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What is Pacerone
AmiodaroneThe Generic name of this drug
Treatment SummaryAmiodarone is a medication used to treat life-threatening heart rhythm disorders. It is also sometimes used off-label to treat atrial fibrillation. However, it can cause serious side effects and even death, so it should only be used for its approved indications.
Cordaroneis the brand name
Pacerone Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Cordarone
Amiodarone
1985
144
Approved as Treatment by the FDA
Amiodarone, also known as Cordarone, is approved by the FDA for 2 uses like Tachycardia, Ventricular and recurrent Ventricular fibrillation .Tachycardia, Ventricular
Helps manage recurrent hemodynamically unstable Ventricular tachycardia
recurrent Ventricular fibrillation
Helps manage recurrent Ventricular fibrillation
Effectiveness
How Pacerone Affects PatientsAmiodarone helps to relax the muscles in blood vessels, which reduces the resistance that blood has to flow, and increases the blood flow to the heart. When taken orally, it does not have a significant effect on the heart's ability to pump blood. Taking amiodarone can also lengthen the time it takes for electrical signals to move through the heart, which can help to prevent and treat arrhythmias. However, studies have not shown that taking amiodarone increases survival. Taking amiodarone can also interfere with normal thyroid function and can cause symptoms of hyperthyroidism or hypothyroidism.
How Pacerone works in the bodyAmiodarone is a drug used to treat abnormal heart rhythms. It works by blocking potassium currents that help the heart muscle relax after it contracts. This makes the muscle's action potential last longer, and prevents it from becoming overactive. Amiodarone also affects beta-adrenergic receptors, sodium channels, and calcium channels, which can lead to low blood pressure, slow heart rate, and dangerous heart rhythms. Additionally, it may cause steatogenic changes in the liver or other organs, and can interfere with the thyroid gland.
When to interrupt dosage
The proposed measure of Pacerone is contingent upon the identified disorder, including recurrent Ventricular fibrillation, Tachycardia, Ventricular and Cardiothoracic Surgery. The quantity of dosage can be found in the table below, depending on the method of administration (e.g. Tablet or Injection, solution - Intravenous).Condition
Dosage
Administration
Atrial Fibrillation
, 200.0 mg, 50.0 mg/mL, 1.8 mg/mL, 100.0 mg, 400.0 mg, 1.5 mg/mL, 300.0 mg, 150.0 mg/mL, 450.0 mg/mL, 90.0 mg/mL
Oral, Tablet, , Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous
Tachycardia, Ventricular
, 200.0 mg, 50.0 mg/mL, 1.8 mg/mL, 100.0 mg, 400.0 mg, 1.5 mg/mL, 300.0 mg, 150.0 mg/mL, 450.0 mg/mL, 90.0 mg/mL
Oral, Tablet, , Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous
recurrent Ventricular fibrillation
, 200.0 mg, 50.0 mg/mL, 1.8 mg/mL, 100.0 mg, 400.0 mg, 1.5 mg/mL, 300.0 mg, 150.0 mg/mL, 450.0 mg/mL, 90.0 mg/mL
Oral, Tablet, , Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous
Cardiothoracic Surgery
, 200.0 mg, 50.0 mg/mL, 1.8 mg/mL, 100.0 mg, 400.0 mg, 1.5 mg/mL, 300.0 mg, 150.0 mg/mL, 450.0 mg/mL, 90.0 mg/mL
Oral, Tablet, , Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous
Supraventricular Tachycardia (SVT)
, 200.0 mg, 50.0 mg/mL, 1.8 mg/mL, 100.0 mg, 400.0 mg, 1.5 mg/mL, 300.0 mg, 150.0 mg/mL, 450.0 mg/mL, 90.0 mg/mL
Oral, Tablet, , Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous
Warnings
Pacerone ContraindicationsCondition
Risk Level
Notes
Shock, Cardiogenic
Do Not Combine
Syncope
Do Not Combine
third degree AV block
Do Not Combine
pathologic fistula
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Amiodarone may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Amiodarone may interact with Pulse Frequency
Common Pacerone Drug Interactions
Drug Name
Risk Level
Description
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be decreased when combined with Amiodarone.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Amiodarone.
3-isobutyl-1-methyl-7H-xanthine
Major
The serum concentration of 3-isobutyl-1-methyl-7H-xanthine can be increased when it is combined with Amiodarone.
5-androstenedione
Major
The metabolism of 5-androstenedione can be decreased when combined with Amiodarone.
6-O-benzylguanine
Major
The metabolism of 6-O-benzylguanine can be decreased when combined with Amiodarone.
Pacerone Toxicity & Overdose RiskThe lowest toxic dose of amiodarone in mice and rats is greater than 3,000mg/kg. An overdose of amiodarone can be fatal as it can cause abnormal heart rhythms. Symptoms of an overdose may include low blood pressure, slow heartbeat, problems with the heart's electrical signals, and liver damage. If an overdose occurs, treatment should include supportive care and monitoring of the patient's liver function. Amiodarone and its main metabolite cannot be removed from the bloodstream through dialysis.
Pacerone Novel Uses: Which Conditions Have a Clinical Trial Featuring Pacerone?
161 active trials are currently underway to investigate the use of Pacerone to address recurrent Ventricular fibrillation, Cardiothoracic Surgery and Ventricular Tachycardia.Condition
Clinical Trials
Trial Phases
recurrent Ventricular fibrillation
0 Actively Recruiting
Supraventricular Tachycardia (SVT)
1 Actively Recruiting
Not Applicable
Cardiothoracic Surgery
0 Actively Recruiting
Atrial Fibrillation
146 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
Tachycardia, Ventricular
0 Actively Recruiting
Pacerone Reviews: What are patients saying about Pacerone?
5Patient Review
12/30/2013 I'm on 200mg Pacerone/Amiodarone for my AFib. There are a lot of side effects that I don't like, but fortunately my liver can handle the medication.
5Patient Review
9/11/2014 I've had Atrial Fib for a while, and Pacerone has really helped me. I haven't experienced any negative side effects, which is amazing.
4.7Patient Review
8/5/2014 I'm very pleased to report that I haven't experienced a return of atrial fib in the year since my initial episode.
4.7Patient Review
12/21/20104.3Patient Review
4/16/2012 Although I'm still having episodes, this medication has been helpful.
4.3Patient Review
7/16/2014 I was on this medication for over two years before I started noticing serious side effects like lung damage and hair loss. My doctor took me off the drug and told me I should have come in sooner. I think it's important that doctors warn their patients about the potential risks of taking this medication, so that people can make an informed decision about whether or not to take it.
4Patient Review
4/16/20113.3Patient Review
11/16/2013 While this did help me, I experienced some serious gastro problems as a result. Additionally, I fainted while taking it.
3.3Patient Review
10/21/2012 I had some negative side effects after being on this medication for four months. I developed a-fib and edema, as well as pain and burning in my mouth. These problems persisted even after I stopped taking the medication, which was a month ago.
3Patient Review
11/6/2013 This drug is very potent and can have serious side effects if not used correctly. Be sure to consult a doctor before taking this, especially if you are on other medications.
3Patient Review
5/31/2014 I am also taking Lovastatin. Will the Pacerone affect the Lovastatin?
3Patient Review
1/12/2012 I'm not thrilled with the fact that pacerone has turned my hands black, and I bruise easily now.
3Patient Review
2/8/20112.3Patient Review
5/20/2013 I'm only two days in, and I'm already feeling exhausted.
2.3Patient Review
8/12/2011 I'm also taking warferin and my blood has become too thick. Could amiodarone be the cause of this problem?
2.3Patient Review
4/21/2013 This medication dangerously lowed my thyroid level.
Patient Q&A Section about pacerone
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What's the side effects of Pacerone?
"You may have a general feeling of being unwell, fatigue, tremor and involuntary movements, poor coordination and gait, numbness and tingling of extremities, nausea, vomiting, and constipation."
Answered by AI
Is Pacerone and amiodarone the same?
"Amiodarone is an antiarrhythmic that works by blocking various receptors and channels in your heart, which play a major part in your heart's electrical activity. Amiodarone slows down the electrical activity to help your heartbeat stay in a normal 'sinus' rhythm."
Answered by AI
What should be avoided while taking amiodarone?
"Grapefruit and grapefruit juice may increase the side effects of amiodarone by increasing the amount of this medicine in your body. You should not eat grapefruit or drink grapefruit juice while you are using this medicine. Take other medicines only as discussed with your doctor."
Answered by AI
Does Pacerone lower heart rate?
"Pacerone is a medication used to help regulate heartbeats. It is primarily used for people who have life-threatening heart rhythm disorders affecting the ventricles."
Answered by AI