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What is Modafinil
ModafinilThe Generic name of this drug
Treatment SummaryArmodafinil is a prescription drug used to increase alertness in adults with excessive sleepiness caused by obstructive sleep apnea, narcolepsy, or shift work disorder. Studies have shown that armodafinil can improve driving performance in people with shift work disorder. Armodafinil is the single-enantiomer form of modafinil, and is manufactured by Cephalon Inc., a subsidiary of Teva Pharmaceutical Industries. It was approved for use in the United States by the FDA in June 2007.
Provigilis the brand name
Modafinil Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Provigil
Modafinil
1998
99
Approved as Treatment by the FDA
Modafinil, also known as Provigil, is approved by the FDA for 3 uses like Obstructive Sleep Apnea and Narcolepsy .Obstructive Sleep Apnea
Narcolepsy
Shift-work related sleep disturbance
Effectiveness
How Modafinil works in the bodyWe do not know exactly how Nuvigil works, but it is believed to be a stimulant that causes long-lasting mental arousal. It does not directly affect dopamine receptors, but it does bind to the dopamine transporter, preventing the reuptake of dopamine.
When to interrupt dosage
The prescribed amount of Modafinil is contingent upon the diagnosed disorder, including Narcolepsy, Shift-work related sleep disturbance and Somnolence. The measure of dosage also alters, as per the technique of delivery featured in the table beneath.Condition
Dosage
Administration
Shift-work related sleep disturbance
, 100.0 mg, 200.0 mg
, Oral, Tablet, Tablet - Oral
Depression
, 100.0 mg, 200.0 mg
, Oral, Tablet, Tablet - Oral
Narcolepsy
, 100.0 mg, 200.0 mg
, Oral, Tablet, Tablet - Oral
Multiple Sclerosis
, 100.0 mg, 200.0 mg
, Oral, Tablet, Tablet - Oral
Chronic Fatigue Syndrome
, 100.0 mg, 200.0 mg
, Oral, Tablet, Tablet - Oral
Obstructive Sleep Apnea
, 100.0 mg, 200.0 mg
, Oral, Tablet, Tablet - Oral
Attention Deficit Hyperactivity Disorder
, 100.0 mg, 200.0 mg
, Oral, Tablet, Tablet - Oral
Warnings
There are 20 known major drug interactions with Modafinil.Common Modafinil Drug Interactions
Drug Name
Risk Level
Description
Cabozantinib
Major
The metabolism of Cabozantinib can be decreased when combined with Modafinil.
Capecitabine
Major
The metabolism of Capecitabine can be decreased when combined with Modafinil.
Capmatinib
Major
The serum concentration of Capmatinib can be decreased when it is combined with Modafinil.
Cariprazine
Major
The metabolism of Cariprazine can be increased when combined with Modafinil.
Daridorexant
Major
The metabolism of Daridorexant can be increased when combined with Modafinil.
Modafinil Novel Uses: Which Conditions Have a Clinical Trial Featuring Modafinil?
13 clinical trials are currently examining the potential of Modafinil in alleviating Shift-work related sleep disruption, Somnolence and Narcolepsy.Condition
Clinical Trials
Trial Phases
Shift-work related sleep disturbance
6 Actively Recruiting
Not Applicable, Phase 4, Phase 2
Narcolepsy
10 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 4, Phase 1
Multiple Sclerosis
195 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 1, Phase 4, Early Phase 1
Attention Deficit Hyperactivity Disorder
71 Actively Recruiting
Phase 4, Not Applicable, Phase 1, Phase 2, Phase 3, Early Phase 1
Chronic Fatigue Syndrome
88 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Early Phase 1, Phase 1, Phase 4
Obstructive Sleep Apnea
98 Actively Recruiting
Not Applicable, Phase 2, Phase 1, Phase 3, Phase 4, Early Phase 1
Depression
199 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1
Modafinil Reviews: What are patients saying about Modafinil?
5Patient Review
8/12/2016 I've been taking Modafinil/provigil for the last 15 years to help with my sleep apnea. It completely gets rid of the fatigue I would normally feel during the day. It's an excellent drug that shouldn't be so difficult to get access to.
5Patient Review
9/20/2017 This drug has both helped me focus and stay awake. It's prevented me from falling asleep at the wheel, which is amazing.
5Patient Review
6/14/2020 I was initially prescribed this once a day, but found that I needed to take it twice a day to be effective. It's really helped me get back on track in terms of sleep and energy levels during the day.
5Patient Review
2/27/2022 I've been struggling with narcolepsy since I was young, but this medication has really helped me. I started with the brand name version when I was still working, but now that I'm retired, I switched to the generic Modafinil. It works just as well for me and is a lot cheaper.
5Patient Review
12/2/2021 This medication changed my life from day 1. I am just awake, not agitated or restless, just awake.
4.7Patient Review
3/27/2019 This revision helper was extremely helpful in allowing me to complete my exams quickly and efficiently. I was able to get through six hours of work in just under three hours, which is very impressive. The only downside is that I had a small headache eight hours later.
4Patient Review
1/21/2019 I appreciate how this treatment helps me feel more awake without the jitters. I definitely feel less fatigued when I take it as directed.
3.3Patient Review
7/19/2017 This pill was effective at first, but I've started to see diminishing returns after the second week. In addition, I've started experiencing some unpleasant side effects like dizziness and nausea. chest pain is the latest development, so I'm going to take a break from this medication and see how things go.
1Patient Review
7/6/2021 I've had narcolepsy for a while and Adderall worked great for me with no side effects. However, I changed doctors and decided to try Modanifil. Unfortunately, this made me feel mentally unstable; like I just ingested dirty bathtub crank!
Patient Q&A Section about modafinil
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is modafinil a narcotic?
"Modafinil is a drug that has been classified by the United States FDA as a schedule IV controlled substance. This means that it has been determined to have valid medical uses and low addiction potential. The International Narcotics Control Board does not consider modafinil to be a narcotic or a psychotropic substance."
Answered by AI
What happens when you take modafinil?
"It is also used to help you stay awake during work hours if you have a work schedule that keeps you from having a normal sleep routine (shift work sleep disorder).
Modafinil helps people with narcolepsy and other sleep disorders by reducing extreme sleepiness. It can also help people with irregular work schedules stay awake during work hours."
Answered by AI
What is modafinil used for?
"Modafinil is a psychoactive drug used to maintain wakefulness, especially during periods of sleep deprivation. It is considered a eugeroic medication, which is a medication that counteract sleepiness and promotes wakefulness. Modafinil is used to help narcolepsy, obstructive sleep apnea/hypopnea syndrome (OSAHS), and shift work sleep disorder (SWSD) patients stay awake during the day. The effects of Modafinil are typically short-lived and stop working once the drug is no longer consumed."
Answered by AI
How does modafinil make you feel?
"The author is saying that modafinil makes him feel like he is able to focus and put all his effort into what he is doing. However, the author feels that modafinil is not the best option because it made him feel less than his best."
Answered by AI