What is Plendil
FelodipineThe Generic name of this drug
Treatment SummaryFelodipine is a medication used to lower blood pressure. It works by blocking calcium channels in the blood vessels, which helps to relax the blood vessels and reduce blood pressure. Felodipine is more powerful than other calcium channel blockers and it has some additional effects, such as binding to a number of proteins and mineralcorticoid receptor. It is used to treat mild to moderate essential hypertension.
Plendilis the brand name
Plendil Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Plendil
Felodipine
1991
122
Approved as Treatment by the FDA
Felodipine, also known as Plendil, is approved by the FDA for 1 uses including Hypertensive disease .Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Effectiveness
How Plendil Affects PatientsFelodipine is a type of calcium channel blocker, a medicine used to reduce blood pressure. Felodipine targets multiple components in the body, including L-type calcium channels, T-type calcium channels, calmodulin, mineralcorticoid receptors, and troponin C. It also binds to inactive calcium channels to keep them from activating, making it more effective in artery smooth muscle cells. At regular doses, felodipine does not affect cardiac and conduction cells in the body.
How Plendil works in the bodyFelodipine relaxes the muscles of your blood vessels, allowing them to widen, or dilate. This lowers your blood pressure and helps treat essential hypertension. It works by blocking calcium from entering the cells of your blood vessels. Calcium is needed for muscles to contract and by blocking it, felodipine causes the muscles to relax and the vessels to widen.
When to interrupt dosage
The measure of Plendil is subject to the diagnosed condition. The quantity of dosage likewise varies as per the technique of delivery listed in the table below.Condition
Dosage
Administration
Hypertensive disease
2.5 mg, , 5.0 mg, 10.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated, extended release - Oral, Tablet, Tablet, film coated - Oral, Tablet - Oral, Tablet, film coated, extended release
previous failed monotherapy
2.5 mg, , 5.0 mg, 10.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated, extended release - Oral, Tablet, Tablet, film coated - Oral, Tablet - Oral, Tablet, film coated, extended release
Warnings
There are 20 known major drug interactions with Plendil.Common Plendil Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Major
The metabolism of (R)-warfarin can be decreased when combined with Felodipine.
(S)-Warfarin
Major
The metabolism of (S)-Warfarin can be decreased when combined with Felodipine.
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Felodipine.
Almotriptan
Major
The metabolism of Almotriptan can be decreased when combined with Felodipine.
Amifostine
Major
Felodipine may increase the hypotensive activities of Amifostine.
Plendil Toxicity & Overdose RiskSigns of an overdose of this drug may include wide blood vessel dilation, low blood pressure, and a slow heartbeat. The lowest toxic dose in rats has been found to be 1050mg/kg.
Plendil Novel Uses: Which Conditions Have a Clinical Trial Featuring Plendil?
18 active research projects are examining the potential of Plendil to be utilized as a treatment option for patients who have failed to respond to previous monotherapy.Condition
Clinical Trials
Trial Phases
previous failed monotherapy
0 Actively Recruiting
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4
Plendil Reviews: What are patients saying about Plendil?
5Patient Review
12/1/2010 I had been on 5mg zestril for months when my BP shot up to 160/80. My doctor added 5mg plendil, which did reduce my BP to 116/74. However, the side effect of plendil was palpitations with a racing heart at 140BPM. I had to be rushed to emergency room.
5Patient Review
10/20/2011 Felodipine has been a godsend for me. After years of struggling with high blood pressure and trying out different medications, this one finally does the trick with no nasty side effects. I highly recommend it!
5Patient Review
4/8/2011 Plendil has been a godsend for me. I've been taking it for over 10 years with no ill effects that I know of.
5Patient Review
6/28/20085Patient Review
9/24/20085Patient Review
1/16/2009 Plendil was dropped by AstraZenica in October. Plendil is no longer supported by that drug company, so I can't get it anymore.
5Patient Review
11/10/2008 This treatment is always effective and I've never had a problem with it.
4.3Patient Review
2/28/2020 The Plendil did not have the desired effect of lowering my blood pressure. In fact, it made my legs and ankles swell painfully. Additionally, I found that my knees started to hurt more and it was difficult to walk or stand for long periods of time.
4.3Patient Review
5/8/2012 This medication has been great in managing my blood pressure. I originally started taking it after an accident where I hit my head.
4.3Patient Review
9/25/2009 I had a slight headache when I first started taking this medication, but it quickly went away and has not returned since.
3.3Patient Review
5/28/2009 I was prescribed this in addition to my Diovan RX for my blood pressure. Unfortunately, not only did it not lower my BP at all, but it also caused an intense headache within an hour of taking it. I gave it a fair chance by sticking it out for three weeks, but there was no improvement.
3.3Patient Review
3/7/2010 The pain relief I experienced from this medication was unfortunately not worth the other issues I had to deal with. These included severe upper arm and shoulder pain, as well as upper right quadrant pain that wrapped around to my kidney area. After stopping the medication for two days, though, all of my pain subsided.
3.3Patient Review
9/23/20083.3Patient Review
5/21/2009 I've been on this medication for seven years and it works great! My blood pressure is always perfect.
2.3Patient Review
5/14/2009 I have used this product for many years and it has always been effective.
1Patient Review
9/2/2019 Recently started taking this medication and have already experienced some negative side-effects, like headaches. That said, my chest pain has vanished and blood pressure has returned to normal. Here's hoping the headaches go away soon.
Patient Q&A Section about plendil
Is Plendil discontinued?
"is the most recent update to this information. The Plendil brand name has been discontinued in the U.S., however, if generic versions of this product have been approved by the FDA, there may be generic equivalents available." - Anonymous Online Contributor
Unverified Answer
What is the best time to take Plendil?
"To treat stable angina, the usual starting dose of Plendil ER is 5 mg taken once a day in the morning. If needed, your doctor may increase the dose to 10 mg once a day." - Anonymous Online Contributor
Unverified Answer
What are the side effects of Plendil?
"You may experience some side effects such as dizziness, lightheadedness, headaches, flushing, or stomach upset as your body adjusts to the medication. However, these side effects should disappear after a few days." - Anonymous Online Contributor
Unverified Answer
What is Plendil used for?
"Felodipine is a calcium channel blocker that is used to treat high blood pressure by relaxing and widening blood vessels so that blood can flow more easily." - Anonymous Online Contributor
Unverified Answer