Norflex

Muscle Pain, Bursitis, Pain + 17 more
Treatment
7 FDA approvals
20 Active Studies for Norflex

What is Norflex

OrphenadrineThe Generic name of this drug
Treatment SummaryA muscarinic antagonist is a type of medication used to reduce the symptoms of drug-induced parkinsonism and to relieve pain from muscle spasms.
Norflexis the brand name
image of different drug pills on a surface
Norflex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Norflex
Orphenadrine
1959
68

Approved as Treatment by the FDA

Orphenadrine, otherwise called Norflex, is approved by the FDA for 7 uses which include Musculoskeletal Diseases and Muscle Spasms .
Musculoskeletal Diseases
Used to treat mild Musculoskeletal Disorder in combination with Acetylsalicylic acid
Muscle Spasms
other pain relief measures
Used to treat other pain relief measures in combination with Acetylsalicylic acid
Physical Therapy
Used to treat Physical Therapy in combination with Acetylsalicylic acid
Rest
Used to treat Rest in combination with Acetylsalicylic acid
Spasm
Musculoskeletal Diseases
Used to treat moderate Musculoskeletal Disorder in combination with Acetylsalicylic acid

Effectiveness

How Norflex Affects PatientsOrphenadrine is a medication prescribed to help reduce muscle discomfort related to a variety of musculoskeletal conditions. It works by blocking certain nerve signals in the brain, and has a mild effect in reducing histamines and providing local anesthesia. Orphenadrine is also used to treat Parkinson's Disease and similar conditions. It helps restore the balance between chemicals that control movement in the brain, which can help reduce stiffness and shaking associated with Parkinson's. It is not as effective in treating slowed movement associated with the condition.
How Norflex works in the bodyOrphenadrine works by blocking two types of receptors in the body. The first is the histamine H1 receptor, which helps regulate movement. The second is the NMDA receptor, which helps control mood. By blocking these receptors, orphenadrine can reduce muscle spasms and have a calming effect. It can also help improve mood.

When to interrupt dosage

The measure of Norflex is contingent upon the diagnosed affliction, including Musculoskeletal Diseases, Mild pain and Musculoskeletal Diseases. The quantity of dosage also differs, in accordance with the mode of delivery (e.g. Liquid or Liquid - Intramuscular; Intravenous) specified in the table beneath.
Condition
Dosage
Administration
Muscle Pain
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Fever
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Sprains and Strains
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Musculoskeletal Diseases
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Wounds and Injuries
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Muscle Strain
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Mild pain
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Pain
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Inflammation
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Musculoskeletal Diseases
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Musculoskeletal Diseases
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
other pain relief measures
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Bursitis
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Pain
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Physical Therapy
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Rheumatism
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Rest
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Dysmenorrhea
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Spasm
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Low Back Pain
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous

Warnings

Norflex has eight contraindications and should not be utilized in the presence of any of the conditions indicated in the table below.Norflex Contraindications
Condition
Risk Level
Notes
Prostatic Hyperplasia
Do Not Combine
Peptic Ulcer
Do Not Combine
Duodenal Obstruction
Do Not Combine
Esophageal Achalasia
Do Not Combine
Pyloric Stenosis
Do Not Combine
Open-angle glaucoma
Do Not Combine
Urinary Bladder Neck Obstruction
Do Not Combine
Myasthenia Gravis
Do Not Combine
There are 20 known major drug interactions with Norflex.
Common Norflex Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Orphenadrine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Orphenadrine.
Acebutolol
Major
The metabolism of Acebutolol can be decreased when combined with Orphenadrine.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Orphenadrine is combined with Aclidinium.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Orphenadrine.
Norflex Toxicity & Overdose RiskThe toxic dose of the drug in mice has been found to be 100 mg/kg and in rats it is 255 mg/kg when taken orally.
image of a doctor in a lab doing drug, clinical research

Norflex Novel Uses: Which Conditions Have a Clinical Trial Featuring Norflex?

220 active studies are being conducted to investigate the potential of Norflex in mitigating Osteoarthritis, Dysmenorrhea and Musculoskeletal Ailments.
Condition
Clinical Trials
Trial Phases
Dysmenorrhea
0 Actively Recruiting
Musculoskeletal Diseases
2 Actively Recruiting
Not Applicable
Fever
1 Actively Recruiting
Phase 4
Mild pain
0 Actively Recruiting
Rest
0 Actively Recruiting
Wounds and Injuries
6 Actively Recruiting
Phase 3, Not Applicable
Rheumatism
0 Actively Recruiting
other pain relief measures
0 Actively Recruiting
Spasm
0 Actively Recruiting
Sprains and Strains
0 Actively Recruiting
Pain
0 Actively Recruiting
Pain
0 Actively Recruiting
Muscle Pain
1 Actively Recruiting
Phase 4
Inflammation
0 Actively Recruiting
Bursitis
0 Actively Recruiting
Musculoskeletal Diseases
0 Actively Recruiting
Low Back Pain
6 Actively Recruiting
Not Applicable, Phase 4
Muscle Strain
0 Actively Recruiting
Physical Therapy
7 Actively Recruiting
Not Applicable
Musculoskeletal Diseases
23 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3

Norflex Reviews: What are patients saying about Norflex?

5Patient Review
3/17/2011
Norflex for Muscle Spasm
I unfortunately did not experience any relief from this medication, even though I have a pulled muscle in my chest wall.
4.7Patient Review
4/16/2011
Norflex for Muscle Spasm
This medication is really helpful for me because I have a genetic disorder in my lower back. It often causes pain there and in my left leg and ankle when I over exert myself, but this allows me to sleep restfully and wake up without any stiffness.
4.3Patient Review
7/30/2012
Norflex for Muscle Spasm
Norflex has been a godsend for me, allowing me to avoid surgery for my chronic neck and back pain.
3.7Patient Review
1/9/2012
Norflex for Muscle Spasm
I've been using Norflex for over a year now, and just recently started having blurred vision about three months ago. It's gotten to the point where it was difficult to pass my state license exam, even with glasses. I contacted my pharmacist who said to reach out to my doctor. My doctor wants me to stop taking the medication and see if that helps; so, I'm going to give it at least two months.
3.3Patient Review
4/18/2012
Norflex for Muscle Spasm
I took this for some really bad back spasms. It let me get on with my life while I was taking it, but I started getting muscle twitches all over my body that I never had before. After a week or so of taking the medicine, I stopped and hope the twitching goes away soon.
View All Reviews

Patient Q&A Section about norflex

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Will Norflex make you sleepy?

"If you experience any of the following symptoms while taking NORFLEX, do not operate machinery or drive: blurred vision, drowsiness, dizziness, lightheadedness, or fainting. NORFLEX may also cause muscle weakness."

Answered by AI

Is Norflex a painkiller?

"- Norflex is a muscle relaxant. It is usually used together with rest and physical therapy to treat conditions that cause pain or injury in the skeletal muscles. Norflex may also be used for other purposes that are not listed in this medication guide."

Answered by AI

Is Norflex a good muscle relaxer?

"Studies have shown that drugs that relax the muscles, like Norflex, are effective, have tolerable side effects, and can help treat painful conditions that come with muscle spasms."

Answered by AI

Is Norflex used for anxiety?

"Norflex (orphenadrine) alleviates stress. Valium (diazepam) is ideal for infrequent or ephemeral usage for nuisances and muscle spasm. Valium (diazepam) works rapidly, but can have reactions with other drugs, in comparison to similar drugs."

Answered by AI

Clinical Trials for Norflex

Have you considered Norflex clinical trials? We made a collection of clinical trials featuring Norflex, we think they might fit your search criteria.
Have you considered Norflex clinical trials? We made a collection of clinical trials featuring Norflex, we think they might fit your search criteria.
Have you considered Norflex clinical trials? We made a collection of clinical trials featuring Norflex, we think they might fit your search criteria.
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