Phentermine Hydrochloride

Caloric Restriction, Obesity, Type 2 Diabetes + 6 more

Treatment

3 FDA approvals

20 Active Studies for Phentermine Hydrochloride

What is Phentermine Hydrochloride

Phentermine

The Generic name of this drug

Treatment Summary

Phentermine is an anti-obesity medication that was introduced in 1959. It is related to amphetamine but does not have the same addictive potential, so it is classified as a Schedule IV drug with low abuse potential. It is usually prescribed for short-term weight management and was approved by the FDA in 1959. In 2012, phentermine was also approved to be used in combination with another drug, topiramate, at lower doses to achieve the same effect.

Ionamin

is the brand name

image of different drug pills on a surface

Phentermine Hydrochloride Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Ionamin

Phentermine

1959

298

Approved as Treatment by the FDA

Phentermine, also known as Ionamin, is approved by the FDA for 3 uses including Obesity and Comorbidity .

Obesity

Used to treat Obesity in combination with Topiramate

Comorbidity

Used to treat one related comorbidity in combination with Topiramate

Regime of weight reduction

Effectiveness

How Phentermine Hydrochloride Affects Patients

Phentermine is used to suppress appetite, which may be caused by the increase of the hormone leptin. It has been found to help people lose an average of 3.6 kilograms over a period of 2-24 weeks. In addition, the effects of phentermine continue even after the treatment is stopped. It is not known to have any effects on the central nervous system, blood pressure, or heart rate like amphetamine drugs.

How Phentermine Hydrochloride works in the body

Phentermine works by increasing the amount of noradrenaline in a certain area of the brain. This increases the activity of certain receptors and creates a "flight-or-fight" response, which reduces hunger signals. It may also reduce the production of a hormone called neuropeptide Y, which is linked to hunger. Phentermine also weakly inhibits monoamine oxidase, but this doesn't have a significant effect.

When to interrupt dosage

The suggested portion of Phentermine Hydrochloride is contingent upon the diagnosed condition, including Regime of weight reduction, Hyperlipidemia and Type 2 Diabetes. The amount of dosage is contingent upon the delivery approach (e.g. Oral or Tablet) featured in the table below.

Condition

Dosage

Administration

Obesity

, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg

Oral, , Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet - Oral, Tablet, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating

Caloric Restriction

, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg

Oral, , Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet - Oral, Tablet, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating

Type 2 Diabetes

, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg

Oral, , Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet - Oral, Tablet, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating

Hypertensive disease

, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg

Oral, , Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet - Oral, Tablet, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating

High Cholesterol

, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg

Oral, , Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet - Oral, Tablet, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating

Regime of weight reduction

, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg

Oral, , Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet - Oral, Tablet, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating

Chronic Weight Management therapy

, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg

Oral, , Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet - Oral, Tablet, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating

increase in physical activity

, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg

Oral, , Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet - Oral, Tablet, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating

Comorbidity

, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg

Oral, , Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet - Oral, Tablet, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating

Warnings

Phentermine Hydrochloride Contraindications

Condition

Risk Level

Notes

Hyperthyroidism

Do Not Combine

concomitant use or 14 days after discontinuation

Do Not Combine

Agitation

Do Not Combine

Drug abuse

Do Not Combine

Cardiovascular Diseases

Do Not Combine

Open-angle glaucoma

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Phentermine may interact with Pulse Frequency

There are 20 known major drug interactions with Phentermine Hydrochloride.

Common Phentermine Hydrochloride Drug Interactions

Drug Name

Risk Level

Description

Iobenguane

Major

Phentermine can cause a decrease in the absorption of Iobenguane resulting in a reduced serum concentration and potentially a decrease in efficacy.

Methylene blue

Major

Phentermine may increase the serotonergic activities of Methylene blue.

Mirtazapine

Major

Phentermine may increase the serotonergic activities of Mirtazapine.

1-benzylimidazole

Minor

The therapeutic efficacy of 1-benzylimidazole can be decreased when used in combination with Phentermine.

4-Methoxyamphetamine

Minor

The risk or severity of hypertension can be increased when Phentermine is combined with 4-Methoxyamphetamine.

Phentermine Hydrochloride Toxicity & Overdose Risk

The lethal dose of phentermine in rats is 151mg/kg. An overdose can lead to restlessness, tremors, confusion, hallucinations, fatigue, depression, rapid heart rate, irregular heartbeat, high or low blood pressure, nausea, vomiting, diarrhea, abdominal cramps, and skin irritation. In severe cases, it could cause a psychotic disorder similar to schizophrenia. Studies have not shown phentermine to be carcinogenic or mutagenic.

image of a doctor in a lab doing drug, clinical research

Phentermine Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Phentermine Hydrochloride?

104 active clinical trials are being conducted to evaluate the potential of Phentermine Hydrochloride in treating Type 2 Diabetes, Weight Loss Regimen and Disease.

Condition

Clinical Trials

Trial Phases

Type 2 Diabetes

90 Actively Recruiting

Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4, Early Phase 1

Obesity

0 Actively Recruiting

Hypertensive disease

0 Actively Recruiting

Comorbidity

0 Actively Recruiting

High Cholesterol

19 Actively Recruiting

Phase 2, Phase 3, Not Applicable, Early Phase 1

Caloric Restriction

0 Actively Recruiting

Regime of weight reduction

0 Actively Recruiting

increase in physical activity

0 Actively Recruiting

Chronic Weight Management therapy

0 Actively Recruiting

Phentermine Hydrochloride Reviews: What are patients saying about Phentermine Hydrochloride?

5

Patient Review

5/26/2022

Phentermine Hydrochloride for Weight Gain

I have been really pleased with this medication. It's helped me lose weight gradually and steadily, without any adverse side effects that I can tell.

5

Patient Review

6/23/2022

Phentermine Hydrochloride for Weight Loss Management for an Obese Person

This medicine has been really effective for me. It's helped me control my hunger and I've been able to cut down on the amount I eat at each meal by 66%. In one month, I've lost 20 pounds and 4 inches off my waist. The only side effect I've noticed is that I get a dry mouth, but it's not a big deal since I always have water with me.

5

Patient Review

3/29/2022

Phentermine Hydrochloride for Weight Loss Management for an Obese Person

I haven't experienced any negative side effects and I'm seeing great results—about a pound of weight loss per day. Plus, I have more energy and can concentrate better at work.

5

Patient Review

6/7/2022

Phentermine Hydrochloride for Weight Loss Management for an Obese Person

Really helped me when I reached a point where I wasn't seeing any more progress. Sometimes, I would split the pill in order to make it last longer.

5

Patient Review

5/26/2022

Phentermine Hydrochloride for Weight Loss Management for Overweight Person with BMI 27 to 29 and Weight-Related Comorbidity

The dry mouth was the only side effect I experienced. Overall, this treatment is easy to administer and highly effective.

5

Patient Review

6/27/2022

Phentermine Hydrochloride for Overweight

I started taking 37.5 MG phentermine on 10/08/21 and saw great results. I lost 35lbs in just a few months with no adverse side effects. Going back on it tomorrow (06/28/22) to try and lose another 20-25lbs.

4

Patient Review

4/29/2022

Phentermine Hydrochloride for Overweight

For the first few weeks, this treatment was highly effective. However, it stopped working after that point and also caused some nasty side effects like yeast infections and UTIs.

3.7

Patient Review

9/15/2022

Phentermine Hydrochloride for Weight Loss Management for Overweight Person with BMI 27 to 29 and Weight-Related Comorbidity

While this pill did help me lose weight, it also caused some serious emotional side effects. I was constantly out of control and once I stopped taking the pill, I gained all the weight back within two weeks. Not worth it in my opinion.

2.7

Patient Review

4/8/2022

Phentermine Hydrochloride for Weight Loss Management for Overweight Person with BMI 27 to 29 and Weight-Related Comorbidity

I was taking 15 mgs for 4 weeks and was increased to 30 for the last 3 weeks. I do not notice much of a decrease in appetite or increase in energy levels. I havent lost any weight. Im 53 so it may have something to do with my hormones but I m overall disappointed

1.7

Patient Review

8/31/2022

Phentermine Hydrochloride for Weight Loss Management for an Obese Person

I stopped taking this medication after two weeks because I noticed an increase in my anxiety levels. However, within just a few days of stopping the medication, I began dealing with depression and panic attacks worse than ever before.

1.7

Patient Review

10/7/2022

Phentermine Hydrochloride for Weight Loss Management for Overweight Person with BMI 27 to 29 and Weight-Related Comorbidity

I saw some great results in the beginning, but then around the fourth week things took a turn. I was really struggling with anxiety and my mood swings were so bad that it started affecting my job. Once I stopped taking this medication, the weight came back. So for me, it wasn't worth it.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about phentermine hydrochloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is phentermine HCL the same as phentermine?

"Phentermine acts as a stimulant on the central nervous system, reducing appetite, and is commonly used as a weight loss medication. Hydrochloride is a common salt form of phentermine, which increases its solubility, making it easier to absorb into the bloodstream."

Answered by AI

Does Phentermine Hydrochloride give you energy?

"Phentermine may help people to eat less by lowering their appetite. This can lead to weight loss because it causes an energy deficit (meaning you are burning more calories than you are eating)."

Answered by AI

How much weight can you lose on phentermine?

"Phentermine is most effective for weight loss when taken for 3 months, leading to an average weight loss of 3% of initial body weight. Some people report even more significant weight loss, with up to 5-7% weight loss after 6 months of taking phentermine."

Answered by AI

What is Phentermine Hydrochloride used for?

"Phentermine is a medication used to speed up weight loss in overweight people. It is only meant to be used for a limited amount of time, and should be combined with diet and exercise. Phentermine works by reducing appetite."

Answered by AI

Clinical Trials for Phentermine Hydrochloride

Image of University of Alberta in Edmonton, Canada.

Pharmacist-led Care for Diabetes

18+
All Sexes
Edmonton, Canada

As of 2024, nine percent of Albertans are living with Type 2 diabetes, which increases their risk for cardiovascular disease, stroke, blindness, and kidney failure. Unfortunately, less than half of patients have controlled Type 2 diabetes. We are well aware of the factors which lead to worsening diabetes, but need to give people more support to help them manage their diabetes. Pharmacists are respected health care professionals who are often easier to see that doctors and can help people with diabetes to stay as healthy as possible. This research project aims to see whether a pharmacist service can help improve diabetes management in people with type 2 diabetes compared to usual care from their family physician or nurse practitionner. The potential impact of this project is to empower people with type 2 diabetes to understand their condition, it's management, and to achieve target blood sugar levels, which will ultimately reduce the risk of diabetes-related complications.

Recruiting
Has No Placebo

University of Alberta

Ross Tsuyuki, BScPharm, PharmD, MSc

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We made a collection of clinical trials featuring Phentermine Hydrochloride, we think they might fit your search criteria.
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Image of Lipid Clinic at Brown University Health in Providence, United States.

2-HOBA Supplementation for High Cholesterol

18 - 69
All Sexes
Providence, RI

The goal of this clinical trial is to learn if a natural supplement called 2-hydroxybenzylamine (2-HOBA) can reduce harmful oxidized lipids and improve the function of lipoprotein(a) in adults with high lipoprotein(a) levels. The main questions it aims to answer are: Does 2-HOBA lower oxidized phospholipids on lipoprotein(a)? Does 2-HOBA reduce markers of inflammation and blood clotting in the blood? Participants will: Take 2-HOBA capsules (400 mg, three times daily with meals) for 6 weeks Provide blood and urine samples at the beginning, middle, and end of the study Have lab tests to measure changes in lipids, inflammation, and clotting markers

Waitlist Available
Has No Placebo

Lipid Clinic at Brown University Health

Wenliang Song, MD

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Image of Sidney & Lois Eskenazi Hospital in Indianapolis, United States.

Composite Intervention for Metabolic Syndrome

18+
All Sexes
Indianapolis, IN

The objective of this study is to pilot a multifaceted, optimized intervention for metabolic syndrome (MetS) in emergency department patients to establish feasibility. Participants (n=20) will be randomized to intervention or control (usual care). The composite intervention will include an educational video outlining the adverse effects of MetS and the benefit of walking, a written exercise prescription with a defined goal of walking 150 minutes per week, a Fitbit accelerometer device, resources for healthy eating practices, periodic text message reminders, and an urgent referral to primary care and our health system's Healthy Me clinic for follow-up visit. Investigators hypothesize that this approach will change patient understanding and motivation to increase physical activity and healthy eating habits.

Recruiting
Has No Placebo

Sidney & Lois Eskenazi Hospital

Image of Duke University Medical Center in Durham, United States.

Cardiometabolic Prevention Clinic for Cardiovascular Disease

18+
All Sexes
Durham, NC

This project is studying whether a team-based specialty clinic can help people with type 2 diabetes and heart disease better manage their blood pressure and cholesterol. The clinic includes coordinated care from heart doctors, kidney doctors, diabetes specialists, and liver doctors. The study will compare two groups of patients: one receiving usual care from their primary care provider, and one referred to the Duke Cardiometabolic Prevention Clinic for multidisciplinary care. The main goals are to find out if this clinic improves blood pressure and cholesterol control over 12 months, increases use of recommended heart medications, and reduces hospital visits and other healthcare use. Participants will be randomly assigned to one of the two groups. Those referred to the clinic will: 1) Meet with a cardiologist for an initial evaluation. 2) Be referred to other specialists (such as endocrinology, nephrology, or hepatology) based on their needs. 3) Receive ongoing, coordinated care from a team of specialists working together to improve their heart and metabolic health.

Recruiting
Has No Placebo

Duke University Medical Center

Neha J Pagidipati, MD, MPH

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