruiting

Bacteremia caused by Enterobacter aerogenes

0 Actively Recruiting

Polymyxin B Sulfate Reviews: What are patients saying about Polymyxin B Sulfate?

5Patient Review

9/20/2020

Polymyxin B Sulfate for Pink Eye from Bacterial Infection

I had conjunctivitis with blurry vision for four days, then I started taking this medication. I am at almost 100% recovery after 48 hours. Very pleased.

5Patient Review

10/7/2017

Polymyxin B Sulfate for Pink Eye from Bacterial Infection

Though this medication is intended for children, it can be used on adults with similar reactions such as itching, swelling and pain.

5Patient Review

12/1/2017

Polymyxin B Sulfate for Pink Eye from Bacterial Infection

This treatment was very easy to use and I didn't experience any pain at all.

4.3Patient Review

8/31/2017

Polymyxin B Sulfate for Inflammation of Eyelid Edges and the Lining of the Eye

It took a little longer to work than I would have liked, but it did the job perfectly. There was some redness in my eye for a few days afterwards, but that cleared up within a week.

2.7Patient Review

11/14/2019

Polymyxin B Sulfate for Pink Eye from Bacterial Infection

Ever since my daughter started using this medication, she's been complaining of more burning and stinging in her eyes. She's also having difficulty seeing.

View All Reviews

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Patient Q&A Section about polymyxin b sulfate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How long does polymyxin take to work for pink eye?

"If your pink eye is caused by bacteria, it will improve within 24-48 hours of taking antibiotics. If it is caused by a virus, it may take a few days to more than a week to resolve."

Answered by AI

What are the side effects of polymyxin eye drops?

"Please seek medical help if you experience any of the following symptoms: severe eye pain, swelling, or redness; crusting or drainage (which may be signs of infection); swelling or redness of your eyelids; or new or worsening symptoms."

Answered by AI

What is polymyxin B sulfate drops used for?

"This medicine is a combination of two antibiotics, polymyxin B and trimethoprim, and is used to treat eye infections, including acute bacterial conjunctivitis and blepharoconjunctivitis. This medicine works by killing the bacteria or preventing their growth."

Answered by AI

Is polymyxin B sulfate used for pink eye?

"Polymyxin B and trimethoprim ophthalmic combination are used to treat bacterial infections of the eye, including conjunctivitis (pinkeye; infection of the membrane that covers the outside of the eyeball and the inside of the eyelid) or blepharoconjunctivitis (infection of the membrane that covers the outside of the eyelid and the inner surface of the eyelid)."

Answered by AI

Clinical Trials for Polymyxin B Sulfate

Have you considered Polymyxin B Sulfate clinical trials? We made a collection of clinical trials featuring Polymyxin B Sulfate, we think they might fit your search criteria.

Have you considered Polymyxin B Sulfate clinical trials? We made a collection of clinical trials featuring Polymyxin B Sulfate, we think they might fit your search criteria.