Polymyxin B Sulfate

Q: What is polymyxin B sulfate drops used for?

<p>This medicine is a combination of two <a href="https://www.withpower.com/clinical-trials/antibiotics">antibiotics</a>, polymyxin B and trimethoprim, and is used to treat eye infections, including acute bacterial conjunctivitis and blepharoconjunctivitis. This medicine works by killing the bacteria or preventing their growth.</p>

Pseudomonas Infections, Otitis Externa, Klebsiella + 15 more

Treatment

9 FDA approvals

18 Active Studies for Polymyxin B Sulfate

Treatment for

Pseudomonas Infections

What is Polymyxin B Sulfate

Polymyxin BThe Generic name of this drug

Treatment SummaryTrimethoprim is an antibiotic used to treat urinary tract infections. It works by blocking a bacterial enzyme that helps the bacteria produce DNA, which leads to the bacteria's death. Trimethoprim is often used in combination with sulfamethoxazole, but can also be used on its own. It is structurally similar to pyrimethamine, another antibiotic used to treat infections caused by parasites.

Polysporinis the brand name

image of different drug pills on a surface

Polymyxin B Sulfate Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Polysporin

Polymyxin B

1951

279

Approved as Treatment by the FDA

Polymyxin B, commonly known as Polysporin, is approved by the FDA for 9 uses like Meningitis, Bacterial and Conjunctivitis .

Meningitis, Bacterial

Conjunctivitis

Used to treat Ocular Inflammation in combination with Dexamethasone

Ocular Inflammation

Used to treat Ocular Inflammation in combination with Dexamethasone

Bacterial Infections

Urinary Tract Infections

ocular bacterial infections

Used to treat ocular bacterial infections in combination with Bacitracin

Bacteremia caused by Enterobacter aerogenes

Pseudomonas Infections

Urinary Tract Infection (UTI)

Effectiveness

How Polymyxin B Sulfate Affects PatientsTrimethoprim helps fight bacterial infections by blocking an essential step in the creation of bacterial proteins and nucleic acids. It is effective against some gram-negative bacteria and certain types of _Staphylococcus_. Sometimes bacteria can become resistant to trimethoprim, either by changing their cell wall, overproducing an enzyme, or making a resistant form of the enzyme. Taking trimethoprim can very rarely cause blood disorders like low platelet count or low white blood cell count. Signs like fever, sore throat, and pale skin may happen before the blood disorder develops. To make sure this drug will work, local antibiotic

How Polymyxin B Sulfate works in the bodyTrimethoprim works to kill bacteria by stopping them from making the proteins and nucleic acids they need to survive. It does this by blocking an enzyme in the process of making these molecules. When used alone, trimethoprim can only stop bacteria from reproducing, but when combined with sulfamethoxazole, the two work together to actually kill the bacteria. This combination blocks two steps in the process of making proteins and nucleic acids, making it much more effective than trimethoprim alone.

When to interrupt dosage

The proposed measure of Polymyxin B Sulfate is contingent upon the determined condition, for example Urinary tract infection, Immunocompromised and Pneumocystis Jirovecii Pneumonia. The dosage also varies as indicated by the delivery approach (e.g. Tablet - Oral or Tablet) listed in the table following.

Condition

Dosage

Administration

Urinary tract infection

, 100000.0 [USP'U]/mL, 5.0 [USP'U]/mg, 10.0 [USP'U]/mg, 10.0 [iU]/mg, 5.0 [iU]/mg, 200000.0 [USP'U]/mL, 10000.0 [USP'U]/mL, 1.0 [USP'U]/mg, 10000.0 units/mL, 10000.0 mL/mL, 10.0 mg/mg, 10000.0 mg/mL, 500000.0 [iU], 500000.0 [USP'U], 10.0 units/mg, 5000.0 [USP'U], 5.0 units/mg, 5.3228 [iU]/mg, 10000.0 [iU]/mL, 200000.0 [iU]/mL, 0.5 units/mg, 0.0052 mg/mg, 1.0 [iU]/mg, 16250.0 units/mL, 1500.0 units, 50.0 [iU]/mg, 0.01 mg/mg, 0.1 [USP'U]/mg, 10000.0 mg/mg, 50.0 mg, 500000.0 units, 0.77 mg/mL, 5000.0 units/mL, 15.0 [USP'U]/mg, 0.006 mg/mg, 6.0 units/mg, 6000.0 units/mL, 200000.0 units/mL, 1.0 units/mg

Ophthalmic, Solution / drops - Ophthalmic, Topical, Ointment - Topical, , Cream - Topical, Ointment - Ophthalmic, Irrigant - Irrigation, Irrigation, Suspension / drops - Auricular (otic), Auricular (otic), Solution / drops - Auricular (otic), Suspension / drops - Ophthalmic, Suspension - Ophthalmic, Solution - Ophthalmic, Intramuscular; Intrathecal; Intravenous; Ophthalmic, Injection, powder, lyophilized, for solution - Intramuscular; Intrathecal; Intravenous; Ophthalmic, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Solution - Irrigation, Stick - Topical, Suspension - Auricular (otic), Powder - Topical, Solution - Auricular (otic), Liquid - Auricular (otic), Cream, Kit, Injection, solution - Intramuscular; Intrathecal; Intravenous; Ophthalmic, Intramuscular; Intrathecal; Intravenous, Intramuscular; Intrathecal; Intravenous; Respiratory (inhalation); Topical, Ointment, Kit - Topical, Liquid - Ophthalmic, Solution / drops, Solution, Suspension, Suspension / drops, Lozenge, Gel - Topical, Liquid, Buccal, Auricular (otic); Ophthalmic, Ointment - Ophthalmic; Topical, Lozenge - Oral, Lozenge - Buccal, Oral, Injection - Intramuscular; Intrathecal; Intravenous, Solution / drops - Auricular (otic); Ophthalmic, Powder, for solution, Injection, powder, lyophilized, for solution, Injection, powder, for solution - Intramuscular; Intrathecal; Intravenous; Ophthalmic, Ointment; Swab - Topical, Intramuscular; Intravenous, Powder, Injection, Injection, powder, for solution, Solution - Auricular (otic); Ophthalmic, Stick, Ophthalmic; Topical, Injection, solution, Powder, for solution - Intramuscular; Intrathecal; Intravenous; Respiratory (inhalation); Topical, Kit - Oral; Topical, Oral; Topical, Gel, Swab - Topical, Ointment; Swab, Suspension - Topical, Powder, for solution - Intramuscular; Intrathecal; Intravenous; Ophthalmic, Swab, Irrigant, Liquid - Auricular (otic); Ophthalmic, Solution - Urethral, Urethral, Injection, powder, lyophilized, for solution - Intramuscular; Intrathecal; Intravenous, Kit - Irrigation; Ophthalmic; Respiratory (inhalation); Topical, Irrigation; Ophthalmic; Respiratory (inhalation); Topical, Kit - Irrigation; Ophthalmic; Topical, Irrigation; Ophthalmic; Topical, Kit - Ophthalmic, Electro-osmosis, Kit - Ophthalmic; Topical, Kit - Electro-osmosis, Kit - Ophthalmic; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Respiratory (inhalation); Topical, Kit - Irrigation; Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Irrigation; Oral; Respiratory (inhalation); Topical, Irrigation; Oral; Respiratory (inhalation); Topical, Irrigation; Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Topical, Kit - Ophthalmic; Oral; Topical, Kit - Respiratory (inhalation); Topical, Respiratory (inhalation); Topical, Oral; Respiratory (inhalation); Topical, Kit - Oral; Respiratory (inhalation); Topical, Suspension / drops - Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated

Otitis

Pseudomonas Infections

Klebsiella

Otorrhoea

Urinary Tract Infections

Conjunctivitis, Bacterial

Conjunctivitis

Bacteria

Meningitis, Bacterial

Bacteremia caused by Enterobacter aerogenes

Communicable Diseases

Otitis Externa

Ear Inflammation

Conjunctivitis

Meningitis caused by Haemophilus influenzae

ocular bacterial infections

Urinary Tract Infection (UTI)

Warnings

Polymyxin B Sulfate has eight contraindications and should not be combined with any of the situations outlined in the table below.Polymyxin B Sulfate Contraindications

Condition

Risk Level

Notes

conjunctiva

Do Not Combine

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Polymyxin B Sulfate.

Common Polymyxin B Sulfate Drug Interactions

Drug Name

Risk Level

Description

Vibrio cholerae CVD 103-HgR strain live antigen

Major

The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Polymyxin B.

Naxitamab

Minor

Polymyxin B may increase the neurotoxic activities of Naxitamab.

Typhoid vaccine

Minor

The therapeutic efficacy of Typhoid vaccine can be decreased when used in combination with Polymyxin B.

(R)-warfarin

Moderate

The risk or severity of bleeding can be increased when Polymyxin B is combined with (R)-warfarin.

(S)-Warfarin

Moderate

The risk or severity of bleeding can be increased when Polymyxin B is combined with (S)-Warfarin.

Polymyxin B Sulfate Toxicity & Overdose RiskIn mice and rats, the lowest toxic dose of trimethoprim is 2764 mg/kg and greater than 5300 mg/kg, respectively. If someone takes a higher dose than 1 gram, they may feel nausea, vomiting, dizziness, headaches, mental depression, confusion, or bone marrow issues. To treat this, supportive care and stomach pumping should be given. Increasing the acidity of the urine may help rid the body of the drug and hemodialysis can also be used, though it is not very effective.

Polymyxin B Sulfate Novel Uses: Which Conditions Have a Clinical Trial Featuring Polymyxin B Sulfate?

8 active clinical trials are currently underway to assess the utility of Polymyxin B Sulfate in treating Shigella flexneri-induced Enteritis, Bacterial-induced Blepharoconjunctivitis and Diarrhea.

Condition

Clinical Trials

Trial Phases

Otitis

3 Actively Recruiting

Not Applicable

Urinary Tract Infections

7 Actively Recruiting

Not Applicable, Phase 4

Urinary Tract Infection (UTI)

6 Actively Recruiting

Phase 1, Phase 3, Phase 4, Phase 2

Bacteria

2 Actively Recruiting

Phase 3

Communicable Diseases

0 Actively Recruiting

Meningitis, Bacterial

0 Actively Recruiting

Pseudomonas Infections

0 Actively Recruiting

Otitis Externa

0 Actively Recruiting

ocular bacterial infections

0 Actively Recruiting

Urinary tract infection

0 Actively Recruiting

Conjunctivitis, Bacterial

0 Actively Recruiting

Conjunctivitis

0 Actively Recruiting

Klebsiella

0 Actively Recruiting

Ear Inflammation

0 Actively Recruiting

Meningitis caused by Haemophilus influenzae

0 Actively Recruiting

Conjunctivitis

0 Actively Recruiting

Otorrhoea

0 Actively Recruiting

Bacteremia caused by Enterobacter aerogenes

0 Actively Recruiting

Polymyxin B Sulfate Reviews: What are patients saying about Polymyxin B Sulfate?

5Patient Review

9/20/2020

Polymyxin B Sulfate for Pink Eye from Bacterial Infection

I had conjunctivitis with blurry vision for four days, then I started taking this medication. I am at almost 100% recovery after 48 hours. Very pleased.

5Patient Review

10/7/2017

Polymyxin B Sulfate for Pink Eye from Bacterial Infection

Though this medication is intended for children, it can be used on adults with similar reactions such as itching, swelling and pain.

5Patient Review

12/1/2017

Polymyxin B Sulfate for Pink Eye from Bacterial Infection

This treatment was very easy to use and I didn't experience any pain at all.

4.3Patient Review

8/31/2017

Polymyxin B Sulfate for Inflammation of Eyelid Edges and the Lining of the Eye

It took a little longer to work than I would have liked, but it did the job perfectly. There was some redness in my eye for a few days afterwards, but that cleared up within a week.

2.7Patient Review

11/14/2019

Polymyxin B Sulfate for Pink Eye from Bacterial Infection

Ever since my daughter started using this medication, she's been complaining of more burning and stinging in her eyes. She's also having difficulty seeing.

2.7Patient Review

11/25/2018

Polymyxin B Sulfate for Pink Eye from Bacterial Infection

I've been using this medication for five days now, and I'm still experiencing itchy eyes and dry, blotchy skin around my eyes. This product hasn't worked well for me so far.

2.3Patient Review

9/5/2017

Polymyxin B Sulfate for Pink Eye from Bacterial Infection

Three days in and my vision seems to have gotten worse. I'm missing work as a result, which is extremely frustrating. I'll be calling the doctor today for something else entirely.

2Patient Review

9/2/2020

Polymyxin B Sulfate for Eye infection Caused by Bacteria

Unfortunately, I had really adverse reactions to this medication. Burning, itching, blurred vision, and redness were all problems I experienced shortly after using the drops. These reactions were far from mild.

2Patient Review

6/14/2018

Polymyxin B Sulfate for Pink Eye from Bacterial Infection

The sulfuric acid in this medication caused burning around my eyes. I had to get a different prescription which cleared the infection in five days.

2Patient Review

2/19/2018

Polymyxin B Sulfate for Pink Eye from Bacterial Infection

The burning and itching got so bad after just three days of using this drug that I had to stop. It was horrible and did nothing to help my pink eye. Avoid this treatment at all cost.

2Patient Review

3/5/2018

Polymyxin B Sulfate for Pink Eye from Bacterial Infection

I've been on this medication for two days now and have yet to see any improvement.

1.7Patient Review

2/7/2020

Polymyxin B Sulfate for Pink Eye from Bacterial Infection

Unfortunately, after using this treatment for just two days, my eyes became more irritated. They were swollen and red, itchy, and crusty.

1.3Patient Review

8/24/2017

Polymyxin B Sulfate for Pink Eye from Bacterial Infection

My eyes felt incredibly irritated after using this product for just a few days.

1Patient Review

7/24/2019

Polymyxin B Sulfate for Pink Eye from Bacterial Infection

This pink eye medication is terrible. If anything, it made my symptoms worse. Avoid if you can.

1Patient Review

9/5/2020

Polymyxin B Sulfate for Pink Eye from Bacterial Infection

I had an allergic reaction to this that led to burning and itching all over my body.

1Patient Review

7/24/2019

Polymyxin B Sulfate for Pink Eye from Bacterial Infection

This pink eye medication is awful. My eyes are more itchy and irritated than before, and it doesn't help at all. It just makes the Pink Eye worse by drying out my eyes.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about polymyxin b sulfate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How long does polymyxin take to work for pink eye?

"If your pink eye is caused by bacteria, it will improve within 24-48 hours of taking antibiotics. If it is caused by a virus, it may take a few days to more than a week to resolve."

Answered by AI

What are the side effects of polymyxin eye drops?

"Please seek medical help if you experience any of the following symptoms: severe eye pain, swelling, or redness; crusting or drainage (which may be signs of infection); swelling or redness of your eyelids; or new or worsening symptoms."

Answered by AI

What is polymyxin B sulfate drops used for?

"This medicine is a combination of two antibiotics, polymyxin B and trimethoprim, and is used to treat eye infections, including acute bacterial conjunctivitis and blepharoconjunctivitis. This medicine works by killing the bacteria or preventing their growth."

Answered by AI

Is polymyxin B sulfate used for pink eye?

"Polymyxin B and trimethoprim ophthalmic combination are used to treat bacterial infections of the eye, including conjunctivitis (pinkeye; infection of the membrane that covers the outside of the eyeball and the inside of the eyelid) or blepharoconjunctivitis (infection of the membrane that covers the outside of the eyelid and the inner surface of the eyelid)."

Answered by AI

Clinical Trials for Polymyxin B Sulfate

Image of Baylor College of Medicine in Houston, United States.

Educational Tool for Urinary Tract Infections

18+

All Sexes

Houston, TX

Urine culture is the most common microbiological test in the outpatient setting in the United States. Unfortunately, contamination during collection is prevalent and undermines test accuracy, leading to incorrect diagnosis, unnecessary treatment, wasted laboratory resources, and inflated costs. Unnecessary antibiotic treatment increases the risk of developing antimicrobial resistance, one of the most serious threats to patients and public health. The goal of this clinical trial is to test whether a bilingual (English and Spanish) educational intervention, an animated video and pictorial flyer, can reduce urine culture contamination and associated inappropriate antibiotic use in adult patients visiting safety-net primary care clinics. The main questions it aims to answer are: 1. Does providing patients with a bilingual educational intervention reduce urine culture contamination rates? 2. Does the intervention lead to fewer unnecessary urinary antibiotic prescriptions? 3. Does providing patients with a bilingual educational intervention reduce contaminated urinalyses? Researchers will compare patients randomized to receive the educational intervention (video and flyer) to those receiving usual care to see if the intervention improves urine collection accuracy and reduces inappropriate antibiotic use. Participants will watch a short, animated video with step-by-step instructions for proper midstream clean-catch urine (MSCC) collection, receive a pictorial flyer (with stills from the video) reinforcing the instructions, and provide a urine sample for culture. For our hypothesis, patients who receive the educational intervention will have: lower urine culture contamination rates (primary outcome), fewer urinary antibiotic prescriptions (secondary outcome), and fewer contaminated urinalyses (secondary outcome). The objectives are to (1) develop educational tools: Create an animated video and pictorial flyer with step-by-step urine collection instructions for women and men, developed through an iterative, stakeholder-engaged process, (2) assess acceptability: Use mixed methods (quantitative surveys and qualitative interviews) to evaluate and refine the tools for usability and cultural/linguistic appropriateness, and (3) test effectiveness: Conduct a randomized controlled trial to assess the intervention's impact on urine contamination rates, antibiotic prescribing, and patient satisfaction.

Waitlist Available

Has No Placebo

Baylor College of MedicineLarissa Grigoryan, MD, PhD

Have you considered Polymyxin B Sulfate clinical trials? We made a collection of clinical trials featuring Polymyxin B Sulfate, we think they might fit your search criteria.

Have you considered Polymyxin B Sulfate clinical trials? We made a collection of clinical trials featuring Polymyxin B Sulfate, we think they might fit your search criteria.

Image of University of Missouri in Columbia, United States.

Antibiotics for Cat Bite Injuries

18+

All Sexes

Columbia, MO

Cat bites are puncture wounds that have the potential to seed bacteria deep within the joint capsule, periosteum, and bone. The hand is the most common site of bite injuries. Pasteurella multocida is the is the most common organism isolated from the mouths of cats that can cause infections after a bite. Prophylactic antibiotics are often recommended with amoxicillin-clavulanate for 3-5 days to decrease the incidence of developing an infection. However, only one randomized controlled clinical trial consisting of 12 patients has been performed to justify this course of treatment, raising the possibility that the use of antibiotics could be reduced or even eliminated. Investigators will compare different durations of prophylactic antibiotics and a placebo control for cat bites to the hand/forearm presenting to the Emergency Department, Urgent Care, Plastic Surgery Clinic using a randomized, controlled, double-blind clinical trial. Participants presenting to the University of Missouri Hospital Emergency Department, Missouri University (MU) Healthcare Urgent Care, Plastic Surgery Clinic over the next year will be offered the chance to enroll if they meet the inclusion/exclusion criteria. For inclusion, participants will be \>18 years of age, have cat bites to the hand or distal to elbow, and present within 24 hours of the cat bite injury. Participants must not present with active local or systemic infections, have received antibiotics within the past 30 days, or be immunocompromised (primary and secondary immunodeficiencies). Participants will be randomized to one of three treatment arms (placebo; amoxicillin-clavulanate 1 day; amoxicillin-clavulanate 5 days). Outcomes are the development of an infection at the location of the cat bite and/or systemic infection, adverse effects of interventions, disability assessed by Quick Disabilities of Arm, Shoulder and Hand (QuickDASH) scores, and quality of life (QOL) assessed by HAND Questionnaire (HAND-Q) scores. Infection will be assessed at day 0, day 2, day 7+/-2, day 14+/-2, and day 30+/-2 by vital signs, laboratory values, physical examination and with an infrared and digital camera. All measures will be within the standard of care, apart from the infrared camera, QuickDASH, and HAND-Q scores. The anatomic locations of cat bites to the hand/forearm will be assessed for correlations with infections.

Phase 4

Recruiting

Paid Trial

University of MissouriKevin M Klifto, DO, PharmD

Have you considered Polymyxin B Sulfate clinical trials? We made a collection of clinical trials featuring Polymyxin B Sulfate, we think they might fit your search criteria.