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What is Nadolol
NadololThe Generic name of this drug
Treatment SummaryNadolol is a medication that blocks the action of adrenaline in the body, which helps to lower blood pressure. Although it is not the most commonly prescribed drug for hypertension, as newer medications have fewer side effects, it is still available and used to treat high blood pressure. Nadolol was approved by the FDA in 1979.
Corgardis the brand name
Nadolol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Corgard
Nadolol
1979
120
Approved as Treatment by the FDA
Nadolol, commonly known as Corgard, is approved by the FDA for 2 uses which include Chest Pain and Hypertensive disease .Chest Pain
Helps manage Angina Pectoris
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Effectiveness
How Nadolol Affects PatientsNadolol is a medication used to reduce blood pressure. It works by blocking adrenaline receptors in the body, and is taken once a day. Most patients start with a dose of 40 mg a day and can increase up to 240 mg a day over time. When discontinuing nadolol, it is important to do so slowly and gradually as sudden discontinuation may worsen heart disease.
How Nadolol works in the bodyNadolol is a medication that acts on the beta-1 and beta-2 adrenal receptors. It weakens and slows down the muscles in the heart and also increases the resistance of the blood vessels, reducing the risk of low blood pressure. It also reduces the release of renin, which can cause high blood pressure and water retention. Nadolol also reduces the release of insulin in the pancrease, which can lead to increased insulin sensitivity. Finally, it prevents bronchodilation in the lungs, glycogenolysis in the liver and skeletal muscles, and inhibits epinephrine release.
When to interrupt dosage
The advised measure of Nadolol is contingent on the recognized situation, including Chest Pain, Atrial Fibrillation and Thyrotoxicosis. The quantity of dosage fluctuates as indicated by the technique of delivery featured in the table beneath.Condition
Dosage
Administration
Migraine
20.0 mg, , 40.0 mg, 80.0 mg, 160.0 mg, 120.0 mg
, Tablet, Oral, Tablet - Oral
prophylaxis of migraine headaches
20.0 mg, , 40.0 mg, 80.0 mg, 160.0 mg, 120.0 mg
, Tablet, Oral, Tablet - Oral
Gastroesophageal variceal hemorrhage prophylaxis
20.0 mg, , 40.0 mg, 80.0 mg, 160.0 mg, 120.0 mg
, Tablet, Oral, Tablet - Oral
Chest Pain
20.0 mg, , 40.0 mg, 80.0 mg, 160.0 mg, 120.0 mg
, Tablet, Oral, Tablet - Oral
Hypertensive disease
20.0 mg, , 40.0 mg, 80.0 mg, 160.0 mg, 120.0 mg
, Tablet, Oral, Tablet - Oral
Thyrotoxicosis
20.0 mg, , 40.0 mg, 80.0 mg, 160.0 mg, 120.0 mg
, Tablet, Oral, Tablet - Oral
Atrial Fibrillation
20.0 mg, , 40.0 mg, 80.0 mg, 160.0 mg, 120.0 mg
, Tablet, Oral, Tablet - Oral
Warnings
Nadolol ContraindicationsCondition
Risk Level
Notes
overt cardiac failure
Do Not Combine
Heart Block
Do Not Combine
Sinus Bradycardia
Do Not Combine
Shock, Cardiogenic
Do Not Combine
Bronchial Asthma
Do Not Combine
Common Nadolol Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyphenethylamine can be decreased when used in combination with Nadolol.
4-Methoxyamphetamine
Major
The therapeutic efficacy of 4-Methoxyamphetamine can be decreased when used in combination with Nadolol.
Abediterol
Major
Nadolol may decrease the bronchodilatory activities of Abediterol.
Abemaciclib
Major
The excretion of Abemaciclib can be decreased when combined with Nadolol.
Adrafinil
Major
The therapeutic efficacy of Adrafinil can be decreased when used in combination with Nadolol.
Nadolol Toxicity & Overdose RiskThe lowest toxic dose of the drug in mice is 4500mg/kg. An overdose may lead to a slow heart rate, heart failure, low blood pressure, or difficulty breathing. To treat these symptoms, doctors may recommend atropine, digitalis and diuretics for heart failure, vasopressors for low blood pressure, beta-2 stimulants for breathing difficulties, stomach pumping, and dialysis.
Nadolol Novel Uses: Which Conditions Have a Clinical Trial Featuring Nadolol?
245 active clinical trials are currently examining the potential of Nadolol to prevent Gastroesophageal variceal hemorrhage, mitigate Thyrotoxicosis and address Hypertensive disease.Condition
Clinical Trials
Trial Phases
Migraine
52 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Atrial Fibrillation
146 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
Gastroesophageal variceal hemorrhage prophylaxis
0 Actively Recruiting
prophylaxis of migraine headaches
0 Actively Recruiting
Chest Pain
6 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 4
Thyrotoxicosis
0 Actively Recruiting
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Nadolol Reviews: What are patients saying about Nadolol?
5Patient Review
4/25/2014 Ideral (propranolol) didn't work very well for me, but my new doctor put me on Corgard (nadolol) and it's been much better. The only downside is that it's way more expensive than propranolol was.
5Patient Review
2/25/2020 I've been taking this medication for 32 years to help with my essential tremors. It's worked well, but in the last three years the tremors have gotten worse so I'm now taking 160 mg daily. There are some side effects that come with this drug, but they are manageable and worth it considering there is no cure for essential tremor currently.
5Patient Review
10/15/2019 Nadolol has been a real lifesaver for me. After my brain surgery, I was getting migraines all the time. This medication has completely prevented that with zero side effects.
5Patient Review
3/18/2013 Nadolol is the only medication I've found that really helps control my migraines and cluster headaches. I usually take it at bedtime, and it's been working great for me for the past 8 years.
5Patient Review
10/17/2013 Not only does this medication help with my blood pressure, but it also keeps my heart rate steady. I'm so glad to have found a medication that works for me!
5Patient Review
10/19/2014 I had what is called essential Tremor[ and I disagree with terminology they should be unessential] because i do not need them!!! But it did work so go figure?
4.3Patient Review
7/19/2014 I've only been on this medication for 9 days, but I have already noticed a significant decrease in my blood pressure. Additionally, my heart rate has decreased and I feel tired after taking it for 6 hours.
4.3Patient Review
1/9/2014 Nadolol has been a gamechanger for me, reducing the frequency of my migraines from nearly 2 per week to just 1 every 3 months. I take a very small dose of only 10 mgs each morning. The only downside is that I've had ectopic beats for the past 3 years; however, this is a manageable side effect.
4.3Patient Review
11/4/2013 My doctor gave me this medication after a bleeding and banding in my esophagus from cirrhosis.
4.3Patient Review
4/15/2018 I've only been taking it for a week, so I can't speak to its long-term effects; however, so far it's been working well.
4Patient Review
4/9/2014 This medication effectively stopped my arrhythmia. However, after taking it for four years, I experienced some serious side effects such as weight gain, numbness in my legs and feet, memory loss, and vision problems. It wasn't until I saw a different doctor that I realized the nadolol was to blame.
4Patient Review
11/9/2022 The yellow 20mg pills worked well for me, but the blue ones caused an allergic reaction including itching and swelling of hands and feet. I had to discontinue use and get rid of the product.
3Patient Review
5/8/2016 I had to reduce my dosage from 40mg to 10mg due to drowsiness and some lightheadedness. I'm not entirely convinced this is working, except that my pulse is slower and readings at home seem more stable.
1.7Patient Review
12/19/2017 I didn't find this effective in reducing the number of premature ventricular contractions I was experiencing.
1.3Patient Review
9/5/2015 I was prescribed this medication to prevent seizures during the aura of my migraines, but it has been ineffective. The pill is also very unpleasant, as it dissolves and causes me to gag. In addition, I still experience migraines, tingling sensations, numbness in my legs, and pins and needles.
Patient Q&A Section about nadolol
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Why has nadolol been discontinued?
"The manufacturer of nadolol (Corgard®) has confirmed that this product is no longer available. The product is no longer available for commercial reasons. Nadolol, a beta blocker, was licensed for use in hypertension, angina, arrhythmias, migraine prophylaxis and adjunctive treatment of thyrotoxicosis."
Answered by AI
What kind of beta blocker is nadolol?
"Nadolol is a drug that blocks the beta-adrenergic receptor, and is also an inverse agonist."
Answered by AI
When should you not take nadolol?
"If you are allergic to nadolol or have asthma, a serious heart condition, or severe heart failure, you should not use this medication."
Answered by AI
What is nadolol drug used for?
"Nadolol is a medication used to treat high blood pressure. It can be used alone or with other medications. High blood pressure puts extra strain on the heart and arteries. Over time, this can damage the heart and arteries if it is not treated."
Answered by AI