Methylphenidate

Narcolepsy, Attention Deficit Hyperactivity Disorder
Treatment
20 Active Studies for Methylphenidate

What is Methylphenidate

MethylphenidateThe Generic name of this drug
Treatment SummaryMethylphenidate is a medication used to treat Attention Deficit/Hyperactivity Disorder (ADHD) and narcolepsy. It is sold under the brand names Ritalin, Concerta, and Biphentin. Methylphenidate works by increasing the activity of certain brain chemicals, like dopamine and norepinephrine, which help to improve focus and attention. The effects of methylphenidate last up to 10-12 hours, so it can be taken once a day. However, methylphenidate has the potential to be abused and can cause addiction, so it is important to take it as prescribed by your doctor
Methylphenidate Hydrochlorideis the brand name
image of different drug pills on a surface
Methylphenidate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Methylphenidate Hydrochloride
Methylphenidate
1955
490

Effectiveness

How Methylphenidate Affects PatientsMethylphenidate is a combination of two different isomers (d- and l-). The d-isomer is the active part of the drug, and binds to dopamine-rich areas of the brain, especially in the prefrontal cortex. This area is thought to be important in attention-deficit / hyperactivity disorder (ADHD). In animal studies, this drug has been shown to increase movement activity and cause repetitive behaviors.
How Methylphenidate works in the bodyMethylphenidate helps people with ADHD by increasing the activity of two neurotransmitters, norepinephrine and dopamine, in the brain. Low doses of methylphenidate work to reduce impulsivity and improve cognitive functions like attention and memory. It also has an effect on alpha-1 adrenergic receptors, which helps with sustained attention. People with ADHD may have genetic abnormalities that affect the dopamine transporter gene, D4 receptor gene, and D2 receptor gene. Methylphenidate can help to overcome these genetic issues by increasing dopamine activity in the brain.

When to interrupt dosage

The amount of Methylphenidate is reliant upon the diagnosed situation. The dosage quantity may differ depending upon the technique of delivery featured in the table beneath.
Condition
Dosage
Administration
Narcolepsy
20.0 mg, , 30.0 mg, 40.0 mg, 10.0 mg, 60.0 mg, 27.0 mg, 36.0 mg, 54.0 mg, 50.0 mg, 5.0 mg, 2.5 mg, 5.0 mg/mL, 10.0 mg/mL, 18.0 mg, 80.0 mg, 15.0 mg, 10.0 mg/hour, 20.0 mg/hour, 15.0 mg/hour, 30.0 mg/hour, 30.0 mg/mL, 6.0 mg/mL, 7.5 mg/mL, 9.0 mg/mL, 8.6 mg, 25.9 mg, 17.3 mg, 1.0 mg/mL, 2.0 mg/mL, 25.0 mg, 35.0 mg, 55.0 mg, 70.0 mg, 85.0 mg, 100.0 mg, 45.0 mg, 72.0 mg, 63.0 mg
, Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, chewable, Tablet, chewable - Oral, Solution, Solution - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Chewable, Extended Release, Tablet, Chewable, Extended Release - Oral, Transdermal, Patch, Patch - Transdermal, Suspension, extended release, Suspension, extended release - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Attention Deficit Hyperactivity Disorder
20.0 mg, , 30.0 mg, 40.0 mg, 10.0 mg, 60.0 mg, 27.0 mg, 36.0 mg, 54.0 mg, 50.0 mg, 5.0 mg, 2.5 mg, 5.0 mg/mL, 10.0 mg/mL, 18.0 mg, 80.0 mg, 15.0 mg, 10.0 mg/hour, 20.0 mg/hour, 15.0 mg/hour, 30.0 mg/hour, 30.0 mg/mL, 6.0 mg/mL, 7.5 mg/mL, 9.0 mg/mL, 8.6 mg, 25.9 mg, 17.3 mg, 1.0 mg/mL, 2.0 mg/mL, 25.0 mg, 35.0 mg, 55.0 mg, 70.0 mg, 85.0 mg, 100.0 mg, 45.0 mg, 72.0 mg, 63.0 mg
, Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, chewable, Tablet, chewable - Oral, Solution, Solution - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Chewable, Extended Release, Tablet, Chewable, Extended Release - Oral, Transdermal, Patch, Patch - Transdermal, Suspension, extended release, Suspension, extended release - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral

Warnings

Methylphenidate Contraindications
Condition
Risk Level
Notes
advanced arteriosclerosis
Do Not Combine
Gilles de la Tourette syndrome
Do Not Combine
Thyrotoxicosis
Do Not Combine
Pulse Frequency
Do Not Combine
Open-angle glaucoma
Do Not Combine
Hypertensive disease
Do Not Combine
Pulse Frequency
Do Not Combine
Tension-Type Headache
Do Not Combine
Generalized Anxiety Disorder
Do Not Combine
symptomatic cardiovascular disease
Do Not Combine
Tourette Syndrome
Do Not Combine
Pheochromocytoma
Do Not Combine
Tics
Do Not Combine
Agitation
Do Not Combine
There are 20 known major drug interactions with Methylphenidate.
Common Methylphenidate Drug Interactions
Drug Name
Risk Level
Description
Desflurane
Major
Methylphenidate may increase the hypertensive activities of Desflurane.
Diethyl ether
Major
Methylphenidate may increase the hypertensive activities of Diethyl ether.
Enflurane
Major
Methylphenidate may increase the hypertensive activities of Enflurane.
Halothane
Major
Methylphenidate may increase the hypertensive activities of Halothane.
Isoflurane
Major
Methylphenidate may increase the hypertensive activities of Isoflurane.
Methylphenidate Toxicity & Overdose RiskOverdosing on morphine can cause vomiting, restlessness, tremors, overactive reflexes, muscle spasms, seizures (sometimes followed by a coma), feeling happy and excited, confusion, seeing or hearing things that aren't real, delirium, sweating, redness of the face, headaches, high body temperature, rapid heartbeat, heart rhythm problems, high blood pressure, wide pupils, and dryness of the mouth. The lowest toxic dose for mice is 190mg/kg when given orally.
image of a doctor in a lab doing drug, clinical research

Methylphenidate Novel Uses: Which Conditions Have a Clinical Trial Featuring Methylphenidate?

84 active studies are presently assessing the potential of Methylphenidate to provide relief for Attention Deficit Hyperactivity Disorder.
Condition
Clinical Trials
Trial Phases
Attention Deficit Hyperactivity Disorder
65 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Phase 2, Phase 1, Early Phase 1
Narcolepsy
1 Actively Recruiting
Phase 1

Methylphenidate Reviews: What are patients saying about Methylphenidate?

5Patient Review
9/8/2015
Methylphenidate for Attention Deficit Disorder with Hyperactivity
I've been using these patches for eight years now and they're still the most effective treatment I've found. It's really convenient not having to remember pills, and it doesn't screw with my diet the way some other medications can.
5Patient Review
4/8/2019
Methylphenidate for Attention Deficit Disorder with Hyperactivity
I have severe ADHD and this medicine makes me feel more normal than with out it. I also have depression and it helps that as well.... I actuallt dont jave any sode effects either. Hope it continues to help me.
5Patient Review
5/31/2019
Methylphenidate for Attention Deficit Disorder with Hyperactivity
I've only been giving my son this medication for a short time, but I'm already seeing such an amazing difference in his behavior and school performance. His teacher even contacted me to tell me how much progress he's made! I really hope that this continues to work well for him. The only side effects he's mentioned are feeling slightly dizzy and nauseous, but other than that he says he feels fine.
5Patient Review
9/8/2015
Methylphenidate for Attention Deficit Disorder with Hyperactivity
I've been using the datrayna patches for eight years now, and they're by far the most effective treatment I've tried. I love not having to worry about forgetting pills, and it doesn't screw with my diet nearly as much as other medications have in the past.
5Patient Review
4/8/2019
Methylphenidate for Attention Deficit Disorder with Hyperactivity
This medication has been instrumental in managing my ADHD and depression. I haven't experienced any negative side effects, which is great.
View All Reviews
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about methylphenidate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What will methylphenidate do to a normal person?

"Do not drive after taking methylphenidate until you know how the medicine affects you, as it may cause dizziness, drowsiness, or changes in vision. Methylphenidate may also cause serious heart or blood vessel problems, which are more likely in patients with a family history of heart disease."

Answered by AI

Is methylphenidate a serious drug?

"Methylphenidate should only be used as prescribed by a doctor to avoid any serious health problems, including heart and blood pressure problems that could potentially be fatal. This medication has a risk of being habit-forming, so it should be used with caution by people who have mental/mood disorders or a substance use disorder."

Answered by AI

Is methylphenidate the same as Adderall?

"Adderall is the brand name for a mix of two stimulants called amphetamine-dextroamphetamine. Ritalin is the brand name for a stimulant called methylphenidate."

Answered by AI

Is methylphenidate a stimulant?

"Heres a rundown of how these drugs work:

These drugs work by increasing levels of the neurotransmitters dopamine and norepinephrine in the brain. This can help to improve focus, concentration, and task completion.

Stimulant medications that increase levels of dopamine and norepinephrine in the brain are often prescribed to treat children, adolescents, or adults diagnosed with attention-deficit hyperactivity disorder (ADHD). These drugs can help improve focus, concentration, and task completion."

Answered by AI

Clinical Trials for Methylphenidate

Have you considered Methylphenidate clinical trials? We made a collection of clinical trials featuring Methylphenidate, we think they might fit your search criteria.
Have you considered Methylphenidate clinical trials? We made a collection of clinical trials featuring Methylphenidate, we think they might fit your search criteria.
Have you considered Methylphenidate clinical trials? We made a collection of clinical trials featuring Methylphenidate, we think they might fit your search criteria.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top