Imaging Muscle Activity for Acute Lymphoblastic Leukemia Survivors
What You Need to Know Before You Apply
What is the purpose of this trial?
The participants are being asked to take part in this trial, because the participant is a survivor of childhood cancer or agreed to be part of a volunteer group to understand the relation between cancer and cancer treatment and muscle weakness in survivors of Acute Lymphoblastic Leukemia (ALL). ALL is cancer of the blood and bone marrow.Primary Objective• To compare muscle mtOXPHOS activity and satellite cell content among ALL survivors and controls.Secondary Objective* To evaluate the association between muscle mtOXPHOS, muscle satellite cell content and physical performance in ALL survivors.* To evaluate the association of muscle morphology and epigenetics with muscle mtOXPHOS in ALL survivors.
Who Is on the Research Team?
Puneet Bagga, PhD
Principal Investigator
St. Jude Children's Research Hospital
Are You a Good Fit for This Trial?
This trial is for survivors of childhood Acute Lymphoblastic Leukemia (ALL) and healthy volunteers interested in studying the effects of cancer and its treatment on muscle weakness. Specific eligibility criteria are not provided, but typically participants must meet certain health conditions to be included.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Baseline Assessment
Participants undergo baseline assessments including MRI/MRS sessions, physical function tests, and muscle ultrasound
Sample Collection
Participants provide peripheral blood and muscle samples for analysis
Follow-up
Participants are monitored for safety and effectiveness after assessments
What Are the Treatments Tested in This Trial?
Interventions
- Skeletal muscle biopsy
Find a Clinic Near You
Who Is Running the Clinical Trial?
St. Jude Children's Research Hospital
Lead Sponsor