Macitentan
Pulmonary Arterial Hypertension
Treatment
2 FDA approvals
0 Active Studies for Macitentan
Treatment for
Pulmonary Arterial Hypertension
What is Macitentan
Macitentan
The Generic name of this drug
Treatment Summary
Macitentan is a medication used to treat pulmonary arterial hypertension (high blood pressure in the lungs). It was approved by the FDA in 2013 and is considered safer than its predecessor due to its lower risk of causing liver damage.
Opsumit
is the brand name
Macitentan Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Opsumit
Macitentan
2013
1
Approved as Treatment by the FDA
Macitentan, otherwise called Opsumit, is approved by the FDA for 2 uses such as Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH) and Pulmonary Arterial Hypertension .
Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH)
Helps manage Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH)
Pulmonary Arterial Hypertension
Helps manage Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH)
Effectiveness
How Macitentan Affects Patients
Macitentan works by reducing how much blood vessels constrict and how much cells multiply when there is too much endothelin in the body.
How Macitentan works in the body
Macitentan helps treat pulmonary arterial hypertension (PAH) by blocking signals coming from endothelin-1 and -2, which are molecules released by the vascular endothelium. It does this by binding to two receptors in the body, E<sub>A</sub> and E<sub>B</sub>. When endothelin molecules bind to the E<sub>A</sub> receptor, it causes the cells to release calcium, which makes the cells contract and narrow the blood vessels. This leads to PAH. When endothelin binds to the E<sub>B</sub> receptor, it
When to interrupt dosage
The amount of Macitentan is contingent upon the identified affliction. The measure of dosage differs as per the technique of delivery (e.g. Tablet or Tablet, film coated - Oral), as indicated in the table beneath.
Condition
Dosage
Administration
Pulmonary Arterial Hypertension
, 10.0 mg
, Oral, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet
Warnings
Macitentan Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Macitentan may interact with Pulse Frequency
There are 20 known major drug interactions with Macitentan.
Common Macitentan Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Macitentan may increase the hypotensive activities of Amifostine.
Acrivastine
Minor
Macitentan may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Albutrepenonacog alfa
Minor
Macitentan may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Aliskiren
Minor
Macitentan may increase the hypotensive activities of Aliskiren.
Almasilate
Minor
Macitentan may decrease the excretion rate of Almasilate which could result in a higher serum level.
Macitentan Toxicity & Overdose Risk
Taking too much macitentan may lead to headaches, nausea, and vomiting. If this happens, supportive care is recommended. Macitentan binds to proteins in the blood, so it cannot be removed from the body through dialysis.
Macitentan Novel Uses: Which Conditions Have a Clinical Trial Featuring Macitentan?
53 active investigations are currently underway to assess the potential of Macitentan to mitigate Pulmonary Arterial Hypertension.
Condition
Clinical Trials
Trial Phases
Pulmonary Arterial Hypertension
0 Actively Recruiting
Macitentan Reviews: What are patients saying about Macitentan?
2
Patient Review
1/14/2015
Macitentan for Pulmonary Arterial Hypertension
Patient Q&A Section about macitentan
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What is macitentan tablets used for?
"Macitentan is used to manage PAH, which is high blood pressure in the vessels that carry blood to the lungs."
Answered by AI
Is macitentan a controlled substance?
"The product is a Schedule II controlled substance and is subject to FDA Medication Guide requirements. It has a risk evaluation and mitigation strategy to help make sure it is used safely."
Answered by AI
How is macitentan administered?
"Macitentan can be taken orally, with or without food. The recommended dose is 10 mg once daily. The tablets should not be split, crushed, or chewed."
Answered by AI