Lopressor Hct

Atrial Fibrillation, Thyroid Crisis, Migraine + 9 more

Treatment

4 FDA approvals

20 Active Studies for Lopressor Hct

What is Lopressor Hct

Metoprolol

The Generic name of this drug

Treatment Summary

Metoprolol is a type of medication used to reduce blood pressure. It comes in two forms, immediate-release and extended-release. The extended-release version is more widely used because it has lower levels of absorption into the bloodstream. Metoprolol has been widely prescribed in the US, Netherlands, and New Zealand since it was approved by the FDA in 1978. It is one of the most commonly used beta-blockers for treating high blood pressure.

Lopressor

is the brand name

image of different drug pills on a surface

Lopressor Hct Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Lopressor

Metoprolol

1978

983

Approved as Treatment by the FDA

Metoprolol, also known as Lopressor, is approved by the FDA for 4 uses including Hypertensive disease and Hypertension .

Hypertensive disease

Used to treat High Blood Pressure (Hypertension) in combination with Hydrochlorothiazide

Hypertension

Used to treat nonresponsive to antihypertensive monotherapy in combination with Hydrochlorothiazide

Hemodynamically Stable

Heart Attack

Effectiveness

How Lopressor Hct Affects Patients

Metoprolol is used to slow the heart rate, reduce cardiac excitability, and decrease the demand for oxygen in the heart. Studies have shown that taking metoprolol can reduce the risk of sudden cardiac death and heart attack. In clinical trials done in 1990, it was found that long-term use of metoprolol after a heart attack could reduce mortality and re-infarction rates by 17%.

How Lopressor Hct works in the body

Metoprolol reduces the activity of certain receptors in the heart, slowing the heart rate and reducing the amount of blood flowing through the heart. This drug has no effect on other parts of the body, such as the nervous system.

When to interrupt dosage

The suggested portion of Lopressor Hct is contingent upon the identified condition, including Hemodynamically Stable, Thyroid Crisis and Atrial Fibrillation. The amount of dosage is specified, as per the method of delivery (e.g. Tablet, coated or Tablet - Oral) recorded in the table beneath.

Condition

Dosage

Administration

Chest Pain

, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg

Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, coated

Heart Attack

, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg

Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, coated

Hypertensive disease

, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg

Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, coated

Hypertension

, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg

Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, coated

Migraine Disorders

, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg

Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, coated

Atrial Fibrillation

, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg

Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, coated

Thyroid Crisis

, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg

Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, coated

Migraine

, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg

Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, coated

Hypesthesia

, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg

Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, coated

Hypesthesia

, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg

Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, coated

Hemodynamically Stable

, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg

Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, coated

Tachycardia, Supraventricular

, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg

Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, coated

Warnings

Lopressor Hct Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Metoprolol may interact with Pulse Frequency

Heart Block

Do Not Combine

Shock, Cardiogenic

Do Not Combine

Heart Decompensation

Do Not Combine

Pulse Frequency

Do Not Combine

severe bradycardia

Do Not Combine

Sick Sinus Syndrome

Do Not Combine

There are 20 known major drug interactions with Lopressor Hct.

Common Lopressor Hct Drug Interactions

Drug Name

Risk Level

Description

4-Bromo-2,5-dimethoxyphenethylamine

Major

The therapeutic efficacy of 4-Bromo-2,5-dimethoxyphenethylamine can be decreased when used in combination with Metoprolol.

Abediterol

Major

The therapeutic efficacy of Abediterol can be decreased when used in combination with Metoprolol.

Adrafinil

Major

The therapeutic efficacy of Adrafinil can be decreased when used in combination with Metoprolol.

Agrostis gigantea pollen

Major

The risk of a hypersensitivity reaction to Agrostis gigantea pollen is increased when it is combined with Metoprolol.

Agrostis stolonifera pollen

Major

The risk of a hypersensitivity reaction to Agrostis stolonifera pollen is increased when it is combined with Metoprolol.

Lopressor Hct Toxicity & Overdose Risk

The highest toxic dose of metoprolol in rats is estimated to be between 3090 and 4670 milligrams per kilogram. Overdosing on metoprolol may cause a slow heartbeat, low blood pressure, difficulty breathing, and heart failure. In the event of an overdose, treatment involves emptying the stomach and then addressing the symptoms. There is no evidence to suggest that metoprolol causes cancer, genetic mutations, or infertility. If taken for a long period of time at high doses, it has been linked to small harmless lung tumors.

image of a doctor in a lab doing drug, clinical research

Lopressor Hct Novel Uses: Which Conditions Have a Clinical Trial Featuring Lopressor Hct?

319 active clinical trials are currently investigating the potential of Lopressor Hct to mitigate Hypesthesia, Thyroid Crisis and Hypertensive diseases.

Condition

Clinical Trials

Trial Phases

Atrial Fibrillation

94 Actively Recruiting

Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1

Chest Pain

2 Actively Recruiting

Not Applicable, Phase 2, Phase 3

Heart Attack

23 Actively Recruiting

Not Applicable, Phase 1, Phase 4, Phase 2, Early Phase 1, Phase 3

Thyroid Crisis

0 Actively Recruiting

Hypesthesia

8 Actively Recruiting

Not Applicable, Phase 1

Hemodynamically Stable

0 Actively Recruiting

Tachycardia, Supraventricular

0 Actively Recruiting

Migraine

51 Actively Recruiting

Phase 4, Not Applicable, Phase 1, Phase 3, Phase 2, Early Phase 1

Hypesthesia

2 Actively Recruiting

Not Applicable

Hypertension

0 Actively Recruiting

Hypertensive disease

27 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3

Migraine Disorders

1 Actively Recruiting

Phase 3

Lopressor Hct Reviews: What are patients saying about Lopressor Hct?

5

Patient Review

11/16/2013

Lopressor Hct for High Blood Pressure

After Lupron treatment, I started having "heat flashes" or "sweat fits". However, this stopped happening about three years ago. Some have suggested that metoprolol tartrate may be the source of the problem.

5

Patient Review

12/21/2013

Lopressor Hct for High Blood Pressure

I've been taking this medication for 15 years with no issues whatsoever.

5

Patient Review

3/18/2009

Lopressor Hct for High Blood Pressure

4

Patient Review

4/3/2010

Lopressor Hct for High Blood Pressure

I was really pleased with this medication. I'm sensitive to a lot of drugs, but this one didn't bother my stomach or leave me feeling irritated.

4

Patient Review

6/17/2009

Lopressor Hct for High Blood Pressure

Patient Q&A Section about lopressor hct

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does metoprolol have hydrochlorothiazide in it?

"For the extended-release tablets, the recommended starting dose for adults is one tablet containing 25 mg of metoprolol and 12.5 mg of hydrochlorothiazide once daily. Your doctor may adjust the dose as needed."

Answered by AI

Is Lopressor a water pill?

"Lopressor HCT is a combination of a beta-blocker and thiazide diuretic used to treat high blood pressure. Lopressor HCT is available in generic form."

Answered by AI

What is Lopressor HCT used for?

"Metoprolol is a beta-blocker that works by blocking the action of certain natural chemicals in your body (such as epinephrine) that affect the heart and blood vessels. This results in a decrease in heart rate and blood pressure. Hydrochlorothiazide is a "water pill" (diuretic) that causes you to make more urine, which helps your body get rid of extra salt and water.

This medication is for treating high blood pressure. It contains two medications, metoprolol and hydrochlorothiazide. Metoprolol is a beta-blocker that works by blocking the action of certain natural chemicals that affect the heart and blood vessels, which results in a decrease in heart rate and blood pressure. Hydrochlorothiazide is a "water pill" (diuretic) that causes you to make more urine, which helps your body get rid of extra salt and water."

Answered by AI

Is metoprolol tartrate the same as hydrochlorothiazide?

"Hydrochlorothiazide is a thiazide diuretic that helps to remove excess water from the body. Metoprolol is a beta-blocker that works to block the effects of adrenaline, helping to lower blood pressure. Together, these two medications are used to treat hypertension, or high blood pressure."

Answered by AI

Clinical Trials for Lopressor Hct

Image of Miles Square Health Center Chicago in Chicago, United States.

Food is Medicine for High Blood Pressure and Obesity

Any Age
All Sexes
Chicago, IL

The goal of this clinical trial is to treat both hypertension and obesity in adults using a food is medicine framework. Participants will be randomized 1:1 to FIM+DASH or usual-care control. The 24-week trial includes a 12-week FIM+DASH intervention followed by a 12-week maintenance period and leverages existing partnerships with community-based organizations for home food delivery and culinary skill-skill building. The main questions it aims to answer are: (1) What is the effect of FIM+DASH vs. usual care control on blood pressure? (2) What is the effect of FIM+DASH vs. usual care control on DASH diet adherence (diet quality), body weight, and waist circumference? (3) How to identify factors associated with the sustainability and scalability of FIM+DASH in real-world settings?

Phase 2
Waitlist Available

Miles Square Health Center Chicago (+3 Sites)

Image of Northwestern University in Chicago, United States.

Exercise Program for Atrial Fibrillation and Heart Failure

60 - 99
All Sexes
Chicago, IL

Atrial fibrillation (AF) and heart failure with preserved ejection fraction (HFpEF) are very common conditions that often occur together and result in worsening symptoms and reduced quality of life (QoL). Limitations being able to participate in activities of daily living is a primary complaint for AF-HFpEF patients, yet effective strategies to address this issue remain limited. While exercise interventions targeting aerobic training (AT) are recommended for patients with AF and HFpEF, unique challenges exist in this patient population who tend to be older. Specifically, many older patients with AF and HFpEF have muscle weakness, sarcopenia and frailty, that can make aerobic-focused exercise difficult and less tolerable. This study proposes that starting with progressive resistance training (PRT) before aerobic exercise may overcome these issues by improving muscle strength, making AT more manageable, and leading to better health outcomes. The goal of this study is to assess whether a sequential exercise program, named 'PREACTIVE' improves how people feel, decrease the amount of symptoms, and their ability to participate in exercise and activities. This study will specifically test a sequenced exercise approach of resistance training followed by aerobic exercise to improve symptoms, and quality of life in AF-HFpEF.

Waitlist Available
Has No Placebo

Northwestern University

Deepika Laddu, PhD

Image of Arizona State University in Phoenix, United States.

App-based Breathing Program for Migraine

18+
All Sexes
Phoenix, AZ

Migraine is one of the most common neurological disorders, characterized by recurrent headaches, sensitivity to light and movement, nausea, and autonomic dysregulation. Although mind-body interventions like biofeedback have shown their efficacy, they remain underutilized due to barriers such as transportation, time constraints, lack of awareness, stigma, and cost. A targeted approach to enhancing HRV is HRV biofeedback (HRVB), a technique using visual or auditory feedback to help people regulate HRV through slow-paced breathing and positive emotional regulation to promote ANS balance and emotional resilience. Investigators will conduct a remotely delivered pilot RCT of an 8-week, 10 min/day, novel app-based HRVB intervention compared to a sham control intervention (matching intervention time and attention with no biofeedback component) in adult with chronic migraine. Investigators hypothesize data collected from the study will: a) support the feasibility and acceptability of the remotely delivered app-based HRVB intervention among adults with chronic migraine, and b) provide insights into refining the intervention by examining patterns of change in migraine and psychological outcomes from pre- to post-intervention.

Waitlist Available
Online Trial

Arizona State University

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Image of Inova Alexandria Hospital in Alexandria, United States.

Heparin Dosing for Blood Clots and Heart Conditions

18+
All Sexes
Alexandria, VA

The goal of this clinical trial study is to test whether a mathematical calculation, using the patient's gender, weight and kidney function, can better predict a patient's heparin goal dose than a flat number of units per patient weight can. Participants will have the first dose of heparin infusion calculated, after which if adjustments are needed, the Hospital's prebuilt table for results driven dosing for this purpose is used. The researchers will compare the time it takes for the participants to get to the desired goal using the patient's information for calculation versus patients in the past who received the medication using the flat rate. The hypothesis is that the patients with enhanced personal data, gender, weight and kidney function, included for the initial dose, will get to their goal lab value sooner and with less chance of delay or overshooting the goal. A quicker time to goal lab value is beneficial to patients in many ways, including earlier treatment of the clot or coronary issue that the patient is experiencing.

Phase 4
Waitlist Available

Inova Alexandria Hospital

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Image of Johns Hopkins Medicine in Baltimore, United States.

Embolization for Migraine

18 - 80
All Sexes
Baltimore, MD

This study is to test the safety and feasibility of a procedure called embolization of the middle meningeal arteries (MMA), using a product called Onyx. Embolization creates a plug in the arteries. MMA embolization with Onyx is not approved for use in patients with migraines, but is currently used in patients with subdural hematomas. The FDA is allowing the use of Onyx in this study. It is thought that by using Onyx to block the middle meningeal arteries, the amount of migraine-causing substances which are released into the brain's bloodstream will be reduced. The company that manufactures Onyx, Medtronic, is providing the supplies for this study. Participants will be in the study for about 8 months after enrolling, including 6 months of follow up after the procedure. The participants will be asked to complete a daily headache diary and continue the participant's regular migraine medications. Participants will also have several clinic visits and be asked to provide blood samples for research.

Waitlist Available
Has No Placebo

Johns Hopkins Medicine

Risheng Xu, MD, PhD

Medtronic

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