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What is Nexterone
AmiodaroneThe Generic name of this drug
Treatment SummaryAmiodarone is a medication used to treat irregular heartbeats and life-threatening ventricular arrhythmias. It is sometimes prescribed for atrial fibrillation, although this is an off-label use. This drug can be very dangerous, so it should only be used to treat the conditions it is approved for.
Cordaroneis the brand name
Nexterone Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Cordarone
Amiodarone
1985
144
Approved as Treatment by the FDA
Amiodarone, also known as Cordarone, is approved by the FDA for 2 uses like Tachycardia, Ventricular and recurrent Ventricular fibrillation .Tachycardia, Ventricular
Helps manage recurrent hemodynamically unstable Ventricular tachycardia
recurrent Ventricular fibrillation
Helps manage recurrent Ventricular fibrillation
Effectiveness
How Nexterone Affects PatientsWhen injected, amiodarone relaxes the walls of the blood vessels, reduces the pressure of the blood, and increases the amount of blood pumped by the heart. However, taking it orally does not seem to have a major effect on the heart. Taking amiodarone can also make it take longer for electrical signals to move through the heart, which helps prevent and treat arrhythmias. It also contains iodine which can cause problems with your thyroid.
How Nexterone works in the bodyAmiodarone is a medication used to treat abnormal heart rhythms. It does this by blocking potassium currents in the heart, which makes the heart's action potential longer. It also affects beta-adrenergic receptors, sodium channels, and calcium channels, which can cause side effects such as low blood pressure, slow heart rate, and other heart rhythm issues. Additionally, it can increase activity of certain proteins, which can cause fatty changes in the liver or other organs, and it can also bind to the thyroid receptor, leading to thyroid issues.
When to interrupt dosage
The proposed dose of Nexterone is contingent upon the specified state, such as recurrent Ventricular fibrillation, Tachycardia, Ventricular and Cardiothoracic Surgery. The amount of dosage is contingent upon the delivery approach (e.g. Tablet or Injection, solution - Intravenous) displayed in the table beneath.Condition
Dosage
Administration
Atrial Fibrillation
, 200.0 mg, 50.0 mg/mL, 1.8 mg/mL, 100.0 mg, 400.0 mg, 1.5 mg/mL, 300.0 mg, 150.0 mg/mL, 450.0 mg/mL, 90.0 mg/mL
Oral, Tablet, , Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous
Tachycardia, Ventricular
, 200.0 mg, 50.0 mg/mL, 1.8 mg/mL, 100.0 mg, 400.0 mg, 1.5 mg/mL, 300.0 mg, 150.0 mg/mL, 450.0 mg/mL, 90.0 mg/mL
Oral, Tablet, , Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous
recurrent Ventricular fibrillation
, 200.0 mg, 50.0 mg/mL, 1.8 mg/mL, 100.0 mg, 400.0 mg, 1.5 mg/mL, 300.0 mg, 150.0 mg/mL, 450.0 mg/mL, 90.0 mg/mL
Oral, Tablet, , Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous
Cardiothoracic Surgery
, 200.0 mg, 50.0 mg/mL, 1.8 mg/mL, 100.0 mg, 400.0 mg, 1.5 mg/mL, 300.0 mg, 150.0 mg/mL, 450.0 mg/mL, 90.0 mg/mL
Oral, Tablet, , Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous
Supraventricular Tachycardia (SVT)
, 200.0 mg, 50.0 mg/mL, 1.8 mg/mL, 100.0 mg, 400.0 mg, 1.5 mg/mL, 300.0 mg, 150.0 mg/mL, 450.0 mg/mL, 90.0 mg/mL
Oral, Tablet, , Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous
Warnings
Nexterone has six contraindications and should not be utilized together with the conditions recorded in the subsequent table.Nexterone ContraindicationsCondition
Risk Level
Notes
Shock, Cardiogenic
Do Not Combine
Syncope
Do Not Combine
third degree AV block
Do Not Combine
pathologic fistula
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Amiodarone may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Amiodarone may interact with Pulse Frequency
Common Nexterone Drug Interactions
Drug Name
Risk Level
Description
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be decreased when combined with Amiodarone.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Amiodarone.
3-isobutyl-1-methyl-7H-xanthine
Major
The serum concentration of 3-isobutyl-1-methyl-7H-xanthine can be increased when it is combined with Amiodarone.
5-androstenedione
Major
The metabolism of 5-androstenedione can be decreased when combined with Amiodarone.
6-O-benzylguanine
Major
The metabolism of 6-O-benzylguanine can be decreased when combined with Amiodarone.
Nexterone Toxicity & Overdose RiskThe toxic dose of amiodarone in mice and rats is more than 3,000 mg/kg. An overdose on amiodarone can be fatal due to its effect on heart rhythms. Signs of an overdose may include low blood pressure, shock, slow heartbeat, abnormal heart rhythm, and liver damage. Treatment for an overdose includes supportive care, fluids, and drugs to increase blood pressure or heart strength. Temporary pacing of the heart may be necessary and it is important to monitor liver function. Amiodarone and its main metabolite cannot be removed from the body through dialysis.
Nexterone Novel Uses: Which Conditions Have a Clinical Trial Featuring Nexterone?
There are 161 active studies exploring the effectiveness of Nexterone in providing relief from recurrent Ventricular fibrillation, Cardiothoracic Surgery and Ventricular Tachycardia.Condition
Clinical Trials
Trial Phases
recurrent Ventricular fibrillation
0 Actively Recruiting
Supraventricular Tachycardia (SVT)
1 Actively Recruiting
Not Applicable
Cardiothoracic Surgery
0 Actively Recruiting
Atrial Fibrillation
146 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
Tachycardia, Ventricular
0 Actively Recruiting
Nexterone Reviews: What are patients saying about Nexterone?
3.7Patient Review
8/17/2013Patient Q&A Section about nexterone
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What type of medication is NEXTERONE?
"Nexterone is an antiarrhythmic drug that is used to help keep the heart beatings normally in people with life-threatening heart rhythm disorders of the ventricles."
Answered by AI
What are the most common side effects of amiodarone?
"Coughing, feeling dizzy or lightheaded, or fainting may be due to a fever (slight), numbness or tingling in the fingers or toes, painful breathing, sensitivity of the skin to sunlight, trembling or shaking of the hands, or trouble with walking."
Answered by AI
What is NEXTERONE used for?
"This drug is meant to be used on people who have frequently recurring ventricular fibrillation or ventricular tachycardia that has not been controlled by other methods."
Answered by AI
What is the purpose of amiodarone?
"This medication, known as an antiarrhythmic, works by directly affecting the heart tissue to slow down the heart's nerve impulses. This helps to maintain a normal heart rhythm. Amiodarone is only available with a doctor's prescription."
Answered by AI