Neurolite
Single photon emission computerised tomography, Stroke
Treatment
6 Active Studies for Neurolite
Treatment for
Single photon emission computerised tomography
What is Neurolite
Bicisate
The Generic name of this drug
Treatment Summary
Bicisate, also known as Ethyl Cysteinate Dimer (ECD), is a drug used in combination with Technetium Tc99m to measure cerebral blood flow with Single-Photon Emission Computed Tomography (SPECT). It was developed by Lantheus Medcl and approved by the FDA in 1994.
Neurolite
is the brand name
Neurolite Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Neurolite
Bicisate
1994
1
Effectiveness
How Neurolite Affects Patients
Bicisate is a very stable drug due to its N2S2 core. This stability means that bicisate can be used several hours after it is made, and it can easily pass through the blood-brain barrier.
How Neurolite works in the body
Bicisate is quickly taken up by the brain, where it is broken down into hydrophilic acid derivatives. It enters the brain through passive diffusion and hydrolysis. It is mainly the LL isomer that is retained in the brain, but both DD and LL isomers are taken up. The amount of bicisate that gets into the brain depends on blood flow, so if there is a stroke, areas of the brain deprived of blood flow won't get as much bicisate.
When to interrupt dosage
The measure of Neurolite is contingent upon the specified condition. The quantity of dosage likewise varies, in line with the method of administration featured in the table beneath.
Condition
Dosage
Administration
Single photon emission computerised tomography
, 1.35 mg, 0.9 mg
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, Injection - Intravenous
Stroke
, 1.35 mg, 0.9 mg
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, Injection - Intravenous
Warnings
There are 20 known major drug interactions with Neurolite.
Common Neurolite Drug Interactions
Drug Name
Risk Level
Description
Albutrepenonacog alfa
Minor
Bicisate may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Almasilate
Minor
Bicisate may decrease the excretion rate of Almasilate which could result in a higher serum level.
Antithrombin III human
Minor
Bicisate may decrease the excretion rate of Antithrombin III human which could result in a higher serum level.
Apalutamide
Minor
Bicisate may decrease the excretion rate of Apalutamide which could result in a higher serum level.
Baricitinib
Minor
Bicisate may decrease the excretion rate of Baricitinib which could result in a higher serum level.
Neurolite Toxicity & Overdose Risk
Tests in the laboratory have shown that when bicisate and technetium Tc-99m are combined, they can cause changes in DNA and an increased rate of gene mutation. However, there is no evidence that bicisate can cause any changes to chromosomes or affect fertility.
Neurolite Novel Uses: Which Conditions Have a Clinical Trial Featuring Neurolite?
15 active investigations are assessing the potential of Neurolite to ameliorate Stroke-related conditions.
Condition
Clinical Trials
Trial Phases
Stroke
6 Actively Recruiting
Not Applicable, Phase 1
Single photon emission computerised tomography
0 Actively Recruiting
Patient Q&A Section about neurolite
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.