Morphine Sulfate

Chronic Pain, Pain, Therapeutic procedure
Treatment
3 FDA approvals
0 Active Studies for Morphine Sulfate

What is Morphine Sulfate

MorphineThe Generic name of this drug
Treatment SummaryMorphine is a strong painkiller that comes from poppy seeds. It is still widely used today, but there are other opioid medications available that are similar in strength. Morphine was approved by the FDA in 1941, but it can have some side effects like tolerance, withdrawal and the risk of addiction.
Morphine Sulfateis the brand name
image of different drug pills on a surface
Morphine Sulfate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Morphine Sulfate
Morphine
1971
459

Approved as Treatment by the FDA

Morphine, also known as Morphine Sulfate, is approved by the FDA for 3 uses including Chronic Pain and Pain .
Chronic Pain
Helps manage Pain, Chronic
Pain
Pain, Chronic
Helps manage Pain, Chronic

Effectiveness

How Morphine Sulfate Affects PatientsMorphine binds to opioid receptors in the body, blocking pain signals, and reducing pain felt. It generally takes 6-30 minutes for it to start working. Taking too much morphine can cause changes in how the brain works. In general, men need more morphine than women to feel the same effects. Morphine-6-glucuronide is also less effective than morphine, and is 22 times weaker at reducing pupil size.
How Morphine Sulfate works in the bodyMorphine-6-glucuronide is responsible for most of the effects of morphine. Morphine acts on two types of opioid receptors, mu and kappa. It activates the reward pathway in the brain by targeting the delta receptor and stimulates the respiratory system and addiction disorder by targeting the mu receptor.

When to interrupt dosage

The advised dosage of Morphine Sulfate hinges on the recognized state, including Therapeutic procedure, Pain and Chronic Pain. The amount of dosage changes, depending on the method of administration outlined in the table below.
Condition
Dosage
Administration
Pain
10.0 mg/mL, , 20.0 mg, 50.0 mg, 60.0 mg, 30.0 mg, 10.0 mg, 80.0 mg, 100.0 mg, 200.0 mg, 0.5 mg/mL, 1.0 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 3.0 mg/mL, 100.0 mg/mL, 5.0 mg, 15.0 mg, 20.0 mg/mL, 15.0 mg/mL, 5.0 mg/mL, 8.0 mg/mL, 4.0 mg/mL, 90.0 mg, 120.0 mg, 40.0 mg, 70.0 mg, 130.0 mg, 150.0 mg, 2.0 mg/mL, 45.0 mg, 75.0 mg, 25.0 mg, 40.0 mg/mL, 1.1 mg/mL, 0.1 mg/mL
, Oral, Solution, Solution - Oral, Capsule, extended release - Oral, Capsule, extended release, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, solution - Epidural; Intrathecal; Intravenous, Epidural; Intrathecal; Intravenous, Injection, solution, Injection, solution - Intravenous, Intravenous; Subcutaneous, Injection, solution - Intravenous; Subcutaneous, Rectal, Suppository, Suppository - Rectal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Intramuscular; Intravenous; Subcutaneous, Injection, Injection - Intramuscular; Intravenous; Subcutaneous, Injection - Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Tablet - Oral, Tablet, Tablet, extended release, Tablet, extended release - Oral, Intrathecal; Intravenous, Injection, solution - Intrathecal; Intravenous, Epidural; Intramuscular; Intrathecal; Intravenous, Injection, solution - Epidural; Intramuscular; Intrathecal; Intravenous, Capsule, Capsule - Oral, Solution / drops, Solution / drops - Oral, Solution - Intramuscular; Intravenous; Subcutaneous, Epidural, Solution - Epidural, Solution - Intravenous; Subcutaneous, Epidural; Intravenous; Subcutaneous, Solution - Epidural; Intravenous; Subcutaneous, Liquid, Liquid - Intramuscular; Intravenous; Subcutaneous, Liquid - Intravenous; Subcutaneous, Syrup - Oral, Syrup, Solution - Intravenous, Liquid - Intravenous, Tincture, Tincture - Oral, Suppository, extended release, Suppository, extended release - Rectal, Intramuscular, Injection - Intramuscular, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection - Epidural; Intrathecal; Intravenous, Epidural; Intrathecal, Injection, solution - Epidural; Intrathecal, Solution, concentrate, Solution, concentrate - Oral, Liquid - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Parenteral, Solution - Parenteral, Tablet, film coated, Tablet, film coated - Oral, Injection, lipid complex - Epidural, Injection, lipid complex, Injection - Parenteral, Intrathecal, Injection, solution - Intrathecal, Injection - Epidural; Intrathecal, Injection, solution - Epidural; Intraspinal; Intrathecal; Intravenous; Subarachnoid, Epidural; Intraspinal; Intrathecal; Intravenous; Subarachnoid
Therapeutic procedure
10.0 mg/mL, , 20.0 mg, 50.0 mg, 60.0 mg, 30.0 mg, 10.0 mg, 80.0 mg, 100.0 mg, 200.0 mg, 0.5 mg/mL, 1.0 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 3.0 mg/mL, 100.0 mg/mL, 5.0 mg, 15.0 mg, 20.0 mg/mL, 15.0 mg/mL, 5.0 mg/mL, 8.0 mg/mL, 4.0 mg/mL, 90.0 mg, 120.0 mg, 40.0 mg, 70.0 mg, 130.0 mg, 150.0 mg, 2.0 mg/mL, 45.0 mg, 75.0 mg, 25.0 mg, 40.0 mg/mL, 1.1 mg/mL, 0.1 mg/mL
, Oral, Solution, Solution - Oral, Capsule, extended release - Oral, Capsule, extended release, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, solution - Epidural; Intrathecal; Intravenous, Epidural; Intrathecal; Intravenous, Injection, solution, Injection, solution - Intravenous, Intravenous; Subcutaneous, Injection, solution - Intravenous; Subcutaneous, Rectal, Suppository, Suppository - Rectal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Intramuscular; Intravenous; Subcutaneous, Injection, Injection - Intramuscular; Intravenous; Subcutaneous, Injection - Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Tablet - Oral, Tablet, Tablet, extended release, Tablet, extended release - Oral, Intrathecal; Intravenous, Injection, solution - Intrathecal; Intravenous, Epidural; Intramuscular; Intrathecal; Intravenous, Injection, solution - Epidural; Intramuscular; Intrathecal; Intravenous, Capsule, Capsule - Oral, Solution / drops, Solution / drops - Oral, Solution - Intramuscular; Intravenous; Subcutaneous, Epidural, Solution - Epidural, Solution - Intravenous; Subcutaneous, Epidural; Intravenous; Subcutaneous, Solution - Epidural; Intravenous; Subcutaneous, Liquid, Liquid - Intramuscular; Intravenous; Subcutaneous, Liquid - Intravenous; Subcutaneous, Syrup - Oral, Syrup, Solution - Intravenous, Liquid - Intravenous, Tincture, Tincture - Oral, Suppository, extended release, Suppository, extended release - Rectal, Intramuscular, Injection - Intramuscular, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection - Epidural; Intrathecal; Intravenous, Epidural; Intrathecal, Injection, solution - Epidural; Intrathecal, Solution, concentrate, Solution, concentrate - Oral, Liquid - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Parenteral, Solution - Parenteral, Tablet, film coated, Tablet, film coated - Oral, Injection, lipid complex - Epidural, Injection, lipid complex, Injection - Parenteral, Intrathecal, Injection, solution - Intrathecal, Injection - Epidural; Intrathecal, Injection, solution - Epidural; Intraspinal; Intrathecal; Intravenous; Subarachnoid, Epidural; Intraspinal; Intrathecal; Intravenous; Subarachnoid
Chronic Pain
10.0 mg/mL, , 20.0 mg, 50.0 mg, 60.0 mg, 30.0 mg, 10.0 mg, 80.0 mg, 100.0 mg, 200.0 mg, 0.5 mg/mL, 1.0 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 3.0 mg/mL, 100.0 mg/mL, 5.0 mg, 15.0 mg, 20.0 mg/mL, 15.0 mg/mL, 5.0 mg/mL, 8.0 mg/mL, 4.0 mg/mL, 90.0 mg, 120.0 mg, 40.0 mg, 70.0 mg, 130.0 mg, 150.0 mg, 2.0 mg/mL, 45.0 mg, 75.0 mg, 25.0 mg, 40.0 mg/mL, 1.1 mg/mL, 0.1 mg/mL
, Oral, Solution, Solution - Oral, Capsule, extended release - Oral, Capsule, extended release, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, solution - Epidural; Intrathecal; Intravenous, Epidural; Intrathecal; Intravenous, Injection, solution, Injection, solution - Intravenous, Intravenous; Subcutaneous, Injection, solution - Intravenous; Subcutaneous, Rectal, Suppository, Suppository - Rectal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Intramuscular; Intravenous; Subcutaneous, Injection, Injection - Intramuscular; Intravenous; Subcutaneous, Injection - Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Tablet - Oral, Tablet, Tablet, extended release, Tablet, extended release - Oral, Intrathecal; Intravenous, Injection, solution - Intrathecal; Intravenous, Epidural; Intramuscular; Intrathecal; Intravenous, Injection, solution - Epidural; Intramuscular; Intrathecal; Intravenous, Capsule, Capsule - Oral, Solution / drops, Solution / drops - Oral, Solution - Intramuscular; Intravenous; Subcutaneous, Epidural, Solution - Epidural, Solution - Intravenous; Subcutaneous, Epidural; Intravenous; Subcutaneous, Solution - Epidural; Intravenous; Subcutaneous, Liquid, Liquid - Intramuscular; Intravenous; Subcutaneous, Liquid - Intravenous; Subcutaneous, Syrup - Oral, Syrup, Solution - Intravenous, Liquid - Intravenous, Tincture, Tincture - Oral, Suppository, extended release, Suppository, extended release - Rectal, Intramuscular, Injection - Intramuscular, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection - Epidural; Intrathecal; Intravenous, Epidural; Intrathecal, Injection, solution - Epidural; Intrathecal, Solution, concentrate, Solution, concentrate - Oral, Liquid - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Parenteral, Solution - Parenteral, Tablet, film coated, Tablet, film coated - Oral, Injection, lipid complex - Epidural, Injection, lipid complex, Injection - Parenteral, Intrathecal, Injection, solution - Intrathecal, Injection - Epidural; Intrathecal, Injection, solution - Epidural; Intraspinal; Intrathecal; Intravenous; Subarachnoid, Epidural; Intraspinal; Intrathecal; Intravenous; Subarachnoid

Warnings

Morphine Sulfate Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Mental Depression
Do Not Combine
Asthma
Do Not Combine
Gastrointestinal obstruction
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Morphine may interact with Pulse Frequency
There are 20 known major drug interactions with Morphine Sulfate.
Common Morphine Sulfate Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Morphine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Morphine.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Morphine.
Eluxadoline
Major
The risk or severity of constipation can be increased when Morphine is combined with Eluxadoline.
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Morphine.
Morphine Sulfate Toxicity & Overdose RiskThe toxic dose of this drug for males is 0.78µg/mL and for females is 0.98µg/mL. An overdose may cause shallow breathing, sleepiness, limp muscles, cold and clammy skin, small pupils, and large pupils. It can also lead to pulmonary edema, slow heartbeat, low blood pressure, heart failure, and death. Treatment for an overdose includes oxygen, medications to increase blood pressure, and a drug to counteract the effects of the overdose.
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Morphine Sulfate Novel Uses: Which Conditions Have a Clinical Trial Featuring Morphine Sulfate?

Presently, 24 active clinical trials are underway to investigate Morphine Sulfate's potential to reduce Pain, Chronic Pain and facilitate Therapeutic procedures.
Condition
Clinical Trials
Trial Phases
Pain
0 Actively Recruiting
Therapeutic procedure
0 Actively Recruiting
Chronic Pain
0 Actively Recruiting

Morphine Sulfate Reviews: What are patients saying about Morphine Sulfate?

5Patient Review
3/16/2016
Morphine Sulfate for Chronic Pain with Narcotic Drug Tolerance
I switched from fentanyl patches to morphine ER, and was worried about my pain getting worse. However, my doctor gave me an equivalent dose, and it's working great! The only downside is that I have to take it on a schedule because as the first one wears off, I get pain and have to wait for the new pill to get relief.
5Patient Review
8/16/2017
Morphine Sulfate for Severe Pain
I've had chronic pain for over 8 years and was lucky enough to have a Doctor give me morphine because all the additives, fillers in other drugs caused too many problems.
5Patient Review
3/16/2016
Morphine Sulfate for Chronic Pain with Narcotic Drug Tolerance
I switched from fentanyl patches to morphine ER and, surprisingly, found that my pain was better managed. The only downside is having to take it on a schedule because as the 1st one wears off I get pain and have to wait for the new pill to get relief.
5Patient Review
8/16/2017
Morphine Sulfate for Severe Pain
I've had chronic pain for over 8 years and was lucky enough to have a doctor prescribe me morphine.
5Patient Review
11/12/2015
Morphine Sulfate for Severe Pain
So far, this treatment has been working great with no side effects!
View All Reviews
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Patient Q&A Section about morphine sulfate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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