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What is Norflex
OrphenadrineThe Generic name of this drug
Treatment SummaryA muscarinic antagonist is a type of medication used to reduce the symptoms of drug-induced parkinsonism and to relieve pain from muscle spasms.
Norflexis the brand name
Norflex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Norflex
Orphenadrine
1959
68
Approved as Treatment by the FDA
Orphenadrine, otherwise called Norflex, is approved by the FDA for 6 uses which include Rest and Muscle Spasms .Rest
Used to treat Rest in combination with Acetylsalicylic acid
Muscle Spasms
Musculoskeletal Diseases
Used to treat mild Musculoskeletal Disorder in combination with Acetylsalicylic acid
Musculoskeletal Diseases
Used to treat moderate Musculoskeletal Disorder in combination with Acetylsalicylic acid
other pain relief measures
Used to treat other pain relief measures in combination with Acetylsalicylic acid
Physical Therapy
Used to treat Physical Therapy in combination with Acetylsalicylic acid
Effectiveness
How Norflex Affects PatientsOrphenadrine is a medication prescribed to help reduce muscle discomfort related to a variety of musculoskeletal conditions. It works by blocking certain nerve signals in the brain, and has a mild effect in reducing histamines and providing local anesthesia. Orphenadrine is also used to treat Parkinson's Disease and similar conditions. It helps restore the balance between chemicals that control movement in the brain, which can help reduce stiffness and shaking associated with Parkinson's. It is not as effective in treating slowed movement associated with the condition.
How Norflex works in the bodyOrphenadrine works by blocking two types of receptors in the body. The first is the histamine H1 receptor, which helps regulate movement. The second is the NMDA receptor, which helps control mood. By blocking these receptors, orphenadrine can reduce muscle spasms and have a calming effect. It can also help improve mood.
When to interrupt dosage
The measure of Norflex is contingent upon the diagnosed affliction, including Musculoskeletal Diseases, Mild pain and Musculoskeletal Diseases. The quantity of dosage also differs, in accordance with the mode of delivery (e.g. Liquid or Liquid - Intramuscular; Intravenous) specified in the table beneath.Condition
Dosage
Administration
Rest
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Pain
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Muscle Spasms
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
other pain relief measures
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Traumatic Injuries
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Muscle Strain
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Rheumatism
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Muscle Pain
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Pain
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Bursitis
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Musculoskeletal Diseases
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Fever
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Menstrual Distress (Dysmenorrhea)
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Physical Therapy
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Inflammation
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Musculoskeletal Diseases
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Sprains
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Back Pain Lower Back
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Mild pain
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Musculoskeletal Diseases
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Warnings
Norflex has eight contraindications and should not be utilized in the presence of any of the conditions indicated in the table below.Norflex ContraindicationsCondition
Risk Level
Notes
Prostatic Hypertrophy
Do Not Combine
Peptic Ulcer
Do Not Combine
Duodenal Obstruction
Do Not Combine
Achalasia, Esophageal
Do Not Combine
pyloric obstruction
Do Not Combine
Open-angle glaucoma
Do Not Combine
Bladder Neck Obstruction
Do Not Combine
Myasthenia Gravis
Do Not Combine
Common Norflex Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Orphenadrine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Orphenadrine.
Acebutolol
Major
The metabolism of Acebutolol can be decreased when combined with Orphenadrine.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Orphenadrine is combined with Aclidinium.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Orphenadrine.
Norflex Toxicity & Overdose RiskThe toxic dose of the drug in mice has been found to be 100 mg/kg and in rats it is 255 mg/kg when taken orally.
Norflex Novel Uses: Which Conditions Have a Clinical Trial Featuring Norflex?
220 active studies are being conducted to investigate the potential of Norflex in mitigating Osteoarthritis, Dysmenorrhea and Musculoskeletal Ailments.Condition
Clinical Trials
Trial Phases
Sprains
0 Actively Recruiting
Musculoskeletal Diseases
4 Actively Recruiting
Phase 1, Phase 2, Not Applicable
Muscle Pain
8 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Early Phase 1
Mild pain
0 Actively Recruiting
Bursitis
6 Actively Recruiting
Phase 4, Not Applicable
Pain
0 Actively Recruiting
Physical Therapy
7 Actively Recruiting
Not Applicable
Inflammation
0 Actively Recruiting
Rheumatism
0 Actively Recruiting
Muscle Spasms
0 Actively Recruiting
Musculoskeletal Diseases
0 Actively Recruiting
Menstrual Distress (Dysmenorrhea)
1 Actively Recruiting
Phase 4
Musculoskeletal Diseases
0 Actively Recruiting
Pain
0 Actively Recruiting
Traumatic Injuries
6 Actively Recruiting
Phase 3, Not Applicable
Muscle Strain
1 Actively Recruiting
Not Applicable
Rest
0 Actively Recruiting
Back Pain Lower Back
5 Actively Recruiting
Not Applicable, Phase 4
other pain relief measures
0 Actively Recruiting
Fever
18 Actively Recruiting
Phase 3, Phase 4, Phase 2, Phase 1, Not Applicable
Norflex Reviews: What are patients saying about Norflex?
5Patient Review
3/17/2011 I unfortunately did not experience any relief from this medication, even though I have a pulled muscle in my chest wall.
4.7Patient Review
4/16/2011 This medication is really helpful for me because I have a genetic disorder in my lower back. It often causes pain there and in my left leg and ankle when I over exert myself, but this allows me to sleep restfully and wake up without any stiffness.
4.3Patient Review
7/30/2012 Norflex has been a godsend for me, allowing me to avoid surgery for my chronic neck and back pain.
3.7Patient Review
1/9/2012 I've been using Norflex for over a year now, and just recently started having blurred vision about three months ago. It's gotten to the point where it was difficult to pass my state license exam, even with glasses. I contacted my pharmacist who said to reach out to my doctor. My doctor wants me to stop taking the medication and see if that helps; so, I'm going to give it at least two months.
3.3Patient Review
4/18/2012 I took this for some really bad back spasms. It let me get on with my life while I was taking it, but I started getting muscle twitches all over my body that I never had before. After a week or so of taking the medicine, I stopped and hope the twitching goes away soon.
3Patient Review
5/10/2017 I was prescribed disipal/norflex for the burning sensation I experience in my legs when inactive. After taking it for five days, I saw some improvement but then the symptoms would come back a few hours later. I also experienced some of the listed side effects, so I'm hesitant to increase the dose as directed.
2.7Patient Review
10/24/2013 I had to stop taking this after only two doses because I developed an allergic reaction. It was just some mild itchiness and a rash, but it was enough that I didn't want to risk continuing. While I was taking it, I didn't really notice much of a difference in my muscle spasms.
2.7Patient Review
4/25/2013 I've been struggling with chronic pain for a while now, and I haven't found anything that really helps. Trigger point injections and epidurals provide some relief, but it never lasts very long.
2.7Patient Review
5/19/2010 It's alright, I guess.
2.7Patient Review
6/15/2011 I have neuropathy and this is the best muscle relaxer I've ever taken. I'm glad I tried something new.
2.3Patient Review
11/8/2016 My daughter received a shot in her hip for muscle pain and strain. However, I was never informed that this could potentially harm my baby if I were to breastfeed while she had the medication in her system.
2.3Patient Review
1/2/2011 This treatment helps with the muscles in my back and legs.
2Patient Review
9/8/20091.3Patient Review
2/12/2011 Unfortunately, this medicine did not work for me. I was in pain a mere hour after taking it, and it's incredibly overpriced.
Patient Q&A Section about norflex
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Will Norflex make you sleepy?
"If you experience any of the following symptoms while taking NORFLEX, do not operate machinery or drive: blurred vision, drowsiness, dizziness, lightheadedness, or fainting. NORFLEX may also cause muscle weakness."
Answered by AI
Is Norflex a painkiller?
"- Norflex is a muscle relaxant. It is usually used together with rest and physical therapy to treat conditions that cause pain or injury in the skeletal muscles. Norflex may also be used for other purposes that are not listed in this medication guide."
Answered by AI
Is Norflex a good muscle relaxer?
"Studies have shown that drugs that relax the muscles, like Norflex, are effective, have tolerable side effects, and can help treat painful conditions that come with muscle spasms."
Answered by AI
Is Norflex used for anxiety?
"Norflex (orphenadrine) alleviates stress. Valium (diazepam) is ideal for infrequent or ephemeral usage for nuisances and muscle spasm. Valium (diazepam) works rapidly, but can have reactions with other drugs, in comparison to similar drugs."
Answered by AI