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What is Nabumetone
NabumetoneThe Generic name of this drug
Treatment SummaryNabumetone is a non-steroidal anti-inflammatory drug (NSAID) used to reduce inflammation and pain. It is a pro-drug that is converted into a 6-methoxy-2-naphthylacetic acid (6-MNA) metabolite that acts as a potent COX inhibitor, similar to naproxen. It was first approved by the FDA in 1991 under the trade name Relafen. Although it has slightly reduced GI toxicity due to its cyclooxygenase-2 selectivity, it can still cause adverse effects in the gastrointestinal tract.
Relafenis the brand name
Nabumetone Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Relafen
Nabumetone
1993
192
Approved as Treatment by the FDA
Nabumetone, otherwise called Relafen, is approved by the FDA for 2 uses including Osteoarthritis (OA) and Rheumatoid Arthritis .Osteoarthritis (OA)
Rheumatoid Arthritis
Effectiveness
How Nabumetone Affects PatientsNabumetone is a type of drug called a nonsteroidal anti-inflammatory drug (NSAID) that is used as a painkiller. It helps reduce pain by reducing the sensitivity of nerve endings to painful or uncomfortable stimuli. It also helps reduce inflammation and fever by blocking the release of substances that cause inflammation and by affecting the body's temperature regulation system in the brain. However, it can also have adverse effects such as decreased blood flow to the kidneys and increased risk of ulcers and thrombosis.
How Nabumetone works in the bodyNabumetone works by blocking two enzymes, COX-1 and COX-2. This prevents the production of prostaglandins, which are molecules that help to mediate pain sensitivity, inflammation, and fever. It also helps to reduce the amount of neurotransmitters released from nerves, which reduces pain signals. Prostaglandins also regulate blood flow to the kidneys and protect the stomach from acid, so blocking them can lead to adverse effects like kidney problems or ulcers. Finally, it can lead to an imbalance of platelet aggregation, which can increase the risk of blood clots.
When to interrupt dosage
The advised measure of Nabumetone is contingent upon the diagnosed condition. The amount of dosage shifts as indicated by the technique of delivery noted in the table underneath.Condition
Dosage
Administration
Osteoarthritis (OA)
750.0 mg, , 500.0 mg, 1000.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Oral; Topical, Kit - Oral; Topical
Rheumatoid Arthritis
750.0 mg, , 500.0 mg, 1000.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Oral; Topical, Kit - Oral; Topical
Warnings
Nabumetone has eleven contraindications, so it should be avoided in individuals with any of the conditions specified in the table below.Nabumetone ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
NSAID-Induced Asthma
Do Not Combine
Liver Disease
Do Not Combine
Rhinitis caused by NSAIDs
Do Not Combine
Coronary Artery Bypass Grafting
Do Not Combine
worsening renal impairment
Do Not Combine
Polyps, Nasal
Do Not Combine
Gastrointestinal Diseases
Do Not Combine
active liver disease
Do Not Combine
Peptic Ulcer
Do Not Combine
recurrent Peptic Ulcer
Do Not Combine
Common Nabumetone Drug Interactions
Drug Name
Risk Level
Description
Macimorelin
Major
The therapeutic efficacy of Macimorelin can be decreased when used in combination with Nabumetone.
Methotrexate
Major
The serum concentration of Methotrexate can be increased when it is combined with Nabumetone.
Mifamurtide
Major
The therapeutic efficacy of Mifamurtide can be decreased when used in combination with Nabumetone.
Neomycin
Major
The risk or severity of nephrotoxicity can be increased when Nabumetone is combined with Neomycin.
Omacetaxine mepesuccinate
Major
The risk or severity of bleeding can be increased when Nabumetone is combined with Omacetaxine mepesuccinate.
Nabumetone Toxicity & Overdose RiskThe lowest toxic dose of nabumetone in mice is 4290mg/kg when taken orally and 2380mg/kg when taken intraperitoneally. In rats, the lowest toxic dose is 3880mg/kg when taken orally, 1520mg/kg when taken intraperitoneally, and >10g/kg when taken subcutaneously. Signs and symptoms of an overdose include lethargy, drowsiness, nausea, vomiting, and abdominal pain. Serious but rare effects of an overdose include GI bleeding, high blood pressure, kidney damage, respiratory depression, and coma. Activated charcoal and/
Nabumetone Novel Uses: Which Conditions Have a Clinical Trial Featuring Nabumetone?
75 active trials are currently assessing the potential of Nabumetone to treat Osteoarthritis (OA).Condition
Clinical Trials
Trial Phases
Rheumatoid Arthritis
61 Actively Recruiting
Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1
Osteoarthritis (OA)
0 Actively Recruiting
Nabumetone Reviews: What are patients saying about Nabumetone?
5Patient Review
11/16/2015 I'm really pleased with how this medication has helped me. I've only been taking it for a week and feel so much better. No negative effects that I can tell.
5Patient Review
11/26/2020 I don't have any problems taking NSAIDs, and this combined with Tramadol helps to lessen the pain of arthritis.
5Patient Review
7/26/2016 I've been taking this prescription for over ten years with no problems whatsoever. I have found that if I go more than two days without it, the pain comes back.
5Patient Review
4/30/2016 This is the only medication I've taken that has helped with the stiffness I've been experiencing, since Vioxx.
4.3Patient Review
9/22/2018 This medication helps me a lot with pain. It kicks in pretty quickly, which is great.
3.7Patient Review
12/3/2015 The medicine worked great at first, but then its effectiveness decreased after five months. Now I get headaches and blurred vision from taking it, so I have to stop. Not sure what my next plan of action will be for pain management.
2.3Patient Review
2/22/2018 I didn't love this medication because it seemed to weaken my leg muscles and give me more pain at night.
2Patient Review
1/3/2016 I developed a rash and started experiencing headaches after taking this medication for about a month. I will be contacting my doctor in the morning to discuss these side effects.
1.7Patient Review
5/17/2022 The side effects of this medication were way too severe for me, unfortunately. I had intestinal upset and heart palpitations that made me feel very anxious. The dizziness was also a problem. It did help with the pain in my body, but I couldn't handle the negative impacts
1.7Patient Review
10/20/2022 NABUMETONE 500 MG was unfortunately giving me constant diarrhea.
1Patient Review
6/11/2017 This worked for a little while, but never completely took the pain away. I stopped taking it after two months and have not experienced an increase in pain since then.
1Patient Review
10/21/2017 I was given this medication for my herniated discs and sciatica. Unfortunately, I had a terrible reaction to it and ended up unconscious for several hours. When I woke up, I still felt very woozy and my pain was no better.
Patient Q&A Section about nabumetone
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is nabumetone a pain killer?
"Nabumetone is used to reduce pain, swelling, and joint stiffness caused by arthritis. This medication belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). If you have a chronic condition such as arthritis, your doctor may recommend nonsurgical treatments and/or other medications to treat your pain."
Answered by AI
Is nabumetone a strong painkiller?
"Both nabumetone and ibuprofen are effective drugs to relieve pain when used as prescribed. They have been approved by FDA to treat pain and inflammation caused by arthritis. The best NSAID to use is the one that is most effective for your specific condition and symptoms."
Answered by AI
What is nabumetone used for?
"Nabumetone is a nonsteroidal anti-inflammatory drug that can be used to relieve mild to moderate pain caused by conditions like osteoarthritis and rheumatoid arthritis. It can help reduce inflammation, swelling, stiffness, and joint pain. The earliest date this drug can be used is June 1, 2022."
Answered by AI
What are the side effects of nabumetone 500 mg?
"If you experience any of the following symptoms, you may be experiencing a reaction to sugar alcohol: diarrhea, constipation, gas or bloating, dizziness, headache, dry mouth, sores in the mouth, or nervousness."
Answered by AI