Neurolite

Single photon emission computerised tomography, Stroke

Treatment

6 Active Studies for Neurolite

What is Neurolite

Bicisate

The Generic name of this drug

Treatment Summary

Bicisate, also known as Ethyl Cysteinate Dimer (ECD), is a drug used in combination with Technetium Tc99m to measure cerebral blood flow with Single-Photon Emission Computed Tomography (SPECT). It was developed by Lantheus Medcl and approved by the FDA in 1994.

Neurolite

is the brand name

Neurolite Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Neurolite

Bicisate

1994

1

Effectiveness

How Neurolite Affects Patients

Bicisate is a very stable drug due to its N2S2 core. This stability means that bicisate can be used several hours after it is made, and it can easily pass through the blood-brain barrier.

How Neurolite works in the body

Bicisate is quickly taken up by the brain, where it is broken down into hydrophilic acid derivatives. It enters the brain through passive diffusion and hydrolysis. It is mainly the LL isomer that is retained in the brain, but both DD and LL isomers are taken up. The amount of bicisate that gets into the brain depends on blood flow, so if there is a stroke, areas of the brain deprived of blood flow won't get as much bicisate.

When to interrupt dosage

The measure of Neurolite is contingent upon the specified condition. The quantity of dosage likewise varies, in line with the method of administration featured in the table beneath.

Condition

Dosage

Administration

Single photon emission computerised tomography

, 1.35 mg, 0.9 mg

, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, Injection - Intravenous

Stroke

, 1.35 mg, 0.9 mg

, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, Injection - Intravenous

Warnings

There are 20 known major drug interactions with Neurolite.

Common Neurolite Drug Interactions

Drug Name

Risk Level

Description

Albutrepenonacog alfa

Minor

Bicisate may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.

Almasilate

Minor

Bicisate may decrease the excretion rate of Almasilate which could result in a higher serum level.

Antithrombin III human

Minor

Bicisate may decrease the excretion rate of Antithrombin III human which could result in a higher serum level.

Apalutamide

Minor

Bicisate may decrease the excretion rate of Apalutamide which could result in a higher serum level.

Baricitinib

Minor

Bicisate may decrease the excretion rate of Baricitinib which could result in a higher serum level.

Neurolite Toxicity & Overdose Risk

Tests in the laboratory have shown that when bicisate and technetium Tc-99m are combined, they can cause changes in DNA and an increased rate of gene mutation. However, there is no evidence that bicisate can cause any changes to chromosomes or affect fertility.

Neurolite Novel Uses: Which Conditions Have a Clinical Trial Featuring Neurolite?

15 active investigations are assessing the potential of Neurolite to ameliorate Stroke-related conditions.

Condition

Clinical Trials

Trial Phases

Stroke

6 Actively Recruiting

Not Applicable, Phase 1

Single photon emission computerised tomography

0 Actively Recruiting

Patient Q&A Section about neurolite

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Clinical Trials for Neurolite

Image of Brooks Rehabilitation Clinical Research Center in Jacksonville, United States.

Q Therapeutic System for Stroke

18 - 80
All Sexes
Jacksonville, FL

This trial tests a promising new intervention to promote post-stroke neural reorganization and functional recovery. The Q Therapeutic (BQ 3.0) is a wearable medical system that produces and delivers non-invasive, extremely-low-intensity and low-frequency, frequency-tuned electromagnetic fields in order to stimulate neuronal networks with the aim of reducing disability and promoting neurorecovery. This trial is a prospective, single-arm, open-label, single center clinical trial designed to evaluate the safety, feasibility, and efficacy of the Q Therapeutic (BQ 3.0) System in the rehabilitation of people with chronic stroke.

Recruiting
Has No Placebo

Brooks Rehabilitation Clinical Research Center

Emily Fox, PT, DPT, MHS, PhD

BrainQ Technologies Ltd.

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