Nadolol

Atrial Fibrillation, Migraine, Thyrotoxicosis + 4 more
Treatment
2 FDA approvals
20 Active Studies for Nadolol

What is Nadolol

NadololThe Generic name of this drug
Treatment SummaryNadolol is a medication that blocks the action of adrenaline in the body, which helps to lower blood pressure. Although it is not the most commonly prescribed drug for hypertension, as newer medications have fewer side effects, it is still available and used to treat high blood pressure. Nadolol was approved by the FDA in 1979.
Corgardis the brand name
image of different drug pills on a surface
Nadolol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Corgard
Nadolol
1979
120

Approved as Treatment by the FDA

Nadolol, commonly known as Corgard, is approved by the FDA for 2 uses which include Chest Pain and Hypertensive disease .
Chest Pain
Helps manage Angina Pectoris
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)

Effectiveness

How Nadolol Affects PatientsNadolol is a medication used to reduce blood pressure. It works by blocking adrenaline receptors in the body, and is taken once a day. Most patients start with a dose of 40 mg a day and can increase up to 240 mg a day over time. When discontinuing nadolol, it is important to do so slowly and gradually as sudden discontinuation may worsen heart disease.
How Nadolol works in the bodyNadolol is a medication that acts on the beta-1 and beta-2 adrenal receptors. It weakens and slows down the muscles in the heart and also increases the resistance of the blood vessels, reducing the risk of low blood pressure. It also reduces the release of renin, which can cause high blood pressure and water retention. Nadolol also reduces the release of insulin in the pancrease, which can lead to increased insulin sensitivity. Finally, it prevents bronchodilation in the lungs, glycogenolysis in the liver and skeletal muscles, and inhibits epinephrine release.

When to interrupt dosage

The advised measure of Nadolol is contingent on the recognized situation, including Chest Pain, Atrial Fibrillation and Thyrotoxicosis. The quantity of dosage fluctuates as indicated by the technique of delivery featured in the table beneath.
Condition
Dosage
Administration
Migraine
20.0 mg, , 40.0 mg, 80.0 mg, 160.0 mg, 120.0 mg
, Tablet, Tablet - Oral, Oral
Atrial Fibrillation
20.0 mg, , 40.0 mg, 80.0 mg, 160.0 mg, 120.0 mg
, Tablet, Tablet - Oral, Oral
Gastroesophageal variceal hemorrhage prophylaxis
20.0 mg, , 40.0 mg, 80.0 mg, 160.0 mg, 120.0 mg
, Tablet, Tablet - Oral, Oral
Hypertensive disease
20.0 mg, , 40.0 mg, 80.0 mg, 160.0 mg, 120.0 mg
, Tablet, Tablet - Oral, Oral
Thyrotoxicosis
20.0 mg, , 40.0 mg, 80.0 mg, 160.0 mg, 120.0 mg
, Tablet, Tablet - Oral, Oral
Migraine Disorders
20.0 mg, , 40.0 mg, 80.0 mg, 160.0 mg, 120.0 mg
, Tablet, Tablet - Oral, Oral
Chest Pain
20.0 mg, , 40.0 mg, 80.0 mg, 160.0 mg, 120.0 mg
, Tablet, Tablet - Oral, Oral

Warnings

Nadolol Contraindications
Condition
Risk Level
Notes
Heart Failure
Do Not Combine
Heart Block
Do Not Combine
Sinus Bradycardia
Do Not Combine
Shock, Cardiogenic
Do Not Combine
Asthma
Do Not Combine
There are 20 known major drug interactions with Nadolol.
Common Nadolol Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyphenethylamine can be decreased when used in combination with Nadolol.
4-Methoxyamphetamine
Major
The therapeutic efficacy of 4-Methoxyamphetamine can be decreased when used in combination with Nadolol.
Abediterol
Major
Nadolol may decrease the bronchodilatory activities of Abediterol.
Abemaciclib
Major
The excretion of Abemaciclib can be decreased when combined with Nadolol.
Adrafinil
Major
The therapeutic efficacy of Adrafinil can be decreased when used in combination with Nadolol.
Nadolol Toxicity & Overdose RiskThe lowest toxic dose of the drug in mice is 4500mg/kg. An overdose may lead to a slow heart rate, heart failure, low blood pressure, or difficulty breathing. To treat these symptoms, doctors may recommend atropine, digitalis and diuretics for heart failure, vasopressors for low blood pressure, beta-2 stimulants for breathing difficulties, stomach pumping, and dialysis.
image of a doctor in a lab doing drug, clinical research

Nadolol Novel Uses: Which Conditions Have a Clinical Trial Featuring Nadolol?

245 active clinical trials are currently examining the potential of Nadolol to prevent Gastroesophageal variceal hemorrhage, mitigate Thyrotoxicosis and address Hypertensive disease.
Condition
Clinical Trials
Trial Phases
Migraine
51 Actively Recruiting
Phase 4, Not Applicable, Phase 1, Phase 3, Phase 2, Early Phase 1
Thyrotoxicosis
0 Actively Recruiting
Chest Pain
2 Actively Recruiting
Not Applicable, Phase 2, Phase 3
Gastroesophageal variceal hemorrhage prophylaxis
0 Actively Recruiting
Hypertensive disease
27 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Atrial Fibrillation
94 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
Migraine Disorders
1 Actively Recruiting
Phase 3

Nadolol Reviews: What are patients saying about Nadolol?

5Patient Review
4/25/2014
Nadolol for Essential Tremor
Ideral (propranolol) didn't work very well for me, but my new doctor put me on Corgard (nadolol) and it's been much better. The only downside is that it's way more expensive than propranolol was.
5Patient Review
2/25/2020
Nadolol for Essential Tremor
I've been taking this medication for 32 years to help with my essential tremors. It's worked well, but in the last three years the tremors have gotten worse so I'm now taking 160 mg daily. There are some side effects that come with this drug, but they are manageable and worth it considering there is no cure for essential tremor currently.
5Patient Review
10/15/2019
Nadolol for Migraine Prevention
Nadolol has been a real lifesaver for me. After my brain surgery, I was getting migraines all the time. This medication has completely prevented that with zero side effects.
5Patient Review
3/18/2013
Nadolol for Migraine Prevention
Nadolol is the only medication I've found that really helps control my migraines and cluster headaches. I usually take it at bedtime, and it's been working great for me for the past 8 years.
5Patient Review
10/17/2013
Nadolol for High Blood Pressure
Not only does this medication help with my blood pressure, but it also keeps my heart rate steady. I'm so glad to have found a medication that works for me!
5Patient Review
10/19/2014
Nadolol for Essential Tremor
I had what is called essential Tremor[ and I disagree with terminology they should be unessential] because i do not need them!!! But it did work so go figure?
4.3Patient Review
7/19/2014
Nadolol for High Blood Pressure
I've only been on this medication for 9 days, but I have already noticed a significant decrease in my blood pressure. Additionally, my heart rate has decreased and I feel tired after taking it for 6 hours.
4.3Patient Review
1/9/2014
Nadolol for Migraine Prevention
Nadolol has been a gamechanger for me, reducing the frequency of my migraines from nearly 2 per week to just 1 every 3 months. I take a very small dose of only 10 mgs each morning. The only downside is that I've had ectopic beats for the past 3 years; however, this is a manageable side effect.
4.3Patient Review
11/4/2013
Nadolol for Prevent Bleeding Varicose Vein in the Esophagus
My doctor gave me this medication after a bleeding and banding in my esophagus from cirrhosis.
4.3Patient Review
4/15/2018
Nadolol for Migraine Prevention
I've only been taking it for a week, so I can't speak to its long-term effects; however, so far it's been working well.
4Patient Review
4/9/2014
Nadolol for Abnormal Heart Rhythm
This medication effectively stopped my arrhythmia. However, after taking it for four years, I experienced some serious side effects such as weight gain, numbness in my legs and feet, memory loss, and vision problems. It wasn't until I saw a different doctor that I realized the nadolol was to blame.
4Patient Review
11/9/2022
Nadolol for High Blood Pressure
The yellow 20mg pills worked well for me, but the blue ones caused an allergic reaction including itching and swelling of hands and feet. I had to discontinue use and get rid of the product.
3Patient Review
5/8/2016
Nadolol for High Blood Pressure
I had to reduce my dosage from 40mg to 10mg due to drowsiness and some lightheadedness. I'm not entirely convinced this is working, except that my pulse is slower and readings at home seem more stable.
1.7Patient Review
12/19/2017
Nadolol for Abnormal Heart Rhythm
I didn't find this effective in reducing the number of premature ventricular contractions I was experiencing.
1.3Patient Review
9/5/2015
Nadolol for Migraine Prevention
I was prescribed this medication to prevent seizures during the aura of my migraines, but it has been ineffective. The pill is also very unpleasant, as it dissolves and causes me to gag. In addition, I still experience migraines, tingling sensations, numbness in my legs, and pins and needles.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about nadolol

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Why has nadolol been discontinued?

"The manufacturer of nadolol (Corgard®) has confirmed that this product is no longer available. The product is no longer available for commercial reasons. Nadolol, a beta blocker, was licensed for use in hypertension, angina, arrhythmias, migraine prophylaxis and adjunctive treatment of thyrotoxicosis."

Answered by AI

What kind of beta blocker is nadolol?

"Nadolol is a drug that blocks the beta-adrenergic receptor, and is also an inverse agonist."

Answered by AI

When should you not take nadolol?

"If you are allergic to nadolol or have asthma, a serious heart condition, or severe heart failure, you should not use this medication."

Answered by AI

What is nadolol drug used for?

"Nadolol is a medication used to treat high blood pressure. It can be used alone or with other medications. High blood pressure puts extra strain on the heart and arteries. Over time, this can damage the heart and arteries if it is not treated."

Answered by AI

Clinical Trials for Nadolol

Image of U Health in Miami, United States.

Cuffless PPG Monitor for High Blood Pressure

18+
All Sexes
Miami, FL
This study aims to validate the accuracy and reliability of blood pressure (BP) estimates obtained over 24 hours using a PPG-based chest-patch device compared to the gold standard ambulatory blood pressure monitoring (ABPM) method using an upper arm cuff-based oscillometric BP device, in both hypertensive and normotensive individuals referred by their provider to undergo a 24-hours ABPM for clinical indication. The Awake/Asleep test, which is the primary test recommended for automated wearable cuffless BP devices that are cuff-calibrated (based on the 2023 European Society of Hypertension (ESH) recommendations for the validation of cuffless blood pressure measuring devices), will be conducted in this study. The secondary aim of the study is to assess the feasibility and convenience of the PPG-based device.
Waitlist Available
Has No Placebo
U Health (+1 Sites)Ziad Zoghby, M.D., M.B.A.Biobeat Technologies Ltd.
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Embolization for Migraine

18 - 80
All Sexes
Baltimore, MD
This study is to test the safety and feasibility of a procedure called embolization of the middle meningeal arteries (MMA), using a product called Onyx. Embolization creates a plug in the arteries. MMA embolization with Onyx is not approved for use in patients with migraines, but is currently used in patients with subdural hematomas. The FDA is allowing the use of Onyx in this study. It is thought that by using Onyx to block the middle meningeal arteries, the amount of migraine-causing substances which are released into the brain's bloodstream will be reduced. The company that manufactures Onyx, Medtronic, is providing the supplies for this study. Participants will be in the study for about 8 months after enrolling, including 6 months of follow up after the procedure. The participants will be asked to complete a daily headache diary and continue the participant's regular migraine medications. Participants will also have several clinic visits and be asked to provide blood samples for research.
Waitlist Available
Has No Placebo
Johns Hopkins MedicineRisheng Xu, MD, PhDMedtronic
Have you considered Nadolol clinical trials? We made a collection of clinical trials featuring Nadolol, we think they might fit your search criteria.Go to Trials
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REGN7508 + REGN9933 for Atrial Fibrillation

18+
All Sexes
Fremont, CA
This study is researching experimental drugs called REGN7508 and REGN9933. The study is focused on participants who have atrial fibrillation, which means that the heart beats too fast and unevenly. REGN7508 and REGN9933 are designed to help stop blood clots forming in patients with atrial fibrillation. The aim of the study is to see how well REGN7508 and REGN9933 work in patients that get medicine for their atrial fibrillation. The bleeding effects of REGN7508 and REGN9933 will be compared to another medicine (apixaban), which is available on the market to treat and prevent formation of blood clots. The study is looking at several other research questions, including: * What side effects may happen from taking REGN7508 or REGN9933 * How well do the study drugs reduce the risk of having a stroke * How much of REGN7508 or REGN9933 is in the blood at different times * Whether the body makes antibodies against REGN7508 or REGN9933 (which could make the drugs less effective or could lead to side effects)
Phase 2
Recruiting
Mission Cardiovascular Research Institute (+4 Sites)Clinical Trial ManagementRegeneron Pharmaceuticals
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Mind-Body App + Movement Program for Chronic Pain

19 - 75
All Sexes
Chilliwack, Canada
The investigators are evaluating the effects of a mind-body mobile application, in combination with a guided movement program, on the experience of chronic pain. Participants meeting the criteria for chronic/persistent pain (confirmed via self-report) will complete an online baseline questionnaire. Eligible participants will take part in an intervention that involves use of a 6-week free trial of a mind-body focused mobile application in combination with virtual asynchronous audio-guided somatic education sessions (gentle movement). External data from a usual care control arm and a mobile-app-only arm from a previous study by the same research team, National Clinical Trials (NCT) registry number NCT05090683, will be used for comparison with the current combined intervention. All participants will complete online surveys at the start of the study and after 6 weeks to measure pain intensity and interference (primary outcomes), mental health outcomes (depression, anxiety, stress), pain-related thoughts (pain catastrophizing), quality of life, and fear of movement (secondary outcomes). From weeks 2 to 6, participants will fill out weekly surveys to track how often they engage with each: the somatic education (gentle movement) program and the mobile app. Participants will also complete a follow-up survey at 12 weeks (6 weeks post-intervention conclusion).
Waitlist Available
Has No Placebo
University of the Fraser ValleyCynthia J Thomson, PhD
Have you considered Nadolol clinical trials? We made a collection of clinical trials featuring Nadolol, we think they might fit your search criteria.Go to Trials
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Dietary Interventions for Hypertension

18+
All Sexes
Birmingham, AL
Natriuretic peptides (NPs) are hormones produced by the heart and play an important role in maintaining cardiovascular health and have favorable metabolic benefits. Low NP levels are associated with an increased likelihood of the development of cardiometabolic diseases like diabetes and hypertension. NP levels are known to be highly heritable, with up to half of the differences in NP levels being explained by genetics. The investigators aim to describe the genetic architecture of NPs by examining the genetic variants associated with NPs, and generate and validate a polygenic score (PGS) for NPs. The investigators will use this NP PGS to examine the association of genetically determined NP levels with cardiometabolic and cardiovascular outcomes. The investigators will conduct a genotype-guided physiological clinical trial that aims to assess the genetic factors affecting NP levels and their impact on blood pressure and NP response to saline infusion, high-salt diet, and low-salt diet. These findings will help support personal medicine approaches to lower the increasing burden of hypertension in the United States.
Waitlist Available
Has No Placebo
University of Alabama at BirminghamPankaj Arora, MD, FAHA
Have you considered Nadolol clinical trials? We made a collection of clinical trials featuring Nadolol, we think they might fit your search criteria.Go to Trials