Nicorette

Smoke, nicotine

Treatment

2 FDA approvals

2 Active Studies for Nicorette

What is Nicorette

Nicotine

The Generic name of this drug

Treatment Summary

Nicotine is a toxic substance found in tobacco smoke. It is an active ingredient that stimulates neurons, blocking the transmission of messages through the nervous system. Nicotine also has medical uses and can be used to treat certain conditions.

equate Nicotine

is the brand name

image of different drug pills on a surface

Nicorette Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

equate Nicotine

Nicotine

1990

1005

Approved as Treatment by the FDA

Nicotine, otherwise called equate Nicotine, is approved by the FDA for 2 uses which include Smoke and nicotine .

Smoke

Helps manage Smoking cessation therapy

nicotine

Helps manage Withdrawal Nicotine

Effectiveness

How Nicorette Affects Patients

Nicotine is a powerful chemical found in tobacco products. When taken, it binds to certain receptors in the body, such as the adrenal medulla and neuromuscular junctions, and causes the release of several hormones. It has both a stimulating effect on the brain and can produce a 'rewarding' feeling. Nicotine is highly addictive and can cause rapid heart rate, increased blood pressure, and constricted blood vessels. Nicotine inhalers and patches are used to help smokers quit.

How Nicorette works in the body

Nicotine is a stimulant that binds to receptors in the brain, triggering the release of dopamine, which creates euphoric and addictive effects. Nicotine also binds to receptors in the adrenal medulla, which causes the release of epinephrine into the bloodstream. This causes a rise in blood pressure, heart rate, and blood sugar.

When to interrupt dosage

The proposed dosage of Nicorette is contingent upon the diagnosed condition. The measure of dosage is reliant upon the method of administration noted in the table below.

Condition

Dosage

Administration

nicotine

, 1.4 mg/hour, 14.0 mg, 0.7 mg/hour, 2.1 mg/hour, 7.0 mg, 21.0 mg, 4.0 mg, 2.0 mg, 1.0 mL/mL, 1.0 mg/mg, 114.0 mg, 78.0 mg, 36.0 mg, 10.0 mg/mL, 0.18 mg/mg, 0.15 mg/mg, 0.2 mg/mg, 2.0 mg/hour, 4.0 mg/hour, 8.0 mg, 2.5 mg/hour, 0.06 mg/mg, 0.12 mg/mg, 0.21 mg/mg

Transdermal, Patch, extended release, Patch, extended release - Transdermal, Topical, Patch, extended release - Topical, , Oral, Gum, chewing, Gum, chewing - Oral, Gum, chewing - Buccal, Lozenge - Oral, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Inhalant, Powder - Oral, Liquid, Powder, Patch - Transdermal, Patch, Lozenge, Kit, Dental; Oral, Patch - Topical, Buccal, Kit - Transdermal, Liquid - Oral, Nasal, Spray, metered - Nasal, Spray, metered

Smoke

, 1.4 mg/hour, 14.0 mg, 0.7 mg/hour, 2.1 mg/hour, 7.0 mg, 21.0 mg, 4.0 mg, 2.0 mg, 1.0 mL/mL, 1.0 mg/mg, 114.0 mg, 78.0 mg, 36.0 mg, 10.0 mg/mL, 0.18 mg/mg, 0.15 mg/mg, 0.2 mg/mg, 2.0 mg/hour, 4.0 mg/hour, 8.0 mg, 2.5 mg/hour, 0.06 mg/mg, 0.12 mg/mg, 0.21 mg/mg

Transdermal, Patch, extended release, Patch, extended release - Transdermal, Topical, Patch, extended release - Topical, , Oral, Gum, chewing, Gum, chewing - Oral, Gum, chewing - Buccal, Lozenge - Oral, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Inhalant, Powder - Oral, Liquid, Powder, Patch - Transdermal, Patch, Lozenge, Kit, Dental; Oral, Patch - Topical, Buccal, Kit - Transdermal, Liquid - Oral, Nasal, Spray, metered - Nasal, Spray, metered

Warnings

There are 20 known major drug interactions with Nicorette.

Common Nicorette Drug Interactions

Drug Name

Risk Level

Description

Aminophylline

Major

The metabolism of Aminophylline can be increased when combined with Nicotine.

Cisplatin

Major

The serum concentration of Cisplatin can be increased when it is combined with Nicotine.

Clofarabine

Major

The serum concentration of Clofarabine can be increased when it is combined with Nicotine.

Cyclophosphamide

Major

The metabolism of Cyclophosphamide can be decreased when combined with Nicotine.

Dalfampridine

Major

The serum concentration of Dalfampridine can be increased when it is combined with Nicotine.

Nicorette Toxicity & Overdose Risk

Overdosing on this drug can lead to nausea, stomach pain, vomiting, sweating, dizziness, blurred vision or hearing, confusion, weakness, racing heart, altered breathing, and low blood pressure. The lowest toxic dose in mice is 24mg/kg when taken orally.

image of a doctor in a lab doing drug, clinical research

Nicorette Novel Uses: Which Conditions Have a Clinical Trial Featuring Nicorette?

At present, 5 clinical trials are analyzing the potential of Nicorette to alleviate nicotine addiction.

Condition

Clinical Trials

Trial Phases

Smoke

0 Actively Recruiting

nicotine

2 Actively Recruiting

Not Applicable, Phase 1, Phase 2

Nicorette Reviews: What are patients saying about Nicorette?

4.3

Patient Review

12/3/2008

Nicorette for Stop Smoking

I was successfully able to quit smoking with this product, but now I find myself chewing the gum compulsively. It's been four months and I'm feeling pretty bad--headaches, throat problems, anxiety at the thought of running out of gum.

4

Patient Review

10/2/2011

Nicorette for Nicotine Addiction

This gum is very addictive. I considered smoking cigarettes to get off of it. Is that crazy or what?

3.7

Patient Review

9/2/2010

Nicorette for Nicotine Addiction

I was able to quit smoking, but I'm now addicted to the Nicorette gum. How can I stop taking it?

3

Patient Review

4/27/2008

Nicorette for Stop Smoking

I'm tobacco-free for four years now, which is amazing. But the downside is that I'm really struggling to quit gum. I've tried everything with no success. And lately, I've developed this weird habit of constantly clearing my throat even though there's nothing there. It's getting annoying and worrying me a bit. If anyone has any suggestions, please let me know!

3

Patient Review

3/16/2010

Nicorette for Osteoporosis

This treatment is effective. I'm grateful for modern medicine.

3

Patient Review

3/24/2010

Nicorette for Stop Smoking

Please be aware that this medication may cause mild hypoglycemia in Type I diabetics.

3

Patient Review

4/5/2008

Nicorette for Stop Smoking

2.7

Patient Review

8/20/2009

Nicorette for Stop Smoking

The gum helped me for two months, but now I'm struggling with nasty tastes and a lot of throat-clearing. Not sure if this is a long-term side effect, but it's something to be aware of.

1

Patient Review

5/2/2021

Nicorette for Stop Smoking

Even at the recommended starting dose, I started vomiting within a couple of minutes.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about nicorette

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Nicorette gum harmful?

"Chewing the gum too fast can have some unpleasant side effects, like lightheadedness, dizziness, hiccups, nausea, vomiting, or trouble sleeping. If you experience any of these, chew the gum more slowly. Your doctor has determined that the benefits of this medication outweigh the risks of side effects."

Answered by AI

Does Nicorette give you buzz?

"When nicotine enters the bloodstream and reaches the brain, it unlocks a chemical receptor called the dopamine receptor. This action causes the release of a feel-good chemical called dopamine, which gives the smoker a short-lived sense of pleasure or well-being."

Answered by AI

How effective is Nicorette?

"This was also the case for nicotine 4 mg gum (11% v 4%).

The results indicated that the use of chewing gum or patches significantly helped people to quit smoking. The most effective dosage was found to be 2 mg for chewing gum and 11% for patches."

Answered by AI

What is Nicorette side effects?

"The text says that some possible side effects of the medication are mild dizziness, dry mouth, upset stomach, burping or hiccups, mouth or throat soreness, changes in taste, or headache."

Answered by AI

Clinical Trials for Nicorette

Image of Rush University Medical Center in Chicago, United States.

NRT + Quit Practice Strategies for Smoking Cessation

18+
All Sexes
Chicago, IL

Tobacco use disorder is a chronic, relapsing health condition that necessitates a chronic care approach. However, traditional smoking cessation treatment programs allocate nearly all their resources only to those smokers who are willing to set a quit date. This is problematic because few smokers are ready to set a quit date at any given time, and a smoker's stated intention to quit can change rapidly. One novel potential treatment strategy is to foster practice quitting (PQ), defined as attempting to not smoke for a few hours or days, without pressure or expectation to permanently quit. Although a growing body of evidence supports the role of practice quitting in fostering permanent quit attempts and cessation, there is a significant knowledge gap regarding which treatment strategies should be used to engage smokers in practice quitting. The proposed study will test the role of PQ counseling vs. Motivational Interviewing (MI) counseling, and NRT sampling (four-week supply of nicotine lozenges and patches) vs. none.

Phase 1 & 2
Recruiting

Rush University Medical Center

Amanda Mathew, PhD

Image of The Ottawa Hospital General Campus in Ottawa, Canada.

Quit Card Intervention for Cigarette Addiction

18+
All Sexes
Ottawa, Canada

The INITIATE Study is a randomized controlled trial that is testing an intervention designed to increase long-term abstinence among tobacco smokers seen in emergency departments (ED) and other high-volume hospital and community ambulatory care settings. The intervention includes a behavioural incentive and tailored follow-up support on long-term smoking abstinence, health, healthcare utilization, and cost. Tobacco-related illnesses cost the healthcare system millions each year. Quitting smoking improves smoking-related outcomes, like the onset or management of heart disease, stroke, lung diseases, and several cancers. There are approximately 16 million visits to Canadian EDs each year; an estimated 3-4 million of these involve smokers. Effective quit smoking interventions exist, but are underutilized. Few hospital EDs, community healthcare centers, and other inpatient and outpatient clinics in Canada offer tobacco-use interventions. In order for clinicians to offer quit smoking support, interventions need to be simple given the realities of these high-volume environments. Considering that stopping smoking improves health outcomes, that tobacco-use is an important cause of preventable ED use, and the volume of smokers, Canadian EDs and other high-volume hospital and community ambulatory care settings are a missed opportunity in the initiation of quit smoking support. Our intervention has been designed to optimize uptake and smoking abstinence by including the most effective evidence-based behavioural and drug-related approaches, removing specific barriers and challenges that smokers face when trying to quit (e.g., affordability, low confidence and motivation), while packaging the intervention in a quick-to-initiate manner, making it ideal for fast-paced, complex environments.

Recruiting
Has No Placebo

The Ottawa Hospital General Campus (+5 Sites)

Kerri-Anne Mullen, PhD