Ludiomil

Depression, Depressive neurosis, Generalized Anxiety Disorder + 3 more
Treatment
6 FDA approvals
20 Active Studies for Ludiomil

What is Ludiomil

MaprotilineThe Generic name of this drug
Treatment SummaryMaprotiline is a type of antidepressant used to treat depression, dysthymic disorder, and anxiety. It works by blocking the reuptake of norepinephrine, which helps boost mood, and has some anticholinergic properties. It does not affect serotonin levels. Maprotiline is typically used to treat depressive symptoms and the associated anxiety.
Ludiomilis the brand name
image of different drug pills on a surface
Ludiomil Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ludiomil
Maprotiline
1980
6

Approved as Treatment by the FDA

Maprotiline, otherwise called Ludiomil, is approved by the FDA for 6 uses like Behcet Syndrome and Depressive disorder .
Behcet Syndrome
Depressive disorder
Depression
Generalized Anxiety Disorder
Depressive neurosis
Depression

Effectiveness

How Ludiomil Affects PatientsMaprotiline is an antidepressant medication used to treat depression. It can also help reduce anxiety. Studies have shown that maprotiline helps people get more REM sleep, which is important for feeling rested. It works by blocking noradrenaline in the brain and body, and has mild effects on serotonin and histamine levels, which helps with sedation. Maprotiline also has weaker alpha adrenergic blocking activity than another antidepressant, amitriptyline.
How Ludiomil works in the bodyMaprotiline helps improve mood by blocking the reuptake of catecholamines in the brain. This process increases the amount of these chemicals at the synapses, which has a calming effect. Maprotiline also blocks some nerve receptors and inhibits a transporter that helps recycle noradrenaline and norepinephrine. Additionally, Maprotiline blocks the histamine H1 receptor, which has a sedative effect.

When to interrupt dosage

The proposed dose of Ludiomil is contingent upon the determined condition, inclusive of Generalized Anxiety Disorder, Depressive disorder and Manic depressive illness. The measure of dosage fluctuates as per the mode of delivery (e.g. Oral or Tablet) delineated in the table below.
Condition
Dosage
Administration
Depression
25.0 mg, , 50.0 mg, 75.0 mg, 10.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Depressive disorder
25.0 mg, , 50.0 mg, 75.0 mg, 10.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Generalized Anxiety Disorder
25.0 mg, , 50.0 mg, 75.0 mg, 10.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Depression
25.0 mg, , 50.0 mg, 75.0 mg, 10.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Depressive neurosis
25.0 mg, , 50.0 mg, 75.0 mg, 10.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Behcet Syndrome
25.0 mg, , 50.0 mg, 75.0 mg, 10.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet

Warnings

There are 20 known major drug interactions with Ludiomil.
Common Ludiomil Drug Interactions
Drug Name
Risk Level
Description
Aclidinium
Major
The risk or severity of adverse effects can be increased when Maprotiline is combined with Aclidinium.
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Maprotiline.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Maprotiline.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Maprotiline.
Azelastine
Major
Maprotiline may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Ludiomil Toxicity & Overdose RiskThe lowest toxic dose of this drug in rats is around 900mg/kg when taken orally, and 90mg/kg when taken by women. Overdosing can lead to agitation, muscle twitching and stiffness, trembling, loss of coordination, seizures, high fever, dizziness, dilated pupils, vomiting, bluish skin, low blood pressure, rapid heartbeat, abnormal heart rhythms, difficulty breathing, and unconsciousness.
image of a doctor in a lab doing drug, clinical research

Ludiomil Novel Uses: Which Conditions Have a Clinical Trial Featuring Ludiomil?

At present, 1000 active trials are assessing the potential of Ludiomil to mitigate symptoms of Generalized Anxiety Disorder, Depression and Depressive disorder.
Condition
Clinical Trials
Trial Phases
Depression
202 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1
Generalized Anxiety Disorder
244 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Early Phase 1, Phase 4
Behcet Syndrome
2 Actively Recruiting
Not Applicable
Depressive disorder
3 Actively Recruiting
Not Applicable, Phase 1
Depressive neurosis
0 Actively Recruiting
Depression
693 Actively Recruiting
Phase 2, Not Applicable, Phase 3, Phase 1, Early Phase 1, Phase 4

Ludiomil Reviews: What are patients saying about Ludiomil?

5Patient Review
3/21/2010
Ludiomil for Anxiousness associated with Depression
This treatment has done wonders for my anxiety, energy levels, and depression.
5Patient Review
3/8/2009
Ludiomil for Depression
I've been taking Ludiomil for a while now, and it's really the only thing that has worked for me. I tried a bunch of different antidepressants when they first came out, but the doctors always ended up putting me back on Ludiomil. It's been 15 years since I was last hospitalized for depression, and I credit this drug entirely.
5Patient Review
10/30/2009
Ludiomil for Depression
I've been taking a low dose of this medicine for years, and it's really helped me to feel like myself again.
5Patient Review
4/28/2014
Ludiomil for Anxiousness associated with Depression
I'm not sure what's available now that this drug is no longer on the market, but it was really effective while it was still around.
4.3Patient Review
9/7/2012
Ludiomil for Depression
I was on this medication for a long time and it really helped me manage my busy life. I weaned myself off of it eventually, but after a few years I had to start taking it again. I'm not feeling very well on it now, though.
1Patient Review
7/27/2011
Ludiomil for Depression
I had postpartum depression a number of years ago and my doctor put me on this medication even after I told him another med had worked in the past. I'm lucky to be alive today because I had undiagnosed bipolar disorder and this drug made me much worse
1Patient Review
3/27/2013
Ludiomil for Depression
The side effects of this drug are incredibly harsh, including chronic constipation, urinary retention, and loss of balance. The antidepressant effects do not come close to outweighing these drawbacks.

Patient Q&A Section about ludiomil

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Ludiomil used for?

"This antidepressant helps improve mood and promote feelings of wellbeing by affecting the levels of neurotransmitters in the brain. It is part of a class of medications known as tetracyclic antidepressants."

Answered by AI

Is Ludiomil still available?

"As of September 2020, Ludiomil 25 mg tablets are no longer being manufactured and there is no more stock. As of July 2021, Ludiomil 75 mg tablets will also no longer be manufactured and there will be no more stock."

Answered by AI

What is the generic of Ludiomil?

"Maprotiline is an antidepressant that can be used to help with depression and anxiety symptoms."

Answered by AI

What type of antidepressant is maprotiline?

"May 15, 2017

Maprotiline is a type of antidepressant that works by increasing the levels of certain natural substances in the brain that are necessary for maintaining mental balance."

Answered by AI

Clinical Trials for Ludiomil

Have you considered Ludiomil clinical trials? We made a collection of clinical trials featuring Ludiomil, we think they might fit your search criteria.
Have you considered Ludiomil clinical trials? We made a collection of clinical trials featuring Ludiomil, we think they might fit your search criteria.
Have you considered Ludiomil clinical trials? We made a collection of clinical trials featuring Ludiomil, we think they might fit your search criteria.