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What is Myorisan
IsotretinoinThe Generic name of this drug
Treatment SummaryIsotretinoin is a type of vitamin A used to treat severe acne that doesn't respond to other treatments. It was previously sold under the brand name Accutane, but is no longer available. Isotretinoin can cause serious side effects during pregnancy, so it is only available through a special program called iPLEDGE in the United States. The first isotretinoin product was approved by the FDA in 1982.
Accutaneis the brand name
Myorisan Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Accutane
Isotretinoin
1982
78
Effectiveness
How Myorisan Affects PatientsWe don't know much about how isotretinoin works in the body.
How Myorisan works in the bodyIsotretinoin works to clear up acne by blocking pores and killing bacteria in the skin. It does this by reducing sebum production, which helps prevent clogged pores, as well as by killing sebocytes and reducing hyperkeratinization. It also makes the environment less hospitable for acne-causing bacteria and may boost your immune response to fight inflammation. There is some evidence that isotretinoin may interact with a protein called FoxO1, which could explain some of its effects.
When to interrupt dosage
The dose of Myorisan is contingent upon the specified condition, including Acne conglobata, Acne Vulgaris and Pregnancy. The amount of dosage adjusts as per the technique of delivery (e.g. Capsule - Oral or Capsule) mentioned in the table beneath.Condition
Dosage
Administration
Sezary Syndrome
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
refractory Acne vulgaris
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
Rosacea
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
Acne Vulgaris
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
early Mycosis Fungoides (MF)
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
Neuroblastoma (NB)
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
Acne Conglobata
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
Warnings
Myorisan has five contraindications, so it must not be taken when encountering the circumstances listed in the subsequent table.Myorisan ContraindicationsCondition
Risk Level
Notes
history of basal cell carcinoma
Do Not Combine
Squamous cell carcinoma
Do Not Combine
history of squamous cell
Do Not Combine
family history of basal cell carcinoma
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Isotretinoin may interact with Pulse Frequency
Common Myorisan Drug Interactions
Drug Name
Risk Level
Description
Clomocycline
Major
The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Clomocycline.
Demeclocycline
Major
The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Demeclocycline.
Doxycycline
Major
The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Doxycycline.
Eravacycline
Major
The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Eravacycline.
Metacycline
Major
The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Metacycline.
Myorisan Toxicity & Overdose RiskOverdosing on Isotretinoin may lead to symptoms such as vomiting, facial flushing, changes in the lips/mouth, abdominal pain, headache, dizziness, and lack of coordination. Children are particularly sensitive to this drug, with the lowest toxic dose for them being 30mg/kg. Animal studies have found that Isotretinoin can cause tumors in the adrenal glands and testicular atrophy in dogs at doses above the recommended clinical dose. Isotretinoin has been linked to major birth defects, spontaneous abortions, and premature births. There is no evidence that it is expressed in breast milk, but
Myorisan Novel Uses: Which Conditions Have a Clinical Trial Featuring Myorisan?
65 active experiments are being conducted to assess the potential of Myorisan in mitigating Rosacea, Neuroblastoma (NB) and Acne conglobata.Condition
Clinical Trials
Trial Phases
Acne Vulgaris
0 Actively Recruiting
Acne Conglobata
0 Actively Recruiting
refractory Acne vulgaris
0 Actively Recruiting
early Mycosis Fungoides (MF)
0 Actively Recruiting
Rosacea
8 Actively Recruiting
Not Applicable, Early Phase 1, Phase 2, Phase 4
Sezary Syndrome
18 Actively Recruiting
Phase 2, Phase 1
Neuroblastoma (NB)
1 Actively Recruiting
Early Phase 1
Myorisan Reviews: What are patients saying about Myorisan?
5Patient Review
9/21/2014 I was prescribed 80mg a day and this worked well for me. The only side effect I experienced was some soreness in my upper back.
5Patient Review
8/14/2014 This worked very quickly to help with my rosacea. I'm still using it, but at a lower dose now.
3.3Patient Review
6/23/2017 I've been using this medication for three months now. My dermatologist said that my skin would get worse before it got better, but nothing too severe has happened. However, my lips are extremely dry and the sides are cracked. Different parts of my skin will dry out as well. Coconut oil seems to be the best/longest lasting way to keep my skin moisturized; I tried vanicream
2Patient Review
8/9/2020 I had some terrible side effects that were not adequately warned about. It says on the bottom of the Medication Guide that it "may effect bones, muscles and ligaments and cause pain." I wish I would have read that before taking this drug for three weeks, which has now left me with permanently weakened leg muscles. Do physical therapy every day just to stay out of a wheelchair.
1.7Patient Review
4/24/2020 The medication is effective at controlling my acne. However, the box it comes in is terrible!! I have to use something sharp to open it up to get the next pill out every single day. It is very frustrating. Claravis usually works better for me, but it was on backorder so I had to switch to Myorisan temporarily.
1.3Patient Review
8/8/2013 I'm sorry to say that this didn't work for me.
Patient Q&A Section about myorisan
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Myorisan a good brand?
"out of reviewers reported a positive experience, while reported a negative experience."
Answered by AI
Is Myorisan the same as Accutane?
"Isotretinoin is an expensive drug used to treat severe acne that has not responded to other therapy like antibiotics. It is slightly more popular than comparable drugs. It is available in multiple brand and generic versions."
Answered by AI
What are the side effects of Myorisan?
"The side effects of this medication include dryness of your skin, lips, eyes, or nose (you may have nosebleeds); vision problems; headache, back pain, joint pain, muscle problems; skin reactions; or cold symptoms such as stuffy nose, sneezing, sore throat."
Answered by AI
What is Myorisan prescribed for?
"This medication is used to treat severe cystic acne. Cystic acne is a type of acne that is large and painful. It is also known as nodular acne. Benzoyl peroxide and clindamycin are two other treatments that can be applied to the skin. Tetracycline and minocycline can be taken by mouth. This medication belongs to a class of drugs known as retinoids."
Answered by AI