Perphenazine

Depression, Generalized Anxiety Disorder, Schizophrenia + 8 more
Treatment
12 FDA approvals
20 Active Studies for Perphenazine

What is Perphenazine

PerphenazineThe Generic name of this drug
Treatment SummaryAn antipsychotic medication with effects similar to that of chlorpromazine, a medicine used to treat psychosis.
Perphenazineis the brand name
Perphenazine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Perphenazine
Perphenazine
1987
153

Approved as Treatment by the FDA

Perphenazine, also known as Perphenazine, is approved by the FDA for 12 uses like Anxiety and Depression .
Anxiety
Used to treat severe Anxiety in combination with Amitriptyline
Depression
Used to treat Depression in combination with Amitriptyline
Mental Depression
Used to treat severe Depressed mood in combination with Amitriptyline
moderate Anxiety
Used to treat moderate Anxiety in combination with Amitriptyline
Chronic Physical Illness
Used to treat Chronic Physical Illness in combination with Amitriptyline
severe Nausea and vomiting
Mental Depression
Used to treat moderate Depressed mood in combination with Amitriptyline
Nausea
Generalized Anxiety Disorder
Used to treat Anxiety in combination with Amitriptyline
Schizophrenia
Helps manage Schizophrenia
severe agitation
Used to treat severe agitation in combination with Amitriptyline
moderate Agitation
Used to treat moderate Agitation in combination with Amitriptyline

Effectiveness

How Perphenazine Affects PatientsPerphenazine is a member of the phenothiazine class of drugs, which work on the central nervous system and block the action of dopamine in the brain. It is much more powerful than other similar drugs, and is used as a highly effective antipsychotic. In terms of side effects, Perphenazine is about as likely and severe to cause early and late extrapyramidal side effects as Haloperidol.
How Perphenazine works in the bodyPerphenazine blocks the activity of dopamine D1 and D2 receptors. This helps control nausea and vomiting by preventing the dopamine neurotransmitter from stimulating the receptors in the areas of the brain responsible for these symptoms. Perphenazine also binds to alpha andrenergic receptors, which are responsible for activating a cell signaling pathway.

When to interrupt dosage

The proposed measure of Perphenazine is contingent upon the determined condition, like Generalized Anxiety Disorder, moderate Agitation and Depression. The degree of dosage varies as per the approach of delivery (e.g. Syrup - Oral or Tablet, sugar coated - Oral) featured in the table below.
Condition
Dosage
Administration
Depression
, 2.0 mg, 4.0 mg, 8.0 mg, 16.0 mg, 3.0 mg, 5.0 mg/mL, 2.0 mg/mL, 3.2 mg/mL, 16.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Solution, Solution - Intramuscular; Intravenous, Syrup, Syrup - Oral
Nausea
, 2.0 mg, 4.0 mg, 8.0 mg, 16.0 mg, 3.0 mg, 5.0 mg/mL, 2.0 mg/mL, 3.2 mg/mL, 16.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Solution, Solution - Intramuscular; Intravenous, Syrup, Syrup - Oral
Anxiety
, 2.0 mg, 4.0 mg, 8.0 mg, 16.0 mg, 3.0 mg, 5.0 mg/mL, 2.0 mg/mL, 3.2 mg/mL, 16.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Solution, Solution - Intramuscular; Intravenous, Syrup, Syrup - Oral
Chronic Physical Illness
, 2.0 mg, 4.0 mg, 8.0 mg, 16.0 mg, 3.0 mg, 5.0 mg/mL, 2.0 mg/mL, 3.2 mg/mL, 16.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Solution, Solution - Intramuscular; Intravenous, Syrup, Syrup - Oral
moderate Anxiety
, 2.0 mg, 4.0 mg, 8.0 mg, 16.0 mg, 3.0 mg, 5.0 mg/mL, 2.0 mg/mL, 3.2 mg/mL, 16.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Solution, Solution - Intramuscular; Intravenous, Syrup, Syrup - Oral
moderate Agitation
, 2.0 mg, 4.0 mg, 8.0 mg, 16.0 mg, 3.0 mg, 5.0 mg/mL, 2.0 mg/mL, 3.2 mg/mL, 16.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Solution, Solution - Intramuscular; Intravenous, Syrup, Syrup - Oral
Mental Depression
, 2.0 mg, 4.0 mg, 8.0 mg, 16.0 mg, 3.0 mg, 5.0 mg/mL, 2.0 mg/mL, 3.2 mg/mL, 16.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Solution, Solution - Intramuscular; Intravenous, Syrup, Syrup - Oral
Mental Depression
, 2.0 mg, 4.0 mg, 8.0 mg, 16.0 mg, 3.0 mg, 5.0 mg/mL, 2.0 mg/mL, 3.2 mg/mL, 16.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Solution, Solution - Intramuscular; Intravenous, Syrup, Syrup - Oral
Generalized Anxiety Disorder
, 2.0 mg, 4.0 mg, 8.0 mg, 16.0 mg, 3.0 mg, 5.0 mg/mL, 2.0 mg/mL, 3.2 mg/mL, 16.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Solution, Solution - Intramuscular; Intravenous, Syrup, Syrup - Oral
Schizophrenia
, 2.0 mg, 4.0 mg, 8.0 mg, 16.0 mg, 3.0 mg, 5.0 mg/mL, 2.0 mg/mL, 3.2 mg/mL, 16.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Solution, Solution - Intramuscular; Intravenous, Syrup, Syrup - Oral
severe agitation
, 2.0 mg, 4.0 mg, 8.0 mg, 16.0 mg, 3.0 mg, 5.0 mg/mL, 2.0 mg/mL, 3.2 mg/mL, 16.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Solution, Solution - Intramuscular; Intravenous, Syrup, Syrup - Oral

Warnings

Perphenazine has seven contraindications, consequently it should not be taken when any of the conditions specified in the following table occur.Perphenazine Contraindications
Condition
Risk Level
Notes
large dose of CNS depressants
Do Not Combine
Brain Injuries
Do Not Combine
Liver Damage
Do Not Combine
Coma
Do Not Combine
Disease
Do Not Combine
greatly obtunded patients
Do Not Combine
Bone Marrow
Do Not Combine
There are 20 known major drug interactions with Perphenazine.
Common Perphenazine Drug Interactions
Drug Name
Risk Level
Description
Amisulpride
Major
Perphenazine may increase the antipsychotic activities of Amisulpride.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Perphenazine.
Azelastine
Major
Perphenazine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Dacomitinib
Major
The metabolism of Dacomitinib can be decreased when combined with Perphenazine.
Deutetrabenazine
Major
The risk or severity of adverse effects can be increased when Perphenazine is combined with Deutetrabenazine.
Perphenazine Toxicity & Overdose RiskSigns of overdosing on amitriptyline include stupor or unconsciousness, and in some cases, seizures in children. Patients may not regain consciousness for up to two days. The lowest toxic dose for rats is 318mg/kg, and 64mg/kg for mice.
image of a doctor in a lab doing drug, clinical research

Perphenazine Novel Uses: Which Conditions Have a Clinical Trial Featuring Perphenazine?

985 active investigations are currently assessing the potential of Perphenazine to palliate moderate Agitation, Anxiety and Nausea.
Condition
Clinical Trials
Trial Phases
Generalized Anxiety Disorder
205 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Early Phase 1, Phase 4, Phase 1
Schizophrenia
108 Actively Recruiting
Phase 3, Not Applicable, Early Phase 1, Phase 4, Phase 2, Phase 1
moderate Anxiety
0 Actively Recruiting
Nausea
0 Actively Recruiting
Anxiety
0 Actively Recruiting
moderate Agitation
0 Actively Recruiting
Chronic Physical Illness
0 Actively Recruiting
severe agitation
0 Actively Recruiting
Depression
335 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 4, Phase 3
Mental Depression
0 Actively Recruiting
Mental Depression
0 Actively Recruiting

Perphenazine Reviews: What are patients saying about Perphenazine?

5Patient Review
12/28/2020
Perphenazine for Schizophrenia
I was originally prescribed 2mg of this medication, but I still felt like evil spirits were touching me. My doctor then increased the dosage to 4mg and then 6mg, and I no longer have those sensations. I am a bit tired during the day, but overall I'm much happier now.
5Patient Review
8/26/2015
Perphenazine for Schizophrenia
I've tried a lot of different medications, but this is the best one I've found so far. It helps me manage my symptoms without making me feel sedated or like a zombie. Life is more worth living with this medication.
5Patient Review
4/2/2016
Perphenazine for Schizophrenia
This medication is highly effective for me with very few side effects. I take it at night to avoid feeling sedated or dizzy during the day.
5Patient Review
2/27/2010
Perphenazine for Mental Disorder with Loss of Normal Personality & Reality
5Patient Review
4/16/2011
Perphenazine for Schizophrenia
This pill has been helping me since I started taking it.
View All Reviews

Patient Q&A Section about perphenazine

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the drug perphenazine used for?

"Perphenazine is used to treat symptoms of schizophrenia, such as disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions. Perphenazine is also used to control severe nausea and vomiting in adults."

Answered by AI

Is perphenazine good for anxiety?

"Perphenazine is an effective medication for patients with varying degrees of anxiety and agitation, from mild tension or hyperactivity to severe psychosis or psychomotor hyperactivity."

Answered by AI

Is perphenazine a sedative?

"Perphenazine has properties that help to calm patients and reduce anxiety, making the drug useful for treating psychotic patients who are agitated."

Answered by AI

Is perphenazine used for depression?

"This medicine is used to treat depression that may be accompanied by anxiety or agitation. It is also used to treat schizophrenia."

Answered by AI

Clinical Trials for Perphenazine

Have you considered Perphenazine clinical trials? We made a collection of clinical trials featuring Perphenazine, we think they might fit your search criteria.
Have you considered Perphenazine clinical trials? We made a collection of clinical trials featuring Perphenazine, we think they might fit your search criteria.
Have you considered Perphenazine clinical trials? We made a collection of clinical trials featuring Perphenazine, we think they might fit your search criteria.
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