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What is Nicotrol
NicotineThe Generic name of this drug
Treatment SummaryNicotine is a toxic chemical found in tobacco smoke. It acts on the brain by attaching to specific receptors, which causes neurons to become overly stimulated and block brain signals. Nicotine has medical implications as it can cause serious health issues when it is inhaled through smoking.
equate Nicotineis the brand name
Nicotrol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
equate Nicotine
Nicotine
1990
1005
Approved as Treatment by the FDA
Nicotine, otherwise called equate Nicotine, is approved by the FDA for 2 uses which include Smoke and nicotine .Smoke
Helps manage Smoking cessation therapy
nicotine
Helps manage Withdrawal Nicotine
Effectiveness
How Nicotrol Affects PatientsNicotine, found in tobacco products, attaches to certain receptors in the body and brain. This causes a stimulant effect that can lead to increased heart rate and blood pressure. Nicotine is highly addictive, and is used in inhalers and patches to treat people who are trying to quit smoking. Nicotine is classified as a stimulant.
How Nicotrol works in the bodyNicotine is a stimulant that works on two different areas of the body. In the brain, it binds to nicotinic acetylcholine receptors, allowing ions like sodium and calcium to enter the neuron. This causes more dopamine to be released, which gives a sense of euphoria and leads to nicotine addiction. In the adrenal medulla, nicotine binds to nicotinic acetylcholine receptors and triggers the release of epinephrine. This causes vasoconstriction, increased blood pressure, higher heart rate, and increased blood sugar.
When to interrupt dosage
The advised dose of Nicotrol is contingent upon the recognized condition. The quantity of dose fluctuates, contingent upon the technique of delivery featured in the table beneath.Condition
Dosage
Administration
Smoke
, 1.4 mg/hour, 14.0 mg, 0.7 mg/hour, 2.1 mg/hour, 7.0 mg, 21.0 mg, 4.0 mg, 2.0 mg, 1.0 mL/mL, 1.0 mg/mg, 114.0 mg, 78.0 mg, 36.0 mg, 10.0 mg/mL, 0.18 mg/mg, 0.15 mg/mg, 0.2 mg/mg, 2.0 mg/hour, 4.0 mg/hour, 8.0 mg, 2.5 mg/hour, 0.06 mg/mg, 0.12 mg/mg, 0.21 mg/mg
, Transdermal, Patch, extended release, Patch, extended release - Transdermal, Topical, Patch, extended release - Topical, Kit, Oral, Gum, chewing, Gum, chewing - Oral, Lozenge, Lozenge - Oral, Buccal, Gum, chewing - Buccal, Kit - Transdermal, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Inhalant, Patch, Patch - Transdermal, Liquid, Liquid - Oral, Powder, Powder - Oral, Nasal, Spray, metered - Nasal, Spray, metered, Dental; Oral, Patch - Topical
nicotine
, 1.4 mg/hour, 14.0 mg, 0.7 mg/hour, 2.1 mg/hour, 7.0 mg, 21.0 mg, 4.0 mg, 2.0 mg, 1.0 mL/mL, 1.0 mg/mg, 114.0 mg, 78.0 mg, 36.0 mg, 10.0 mg/mL, 0.18 mg/mg, 0.15 mg/mg, 0.2 mg/mg, 2.0 mg/hour, 4.0 mg/hour, 8.0 mg, 2.5 mg/hour, 0.06 mg/mg, 0.12 mg/mg, 0.21 mg/mg
, Transdermal, Patch, extended release, Patch, extended release - Transdermal, Topical, Patch, extended release - Topical, Kit, Oral, Gum, chewing, Gum, chewing - Oral, Lozenge, Lozenge - Oral, Buccal, Gum, chewing - Buccal, Kit - Transdermal, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Inhalant, Patch, Patch - Transdermal, Liquid, Liquid - Oral, Powder, Powder - Oral, Nasal, Spray, metered - Nasal, Spray, metered, Dental; Oral, Patch - Topical
Warnings
There are 20 known major drug interactions with Nicotrol.Common Nicotrol Drug Interactions
Drug Name
Risk Level
Description
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Nicotine.
Cisplatin
Major
The serum concentration of Cisplatin can be increased when it is combined with Nicotine.
Clofarabine
Major
The serum concentration of Clofarabine can be increased when it is combined with Nicotine.
Cyclophosphamide
Major
The metabolism of Cyclophosphamide can be decreased when combined with Nicotine.
Dalfampridine
Major
The serum concentration of Dalfampridine can be increased when it is combined with Nicotine.
Nicotrol Toxicity & Overdose RiskOverdosing on this drug can lead to symptoms such as nausea, stomach pain, vomiting, sweating, redness of the skin, dizziness, hearing or vision problems, confusion, weakness, heart palpitations, changes in breathing, and low blood pressure. The lowest toxic dose of this drug in mice has been found to be 24 mg/kg when taken orally.
Nicotrol Novel Uses: Which Conditions Have a Clinical Trial Featuring Nicotrol?
5 active studies are currently in progress to assess the efficacy of Nicotrol in treating nicotine-related conditions.Condition
Clinical Trials
Trial Phases
nicotine
5 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Smoke
0 Actively Recruiting
Nicotrol Reviews: What are patients saying about Nicotrol?
5Patient Review
5/11/2008 I was able to successfully quit smoking after only two months of use. However, I did have a slip-up about a year later. I've started using the medication again and am confident that I will be successful this time around.
5Patient Review
1/4/2010 I haven't had a cigarette in three months since starting this treatment, and it's really helping me stick to my resolution to quit smoking.
5Patient Review
12/14/2010 This worked well for me. I tried other treatments before this one, but this is the one that finally did the trick.
5Patient Review
1/12/2018 I smoked for 40 years and tried everything on the market to quit. This was the first treatment that actually worked for me, and I've been smoke-free for 72 days now. The first week was tough, but it got better after that. There's a slight burning in the mouth and affect on taste, but I had that when I smoked. Overall, this treatment has greatly improved my quality of life.
5Patient Review
6/24/2018 I'm surprised to read that some have a burning sensation while using this product. I never experienced that, and it's the only thing that helped me quit smoking. I get the hand-to-mouth movement plus the feeling of smoke hitting the back of my throat. It really works for me.
5Patient Review
9/14/2022 I'm so glad I found this device! It helped me quit smoking after 50 years.
5Patient Review
4/6/2009 The Nicotrol Inhaler was a huge help when I quit smoking over 10 years ago. I only needed to use it for a short time, and it's been incredibly effective. Not only that, but I'm convinced it's added years to my life by helping me kick the habit.
5Patient Review
9/14/2009 The nicotine in this product did cause a bit of discomfort at first, but it was totally worth it for the results. I still have cravings, but they're manageable and getting less and less intense. It's only been two weeks, so I know there's still a ways to go, but I'm confident that I can stick with it.
5Patient Review
3/14/2008 Even after five years, I'm still addicted to nicotine. This drug has helped me curb my cravings, but I'm afraid that if I go off of it I'll start smoking again.
4.3Patient Review
7/17/2022 This provides a similar effect to smoking cigarettes, but without all the tar and other nastiness in my lungs. I wish they could put THC oil in them though!
4Patient Review
5/11/2019 Can anyone tell me how expensive the inhaler is? I don't want to get a prescription and find out I can't afford it. I see it is used for quite awhile. Thank you.
3Patient Review
2/6/2010 This product helps with the cravings, but I still feel like something is missing. It doesn't have the same effect as smoking did, both in terms of satisfying the craving and physiologically.
2.7Patient Review
3/9/2011 My husband found this effective from the start, but given his addiction problems, it might not have been the best choice for him. He's used it for over eight years now and his doctor keeps prescribing it. He's tried to quit twice but failed; there's also a chemical odor that comes from his skin which is likely from Nicotrol use.
Patient Q&A Section about nicotrol
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Can you smoke with Nicotrol inhaler?
"Do not use the NICOTROL Inhaler if you are currently smoking or using any other tobacco products, as this could result in nicotine overdose. Symptoms of overdose include dizziness, headache, weakness, and nausea. If you experience any of these symptoms, call a doctor or Poison Control Center immediately."
Answered by AI
What are the side effects of nicotrol?
"You may experience headache, nausea, mouth or tooth pain, cough, runny or stuffy nose, change in taste, heartburn, hiccups, sweating, or diarrhea."
Answered by AI
How long can you use Nicotrol inhaler?
"A minimum of 4 and a maximum of 20 NICOTROL Inhaler cartridges were used per day. In both studies, the recommended treatment duration was 3 months, but patients were allowed to continue using the product for up to 6 months if they wanted to."
Answered by AI
Do I need a prescription for nicotrol?
"You will need a prescription from a prescribing healthcare provider in order to use the nicotine oral inhaler. The nicotine oral inhaler may resemble a cigarette, but it must be used differently. You do not need to inhale as deeply for the medicine to be effective."
Answered by AI