Upright Bed Positioning for ARDS
(ARISE Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a new method of positioning patients in bed to assist with Acute Respiratory Distress Syndrome (ARDS), a serious lung condition that makes breathing difficult. The study compares two groups: one using a special upright bed position and the other using the usual bed position with the head elevated. The researchers aim to determine if the upright position improves breathing. Individuals with ARDS who do not have cancer or an active tracheostomy (a tube in the neck to aid breathing) may be suitable for this trial. As an unphased trial, this study provides a unique opportunity to contribute to innovative research that could enhance ARDS treatment strategies.
Do I need to stop taking my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that upright bed positioning is safe for ARDS patients?
Research has shown that raising the head of the bed for patients with ARDS (Acute Respiratory Distress Syndrome) is generally safe. Studies indicate that this position can be used without causing serious side effects. It can help patients breathe better by increasing lung capacity and oxygen levels. Some studies have found improvements in breathing and blood oxygen levels with few negative effects. Overall, evidence suggests that this bed position is well-tolerated and safe for patients with ARDS.12345
Why are researchers excited about this trial?
Researchers are excited about upright bed positioning for ARDS (Acute Respiratory Distress Syndrome) because it offers a simple, non-invasive way to potentially improve breathing without the need for additional medication. Unlike the standard of care, which typically includes elevating the head of the bed, the upright positioning could enhance lung function by allowing better air distribution and reducing pressure on the lungs. This method could provide a cost-effective and accessible option to support patients' breathing naturally, making it an attractive area of exploration.
What evidence suggests that upright bed positioning is effective for ARDS?
Research has shown that sitting up in bed can benefit people with Acute Respiratory Distress Syndrome (ARDS). In this trial, participants will join either an upright bed positioning group or a standard of care group. Studies have found that when patients sit more upright, their oxygen levels improve and their lungs function better. This likely occurs because sitting up enhances blood flow and allows the lungs to expand more. Specifically, raising the head of the bed to an angle greater than 45 degrees has been linked to better oxygen levels. This position helps by allowing more air into the lungs and making breathing easier.35678
Are You a Good Fit for This Trial?
This trial is for patients with Acute Respiratory Distress Syndrome (ARDS). To be eligible, participants should not have a history of cancer or an active tracheostomy.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants are randomized to receive either daily upright bed positioning or standard of care with head of bed elevation
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Upright Bed positioning
Trial Overview
The ARISE Study is testing the effects of upright bed positioning on ARDS patients. It's a pilot study where half the patients will be randomly assigned to this new position and the other half will receive standard care with head elevation.
How Is the Trial Designed?
Upright bed positioning
Standard of Care Head of Bed Elevation
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Alabama at Birmingham
Lead Sponsor
Citations
Efficacy of prone position in acute respiratory distress ...
Current evidence strongly supports that prone positioning has beneficial effects on gas exchange, respiratory mechanics, lung protection and hemodynamics.
Physiological effects and safety of bed verticalization in ...
Verticalization to 90° is feasible in ARDS patients, improving EELV and oxygenation up to 30°, likely due to alveolar recruitment and blood flow redistribution.
Prone Positioning for Acute Hypoxemic Respiratory Failure ...
The use of the prone position has numerous physiologic benefits in patients with acute hypoxemic respiratory failure and ARDS. Although ...
The efficacy and safety of prone positioning in adults patients ...
Conclusions: Prone positioning tends to reduce the mortality rates in ARDS patients, especially when used in conjunction with a lung protective strategy and ...
Effects of patient positioning on respiratory mechanics in ...
In ARDS patients, upright position (head of the bed angle >45°) was associated with an improvement of oxygenation despite no change in respiratory system ...
Physiological effects and safety of bed verticalization in ...
Conclusions. Verticalization to 90° is feasible in ARDS patients, improving EELV and oxygenation up to 30°, likely due to alveolar recruitment ...
7.
atsjournals.org
atsjournals.org/doi/pdf/10.1164/ajrccm-conference.2022.205.1_MeetingAbstracts.A5033?download=truePhysiological Effects and Safety of Bed Verticalization in ...
CONCLUSION : Bed verticalization in ARDS is feasible, safe, and shows promising results on hematosis and respiratory mechanic with minimal ...
8.
aacnjournals.org
aacnjournals.org/ajcconline/article/34/2/145/32654/Pulmonary-Focused-Verticalization-Therapy-inPulmonary-Focused Verticalization Therapy in Patients ...
Although this literature consists of small studies, it suggests that vertical positioning can be performed without serious side effects or ...
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