Morphine Sulfate

Chronic Pain, Pain, Therapeutic procedure

Treatment

3 FDA approvals

0 Active Studies for Morphine Sulfate

Treatment for

Chronic Pain

What is Morphine Sulfate

Morphine

The Generic name of this drug

Treatment Summary

Morphine is a strong painkiller that comes from poppy seeds. It is still widely used today, but there are other opioid medications available that are similar in strength. Morphine was approved by the FDA in 1941, but it can have some side effects like tolerance, withdrawal and the risk of addiction.

Morphine Sulfate

is the brand name

image of different drug pills on a surface

Morphine Sulfate Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Morphine Sulfate

Morphine

1971

459

Approved as Treatment by the FDA

Morphine, also known as Morphine Sulfate, is approved by the FDA for 3 uses including Pain, Chronic and Chronic Pain .

Pain, Chronic

Helps manage Pain, Chronic

Chronic Pain

Helps manage Pain, Chronic

Pain

Effectiveness

How Morphine Sulfate Affects Patients

Morphine binds to opioid receptors in the body, blocking pain signals, and reducing pain felt. It generally takes 6-30 minutes for it to start working. Taking too much morphine can cause changes in how the brain works. In general, men need more morphine than women to feel the same effects. Morphine-6-glucuronide is also less effective than morphine, and is 22 times weaker at reducing pupil size.

How Morphine Sulfate works in the body

Morphine-6-glucuronide is responsible for most of the effects of morphine. Morphine acts on two types of opioid receptors, mu and kappa. It activates the reward pathway in the brain by targeting the delta receptor and stimulates the respiratory system and addiction disorder by targeting the mu receptor.

When to interrupt dosage

The advised dosage of Morphine Sulfate hinges on the recognized state, including Therapeutic procedure, Pain and Chronic Pain. The amount of dosage changes, depending on the method of administration outlined in the table below.

Condition

Dosage

Administration

Therapeutic procedure

10.0 mg/mL, , 20.0 mg, 50.0 mg, 60.0 mg, 30.0 mg, 10.0 mg, 80.0 mg, 100.0 mg, 200.0 mg, 0.5 mg/mL, 1.0 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 3.0 mg/mL, 100.0 mg/mL, 5.0 mg, 15.0 mg, 20.0 mg/mL, 15.0 mg/mL, 5.0 mg/mL, 8.0 mg/mL, 4.0 mg/mL, 90.0 mg, 120.0 mg, 40.0 mg, 70.0 mg, 130.0 mg, 150.0 mg, 2.0 mg/mL, 45.0 mg, 75.0 mg, 25.0 mg, 40.0 mg/mL, 1.1 mg/mL, 0.1 mg/mL

Oral, Solution - Oral, Capsule, extended release, Capsule, extended release - Oral, , Injection, solution, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, solution - Epidural; Intrathecal; Intravenous, Intravenous; Subcutaneous, Injection, solution - Intravenous; Subcutaneous, Solution, Rectal, Suppository - Rectal, Suppository, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, solution - Intravenous, Intrathecal; Intravenous, Epidural; Intramuscular; Intrathecal; Intravenous, Injection, solution - Epidural; Intramuscular; Intrathecal; Intravenous, Capsule, Capsule - Oral, Solution - Epidural; Intravenous; Subcutaneous, Suppository, extended release, Suppository, extended release - Rectal, Syrup, Syrup - Oral, Injection, Injection - Intravenous, Injection, solution - Intramuscular; Intravenous, Intramuscular; Intravenous, Epidural; Intrathecal; Intravenous, Injection - Epidural; Intrathecal; Intravenous, Epidural; Intrathecal, Injection, solution - Epidural; Intrathecal, Solution, concentrate, Solution, concentrate - Oral, Tincture, Tincture - Oral, Liquid - Oral, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Parenteral, Injection - Intramuscular; Intravenous; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intrathecal; Intravenous, Solution / drops, Solution / drops - Oral, Epidural, Solution - Epidural, Solution - Intramuscular; Intravenous; Subcutaneous, Solution - Intravenous; Subcutaneous, Epidural; Intravenous; Subcutaneous, Liquid, Liquid - Intramuscular; Intravenous; Subcutaneous, Liquid - Intravenous; Subcutaneous, Solution - Intravenous, Liquid - Intravenous, Intramuscular, Injection - Intramuscular, Tablet, film coated, Tablet, film coated - Oral, Injection, lipid complex, Injection, lipid complex - Epidural, Solution - Parenteral, Injection - Parenteral, Intrathecal, Injection, solution - Intrathecal, Injection - Epidural; Intrathecal, Injection, solution - Epidural; Intraspinal; Intrathecal; Intravenous; Subarachnoid, Epidural; Intraspinal; Intrathecal; Intravenous; Subarachnoid

Pain

Chronic Pain

Warnings

Morphine Sulfate Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Morphine may interact with Pulse Frequency

Pulse Frequency

Do Not Combine

Mental Depression

Do Not Combine

Asthma

Do Not Combine

Gastrointestinal obstruction

Do Not Combine

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Morphine Sulfate.

Common Morphine Sulfate Drug Interactions

Drug Name

Risk Level

Description

Azelastine

Major

Morphine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.

Brigatinib

Major

The metabolism of Brigatinib can be decreased when combined with Morphine.

Cabazitaxel

Major

The metabolism of Cabazitaxel can be decreased when combined with Morphine.

Eluxadoline

Major

The risk or severity of constipation can be increased when Morphine is combined with Eluxadoline.

Enasidenib

Major

The metabolism of Enasidenib can be decreased when combined with Morphine.

Morphine Sulfate Toxicity & Overdose Risk

The toxic dose of this drug for males is 0.78µg/mL and for females is 0.98µg/mL. An overdose may cause shallow breathing, sleepiness, limp muscles, cold and clammy skin, small pupils, and large pupils. It can also lead to pulmonary edema, slow heartbeat, low blood pressure, heart failure, and death. Treatment for an overdose includes oxygen, medications to increase blood pressure, and a drug to counteract the effects of the overdose.

image of a doctor in a lab doing drug, clinical research

Morphine Sulfate Novel Uses: Which Conditions Have a Clinical Trial Featuring Morphine Sulfate?

Presently, 24 active clinical trials are underway to investigate Morphine Sulfate's potential to reduce Pain, Chronic Pain and facilitate Therapeutic procedures.

Condition

Clinical Trials

Trial Phases

Pain

0 Actively Recruiting

Therapeutic procedure

0 Actively Recruiting

Chronic Pain

0 Actively Recruiting

Morphine Sulfate Reviews: What are patients saying about Morphine Sulfate?

Patient Review

3/16/2016

Morphine Sulfate for Chronic Pain with Narcotic Drug Tolerance

I switched from fentanyl patches to morphine ER, and was worried about my pain getting worse. However, my doctor gave me an equivalent dose, and it's working great! The only downside is that I have to take it on a schedule because as the first one wears off, I get pain and have to wait for the new pill to get relief.

Patient Review

8/16/2017

Morphine Sulfate for Severe Pain

I've had chronic pain for over 8 years and was lucky enough to have a Doctor give me morphine because all the additives, fillers in other drugs caused too many problems.

Patient Review

3/16/2016

Morphine Sulfate for Chronic Pain with Narcotic Drug Tolerance

I switched from fentanyl patches to morphine ER and, surprisingly, found that my pain was better managed. The only downside is having to take it on a schedule because as the 1st one wears off I get pain and have to wait for the new pill to get relief.

Patient Review

8/16/2017

Morphine Sulfate for Severe Pain

I've had chronic pain for over 8 years and was lucky enough to have a doctor prescribe me morphine.

Patient Review

11/12/2015

Morphine Sulfate for Severe Pain

So far, this treatment has been working great with no side effects!

Patient Review

11/12/2015

Morphine Sulfate for Severe Pain

So far, I'm really liking this treatment! No side effects and it's working great.

4.7

Patient Review

10/4/2021

Morphine Sulfate for severe chronic pain requiring long-term opioid treatment

I've had chronic lower back pain for over two decades now, and this ER 15mg Morphine has really helped. It's much more consistent than hydrocodone, and doesn't have the same highs and lows. I definitely recommend it to others in my situation.

4.7

Patient Review

3/17/2016

Morphine Sulfate for Severe Pain

Liquid morphine is easing my back pain and helping me to avoid falling. It's not a perfect solution, but it's much better than nothing. I'm struggling on bad days, but this medication has helped me immensely.

4.7

Patient Review

3/17/2016

Morphine Sulfate for Severe Pain

Liquid morphine has been a game-changer for me and my back pain. Some days are still tough, but I definitely couldn't make it without this medication.

4.7

Patient Review

10/4/2021

Morphine Sulfate for severe chronic pain requiring long-term opioid treatment

I've had chronic lower back pain for over two decades now. I've had five surgeries and been on various medications, but this ER 15mg Morphine is great. It's much more manageable than other drugs I've tried, with none of the downsides (like addiction potential).

4.3

Patient Review

4/27/2018

Morphine Sulfate for Chronic Pain with Narcotic Drug Tolerance

I find that 100mg is a good amount to take in order to get through my work day without any major side effects. This medication doesn't cause bowel problems like some of the other stronger medications I've been on, which is a big plus.

4.3

Patient Review

4/27/2018

Morphine Sulfate for Chronic Pain with Narcotic Drug Tolerance

I take one 100mg a day of this medication and it works just as well as some of the stronger medications I've been on, without the nasty side effects. This doesn't cause bowel problems like Opana and Fentanyl did, which is great. It's easy to take once a day and get through my work days.

Patient Review

12/28/2016

Morphine Sulfate for Severe Pain

I'm always worried that the government will get involved and make it harder to obtain this medication. They think it's too easy to get on the streets, but what they don't realize is that making it more difficult for people who need it only creates a black market for those who can afford it.

Patient Review

2/18/2020

Morphine Sulfate for Chronic Pain

This treatment has been really helpful for me in managing my pain. I have nerve damage and peripheral neuropathy, so finding something that is strong enough to take the edge off but not make me feel sick has been a challenge. Morphine seems to be just the right balance for me. I can function reasonably well as long as I stick to my schedule, and if I go over by a few hours I don't get too sick.

Patient Review

12/28/2016

Morphine Sulfate for Severe Pain

I worry that the government will get involved in this and make it harder to obtain. They already made it difficult to get a prescription for hydrocodone, but now it's even easier to find on the street. This only makes life more difficult for those of us who need it for legitimate pain management.

Patient Review

2/18/2020

Morphine Sulfate for Chronic Pain

I've got some serious nerve damage, and this medication really takes the edge off. It's not so strong that I feel out of it, but it definitely makes living with the pain more bearable.

3.7

Patient Review

4/12/2016

Morphine Sulfate for Chronic Pain with Narcotic Drug Tolerance

It takes a little while for this medication to build up in your system before you start feeling pain relief. I was taking lortabs for 14 years, and only switched to morphine sulfate about 60 days ago.

3.7

Patient Review

10/5/2019

Morphine Sulfate for Chronic Pain

I find that the pain is quite bad when I wake up in the morning, but this medication does help to ease it. However, it works very slowly; it takes about 9 hours before I really start feeling relief.

3.7

Patient Review

4/12/2016

Morphine Sulfate for Chronic Pain with Narcotic Drug Tolerance

It takes a little while for this medication to start working, but it's been much more effective than lortabs for me. I've only been taking it for about two months now.

3.7

Patient Review

10/5/2019

Morphine Sulfate for Chronic Pain

The pain is pretty bad when I wake up, but this medication does help. It's just very slow-acting. I take three 30mg tablets per day, starting in the morning, and the pain finally begins to ease up in late evening.

Patient Review

6/29/2018

Morphine Sulfate for Chronic Pain

In comparison to the smaller dark blue morphine pills, this treatment was not as effective at easing my pain. I had to go to a different pharmacy in another town because my doctor is located there. Even after taking the 270 morphine pill, my pain was only reduced from a 6 to a 3. The lortab thankfully helped with breakthrough pain.

Patient Review

8/29/2017

Morphine Sulfate for Severe Pain

I've been dealing with severe pain for two years now, and this treatment didn't do anything to help alleviate it.

Patient Review

6/29/2018

Morphine Sulfate for Chronic Pain

I didn't find this to be as effective as the other, smaller dark blue morphine I was taking. The pain is still a 6 after taking the 270 morphine. Thank God for the lortab I have for break through pain.

Patient Review

8/29/2017

Morphine Sulfate for Severe Pain

I've been dealing with severe pain for two years now, and this treatment did nothing to help.