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What is Lotensin Hct
HydrochlorothiazideThe Generic name of this drug
Treatment SummaryHydrochlorothiazide is a diuretic medication that is used to reduce swelling and treat high blood pressure. It is the most commonly prescribed thiazide diuretic, but is now used less frequently in favor of newer medications like angiotensin converting enzyme inhibitors and angiotensin II receptor blockers. These medications are often combined with hydrochlorothiazide for better results. Hydrochlorothiazide was approved by the FDA in 1959 and is still used today.
Esidrixis the brand name
Lotensin Hct Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Esidrix
Hydrochlorothiazide
1959
2181
Approved as Treatment by the FDA
Hydrochlorothiazide, also called Esidrix, is approved by the FDA for 30 uses including Nephrotic Syndrome and Hypertension, Essential Hypertension .Nephrotic Syndrome
Used to treat Nephrotic Syndrome in combination with Spironolactone
Hypertension, Essential Hypertension
Used to treat Hypertension, Essential Hypertension in combination with Spironolactone
Cirrhosis of the Liver
Used to treat Cirrhosis of the Liver in combination with Spironolactone
Hypertension
Used to treat blood pressure inadequately controlled with monotherapy in combination with Irbesartan
Congestive Heart Failure (CHF)
Used to treat Congestive Heart Failure (CHF) in combination with Spironolactone
Congestive Heart Failure
Used to treat Congestive Heart Failure (CHF) in combination with Spironolactone
Hypertensive disease
Used to treat Hypertension, Essential Hypertension in combination with Spironolactone
Hypokalemia
Used to treat hypokalemia with solo treatment in combination with Triamterene
Antepartum magnesium sulfate prophylaxis
Helps manage prophylaxis of preeclampsia
prophylaxis of preeclampsia
Helps manage prophylaxis of preeclampsia
Ascites
Used to treat Ascites in combination with Spironolactone
Premenstrual tension with edema
Helps manage Premenstrual tension with edema
Hypertrophy, Left Ventricular
Used to treat Left Ventricular Hypertrophy in combination with Losartan
Swollen feet or ankles
Used to treat Edema in combination with Triamterene
Left Ventricular Hypertrophy
Used to treat Left Ventricular Hypertrophy in combination with Losartan
calcium channel blockers
Used to treat calcium channel blockers in combination with Eprosartan
Edema
Used to treat Edema in combination with Triamterene
Hypertension
Used to treat Antihypertensive Treatment in combination with Eprosartan
Hypertension
Used to treat inadequate control of blood pressure with monotherapy in combination with Aliskiren
Therapeutic procedure
Used to treat inadequate response to treatment in combination with Spironolactone
Ascites
Used to treat Ascites in combination with Spironolactone
Hypertensive disease
Used to treat High Blood Pressure (Hypertension) in combination with Losartan
Stroke
Used to treat Cerebrovascular Accident in combination with Losartan
Sodium retention
Used to treat Sodium retention in combination with Spironolactone
inadequate response to other therapeutic measures
Used to treat inadequate response to other therapeutic measures in combination with Spironolactone
Bedrest
Used to treat Bedrest in combination with Spironolactone
Cirrhosis
Used to treat Cirrhosis of the Liver in combination with Spironolactone
restriction of fluid and sodium
Used to treat restriction of fluid and sodium in combination with Spironolactone
Edema
Helps manage Premenstrual tension with edema
Diuretics
Used to treat Hypokalemia caused by diuretics in combination with Amiloride
Effectiveness
How Lotensin Hct Affects PatientsHydrochlorothiazide helps the body get rid of extra water by blocking the kidneys from absorbing too much salt and water. The amount of the drug taken depends on the individual, but it generally ranges from 25-100mg. People with reduced kidney or liver function should be careful when taking this drug.
How Lotensin Hct works in the bodyHydrochlorothiazide works by blocking the absorption of sodium and chlorine ions from the distal convoluted tubule of the kidneys. Normally, sodium ions are regularly taken up into cells in the tubule and pumped into the surrounding area, creating a concentration gradient that helps pull water in from the tubule. Hydrochlorothiazide stops this process by blocking the transporter that takes up sodium and chlorine ions. As a result, the concentration gradient is reduced and less water is reabsorbed.
When to interrupt dosage
The advisable measure of Lotensin Hct is contingent upon the identified illness, for instance Antepartum magnesium sulfate prophylaxis, blood pressure inadequately controlled with monotherapy and antihypertensives. The amount of dosage fluctuates as per the technique of delivery (e.g. Tablet, coated - Oral or Oral) set out in the table below.Condition
Dosage
Administration
Edema
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
calcium channel blockers
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Antepartum magnesium sulfate prophylaxis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Renal tubular acidosis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Nephrolithiasis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypertension
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Diuretics
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Cirrhosis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypokalemia
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypertension
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
prophylaxis of calcium nephrolithiasis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
inadequate response to other therapeutic measures
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Stroke
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypertension
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Nephrotic Syndrome
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Swollen feet or ankles
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Ascites
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Diabetes Insipidus
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Congestive Heart Failure
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
Lotensin Hct has two counter-indications and should not be combined with the conditions listed in the table below.Lotensin Hct ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Anuria
Do Not Combine
Common Lotensin Hct Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Hydrochlorothiazide may increase the hypotensive activities of Amifostine.
Cyclopentamine
Major
The risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Cyclopentamine.
Dofetilide
Major
The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Dofetilide.
Fenofibrate
Major
The therapeutic efficacy of Fenofibrate can be decreased when used in combination with Hydrochlorothiazide.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Hydroxyzine.
Lotensin Hct Toxicity & Overdose RiskThe lowest toxic dose of hydrochlorothiazide in mice and rats is higher than 10g/kg. An overdose of hydrochlorothiazide could cause low blood potassium, chloride, or sodium levels. Treatment of overdose includes providing fluids and electrolytes to the patient, as well as using vasopressors to raise blood pressure and oxygen for respiratory issues.
Lotensin Hct Novel Uses: Which Conditions Have a Clinical Trial Featuring Lotensin Hct?
Presently, 158 active clinical trials are investigating the potential of Lotensin Hct to alleviate Cirrhosis, Edema and Congestive Heart Failure.Condition
Clinical Trials
Trial Phases
Cirrhosis
56 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4, Early Phase 1
Sodium retention
0 Actively Recruiting
Ascites
3 Actively Recruiting
Not Applicable, Phase 2
Congestive Heart Failure
12 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Therapeutic procedure
0 Actively Recruiting
Diuretics
0 Actively Recruiting
Antepartum magnesium sulfate prophylaxis
18 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Early Phase 1, Phase 2, Phase 1
Swollen feet or ankles
7 Actively Recruiting
Phase 2, Not Applicable, Phase 4
restriction of fluid and sodium
0 Actively Recruiting
Hypertrophy, Left Ventricular
0 Actively Recruiting
Nephrotic Syndrome
4 Actively Recruiting
Phase 2, Not Applicable, Phase 3
prophylaxis of calcium nephrolithiasis
0 Actively Recruiting
calcium channel blockers
0 Actively Recruiting
Hypokalemia
0 Actively Recruiting
Hypertension
0 Actively Recruiting
Hypertension
0 Actively Recruiting
Bedrest
0 Actively Recruiting
Edema
0 Actively Recruiting
Hypertension
298 Actively Recruiting
Not Applicable, Phase 2, Phase 1, Phase 3, Early Phase 1, Phase 4
Diabetes Insipidus
1 Actively Recruiting
Phase 2
Lotensin Hct Reviews: What are patients saying about Lotensin Hct?
5Patient Review
3/24/2009 My blood pressure has remained in the 130/90 range, which is lower than it was before I started taking Norvasc. However, I have experienced extreme dizziness as a side effect.
5Patient Review
8/19/2013 I've been using this medication for years without any issues. I had a problem with swelling in my feet when I switched to a certain generic manufacturer, however. But luckily, the side effects cleared up when I changed manufacturers.
5Patient Review
5/11/2011 This treatment lowered my blood pressure, but I stopped taking it after six weeks because the side effects were too much for me. These included a constant tickle in my throat and cough, as well as severe muscle cramps and post-nasal drip.
5Patient Review
1/10/2011 I've been taking Benezepril/HCTZ for a while now and it's doing great things for my blood pressure. The only downside is that I sometimes have to urinate very soon after going, which can be uncomfortable on long trips.
4.7Patient Review
3/22/2009Patient Q&A Section about lotensin hct
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of benazepril HCTZ?
"You might feel dizzy, lightheaded, tired, have a headache, or feel like you're going to vomit when you first start taking this medication. ... , This product can cause you to become dehydrated or to have an electrolyte imbalance."
Answered by AI
Does Lotensin cause weight gain?
"Weight gain is not a known side effect of benazepril (Lotensin). However, if you experience any unexpected weight gain while taking this medication, please consult your doctor."
Answered by AI
What is Lotensin HCT used for?
"This lowers blood pressure and increases the supply of blood and oxygen to the heart. Hydrochlorothiazide decreases the amount of water in the body by increasing the amount of urine produced and because it is a water pill it will make you go to the bathroom more often.
This medication contains two drugs, an ACE inhibitor (benazepril) and a diuretic (hydrochlorothiazide). It is used to lower blood pressure (hypertension). Benazepril works by relaxing blood vessels, causing them to widen. This lowers blood pressure and increases the supply of blood and oxygen to the heart. Hydrochlorothiazide decreases the amount of water in the body by increasing urine production and making you urinate more frequently."
Answered by AI
Is Lotensin a water pill?
"If it is almost time for your next dose, Skip the missed dose and take your next dose at the regular time. Don't take two doses at the same time.
Because Lotensin HCT contains a diuretic, it is better to take it during the day. If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time."
Answered by AI
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