Phytonadione

Vitamin K deficiency, Hypoprothrombinemia, Fistula, Biliary + 17 more

Treatment

7 FDA approvals

20 Active Studies for Phytonadione

Treatment for

Vitamin K deficiency

What is Phytonadione

PhylloquinoneThe Generic name of this drug

Treatment SummaryVitamin K1, also known as phylloquinone, is a type of fat-soluble vitamin. It helps an enzyme called γ-carboxylase to activate proteins that are needed for blood clotting. Vitamin K1 is used to treat clotting disorders caused by a lack of the vitamin in the body. It has been used since 1939 and was officially approved by the FDA before 1955.

Mephytonis the brand name

image of different drug pills on a surface

Phytonadione Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Mephyton

Phylloquinone

1955

65

Approved as Treatment by the FDA

Phylloquinone, also known as Mephyton, is approved by the FDA for 7 uses including antibacterial therapy and Fistula, Biliary .

antibacterial therapy

Fistula, Biliary

Used to treat Fistula, Biliary in combination with Taurocholic acid

hemorrhagic disease of the newborn

Hemorrhagic Disease of Newborn

Hypoprothrombinemia

Salicylate

Jaundice, Obstructive

Used to treat Jaundice, Obstructive in combination with Taurocholic acid

Effectiveness

How Phytonadione Affects PatientsPhylloquinone is a vitamin K used to treat problems with blood clotting due to a lack of vitamin K or if there is interference with its activity. Vitamin K is cycled through the body, and can usually be taken in large doses without any issues. Prothrombin time should be monitored while taking this medication, and it is important to be aware of the risk of allergic reactions if it is administered through a needle.

How Phytonadione works in the bodyVitamin K helps the body form blood clots when needed. It does this by attaching chemical groups that help proteins bind to calcium. This helps convert certain clotting factors into active form, which works to stop bleeding. Vitamin K may also help prevent joint calcification and increase bone density. Studies are ongoing to determine how Vitamin K impacts osteoarthritis, bone density, and calcification of blood vessels.

When to interrupt dosage

The prescribed dosage of Phytonadione is contingent upon the determined condition, for example Sprue, Vitamin supplementation and Ulcerative Colitis. The measure likewise varies in accordance with the delivery technique indicated in the table below.

Condition

Dosage

Administration

Vitamin supplementation

5.0 mg, 0.2 mg/mL, , 0.2 mg, 0.015 mg/mL, 0.08 mg, 0.15 mg, 0.02 mg, 0.15 mg/mL, 2.0 mg/mL, 10.0 mg/mL, 0.1 mg/mL, 0.02 mg/mL, 1.0 mg

, Injection, solution; Kit, Injection, emulsion, Solution / drops, Oral, Capsule - Oral, Solution / drops - Oral, Intramuscular; Parenteral; Subcutaneous, Injection, Injection, solution; Kit - Intravenous, Injection, solution - Intravenous, Intramuscular; Intravenous; Subcutaneous, Injection, solution, concentrate; Kit - Intravenous, Injection, solution, Kit - Oral, Capsule, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution, concentrate; Kit, Intramuscular, Intravenous, Parenteral, Emulsion, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection - Intravenous, Tablet, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Liquid - Intramuscular, Liquid, Solution - Parenteral, Kit, Injection, emulsion - Parenteral, Tablet - Oral, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Emulsion - Intramuscular; Intravenous; Subcutaneous, Solution - Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Solution

Pancreatic Cystic Fibrosis

5.0 mg, 0.2 mg/mL, , 0.2 mg, 0.015 mg/mL, 0.08 mg, 0.15 mg, 0.02 mg, 0.15 mg/mL, 2.0 mg/mL, 10.0 mg/mL, 0.1 mg/mL, 0.02 mg/mL, 1.0 mg

, Injection, solution; Kit, Injection, emulsion, Solution / drops, Oral, Capsule - Oral, Solution / drops - Oral, Intramuscular; Parenteral; Subcutaneous, Injection, Injection, solution; Kit - Intravenous, Injection, solution - Intravenous, Intramuscular; Intravenous; Subcutaneous, Injection, solution, concentrate; Kit - Intravenous, Injection, solution, Kit - Oral, Capsule, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution, concentrate; Kit, Intramuscular, Intravenous, Parenteral, Emulsion, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection - Intravenous, Tablet, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Liquid - Intramuscular, Liquid, Solution - Parenteral, Kit, Injection, emulsion - Parenteral, Tablet - Oral, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Emulsion - Intramuscular; Intravenous; Subcutaneous, Solution - Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Solution

Jaundice, Obstructive

5.0 mg, 0.2 mg/mL, , 0.2 mg, 0.015 mg/mL, 0.08 mg, 0.15 mg, 0.02 mg, 0.15 mg/mL, 2.0 mg/mL, 10.0 mg/mL, 0.1 mg/mL, 0.02 mg/mL, 1.0 mg

, Injection, solution; Kit, Injection, emulsion, Solution / drops, Oral, Capsule - Oral, Solution / drops - Oral, Intramuscular; Parenteral; Subcutaneous, Injection, Injection, solution; Kit - Intravenous, Injection, solution - Intravenous, Intramuscular; Intravenous; Subcutaneous, Injection, solution, concentrate; Kit - Intravenous, Injection, solution, Kit - Oral, Capsule, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution, concentrate; Kit, Intramuscular, Intravenous, Parenteral, Emulsion, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection - Intravenous, Tablet, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Liquid - Intramuscular, Liquid, Solution - Parenteral, Kit, Injection, emulsion - Parenteral, Tablet - Oral, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Emulsion - Intramuscular; Intravenous; Subcutaneous, Solution - Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Solution

Hemorrhagic Disease of Newborn

5.0 mg, 0.2 mg/mL, , 0.2 mg, 0.015 mg/mL, 0.08 mg, 0.15 mg, 0.02 mg, 0.15 mg/mL, 2.0 mg/mL, 10.0 mg/mL, 0.1 mg/mL, 0.02 mg/mL, 1.0 mg

, Injection, solution; Kit, Injection, emulsion, Solution / drops, Oral, Capsule - Oral, Solution / drops - Oral, Intramuscular; Parenteral; Subcutaneous, Injection, Injection, solution; Kit - Intravenous, Injection, solution - Intravenous, Intramuscular; Intravenous; Subcutaneous, Injection, solution, concentrate; Kit - Intravenous, Injection, solution, Kit - Oral, Capsule, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution, concentrate; Kit, Intramuscular, Intravenous, Parenteral, Emulsion, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection - Intravenous, Tablet, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Liquid - Intramuscular, Liquid, Solution - Parenteral, Kit, Injection, emulsion - Parenteral, Tablet - Oral, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Emulsion - Intramuscular; Intravenous; Subcutaneous, Solution - Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Solution

Sprue

5.0 mg, 0.2 mg/mL, , 0.2 mg, 0.015 mg/mL, 0.08 mg, 0.15 mg, 0.02 mg, 0.15 mg/mL, 2.0 mg/mL, 10.0 mg/mL, 0.1 mg/mL, 0.02 mg/mL, 1.0 mg

, Injection, solution; Kit, Injection, emulsion, Solution / drops, Oral, Capsule - Oral, Solution / drops - Oral, Intramuscular; Parenteral; Subcutaneous, Injection, Injection, solution; Kit - Intravenous, Injection, solution - Intravenous, Intramuscular; Intravenous; Subcutaneous, Injection, solution, concentrate; Kit - Intravenous, Injection, solution, Kit - Oral, Capsule, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution, concentrate; Kit, Intramuscular, Intravenous, Parenteral, Emulsion, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection - Intravenous, Tablet, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Liquid - Intramuscular, Liquid, Solution - Parenteral, Kit, Injection, emulsion - Parenteral, Tablet - Oral, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Emulsion - Intramuscular; Intravenous; Subcutaneous, Solution - Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Solution

Vitamin K deficiency

5.0 mg, 0.2 mg/mL, , 0.2 mg, 0.015 mg/mL, 0.08 mg, 0.15 mg, 0.02 mg, 0.15 mg/mL, 2.0 mg/mL, 10.0 mg/mL, 0.1 mg/mL, 0.02 mg/mL, 1.0 mg

, Injection, solution; Kit, Injection, emulsion, Solution / drops, Oral, Capsule - Oral, Solution / drops - Oral, Intramuscular; Parenteral; Subcutaneous, Injection, Injection, solution; Kit - Intravenous, Injection, solution - Intravenous, Intramuscular; Intravenous; Subcutaneous, Injection, solution, concentrate; Kit - Intravenous, Injection, solution, Kit - Oral, Capsule, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution, concentrate; Kit, Intramuscular, Intravenous, Parenteral, Emulsion, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection - Intravenous, Tablet, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Liquid - Intramuscular, Liquid, Solution - Parenteral, Kit, Injection, emulsion - Parenteral, Tablet - Oral, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Emulsion - Intramuscular; Intravenous; Subcutaneous, Solution - Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Solution

Hypoprothrombinemia

5.0 mg, 0.2 mg/mL, , 0.2 mg, 0.015 mg/mL, 0.08 mg, 0.15 mg, 0.02 mg, 0.15 mg/mL, 2.0 mg/mL, 10.0 mg/mL, 0.1 mg/mL, 0.02 mg/mL, 1.0 mg

, Injection, solution; Kit, Injection, emulsion, Solution / drops, Oral, Capsule - Oral, Solution / drops - Oral, Intramuscular; Parenteral; Subcutaneous, Injection, Injection, solution; Kit - Intravenous, Injection, solution - Intravenous, Intramuscular; Intravenous; Subcutaneous, Injection, solution, concentrate; Kit - Intravenous, Injection, solution, Kit - Oral, Capsule, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution, concentrate; Kit, Intramuscular, Intravenous, Parenteral, Emulsion, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection - Intravenous, Tablet, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Liquid - Intramuscular, Liquid, Solution - Parenteral, Kit, Injection, emulsion - Parenteral, Tablet - Oral, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Emulsion - Intramuscular; Intravenous; Subcutaneous, Solution - Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Solution

Anticoagulant Therapy

5.0 mg, 0.2 mg/mL, , 0.2 mg, 0.015 mg/mL, 0.08 mg, 0.15 mg, 0.02 mg, 0.15 mg/mL, 2.0 mg/mL, 10.0 mg/mL, 0.1 mg/mL, 0.02 mg/mL, 1.0 mg

, Injection, solution; Kit, Injection, emulsion, Solution / drops, Oral, Capsule - Oral, Solution / drops - Oral, Intramuscular; Parenteral; Subcutaneous, Injection, Injection, solution; Kit - Intravenous, Injection, solution - Intravenous, Intramuscular; Intravenous; Subcutaneous, Injection, solution, concentrate; Kit - Intravenous, Injection, solution, Kit - Oral, Capsule, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution, concentrate; Kit, Intramuscular, Intravenous, Parenteral, Emulsion, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection - Intravenous, Tablet, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Liquid - Intramuscular, Liquid, Solution - Parenteral, Kit, Injection, emulsion - Parenteral, Tablet - Oral, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Emulsion - Intramuscular; Intravenous; Subcutaneous, Solution - Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Solution

vitamin K

5.0 mg, 0.2 mg/mL, , 0.2 mg, 0.015 mg/mL, 0.08 mg, 0.15 mg, 0.02 mg, 0.15 mg/mL, 2.0 mg/mL, 10.0 mg/mL, 0.1 mg/mL, 0.02 mg/mL, 1.0 mg

, Injection, solution; Kit, Injection, emulsion, Solution / drops, Oral, Capsule - Oral, Solution / drops - Oral, Intramuscular; Parenteral; Subcutaneous, Injection, Injection, solution; Kit - Intravenous, Injection, solution - Intravenous, Intramuscular; Intravenous; Subcutaneous, Injection, solution, concentrate; Kit - Intravenous, Injection, solution, Kit - Oral, Capsule, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution, concentrate; Kit, Intramuscular, Intravenous, Parenteral, Emulsion, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection - Intravenous, Tablet, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Liquid - Intramuscular, Liquid, Solution - Parenteral, Kit, Injection, emulsion - Parenteral, Tablet - Oral, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Emulsion - Intramuscular; Intravenous; Subcutaneous, Solution - Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Solution

Salicylate

5.0 mg, 0.2 mg/mL, , 0.2 mg, 0.015 mg/mL, 0.08 mg, 0.15 mg, 0.02 mg, 0.15 mg/mL, 2.0 mg/mL, 10.0 mg/mL, 0.1 mg/mL, 0.02 mg/mL, 1.0 mg

, Injection, solution; Kit, Injection, emulsion, Solution / drops, Oral, Capsule - Oral, Solution / drops - Oral, Intramuscular; Parenteral; Subcutaneous, Injection, Injection, solution; Kit - Intravenous, Injection, solution - Intravenous, Intramuscular; Intravenous; Subcutaneous, Injection, solution, concentrate; Kit - Intravenous, Injection, solution, Kit - Oral, Capsule, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution, concentrate; Kit, Intramuscular, Intravenous, Parenteral, Emulsion, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection - Intravenous, Tablet, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Liquid - Intramuscular, Liquid, Solution - Parenteral, Kit, Injection, emulsion - Parenteral, Tablet - Oral, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Emulsion - Intramuscular; Intravenous; Subcutaneous, Solution - Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Solution

Fistula, Biliary

5.0 mg, 0.2 mg/mL, , 0.2 mg, 0.015 mg/mL, 0.08 mg, 0.15 mg, 0.02 mg, 0.15 mg/mL, 2.0 mg/mL, 10.0 mg/mL, 0.1 mg/mL, 0.02 mg/mL, 1.0 mg

, Injection, solution; Kit, Injection, emulsion, Solution / drops, Oral, Capsule - Oral, Solution / drops - Oral, Intramuscular; Parenteral; Subcutaneous, Injection, Injection, solution; Kit - Intravenous, Injection, solution - Intravenous, Intramuscular; Intravenous; Subcutaneous, Injection, solution, concentrate; Kit - Intravenous, Injection, solution, Kit - Oral, Capsule, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution, concentrate; Kit, Intramuscular, Intravenous, Parenteral, Emulsion, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection - Intravenous, Tablet, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Liquid - Intramuscular, Liquid, Solution - Parenteral, Kit, Injection, emulsion - Parenteral, Tablet - Oral, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Emulsion - Intramuscular; Intravenous; Subcutaneous, Solution - Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Solution

Crohn Disease

5.0 mg, 0.2 mg/mL, , 0.2 mg, 0.015 mg/mL, 0.08 mg, 0.15 mg, 0.02 mg, 0.15 mg/mL, 2.0 mg/mL, 10.0 mg/mL, 0.1 mg/mL, 0.02 mg/mL, 1.0 mg

, Injection, solution; Kit, Injection, emulsion, Solution / drops, Oral, Capsule - Oral, Solution / drops - Oral, Intramuscular; Parenteral; Subcutaneous, Injection, Injection, solution; Kit - Intravenous, Injection, solution - Intravenous, Intramuscular; Intravenous; Subcutaneous, Injection, solution, concentrate; Kit - Intravenous, Injection, solution, Kit - Oral, Capsule, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution, concentrate; Kit, Intramuscular, Intravenous, Parenteral, Emulsion, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection - Intravenous, Tablet, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Liquid - Intramuscular, Liquid, Solution - Parenteral, Kit, Injection, emulsion - Parenteral, Tablet - Oral, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Emulsion - Intramuscular; Intravenous; Subcutaneous, Solution - Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Solution

Ulcerative Colitis

5.0 mg, 0.2 mg/mL, , 0.2 mg, 0.015 mg/mL, 0.08 mg, 0.15 mg, 0.02 mg, 0.15 mg/mL, 2.0 mg/mL, 10.0 mg/mL, 0.1 mg/mL, 0.02 mg/mL, 1.0 mg

, Injection, solution; Kit, Injection, emulsion, Solution / drops, Oral, Capsule - Oral, Solution / drops - Oral, Intramuscular; Parenteral; Subcutaneous, Injection, Injection, solution; Kit - Intravenous, Injection, solution - Intravenous, Intramuscular; Intravenous; Subcutaneous, Injection, solution, concentrate; Kit - Intravenous, Injection, solution, Kit - Oral, Capsule, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution, concentrate; Kit, Intramuscular, Intravenous, Parenteral, Emulsion, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection - Intravenous, Tablet, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Liquid - Intramuscular, Liquid, Solution - Parenteral, Kit, Injection, emulsion - Parenteral, Tablet - Oral, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Emulsion - Intramuscular; Intravenous; Subcutaneous, Solution - Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Solution

antibacterial therapy

5.0 mg, 0.2 mg/mL, , 0.2 mg, 0.015 mg/mL, 0.08 mg, 0.15 mg, 0.02 mg, 0.15 mg/mL, 2.0 mg/mL, 10.0 mg/mL, 0.1 mg/mL, 0.02 mg/mL, 1.0 mg

, Injection, solution; Kit, Injection, emulsion, Solution / drops, Oral, Capsule - Oral, Solution / drops - Oral, Intramuscular; Parenteral; Subcutaneous, Injection, Injection, solution; Kit - Intravenous, Injection, solution - Intravenous, Intramuscular; Intravenous; Subcutaneous, Injection, solution, concentrate; Kit - Intravenous, Injection, solution, Kit - Oral, Capsule, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution, concentrate; Kit, Intramuscular, Intravenous, Parenteral, Emulsion, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection - Intravenous, Tablet, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Liquid - Intramuscular, Liquid, Solution - Parenteral, Kit, Injection, emulsion - Parenteral, Tablet - Oral, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Emulsion - Intramuscular; Intravenous; Subcutaneous, Solution - Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Solution

Intestinal resection

5.0 mg, 0.2 mg/mL, , 0.2 mg, 0.015 mg/mL, 0.08 mg, 0.15 mg, 0.02 mg, 0.15 mg/mL, 2.0 mg/mL, 10.0 mg/mL, 0.1 mg/mL, 0.02 mg/mL, 1.0 mg

, Injection, solution; Kit, Injection, emulsion, Solution / drops, Oral, Capsule - Oral, Solution / drops - Oral, Intramuscular; Parenteral; Subcutaneous, Injection, Injection, solution; Kit - Intravenous, Injection, solution - Intravenous, Intramuscular; Intravenous; Subcutaneous, Injection, solution, concentrate; Kit - Intravenous, Injection, solution, Kit - Oral, Capsule, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution, concentrate; Kit, Intramuscular, Intravenous, Parenteral, Emulsion, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection - Intravenous, Tablet, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Liquid - Intramuscular, Liquid, Solution - Parenteral, Kit, Injection, emulsion - Parenteral, Tablet - Oral, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Emulsion - Intramuscular; Intravenous; Subcutaneous, Solution - Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Solution

Vitamin supplementation therapy

5.0 mg, 0.2 mg/mL, , 0.2 mg, 0.015 mg/mL, 0.08 mg, 0.15 mg, 0.02 mg, 0.15 mg/mL, 2.0 mg/mL, 10.0 mg/mL, 0.1 mg/mL, 0.02 mg/mL, 1.0 mg

, Injection, solution; Kit, Injection, emulsion, Solution / drops, Oral, Capsule - Oral, Solution / drops - Oral, Intramuscular; Parenteral; Subcutaneous, Injection, Injection, solution; Kit - Intravenous, Injection, solution - Intravenous, Intramuscular; Intravenous; Subcutaneous, Injection, solution, concentrate; Kit - Intravenous, Injection, solution, Kit - Oral, Capsule, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution, concentrate; Kit, Intramuscular, Intravenous, Parenteral, Emulsion, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection - Intravenous, Tablet, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Liquid - Intramuscular, Liquid, Solution - Parenteral, Kit, Injection, emulsion - Parenteral, Tablet - Oral, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Emulsion - Intramuscular; Intravenous; Subcutaneous, Solution - Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Solution

long-acting anticoagulant rodenticides

5.0 mg, 0.2 mg/mL, , 0.2 mg, 0.015 mg/mL, 0.08 mg, 0.15 mg, 0.02 mg, 0.15 mg/mL, 2.0 mg/mL, 10.0 mg/mL, 0.1 mg/mL, 0.02 mg/mL, 1.0 mg

, Injection, solution; Kit, Injection, emulsion, Solution / drops, Oral, Capsule - Oral, Solution / drops - Oral, Intramuscular; Parenteral; Subcutaneous, Injection, Injection, solution; Kit - Intravenous, Injection, solution - Intravenous, Intramuscular; Intravenous; Subcutaneous, Injection, solution, concentrate; Kit - Intravenous, Injection, solution, Kit - Oral, Capsule, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution, concentrate; Kit, Intramuscular, Intravenous, Parenteral, Emulsion, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection - Intravenous, Tablet, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Liquid - Intramuscular, Liquid, Solution - Parenteral, Kit, Injection, emulsion - Parenteral, Tablet - Oral, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Emulsion - Intramuscular; Intravenous; Subcutaneous, Solution - Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Solution

hemorrhagic disease of the newborn

5.0 mg, 0.2 mg/mL, , 0.2 mg, 0.015 mg/mL, 0.08 mg, 0.15 mg, 0.02 mg, 0.15 mg/mL, 2.0 mg/mL, 10.0 mg/mL, 0.1 mg/mL, 0.02 mg/mL, 1.0 mg

, Injection, solution; Kit, Injection, emulsion, Solution / drops, Oral, Capsule - Oral, Solution / drops - Oral, Intramuscular; Parenteral; Subcutaneous, Injection, Injection, solution; Kit - Intravenous, Injection, solution - Intravenous, Intramuscular; Intravenous; Subcutaneous, Injection, solution, concentrate; Kit - Intravenous, Injection, solution, Kit - Oral, Capsule, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution, concentrate; Kit, Intramuscular, Intravenous, Parenteral, Emulsion, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection - Intravenous, Tablet, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Liquid - Intramuscular, Liquid, Solution - Parenteral, Kit, Injection, emulsion - Parenteral, Tablet - Oral, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Emulsion - Intramuscular; Intravenous; Subcutaneous, Solution - Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Solution

Coagulation Disorder

5.0 mg, 0.2 mg/mL, , 0.2 mg, 0.015 mg/mL, 0.08 mg, 0.15 mg, 0.02 mg, 0.15 mg/mL, 2.0 mg/mL, 10.0 mg/mL, 0.1 mg/mL, 0.02 mg/mL, 1.0 mg

, Injection, solution; Kit, Injection, emulsion, Solution / drops, Oral, Capsule - Oral, Solution / drops - Oral, Intramuscular; Parenteral; Subcutaneous, Injection, Injection, solution; Kit - Intravenous, Injection, solution - Intravenous, Intramuscular; Intravenous; Subcutaneous, Injection, solution, concentrate; Kit - Intravenous, Injection, solution, Kit - Oral, Capsule, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution, concentrate; Kit, Intramuscular, Intravenous, Parenteral, Emulsion, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection - Intravenous, Tablet, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Liquid - Intramuscular, Liquid, Solution - Parenteral, Kit, Injection, emulsion - Parenteral, Tablet - Oral, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Emulsion - Intramuscular; Intravenous; Subcutaneous, Solution - Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Solution

Gluten Enteropathy

5.0 mg, 0.2 mg/mL, , 0.2 mg, 0.015 mg/mL, 0.08 mg, 0.15 mg, 0.02 mg, 0.15 mg/mL, 2.0 mg/mL, 10.0 mg/mL, 0.1 mg/mL, 0.02 mg/mL, 1.0 mg

, Injection, solution; Kit, Injection, emulsion, Solution / drops, Oral, Capsule - Oral, Solution / drops - Oral, Intramuscular; Parenteral; Subcutaneous, Injection, Injection, solution; Kit - Intravenous, Injection, solution - Intravenous, Intramuscular; Intravenous; Subcutaneous, Injection, solution, concentrate; Kit - Intravenous, Injection, solution, Kit - Oral, Capsule, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution, concentrate; Kit, Intramuscular, Intravenous, Parenteral, Emulsion, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection - Intravenous, Tablet, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Liquid - Intramuscular, Liquid, Solution - Parenteral, Kit, Injection, emulsion - Parenteral, Tablet - Oral, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Emulsion - Intramuscular; Intravenous; Subcutaneous, Solution - Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Solution

Warnings

Phytonadione has one contraindication, thus it should not be taken concurrently with any of the conditions in the below table.Phytonadione Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Phylloquinone may interact with Toxoplasma Infections

There are 20 known major drug interactions with Phytonadione.

Common Phytonadione Drug Interactions

Drug Name

Risk Level

Description

(R)-warfarin

Major

The therapeutic efficacy of (R)-warfarin can be decreased when used in combination with Phylloquinone.

(S)-Warfarin

Major

The therapeutic efficacy of (S)-Warfarin can be decreased when used in combination with Phylloquinone.

4-hydroxycoumarin

Major

The therapeutic efficacy of 4-hydroxycoumarin can be decreased when used in combination with Phylloquinone.

Acenocoumarol

Major

The therapeutic efficacy of Acenocoumarol can be decreased when used in combination with Phylloquinone.

Clorindione

Major

The therapeutic efficacy of Clorindione can be decreased when used in combination with Phylloquinone.

Phytonadione Toxicity & Overdose RiskTaking high amounts of vitamin K1 is generally not poisonous, however, intravenous use is more likely to lead to toxic effects. Symptoms should be monitored and treated as needed. The toxic dose of vitamin K1 for mice is 1170 mg/kg when given intravenously, and more than 24180 mg/kg when taken orally.

image of a doctor in a lab doing drug, clinical research

Phytonadione Novel Uses: Which Conditions Have a Clinical Trial Featuring Phytonadione?

100 active clinical trials are examining the potential of Phytonadione in managing Crohn Disease, Hemorrhagic Disease of the Newborn and Obstructive Jaundice.

Condition

Clinical Trials

Trial Phases

Crohn Disease

0 Actively Recruiting

hemorrhagic disease of the newborn

0 Actively Recruiting

Jaundice, Obstructive

0 Actively Recruiting

vitamin K

0 Actively Recruiting

antibacterial therapy

0 Actively Recruiting

Salicylate

0 Actively Recruiting

Vitamin supplementation

0 Actively Recruiting

Pancreatic Cystic Fibrosis

0 Actively Recruiting

Anticoagulant Therapy

0 Actively Recruiting

Vitamin supplementation therapy

0 Actively Recruiting

Hemorrhagic Disease of Newborn

0 Actively Recruiting

Gluten Enteropathy

1 Actively Recruiting

Not Applicable

Fistula, Biliary

0 Actively Recruiting

Vitamin K deficiency

0 Actively Recruiting

Hypoprothrombinemia

0 Actively Recruiting

Coagulation Disorder

5 Actively Recruiting

Phase 1, Phase 2, Phase 4, Phase 3, Not Applicable

Intestinal resection

0 Actively Recruiting

Sprue

0 Actively Recruiting

Ulcerative Colitis

99 Actively Recruiting

Phase 2, Not Applicable, Phase 3, Phase 1, Phase 4, Early Phase 1

long-acting anticoagulant rodenticides

0 Actively Recruiting

Patient Q&A Section about phytonadione

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is phytonadione the same as Vitamin K2?

"Vitamin K is a group of fat-soluble vitamins that share a common chemical structure. They are stored in the body's fatty tissue and liver. The two most common types of vitamin K in our diets are vitamin K1 (also called phylloquinone or phytonadione) and vitamin K2 (also called menaquinones)."

Answered by AI

What is the side effects of phytonadione?

"If you experience any of the following adverse effects after an injection, speak to your doctor or pharmacist. These effects include pain, swelling or soreness at the injection site, temporary flushing, taste changes, dizziness, rapid heartbeat, sweating, shortness of breath, or blue lips/skin/nails. Some of these effects are more rare than others."

Answered by AI

What is phytonadione used to treat?

"Phytonadione (vitamin K) is used to prevent bleeding in people with blood clotting problems or too little vitamin K in the body. Phytonadione is a vitamin that is needed for blood to clot normally in the body. It works by providing vitamin K that is needed for blood to clot normally in the body."

Answered by AI

Is phytonadione vitamin K1 or K2?

"There are several versions of vitamin K found in dietary supplements, including vitamin K1 as phylloquinone or phytonadione (a synthetic form of vitamin K1), and vitamin K2 as MK-4 or MK-7."

Answered by AI

Clinical Trials for Phytonadione

Image of University of Alabama Medicine in Birmingham, United States.

Hyperbaric Oxygen Therapyfor Ulcerative Colitis

This trial aims to confirm if hyperbaric oxygen therapy can improve remission and reduce surgery for ulcerative colitis patients in hospital. It also looks at how it impacts immune and microbial functions.

Waitlist Available

No Prior Treatment

University of Alabama Medicine (+18 Sites)Lauren Balmert Bonner, PhD

Image of Brigham and Women's Hospital in Boston, United States.

CP101for Ulcerative Colitis

This trial will assess an oral microbiome therapy in 30 people with mild-to-moderate Ulcerative Colitis to find if it is safe, effective, and if it works.

Waitlist Available

No Cost For Treatment

Brigham and Women's Hospital

Image of Atlanta Gastroenterology Associates - Emory Saint Joseph's in Atlanta, United States.

NX-13 250mgfor Ulcerative Colitis

This trial tests a drug to treat moderate to severe ulcerative colitis. Results will be studied over time.

Atlanta Gastroenterology Associates - Emory Saint Joseph's (+9 Sites)Fabio Catalidi, MDLandos Biopharma Inc.

Image of Riley Hospital for Children at Indiana University Health in Indianapolis, United States.

Mirikizumab Weight-Based Group 1for Ulcerative Colitis

Indianapolis, IN

This trial studies if a drug is safe & effective in treating UC in children.

Waitlist Available

Riley Hospital for Children at Indiana University Health (+10 Sites)Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)Eli Lilly and Company

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Image of Dedicated Clinical Research in Litchfield Park, United States.

Mirikizumabfor Ulcerative Colitis

Litchfield Park, AZ

This trial will study the effects of mirikizumab on bowel urgency in those with UC, and will last 36 weeks.

Dedicated Clinical Research (+64 Sites)Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)Eli Lilly and Company

Image of New Hope Research Development in Whittier, United States.

APL-1401for Ulcerative Colitis

This trial tests a new drug to treat ulcerative colitis, monitored for safety, side effects, and effectiveness.

No Cost For Treatment

New Hope Research Development (+4 Sites)Qiuyue QUJiangsu Yahong Meditech Co., Ltd aka Asieris

Image of Mayo Clinic Minnesota in Rochester, United States.

Endoscopic Sleeve Gastroplasty (ESG)for Obesity

This trial researches the safety and effectiveness of a weight loss procedure (ESG) for obese patients with UC who need colectomy and eventual IPAA, compared to diet and lifestyle counseling.

Waitlist Available

Mayo Clinic MinnesotaAmanda M Johnson, MD

Image of Wellness Clinical Research (WCR)-Site Number:8400009 in Miami Lakes, United States.

Dupilumabfor Ulcerative Colitis

Miami Lakes, FL

This trial will evaluate the effect of dupilumab on UC symptoms, safety and effectiveness in patients with moderate-severe UC and eosinophilic phenotype.

Wellness Clinical Research (WCR)-Site Number:8400009 (+21 Sites)Sanofi

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Image of Mayo Clinic in Rochester, United States.

Treatmentfor Ulcerative Colitis

This trial tests the safety and effect of an oral probiotic (R-3750) on mild to moderate ulcerative colitis patients, through patient-reported and physician-scored measures, blood, and fecal results.

Mayo Clinic (+2 Sites)Rise Therapeutics LLC

Image of Feinstein Institute for Medical Research at Northwell Health in Lake Success, United States.

Treatmentfor Ulcerative Colitis

Lake Success, NY

This trial studies if a device is safe and effective for people with Ulcerative Colitis, and to find out who responds best to it. It runs 12 weeks with in-clinic & telehealth visits, and subjects use the device twice a day at home.

Feinstein Institute for Medical Research at Northwell HealthCala Health, Inc.

Image of University of Washington in Seattle, United States.

Comprehensive Self-Managementfor Crohn's Disease

This trial is testing a new self-management program for people with IBD to help them manage symptoms. It includes 8 sessions on topics like symptom tracking, behavior strategies, relaxation & sleep, diet, and pain.

University of WashingtonKendra Kamp, PHD, RN

Image of Hoxworth Blood Center in Cincinnati, United States.

Cohort 1for Bleeding

This trial tests if a new medical treatment is safe. It looks at how well the body reacts to increasing doses of a special medical product.

Hoxworth Blood CenterMark Popovsky, MDVelico Medical

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