Nicotrol

Smoke, nicotine
Treatment
2 FDA approvals
2 Active Studies for Nicotrol

What is Nicotrol

NicotineThe Generic name of this drug
Treatment SummaryNicotine is a toxic chemical found in tobacco smoke. It acts on the brain by attaching to specific receptors, which causes neurons to become overly stimulated and block brain signals. Nicotine has medical implications as it can cause serious health issues when it is inhaled through smoking.
equate Nicotineis the brand name
image of different drug pills on a surface
Nicotrol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
equate Nicotine
Nicotine
1990
1005

Approved as Treatment by the FDA

Nicotine, otherwise called equate Nicotine, is approved by the FDA for 2 uses which include Smoke and nicotine .
Smoke
Helps manage Smoking cessation therapy
nicotine
Helps manage Withdrawal Nicotine

Effectiveness

How Nicotrol Affects PatientsNicotine, found in tobacco products, attaches to certain receptors in the body and brain. This causes a stimulant effect that can lead to increased heart rate and blood pressure. Nicotine is highly addictive, and is used in inhalers and patches to treat people who are trying to quit smoking. Nicotine is classified as a stimulant.
How Nicotrol works in the bodyNicotine is a stimulant that works on two different areas of the body. In the brain, it binds to nicotinic acetylcholine receptors, allowing ions like sodium and calcium to enter the neuron. This causes more dopamine to be released, which gives a sense of euphoria and leads to nicotine addiction. In the adrenal medulla, nicotine binds to nicotinic acetylcholine receptors and triggers the release of epinephrine. This causes vasoconstriction, increased blood pressure, higher heart rate, and increased blood sugar.

When to interrupt dosage

The advised dose of Nicotrol is contingent upon the recognized condition. The quantity of dose fluctuates, contingent upon the technique of delivery featured in the table beneath.
Condition
Dosage
Administration
nicotine
, 1.4 mg/hour, 14.0 mg, 0.7 mg/hour, 2.1 mg/hour, 7.0 mg, 21.0 mg, 4.0 mg, 2.0 mg, 1.0 mL/mL, 1.0 mg/mg, 114.0 mg, 78.0 mg, 36.0 mg, 10.0 mg/mL, 0.18 mg/mg, 0.15 mg/mg, 0.2 mg/mg, 2.0 mg/hour, 4.0 mg/hour, 8.0 mg, 2.5 mg/hour, 0.06 mg/mg, 0.12 mg/mg, 0.21 mg/mg
, Transdermal, Patch, extended release, Patch, extended release - Transdermal, Topical, Patch, extended release - Topical, Kit, Oral, Gum, chewing, Gum, chewing - Oral, Lozenge, Lozenge - Oral, Buccal, Gum, chewing - Buccal, Kit - Transdermal, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Inhalant, Patch, Patch - Transdermal, Liquid, Liquid - Oral, Powder, Powder - Oral, Nasal, Spray, metered - Nasal, Spray, metered, Dental; Oral, Patch - Topical
Smoke
, 1.4 mg/hour, 14.0 mg, 0.7 mg/hour, 2.1 mg/hour, 7.0 mg, 21.0 mg, 4.0 mg, 2.0 mg, 1.0 mL/mL, 1.0 mg/mg, 114.0 mg, 78.0 mg, 36.0 mg, 10.0 mg/mL, 0.18 mg/mg, 0.15 mg/mg, 0.2 mg/mg, 2.0 mg/hour, 4.0 mg/hour, 8.0 mg, 2.5 mg/hour, 0.06 mg/mg, 0.12 mg/mg, 0.21 mg/mg
, Transdermal, Patch, extended release, Patch, extended release - Transdermal, Topical, Patch, extended release - Topical, Kit, Oral, Gum, chewing, Gum, chewing - Oral, Lozenge, Lozenge - Oral, Buccal, Gum, chewing - Buccal, Kit - Transdermal, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Inhalant, Patch, Patch - Transdermal, Liquid, Liquid - Oral, Powder, Powder - Oral, Nasal, Spray, metered - Nasal, Spray, metered, Dental; Oral, Patch - Topical

Warnings

There are 20 known major drug interactions with Nicotrol.
Common Nicotrol Drug Interactions
Drug Name
Risk Level
Description
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Nicotine.
Cisplatin
Major
The serum concentration of Cisplatin can be increased when it is combined with Nicotine.
Clofarabine
Major
The serum concentration of Clofarabine can be increased when it is combined with Nicotine.
Cyclophosphamide
Major
The metabolism of Cyclophosphamide can be decreased when combined with Nicotine.
Dalfampridine
Major
The serum concentration of Dalfampridine can be increased when it is combined with Nicotine.
Nicotrol Toxicity & Overdose RiskOverdosing on this drug can lead to symptoms such as nausea, stomach pain, vomiting, sweating, redness of the skin, dizziness, hearing or vision problems, confusion, weakness, heart palpitations, changes in breathing, and low blood pressure. The lowest toxic dose of this drug in mice has been found to be 24 mg/kg when taken orally.
image of a doctor in a lab doing drug, clinical research

Nicotrol Novel Uses: Which Conditions Have a Clinical Trial Featuring Nicotrol?

5 active studies are currently in progress to assess the efficacy of Nicotrol in treating nicotine-related conditions.
Condition
Clinical Trials
Trial Phases
Smoke
0 Actively Recruiting
nicotine
2 Actively Recruiting
Not Applicable, Phase 1, Phase 2

Nicotrol Reviews: What are patients saying about Nicotrol?

5Patient Review
5/11/2008
Nicotrol for Stop Smoking
I was able to successfully quit smoking after only two months of use. However, I did have a slip-up about a year later. I've started using the medication again and am confident that I will be successful this time around.
5Patient Review
1/4/2010
Nicotrol for Stop Smoking
I haven't had a cigarette in three months since starting this treatment, and it's really helping me stick to my resolution to quit smoking.
5Patient Review
12/14/2010
Nicotrol for Nicotine Addiction
This worked well for me. I tried other treatments before this one, but this is the one that finally did the trick.
5Patient Review
1/12/2018
Nicotrol for Stop Smoking
I smoked for 40 years and tried everything on the market to quit. This was the first treatment that actually worked for me, and I've been smoke-free for 72 days now. The first week was tough, but it got better after that. There's a slight burning in the mouth and affect on taste, but I had that when I smoked. Overall, this treatment has greatly improved my quality of life.
5Patient Review
6/24/2018
Nicotrol for Stop Smoking
I'm surprised to read that some have a burning sensation while using this product. I never experienced that, and it's the only thing that helped me quit smoking. I get the hand-to-mouth movement plus the feeling of smoke hitting the back of my throat. It really works for me.
5Patient Review
9/14/2022
Nicotrol for Stop Smoking
I'm so glad I found this device! It helped me quit smoking after 50 years.
5Patient Review
4/6/2009
Nicotrol for Stop Smoking
The Nicotrol Inhaler was a huge help when I quit smoking over 10 years ago. I only needed to use it for a short time, and it's been incredibly effective. Not only that, but I'm convinced it's added years to my life by helping me kick the habit.
5Patient Review
9/14/2009
Nicotrol for Stop Smoking
The nicotine in this product did cause a bit of discomfort at first, but it was totally worth it for the results. I still have cravings, but they're manageable and getting less and less intense. It's only been two weeks, so I know there's still a ways to go, but I'm confident that I can stick with it.
5Patient Review
3/14/2008
Nicotrol for Stop Smoking
Even after five years, I'm still addicted to nicotine. This drug has helped me curb my cravings, but I'm afraid that if I go off of it I'll start smoking again.
4.3Patient Review
7/17/2022
Nicotrol for Stop Smoking
This provides a similar effect to smoking cigarettes, but without all the tar and other nastiness in my lungs. I wish they could put THC oil in them though!
4Patient Review
5/11/2019
Nicotrol for Stop Smoking
Can anyone tell me how expensive the inhaler is? I don't want to get a prescription and find out I can't afford it. I see it is used for quite awhile. Thank you.
3Patient Review
2/6/2010
Nicotrol for Stop Smoking
This product helps with the cravings, but I still feel like something is missing. It doesn't have the same effect as smoking did, both in terms of satisfying the craving and physiologically.
2.7Patient Review
3/9/2011
Nicotrol for Nicotine Addiction
My husband found this effective from the start, but given his addiction problems, it might not have been the best choice for him. He's used it for over eight years now and his doctor keeps prescribing it. He's tried to quit twice but failed; there's also a chemical odor that comes from his skin which is likely from Nicotrol use.

Patient Q&A Section about nicotrol

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can you smoke with Nicotrol inhaler?

"Do not use the NICOTROL Inhaler if you are currently smoking or using any other tobacco products, as this could result in nicotine overdose. Symptoms of overdose include dizziness, headache, weakness, and nausea. If you experience any of these symptoms, call a doctor or Poison Control Center immediately."

Answered by AI

What are the side effects of nicotrol?

"You may experience headache, nausea, mouth or tooth pain, cough, runny or stuffy nose, change in taste, heartburn, hiccups, sweating, or diarrhea."

Answered by AI

How long can you use Nicotrol inhaler?

"A minimum of 4 and a maximum of 20 NICOTROL Inhaler cartridges were used per day. In both studies, the recommended treatment duration was 3 months, but patients were allowed to continue using the product for up to 6 months if they wanted to."

Answered by AI

Do I need a prescription for nicotrol?

"You will need a prescription from a prescribing healthcare provider in order to use the nicotine oral inhaler. The nicotine oral inhaler may resemble a cigarette, but it must be used differently. You do not need to inhale as deeply for the medicine to be effective."

Answered by AI

Clinical Trials for Nicotrol

Image of Rush University Medical Center in Chicago, United States.

NRT + Quit Practice Strategies for Smoking Cessation

18+
All Sexes
Chicago, IL
Tobacco use disorder is a chronic, relapsing health condition that necessitates a chronic care approach. However, traditional smoking cessation treatment programs allocate nearly all their resources only to those smokers who are willing to set a quit date. This is problematic because few smokers are ready to set a quit date at any given time, and a smoker's stated intention to quit can change rapidly. One novel potential treatment strategy is to foster practice quitting (PQ), defined as attempting to not smoke for a few hours or days, without pressure or expectation to permanently quit. Although a growing body of evidence supports the role of practice quitting in fostering permanent quit attempts and cessation, there is a significant knowledge gap regarding which treatment strategies should be used to engage smokers in practice quitting. The proposed study will test the role of PQ counseling vs. Motivational Interviewing (MI) counseling, and NRT sampling (four-week supply of nicotine lozenges and patches) vs. none.
Phase 1 & 2
Recruiting
Rush University Medical CenterAmanda Mathew, PhD
Image of The Ottawa Hospital General Campus in Ottawa, Canada.

Quit Card Intervention for Cigarette Addiction

18+
All Sexes
Ottawa, Canada
The INITIATE Study is a randomized controlled trial that is testing an intervention designed to increase long-term abstinence among tobacco smokers seen in emergency departments (ED) and other high-volume hospital and community ambulatory care settings. The intervention includes a behavioural incentive and tailored follow-up support on long-term smoking abstinence, health, healthcare utilization, and cost. Tobacco-related illnesses cost the healthcare system millions each year. Quitting smoking improves smoking-related outcomes, like the onset or management of heart disease, stroke, lung diseases, and several cancers. There are approximately 16 million visits to Canadian EDs each year; an estimated 3-4 million of these involve smokers. Effective quit smoking interventions exist, but are underutilized. Few hospital EDs, community healthcare centers, and other inpatient and outpatient clinics in Canada offer tobacco-use interventions. In order for clinicians to offer quit smoking support, interventions need to be simple given the realities of these high-volume environments. Considering that stopping smoking improves health outcomes, that tobacco-use is an important cause of preventable ED use, and the volume of smokers, Canadian EDs and other high-volume hospital and community ambulatory care settings are a missed opportunity in the initiation of quit smoking support. Our intervention has been designed to optimize uptake and smoking abstinence by including the most effective evidence-based behavioural and drug-related approaches, removing specific barriers and challenges that smokers face when trying to quit (e.g., affordability, low confidence and motivation), while packaging the intervention in a quick-to-initiate manner, making it ideal for fast-paced, complex environments.
Recruiting
Has No Placebo
The Ottawa Hospital General Campus (+5 Sites)Kerri-Anne Mullen, PhD
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