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TAVO412 for Cancer (TAVO412 Trial)
TAVO412 Trial Summary
This trial will test the safety and effectiveness of a new drug, TAVO412, for advanced/metastatic solid tumors in two parts. Part 1 will determine the best dose and Part 2 will assess safety, effectiveness, and other measures for gastric cancer and NSCLC.
TAVO412 Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.TAVO412 Trial Design
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Who is running the clinical trial?
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- I have colorectal cancer and have been treated with specific chemotherapy and, if applicable, targeted therapy.I do not have an active infection needing treatment.I haven't had any cancer except for skin cancer in the last 5 years.My kidneys work well enough (creatinine clearance ≥ 30 mL/min).I am 18 years old or older.I haven't received blood products or colony stimulating factors in the last 14 days.I am fully active or can carry out light work.My kidneys are not functioning well (creatinine clearance < 30 mL/min).I have active brain metastases or carcinomatous meningitis.I haven't taken any cancer drugs or experimental medications recently.I still have side effects from previous treatments that are not mild.I have an autoimmune disease that needed treatment.I agree to give extra blood or tissue samples for research.My cancer has come back or hasn't responded to treatment and can't be surgically removed with the aim of curing it.My cancer can be measured and has grown in previously treated areas.I agree to use birth control during and for 60 days after the study.My hepatitis C virus levels are undetectable while on treatment.I've been vaccinated for hepatitis B and only have antibodies showing I was exposed.I have liver issues but can tolerate normal medication doses.I haven't had AIDS-related infections in the last year.I have not had serious heart issues or surgeries in the last 6 months.I have had a condition where my lymphocytes grow abnormally.I am a woman who can have children and have a negative pregnancy test.I agree to use birth control methods for 90 days after my last dose.I have had or currently have another type of cancer besides the one being treated.I have not received a live vaccine in the last 30 days.My TNBC has worsened despite treatment with specific drugs.I am willing to have tumor biopsies before and during treatment.I have a history of cancer.My brain metastases are stable, and I haven't needed steroids in the last 14 days.My cancer has worsened after treatment, or I can't tolerate/choose not to have standard treatment.My CD4+ T-cell count is 350 or higher.I have lung inflammation not caused by an infection or a history of lung tissue disease.I am on antiviral therapy for my active chronic HBV before starting cancer treatment.I have stable Hepatitis C and my cancer treatment won't worsen it.I have gastric or gastroesophageal cancer and have been treated with chemotherapy, immune therapy, and possibly HER2 or other targeted therapy.My NSCLC progressed despite EGFR TKIs, or I've had anti-PD1 and platinum-based treatments for cMET alterations.
- Group 1: Part 1 Cohort 0
- Group 2: Part 1 Cohort 1
- Group 3: Part 1 Cohort 2
- Group 4: Part 1 Cohort 3
- Group 5: Part 1 Cohort 4
- Group 6: Part 1 Cohort 5
- Group 7: Part 2 Cohorts
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What potential hazards do people face with this treatment?
"Given the Phase 1 status of this trial, our internal analysis at Power has graded its safety with a score of 1. This is due to little evidence on both efficacy and security at present."
Is enrollment for this research available to participants right now?
"Evidently, the trial is still recruiting according to clinicaltrials.gov records which show that it was originally posted on 8 May 2023 and last amended 9 of the same month."
How many subjects are involved in this clinical experimentation?
"Affirmative. According to clinicaltrials.gov, this research venture is presently looking for participants, with the study having first been posted on May 8th 2023 and last updated on May 9th 2023. This trial requires 50 individuals from a single medical facility."
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