Lopressor

Atrial Fibrillation, Thyroid Crisis, Migraine + 9 more

Treatment

4 FDA approvals

20 Active Studies for Lopressor

What is Lopressor

Metoprolol

The Generic name of this drug

Treatment Summary

Metoprolol is a type of medication used to lower blood pressure and reduce the risk of heart problems. It is available as an immediate-release or extended-release formulation. The medicine was developed in 1969 and approved by the FDA in 1978. Metoprolol is one of the most commonly prescribed medications for heart-related problems in the United States, Netherlands, and New Zealand.

Lopressor

is the brand name

image of different drug pills on a surface

Lopressor Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Lopressor

Metoprolol

1978

983

Approved as Treatment by the FDA

Metoprolol, also known as Lopressor, is approved by the FDA for 4 uses including Hypertensive disease and Hypertension .

Hypertensive disease

Used to treat High Blood Pressure (Hypertension) in combination with Hydrochlorothiazide

Hypertension

Used to treat nonresponsive to antihypertensive monotherapy in combination with Hydrochlorothiazide

Hemodynamically Stable

Heart Attack

Effectiveness

How Lopressor Affects Patients

Metoprolol is a drug used to treat heart rate and cardiac output issues. It works by slowing the electrical signals that control the heart and reducing the amount of blood the heart pumps out. The MAPHY trial showed that metoprolol reduced sudden cardiac death and heart attack when compared to diuretics. Another 1990 study found that taking metoprolol after a heart attack reduced the risk of death and repeat heart attack by 17%.

How Lopressor works in the body

Metoprolol works by blocking certain receptors in the heart. This reduces the heart's rate and strength of contractions, without affecting other parts of the body.

When to interrupt dosage

The measure of Lopressor is contingent upon the diagnosed disorder, for example Hemodynamically Stable, Thyroid Crisis and Atrial Fibrillation. The magnitude of dosage is contingent on the technique of delivery (e.g. Tablet, coated or Tablet - Oral) featured in the table beneath.

Condition

Dosage

Administration

Chest Pain

, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg

Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, coated

Heart Attack

, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg

Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, coated

Hypertensive disease

, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg

Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, coated

Hypertension

, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg

Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, coated

Migraine Disorders

, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg

Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, coated

Atrial Fibrillation

, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg

Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, coated

Thyroid Crisis

, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg

Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, coated

Migraine

, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg

Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, coated

Hypesthesia

, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg

Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, coated

Hypesthesia

, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg

Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, coated

Hemodynamically Stable

, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg

Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, coated

Tachycardia, Supraventricular

, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg

Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, coated

Warnings

Lopressor Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Metoprolol may interact with Pulse Frequency

Heart Block

Do Not Combine

Shock, Cardiogenic

Do Not Combine

Heart Decompensation

Do Not Combine

Pulse Frequency

Do Not Combine

severe bradycardia

Do Not Combine

Sick Sinus Syndrome

Do Not Combine

There are 20 known major drug interactions with Lopressor.

Common Lopressor Drug Interactions

Drug Name

Risk Level

Description

4-Bromo-2,5-dimethoxyphenethylamine

Major

The therapeutic efficacy of 4-Bromo-2,5-dimethoxyphenethylamine can be decreased when used in combination with Metoprolol.

Abediterol

Major

The therapeutic efficacy of Abediterol can be decreased when used in combination with Metoprolol.

Adrafinil

Major

The therapeutic efficacy of Adrafinil can be decreased when used in combination with Metoprolol.

Agrostis gigantea pollen

Major

The risk of a hypersensitivity reaction to Agrostis gigantea pollen is increased when it is combined with Metoprolol.

Agrostis stolonifera pollen

Major

The risk of a hypersensitivity reaction to Agrostis stolonifera pollen is increased when it is combined with Metoprolol.

Lopressor Toxicity & Overdose Risk

The lethal dose of metoprolol in rats has been found to be between 3090 and 4670 mg/kg. Overdosing on metoprolol may cause a slow heartbeat, low blood pressure, difficulty breathing, and heart failure. To treat an overdose, doctors recommend emptying the stomach and then providing treatment based on the symptoms. Metoprolol has not been linked to cancer, mutations, or fertility problems, although long-term use of high doses may cause minor lung tumors.

image of a doctor in a lab doing drug, clinical research

Lopressor Novel Uses: Which Conditions Have a Clinical Trial Featuring Lopressor?

Currently, 319 active studies are assessing the potential of Lopressor in providing relief from Hypesthesia, Thyroid Crisis and Hypertensive diseases.

Condition

Clinical Trials

Trial Phases

Atrial Fibrillation

94 Actively Recruiting

Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1

Chest Pain

2 Actively Recruiting

Not Applicable, Phase 2, Phase 3

Heart Attack

23 Actively Recruiting

Not Applicable, Phase 1, Phase 4, Phase 2, Early Phase 1, Phase 3

Thyroid Crisis

0 Actively Recruiting

Hypesthesia

8 Actively Recruiting

Not Applicable, Phase 1

Hemodynamically Stable

0 Actively Recruiting

Tachycardia, Supraventricular

0 Actively Recruiting

Migraine

51 Actively Recruiting

Phase 4, Not Applicable, Phase 1, Phase 3, Phase 2, Early Phase 1

Hypesthesia

2 Actively Recruiting

Not Applicable

Hypertension

0 Actively Recruiting

Hypertensive disease

27 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3

Migraine Disorders

1 Actively Recruiting

Phase 3

Lopressor Reviews: What are patients saying about Lopressor?

5

Patient Review

11/23/2017

Lopressor for High Blood Pressure

I've been taking this treatment for 34 years with no issues and great results.

5

Patient Review

6/16/2013

Lopressor for Myocardial Reinfarction Prevention

This medication has been effective with no negative side effects, which is great.

4.3

Patient Review

4/29/2013

Lopressor for High Blood Pressure

3.7

Patient Review

3/14/2021

Lopressor for High Blood Pressure

I've only been taking metoprolol for a week, but my blood pressure is already lower. However, my heart rate is still pretty high (up to 100 beats per minute).

3.3

Patient Review

8/1/2014

Lopressor for High Blood Pressure

I haven't been too impressed with this medication. I've been taking it for about a month now and have experienced some bruising, constipation, and sexual side effects that weren't present before. I'm going to continue to monitor these effects.

3.3

Patient Review

11/26/2013

Lopressor for High Blood Pressure

I had to cut the tabs into fourths in order to use them. Unfortunately, I experienced a lot of terrible side effects like chest pain and heart palpitations. Once I stopped taking the medication, I felt much better again.

3.3

Patient Review

8/11/2014

Lopressor for Heart Attack

After having a heart attack, I was put on this medication. While it has prevented migraines, I have been feeling dizzy and depressed since starting to take it.

3.3

Patient Review

7/13/2014

Lopressor for A Feeling of Restlessness with Inability to Sit Still

I'm not entirely sure if this is the right medication for me.

2.3

Patient Review

1/6/2021

Lopressor for Abnormal Heart Rhythm

I experienced significant swelling in my extremities and rapid weight gain. Not a fan.

2.3

Patient Review

2/13/2013

Lopressor for Ventricular Rate Control in Atrial Fibrillation

2

Patient Review

12/18/2013

Lopressor for High Blood Pressure

I started out by taking 1/2 tablet of this medication twice a day, in addition to 100mg of Losartran for my high blood pressure. When that didn't work, they upped my Lopressor dosage to one whole tablet twice a day. I still haven't seen any improvement in my BP and now my feet are swollen, mouth is dry, appetite is gone, and sleep patterns are all off. I'm not feeling well at all and wonder if it's even worth continuing this treatment. I have to call the cardiologist on Friday but, in the meantime, am really struggling with these side effects.

1.7

Patient Review

11/26/2020

Lopressor for High Blood Pressure

The weight gain from this medication has been substantial and it's made my blood pressure harder to control. Additionally, I frequently wheeze and have trouble breathing--side effects which my doctor does not seem interested in hearing about.

1.3

Patient Review

10/5/2013

Lopressor for High Blood Pressure

While Lopressor has been helpful, I don't feel like I'm quite back to my old self since my heart attack.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about lopressor

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Lopressor a blood thinner?

"No, metoprolol does not thin the blood. Instead, it works to relax blood vessels and slow heart rate."

Answered by AI

What are the side effects of Lopressor?

"You may feel dizzy, tired, or depressed. You may also have confusion, memory problems, nightmares, trouble sleeping, diarrhea, or a mild itching or rash."

Answered by AI

What is drug Lopressor used for?

"This medication can help lower your blood pressure to prevent strokes, heart attacks, and kidney problems. It is also used to treat chest pain (angina) and improve your survival after a heart attack."

Answered by AI

Is metoprolol and Lopressor the same?

"Generic name for Lopressor is Metoprolol tartrate. It is a beta blocker used to treat high blood pressure and chronic chest pain. Feb 18, 2020"

Answered by AI

Clinical Trials for Lopressor

Image of Inova Alexandria Hospital in Alexandria, United States.

Heparin Dosing for Blood Clots and Heart Conditions

18+
All Sexes
Alexandria, VA

The goal of this clinical trial study is to test whether a mathematical calculation, using the patient's gender, weight and kidney function, can better predict a patient's heparin goal dose than a flat number of units per patient weight can. Participants will have the first dose of heparin infusion calculated, after which if adjustments are needed, the Hospital's prebuilt table for results driven dosing for this purpose is used. The researchers will compare the time it takes for the participants to get to the desired goal using the patient's information for calculation versus patients in the past who received the medication using the flat rate. The hypothesis is that the patients with enhanced personal data, gender, weight and kidney function, included for the initial dose, will get to their goal lab value sooner and with less chance of delay or overshooting the goal. A quicker time to goal lab value is beneficial to patients in many ways, including earlier treatment of the clot or coronary issue that the patient is experiencing.

Phase 4
Waitlist Available

Inova Alexandria Hospital

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Image of U Health in Miami, United States.

Cuffless PPG Monitor for High Blood Pressure

18+
All Sexes
Miami, FL

This study aims to validate the accuracy and reliability of blood pressure (BP) estimates obtained over 24 hours using a PPG-based chest-patch device compared to the gold standard ambulatory blood pressure monitoring (ABPM) method using an upper arm cuff-based oscillometric BP device, in both hypertensive and normotensive individuals referred by their provider to undergo a 24-hours ABPM for clinical indication. The Awake/Asleep test, which is the primary test recommended for automated wearable cuffless BP devices that are cuff-calibrated (based on the 2023 European Society of Hypertension (ESH) recommendations for the validation of cuffless blood pressure measuring devices), will be conducted in this study. The secondary aim of the study is to assess the feasibility and convenience of the PPG-based device.

Waitlist Available
Has No Placebo

U Health (+1 Sites)

Ziad Zoghby, M.D., M.B.A.

Biobeat Technologies Ltd.

Image of Johns Hopkins Medicine in Baltimore, United States.

Embolization for Migraine

18 - 80
All Sexes
Baltimore, MD

This study is to test the safety and feasibility of a procedure called embolization of the middle meningeal arteries (MMA), using a product called Onyx. Embolization creates a plug in the arteries. MMA embolization with Onyx is not approved for use in patients with migraines, but is currently used in patients with subdural hematomas. The FDA is allowing the use of Onyx in this study. It is thought that by using Onyx to block the middle meningeal arteries, the amount of migraine-causing substances which are released into the brain's bloodstream will be reduced. The company that manufactures Onyx, Medtronic, is providing the supplies for this study. Participants will be in the study for about 8 months after enrolling, including 6 months of follow up after the procedure. The participants will be asked to complete a daily headache diary and continue the participant's regular migraine medications. Participants will also have several clinic visits and be asked to provide blood samples for research.

Waitlist Available
Has No Placebo

Johns Hopkins Medicine

Risheng Xu, MD, PhD

Medtronic

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Image of Mission Cardiovascular Research Institute in Fremont, United States.

REGN7508 + REGN9933 for Atrial Fibrillation

18+
All Sexes
Fremont, CA

This study is researching experimental drugs called REGN7508 and REGN9933. The study is focused on participants who have atrial fibrillation, which means that the heart beats too fast and unevenly. REGN7508 and REGN9933 are designed to help stop blood clots forming in patients with atrial fibrillation. The aim of the study is to see how well REGN7508 and REGN9933 work in patients that get medicine for their atrial fibrillation. The bleeding effects of REGN7508 and REGN9933 will be compared to another medicine (apixaban), which is available on the market to treat and prevent formation of blood clots. The study is looking at several other research questions, including: * What side effects may happen from taking REGN7508 or REGN9933 * How well do the study drugs reduce the risk of having a stroke * How much of REGN7508 or REGN9933 is in the blood at different times * Whether the body makes antibodies against REGN7508 or REGN9933 (which could make the drugs less effective or could lead to side effects)

Phase 2
Recruiting

Mission Cardiovascular Research Institute (+14 Sites)

Clinical Trial Management

Regeneron Pharmaceuticals

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