Your session is about to expire
What is Phytonadione
PhylloquinoneThe Generic name of this drug
Treatment SummaryVitamin K1, also known as phylloquinone, is a type of fat-soluble vitamin. It helps an enzyme called γ-carboxylase to activate proteins that are needed for blood clotting. Vitamin K1 is used to treat clotting disorders caused by a lack of the vitamin in the body. It has been used since 1939 and was officially approved by the FDA before 1955.
Mephytonis the brand name
Phytonadione Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Mephyton
Phylloquinone
1955
65
Approved as Treatment by the FDA
Phylloquinone, also known as Mephyton, is approved by the FDA for 7 uses including antibacterial therapy and hemorrhagic disease of the newborn .antibacterial therapy
hemorrhagic disease of the newborn
Hypoprothrombinemia
Hemorrhagic Disease of Newborn
Fistula, Biliary
Used to treat Fistula, Biliary in combination with Taurocholic acid
Salicylate
Jaundice, Obstructive
Used to treat Jaundice, Obstructive in combination with Taurocholic acid
Effectiveness
How Phytonadione Affects PatientsPhylloquinone is a vitamin K used to treat problems with blood clotting due to a lack of vitamin K or if there is interference with its activity. Vitamin K is cycled through the body, and can usually be taken in large doses without any issues. Prothrombin time should be monitored while taking this medication, and it is important to be aware of the risk of allergic reactions if it is administered through a needle.
How Phytonadione works in the bodyVitamin K helps the body form blood clots when needed. It does this by attaching chemical groups that help proteins bind to calcium. This helps convert certain clotting factors into active form, which works to stop bleeding. Vitamin K may also help prevent joint calcification and increase bone density. Studies are ongoing to determine how Vitamin K impacts osteoarthritis, bone density, and calcification of blood vessels.
When to interrupt dosage
The prescribed dosage of Phytonadione is contingent upon the determined condition, for example Sprue, Vitamin supplementation and Ulcerative Colitis. The measure likewise varies in accordance with the delivery technique indicated in the table below.Condition
Dosage
Administration
Vitamin supplementation therapy
, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL
, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral
Intestinal resection
, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL
, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral
antibacterial therapy
, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL
, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral
Vitamin supplementation
, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL
, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral
Ulcerative Colitis
, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL
, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral
Gluten-Sensitive Enteropathy
, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL
, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral
Sprue
, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL
, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral
vitamin K
, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL
, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral
Vitamin K deficiency
, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL
, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral
Fistula, Biliary
, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL
, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral
Anticoagulant Therapy
, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL
, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral
Jaundice, Obstructive
, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL
, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral
long-acting anticoagulant rodenticides
, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL
, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral
hemorrhagic disease of the newborn
, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL
, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral
Hypoprothrombinemia
, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL
, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral
Hemorrhagic Disease of Newborn
, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL
, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral
Salicylate
, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL
, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral
Crohn Disease
, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL
, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral
Coagulation Disorder
, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL
, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral
Pancreatic Cystic Fibrosis
, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL
, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral
Warnings
Phytonadione has one contraindication, thus it should not be taken concurrently with any of the conditions in the below table.Phytonadione ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Phylloquinone may interact with Pulse Frequency
Common Phytonadione Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Major
The therapeutic efficacy of (R)-warfarin can be decreased when used in combination with Phylloquinone.
(S)-Warfarin
Major
The therapeutic efficacy of (S)-Warfarin can be decreased when used in combination with Phylloquinone.
4-hydroxycoumarin
Major
The therapeutic efficacy of 4-hydroxycoumarin can be decreased when used in combination with Phylloquinone.
Acenocoumarol
Major
The therapeutic efficacy of Acenocoumarol can be decreased when used in combination with Phylloquinone.
Clorindione
Major
The therapeutic efficacy of Clorindione can be decreased when used in combination with Phylloquinone.
Phytonadione Toxicity & Overdose RiskTaking high amounts of vitamin K1 is generally not poisonous, however, intravenous use is more likely to lead to toxic effects. Symptoms should be monitored and treated as needed. The toxic dose of vitamin K1 for mice is 1170 mg/kg when given intravenously, and more than 24180 mg/kg when taken orally.
Phytonadione Novel Uses: Which Conditions Have a Clinical Trial Featuring Phytonadione?
100 active clinical trials are examining the potential of Phytonadione in managing Crohn Disease, Hemorrhagic Disease of the Newborn and Obstructive Jaundice.Condition
Clinical Trials
Trial Phases
Ulcerative Colitis
98 Actively Recruiting
Phase 2, Not Applicable, Phase 3, Phase 1, Phase 4, Early Phase 1
long-acting anticoagulant rodenticides
0 Actively Recruiting
Sprue
0 Actively Recruiting
Hypoprothrombinemia
0 Actively Recruiting
hemorrhagic disease of the newborn
0 Actively Recruiting
Vitamin supplementation
0 Actively Recruiting
Crohn Disease
0 Actively Recruiting
Vitamin K deficiency
0 Actively Recruiting
Salicylate
0 Actively Recruiting
Intestinal resection
0 Actively Recruiting
Fistula, Biliary
0 Actively Recruiting
vitamin K
0 Actively Recruiting
Vitamin supplementation therapy
0 Actively Recruiting
Jaundice, Obstructive
0 Actively Recruiting
Pancreatic Cystic Fibrosis
0 Actively Recruiting
Coagulation Disorder
4 Actively Recruiting
Phase 3, Not Applicable, Phase 1
Gluten-Sensitive Enteropathy
0 Actively Recruiting
Hemorrhagic Disease of Newborn
0 Actively Recruiting
Anticoagulant Therapy
0 Actively Recruiting
antibacterial therapy
0 Actively Recruiting
Patient Q&A Section about phytonadione
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is phytonadione the same as Vitamin K2?
"Vitamin K is a group of fat-soluble vitamins that share a common chemical structure. They are stored in the body's fatty tissue and liver. The two most common types of vitamin K in our diets are vitamin K1 (also called phylloquinone or phytonadione) and vitamin K2 (also called menaquinones)."
Answered by AI
What is the side effects of phytonadione?
"If you experience any of the following adverse effects after an injection, speak to your doctor or pharmacist. These effects include pain, swelling or soreness at the injection site, temporary flushing, taste changes, dizziness, rapid heartbeat, sweating, shortness of breath, or blue lips/skin/nails. Some of these effects are more rare than others."
Answered by AI
What is phytonadione used to treat?
"Phytonadione (vitamin K) is used to prevent bleeding in people with blood clotting problems or too little vitamin K in the body. Phytonadione is a vitamin that is needed for blood to clot normally in the body. It works by providing vitamin K that is needed for blood to clot normally in the body."
Answered by AI
Is phytonadione vitamin K1 or K2?
"There are several versions of vitamin K found in dietary supplements, including vitamin K1 as phylloquinone or phytonadione (a synthetic form of vitamin K1), and vitamin K2 as MK-4 or MK-7."
Answered by AI