Nicorette

Smoke, nicotine
Treatment
2 FDA approvals
3 Active Studies for Nicorette

What is Nicorette

NicotineThe Generic name of this drug
Treatment SummaryNicotine is a toxic substance found in tobacco smoke. It is an active ingredient that stimulates neurons, blocking the transmission of messages through the nervous system. Nicotine also has medical uses and can be used to treat certain conditions.
equate Nicotineis the brand name
image of different drug pills on a surface
Nicorette Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
equate Nicotine
Nicotine
1990
1005

Approved as Treatment by the FDA

Nicotine, otherwise called equate Nicotine, is approved by the FDA for 2 uses which include Smoke and nicotine .
Smoke
Helps manage Smoking cessation therapy
nicotine
Helps manage Withdrawal Nicotine

Effectiveness

How Nicorette Affects PatientsNicotine is a powerful chemical found in tobacco products. When taken, it binds to certain receptors in the body, such as the adrenal medulla and neuromuscular junctions, and causes the release of several hormones. It has both a stimulating effect on the brain and can produce a 'rewarding' feeling. Nicotine is highly addictive and can cause rapid heart rate, increased blood pressure, and constricted blood vessels. Nicotine inhalers and patches are used to help smokers quit.
How Nicorette works in the bodyNicotine is a stimulant that binds to receptors in the brain, triggering the release of dopamine, which creates euphoric and addictive effects. Nicotine also binds to receptors in the adrenal medulla, which causes the release of epinephrine into the bloodstream. This causes a rise in blood pressure, heart rate, and blood sugar.

When to interrupt dosage

The proposed dosage of Nicorette is contingent upon the diagnosed condition. The measure of dosage is reliant upon the method of administration noted in the table below.
Condition
Dosage
Administration
Smoke
, 1.4 mg/hour, 14.0 mg, 0.7 mg/hour, 2.1 mg/hour, 7.0 mg, 21.0 mg, 4.0 mg, 2.0 mg, 1.0 mL/mL, 1.0 mg/mg, 114.0 mg, 78.0 mg, 36.0 mg, 10.0 mg/mL, 0.18 mg/mg, 0.15 mg/mg, 0.2 mg/mg, 2.0 mg/hour, 4.0 mg/hour, 8.0 mg, 2.5 mg/hour, 0.06 mg/mg, 0.12 mg/mg, 0.21 mg/mg
, Transdermal, Patch, extended release, Patch, extended release - Transdermal, Topical, Patch, extended release - Topical, Kit, Oral, Gum, chewing, Gum, chewing - Oral, Lozenge, Lozenge - Oral, Buccal, Gum, chewing - Buccal, Kit - Transdermal, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Inhalant, Patch, Patch - Transdermal, Liquid, Liquid - Oral, Powder, Powder - Oral, Nasal, Spray, metered - Nasal, Spray, metered, Dental; Oral, Patch - Topical
nicotine
, 1.4 mg/hour, 14.0 mg, 0.7 mg/hour, 2.1 mg/hour, 7.0 mg, 21.0 mg, 4.0 mg, 2.0 mg, 1.0 mL/mL, 1.0 mg/mg, 114.0 mg, 78.0 mg, 36.0 mg, 10.0 mg/mL, 0.18 mg/mg, 0.15 mg/mg, 0.2 mg/mg, 2.0 mg/hour, 4.0 mg/hour, 8.0 mg, 2.5 mg/hour, 0.06 mg/mg, 0.12 mg/mg, 0.21 mg/mg
, Transdermal, Patch, extended release, Patch, extended release - Transdermal, Topical, Patch, extended release - Topical, Kit, Oral, Gum, chewing, Gum, chewing - Oral, Lozenge, Lozenge - Oral, Buccal, Gum, chewing - Buccal, Kit - Transdermal, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Inhalant, Patch, Patch - Transdermal, Liquid, Liquid - Oral, Powder, Powder - Oral, Nasal, Spray, metered - Nasal, Spray, metered, Dental; Oral, Patch - Topical

Warnings

There are 20 known major drug interactions with Nicorette.
Common Nicorette Drug Interactions
Drug Name
Risk Level
Description
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Nicotine.
Cisplatin
Major
The serum concentration of Cisplatin can be increased when it is combined with Nicotine.
Clofarabine
Major
The serum concentration of Clofarabine can be increased when it is combined with Nicotine.
Cyclophosphamide
Major
The metabolism of Cyclophosphamide can be decreased when combined with Nicotine.
Dalfampridine
Major
The serum concentration of Dalfampridine can be increased when it is combined with Nicotine.
Nicorette Toxicity & Overdose RiskOverdosing on this drug can lead to nausea, stomach pain, vomiting, sweating, dizziness, blurred vision or hearing, confusion, weakness, racing heart, altered breathing, and low blood pressure. The lowest toxic dose in mice is 24mg/kg when taken orally.
image of a doctor in a lab doing drug, clinical research

Nicorette Novel Uses: Which Conditions Have a Clinical Trial Featuring Nicorette?

At present, 5 clinical trials are analyzing the potential of Nicorette to alleviate nicotine addiction.
Condition
Clinical Trials
Trial Phases
nicotine
3 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Smoke
0 Actively Recruiting

Nicorette Reviews: What are patients saying about Nicorette?

4.3Patient Review
12/3/2008
Nicorette for Stop Smoking
I was successfully able to quit smoking with this product, but now I find myself chewing the gum compulsively. It's been four months and I'm feeling pretty bad--headaches, throat problems, anxiety at the thought of running out of gum.
4Patient Review
10/2/2011
Nicorette for Nicotine Addiction
This gum is very addictive. I considered smoking cigarettes to get off of it. Is that crazy or what?
3.7Patient Review
9/2/2010
Nicorette for Nicotine Addiction
I was able to quit smoking, but I'm now addicted to the Nicorette gum. How can I stop taking it?
3Patient Review
4/27/2008
Nicorette for Stop Smoking
I'm tobacco-free for four years now, which is amazing. But the downside is that I'm really struggling to quit gum. I've tried everything with no success. And lately, I've developed this weird habit of constantly clearing my throat even though there's nothing there. It's getting annoying and worrying me a bit. If anyone has any suggestions, please let me know!
3Patient Review
3/16/2010
Nicorette for Osteoporosis
This treatment is effective. I'm grateful for modern medicine.
3Patient Review
3/24/2010
Nicorette for Stop Smoking
Please be aware that this medication may cause mild hypoglycemia in Type I diabetics.
3Patient Review
4/5/2008
Nicorette for Stop Smoking
2.7Patient Review
8/20/2009
Nicorette for Stop Smoking
The gum helped me for two months, but now I'm struggling with nasty tastes and a lot of throat-clearing. Not sure if this is a long-term side effect, but it's something to be aware of.
1Patient Review
5/2/2021
Nicorette for Stop Smoking
Even at the recommended starting dose, I started vomiting within a couple of minutes.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about nicorette

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Nicorette gum harmful?

"Chewing the gum too fast can have some unpleasant side effects, like lightheadedness, dizziness, hiccups, nausea, vomiting, or trouble sleeping. If you experience any of these, chew the gum more slowly. Your doctor has determined that the benefits of this medication outweigh the risks of side effects."

Answered by AI

Does Nicorette give you buzz?

"When nicotine enters the bloodstream and reaches the brain, it unlocks a chemical receptor called the dopamine receptor. This action causes the release of a feel-good chemical called dopamine, which gives the smoker a short-lived sense of pleasure or well-being."

Answered by AI

How effective is Nicorette?

"This was also the case for nicotine 4 mg gum (11% v 4%).

The results indicated that the use of chewing gum or patches significantly helped people to quit smoking. The most effective dosage was found to be 2 mg for chewing gum and 11% for patches."

Answered by AI

What is Nicorette side effects?

"The text says that some possible side effects of the medication are mild dizziness, dry mouth, upset stomach, burping or hiccups, mouth or throat soreness, changes in taste, or headache."

Answered by AI

Clinical Trials for Nicorette