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What is Mefenamic Acid
Mefenamic acidThe Generic name of this drug
Treatment SummaryIbuprofen is a type of medication that reduces pain, inflammation, and fever. It works by blocking enzymes, known as cyclooxygenase, that are involved in the production of hormones that cause inflammation.
Ponstelis the brand name
Mefenamic Acid Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ponstel
Mefenamic acid
1967
14
Approved as Treatment by the FDA
Mefenamic acid, also known as Ponstel, is approved by the FDA for 3 uses such as Mild pain and Pain .Mild pain
Pain
Primary Dysmenorrhoea
Effectiveness
How Mefenamic Acid Affects PatientsMefenamic acid is a type of medicine that belongs to a group of medicines called NSAIDs. It helps to reduce inflammation, pain, and fever. It works by blocking the production of a natural body chemical called prostaglandin, which helps to reduce the symptoms.
How Mefenamic Acid works in the bodyMefenamic acid reduces pain by blocking the action of prostaglandin synthetase receptors. These receptors control inflammation, which can worsen pain. By reducing the activity of these receptors, mefenamic acid is able to reduce the symptoms of pain.
When to interrupt dosage
The suggested dosage of Mefenamic Acid is contingent upon the identified condition, such as Pain, Muscle Cramp and Primary Dysmenorrhoea. The measure of dosage is contingent upon the approach of administration, which can be found in the table below.Condition
Dosage
Administration
Pain
, 250.0 mg
, Capsule, Capsule - Oral, Oral
Muscle Cramp
, 250.0 mg
, Capsule, Capsule - Oral, Oral
Primary Dysmenorrhoea
, 250.0 mg
, Capsule, Capsule - Oral, Oral
Mild pain
, 250.0 mg
, Capsule, Capsule - Oral, Oral
Warnings
Mefenamic Acid has seven counterindications and should not be administered concurrently with the circumstances outlined in the following table.Mefenamic Acid ContraindicationsCondition
Risk Level
Notes
cardiac bypass surgery
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Mefenamic Acid may interact with Pulse Frequency
gastrointestinal active ulceration
Do Not Combine
preexisting renal disease
Do Not Combine
chronic Gastrointestinal inflammation
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Mefenamic Acid may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Mefenamic Acid may interact with Pulse Frequency
Common Mefenamic Acid Drug Interactions
Drug Name
Risk Level
Description
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Mefenamic acid.
Epirubicin
Major
The metabolism of Epirubicin can be decreased when combined with Mefenamic acid.
Macimorelin
Major
The therapeutic efficacy of Macimorelin can be decreased when used in combination with Mefenamic acid.
Methotrexate
Major
The serum concentration of Methotrexate can be increased when it is combined with Mefenamic acid.
Mifamurtide
Major
The therapeutic efficacy of Mifamurtide can be decreased when used in combination with Mefenamic acid.
Mefenamic Acid Toxicity & Overdose RiskThe toxic dose of this drug in rats is 740mg/kg. Overdosing can lead to abdominal pain, vomiting that looks like coffee grounds, dark stool, ringing in the ears, change in urine output, an abnormally fast or slow heartbeat, muscle weakness, slow or shallow breathing, confusion, intense headaches, or loss of consciousness.
Mefenamic Acid Novel Uses: Which Conditions Have a Clinical Trial Featuring Mefenamic Acid?
Currently, 4 active clinical trials are assessing the potential of Mefenamic Acid to alleviate Mild Pain, Primary Dysmenorrhoea and Muscle Cramps.Condition
Clinical Trials
Trial Phases
Mild pain
0 Actively Recruiting
Pain
0 Actively Recruiting
Muscle Cramp
0 Actively Recruiting
Primary Dysmenorrhoea
2 Actively Recruiting
Phase 4, Not Applicable
Patient Q&A Section about mefenamic acid
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Which is stronger Ibuprofen or mefenamic acid?
"Mean pain relief score and pain intensity difference increased for both groups, with the Ibuprofen group having a higher score within the first 30 minutes. However, the difference was not statistically significant. The pain intensity difference was significantly higher for the Ibufropen group until 20 minutes."
Answered by AI
Who should take mefenamic acid?
"Mefenamic acid is a medication used to relieve mild to moderate pain, as well as cramps associated with menstruation. It is intended for use in people aged 14 and up, and should not be used for more than 7 days at a time."
Answered by AI
What is mefenamic acid used for?
"Mefenamic acid is an anti-inflammatory drug that can be used to treat pain, cramps, and other conditions as determined by a doctor. This drug is only available with a prescription from a doctor."
Answered by AI
Is mefenamic acid the same as Ibuprofen?
"The study found that mefenamic acid and ibuprofen had a similar effect in reducing pain and inflammation, with few side effects. Some people taking ibuprofen reported feeling drowsy, while a smaller number of people taking mefenamic acid reported the same side effect."
Answered by AI