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What is Pentoxil
PentoxifyllineThe Generic name of this drug
Treatment SummaryPentoxifylline (PTX) is a drug that helps to reduce the thickness of blood and has anti-inflammatory and anti-oxidant properties. It was first developed to treat intermittent claudication, a form of leg pain caused by poor circulation. PTX has been studied for its potential to treat many other conditions, like osteoradionecrosis, diabetic kidney disease, and inflammation from COVID-19. It has been available in Europe since 1972 and the United States since the late 1990s under the brand names TRENTAL and PENTOXIL. Generic versions of the drug are also available.
Trentalis the brand name
Pentoxil Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Trental
Pentoxifylline
1984
37
Approved as Treatment by the FDA
Pentoxifylline, also known as Trental, is approved by the FDA for 2 uses including Intermittent Claudication and Peripheral Arterial Disease .Intermittent Claudication
Helps manage Intermittent Claudication
Peripheral Arterial Disease
Helps manage Peripheral Arterial Disease (PAD)
Effectiveness
How Pentoxil Affects PatientsPentoxifylline is a medicine related to theophylline and caffeine that is used to treat peripheral artery disease (PAD). It has anti-inflammatory, anti-oxidative, and blood-thinning properties. When taking pentoxifylline, people with cerebrovascular and coronary artery disease may be at risk of angina, arrhythmia, and low blood pressure. People taking warfarin should have their prothrombin times checked more frequently. Additionally, people with risk factors for bleeding like retinal bleeding, ulcers, and recent surgery should be monitored for signs of bleeding.
How Pentoxil works in the bodyPentoxifylline (PTX) helps treat peripheral arterial disease (PAD) by reducing blood viscosity, decreasing inflammation, and inhibiting white blood cell activation. It is thought to work by targeting a nuclear exporter protein and preventing molecules that suppress tumors from leaving cancerous cells. This keeps these tumor-suppressing molecules in the cell to stop it from reproducing. PTX also increases the response of certain receptors to adenosine and can raise intracellular cAMP levels. This leads to reduced inflammation, decreased pro-inflammatory molecules, increased anti-inflammatory molecules, and decreased production of f
When to interrupt dosage
The preferred measure of Pentoxil is contingent upon the diagnosed condition, including Venous Leg Ulcer (VLU), Alcoholic Liver Diseases and Peripheral Arterial Disease. The quantity of dosage is contingent upon the mode of delivery (e.g. Tablet, film coated, extended release or Gel - Topical) indicated in the table underneath.Condition
Dosage
Administration
Intermittent Claudication
400.0 mg, , 1.0 mg/mg, 0.02 mg/mg, 0.005 mg/mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Topical, Kit, Kit - Topical, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Topical, Gel, Gel - Topical
Alcoholic Liver Diseases
400.0 mg, , 1.0 mg/mg, 0.02 mg/mg, 0.005 mg/mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Topical, Kit, Kit - Topical, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Topical, Gel, Gel - Topical
Venous Leg Ulcer (VLU)
400.0 mg, , 1.0 mg/mg, 0.02 mg/mg, 0.005 mg/mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Topical, Kit, Kit - Topical, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Topical, Gel, Gel - Topical
Peripheral Arterial Disease
400.0 mg, , 1.0 mg/mg, 0.02 mg/mg, 0.005 mg/mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Topical, Kit, Kit - Topical, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Topical, Gel, Gel - Topical
Warnings
Pentoxil has five contraindications. It should not be administered while suffering from the conditions in the following table.Pentoxil ContraindicationsCondition
Risk Level
Notes
Food Intolerance
Do Not Combine
methylxanthine
Do Not Combine
Cerebral Hemorrhage
Do Not Combine
Retinal Hemorrhage
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Pentoxifylline may interact with Pulse Frequency
Common Pentoxil Drug Interactions
Drug Name
Risk Level
Description
Abrocitinib
Major
The risk or severity of bleeding and thrombocytopenia can be increased when Pentoxifylline is combined with Abrocitinib.
Riociguat
Major
Pentoxifylline may increase the hypotensive activities of Riociguat.
Abacavir
Minor
Pentoxifylline may decrease the excretion rate of Abacavir which could result in a higher serum level.
Acebutolol
Minor
Pentoxifylline may increase the hypotensive activities of Acebutolol.
Aclidinium
Minor
Pentoxifylline may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Pentoxil Toxicity & Overdose RiskSigns of an overdose on pentoxifylline can appear 4-5 hours after ingestion, and include agitation, increased body temperature, low blood pressure, seizures, drowsiness, and loss of consciousness. To treat these symptoms, doctors may recommend maintaining proper respiration and blood pressure, and administering activated charcoal to absorb excess pentoxifylline. Even very high doses of the drug have been survived.
Pentoxil Novel Uses: Which Conditions Have a Clinical Trial Featuring Pentoxil?
68 active trials are currently evaluating the potential of Pentoxil to treat Venous Leg Ulcer (VLU), Intermittent Claudication and Alcoholic Liver Diseases.Condition
Clinical Trials
Trial Phases
Alcoholic Liver Diseases
3 Actively Recruiting
Phase 1, Not Applicable
Venous Leg Ulcer (VLU)
8 Actively Recruiting
Not Applicable
Intermittent Claudication
8 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3
Peripheral Arterial Disease
39 Actively Recruiting
Phase 1, Not Applicable, Phase 3, Phase 2, Early Phase 1
Patient Q&A Section about pentoxil
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Pentoxil used for?
"This medication is used to improve the symptoms of a blood flow problem in the legs/arms called intermittent claudication. Intermittent claudication is when you have cramps or pain in your muscles during exercise, including walking. Pentoxifylline can help improve these symptoms by decreasing the muscle aching/pain/cramps during exercise."
Answered by AI
Is pentoxifylline a blood thinner?
"According to the research, pentoxifylline has the ability to thin the blood by increasing the deformability of red blood cells. This makes the cells easier to move and improves their rheological properties."
Answered by AI
Is pentoxifylline a blood pressure medication?
"The use of Trental (pentoxifylline) may increase the effectiveness of blood pressure medications. Close monitoring of blood pressure levels is necessary, and the dosage of blood pressure medication may need to be reduced."
Answered by AI