Modafinil

Chronic Fatigue Syndrome, Narcolepsy, Sleep Disorders, Circadian Rhythm + 4 more

Treatment

5 FDA approvals

20 Active Studies for Modafinil

Treatment for

Chronic Fatigue Syndrome

What is Modafinil

ModafinilThe Generic name of this drug

Treatment SummaryArmodafinil is a prescription drug used to increase alertness in adults with excessive sleepiness caused by obstructive sleep apnea, narcolepsy, or shift work disorder. Studies have shown that armodafinil can improve driving performance in people with shift work disorder. Armodafinil is the single-enantiomer form of modafinil, and is manufactured by Cephalon Inc., a subsidiary of Teva Pharmaceutical Industries. It was approved for use in the United States by the FDA in June 2007.

Provigilis the brand name

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Modafinil Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Provigil

Modafinil

1998

Approved as Treatment by the FDA

Modafinil, also known as Provigil, is approved by the FDA for 5 uses like Sleep Disorders, Circadian Rhythm and Shift-work related sleep disturbance .

Sleep Disorders, Circadian Rhythm

Shift-work related sleep disturbance

Obstructive Sleep Apnea (OSA)

Narcolepsy

Obstructive Sleep Apnea

Effectiveness

How Modafinil works in the bodyWe do not know exactly how Nuvigil works, but it is believed to be a stimulant that causes long-lasting mental arousal. It does not directly affect dopamine receptors, but it does bind to the dopamine transporter, preventing the reuptake of dopamine.

When to interrupt dosage

The prescribed amount of Modafinil is contingent upon the diagnosed disorder, including Narcolepsy, Shift-work related sleep disturbance and Somnolence. The measure of dosage also alters, as per the technique of delivery featured in the table beneath.

Condition

Dosage

Administration

Obstructive Sleep Apnea

, 100.0 mg, 200.0 mg

, Oral, Tablet, Tablet - Oral

Attention Deficit Hyperactivity Disorder

, 100.0 mg, 200.0 mg

, Oral, Tablet, Tablet - Oral

Multiple Sclerosis

, 100.0 mg, 200.0 mg

, Oral, Tablet, Tablet - Oral

Sleep Disorders, Circadian Rhythm

, 100.0 mg, 200.0 mg

, Oral, Tablet, Tablet - Oral

Narcolepsy

, 100.0 mg, 200.0 mg

, Oral, Tablet, Tablet - Oral

Depression

, 100.0 mg, 200.0 mg

, Oral, Tablet, Tablet - Oral

Chronic Fatigue Syndrome

, 100.0 mg, 200.0 mg

, Oral, Tablet, Tablet - Oral

Warnings

There are 20 known major drug interactions with Modafinil.

Common Modafinil Drug Interactions

Drug Name

Risk Level

Description

Cabozantinib

Major

The metabolism of Cabozantinib can be decreased when combined with Modafinil.

Capecitabine

Major

The metabolism of Capecitabine can be decreased when combined with Modafinil.

Capmatinib

Major

The serum concentration of Capmatinib can be decreased when it is combined with Modafinil.

Cariprazine

Major

The metabolism of Cariprazine can be increased when combined with Modafinil.

Daridorexant

Major

The metabolism of Daridorexant can be increased when combined with Modafinil.

image of a doctor in a lab doing drug, clinical research

Modafinil Novel Uses: Which Conditions Have a Clinical Trial Featuring Modafinil?

13 clinical trials are currently examining the potential of Modafinil in alleviating Shift-work related sleep disruption, Somnolence and Narcolepsy.

Condition

Clinical Trials

Trial Phases

Attention Deficit Hyperactivity Disorder

65 Actively Recruiting

Not Applicable, Phase 3, Phase 4, Phase 2, Phase 1, Early Phase 1

Multiple Sclerosis

118 Actively Recruiting

Phase 3, Not Applicable, Phase 4, Phase 2, Phase 1, Early Phase 1

Depression

193 Actively Recruiting

Phase 2, Not Applicable, Phase 4, Phase 1, Early Phase 1, Phase 3

Chronic Fatigue Syndrome

45 Actively Recruiting

Not Applicable, Phase 2, Phase 3, Phase 1, Phase 4

Obstructive Sleep Apnea

81 Actively Recruiting

Not Applicable, Phase 3, Phase 2, Phase 4, Phase 1, Early Phase 1

Narcolepsy

1 Actively Recruiting

Phase 1

Sleep Disorders, Circadian Rhythm

6 Actively Recruiting

Not Applicable, Phase 2, Phase 3

Modafinil Reviews: What are patients saying about Modafinil?

5Patient Review

8/12/2016

Modafinil for Sleepiness Due To Obstructive Sleep Apnea

I've been taking Modafinil/provigil for the last 15 years to help with my sleep apnea. It completely gets rid of the fatigue I would normally feel during the day. It's an excellent drug that shouldn't be so difficult to get access to.

5Patient Review

9/20/2017

Modafinil for Sleepiness Due To Obstructive Sleep Apnea

This drug has both helped me focus and stay awake. It's prevented me from falling asleep at the wheel, which is amazing.

5Patient Review

6/14/2020

Modafinil for Recurring Sleep Episodes During the Day

I was initially prescribed this once a day, but found that I needed to take it twice a day to be effective. It's really helped me get back on track in terms of sleep and energy levels during the day.

5Patient Review

2/27/2022

Modafinil for Sleepiness Due To Obstructive Sleep Apnea

I've been struggling with narcolepsy since I was young, but this medication has really helped me. I started with the brand name version when I was still working, but now that I'm retired, I switched to the generic Modafinil. It works just as well for me and is a lot cheaper.

5Patient Review

12/2/2021

Modafinil for Sleepiness Due To Obstructive Sleep Apnea

This medication changed my life from day 1. I am just awake, not agitated or restless, just awake.

View All Reviews

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Patient Q&A Section about modafinil

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is modafinil a narcotic?

"Modafinil is a drug that has been classified by the United States FDA as a schedule IV controlled substance. This means that it has been determined to have valid medical uses and low addiction potential. The International Narcotics Control Board does not consider modafinil to be a narcotic or a psychotropic substance."

Answered by AI

What happens when you take modafinil?

"It is also used to help you stay awake during work hours if you have a work schedule that keeps you from having a normal sleep routine (shift work sleep disorder).

Modafinil helps people with narcolepsy and other sleep disorders by reducing extreme sleepiness. It can also help people with irregular work schedules stay awake during work hours."

Answered by AI

What is modafinil used for?

"Modafinil is a psychoactive drug used to maintain wakefulness, especially during periods of sleep deprivation. It is considered a eugeroic medication, which is a medication that counteract sleepiness and promotes wakefulness. Modafinil is used to help narcolepsy, obstructive sleep apnea/hypopnea syndrome (OSAHS), and shift work sleep disorder (SWSD) patients stay awake during the day. The effects of Modafinil are typically short-lived and stop working once the drug is no longer consumed."

Answered by AI

How does modafinil make you feel?

"The author is saying that modafinil makes him feel like he is able to focus and put all his effort into what he is doing. However, the author feels that modafinil is not the best option because it made him feel less than his best."

Answered by AI

Clinical Trials for Modafinil

Have you considered Modafinil clinical trials? We made a collection of clinical trials featuring Modafinil, we think they might fit your search criteria.

Have you considered Modafinil clinical trials? We made a collection of clinical trials featuring Modafinil, we think they might fit your search criteria.