Loperamide Hydrochloride

Gastroenteritis, Intestinal stoma leak, Diarrhea + 2 more
Treatment
8 FDA approvals
20 Active Studies for Loperamide Hydrochloride

What is Loperamide Hydrochloride

LoperamideThe Generic name of this drug
Treatment SummaryLoperamide is a medication used to treat diarrhea. It works by blocking the release of certain chemicals in the gut, which reduces the amount of fluid in the stool. It does not get absorbed into the body, so it does not affect the central nervous system or adrenal glands, but it does block histamine and interrupt the release of acetylcholine in the stomach.
Imodium A-Dis the brand name
image of different drug pills on a surface
Loperamide Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Imodium A-D
Loperamide
1989
401

Approved as Treatment by the FDA

Loperamide, otherwise called Imodium A-D, is approved by the FDA for 8 uses including Diarrhea and Traveler's Diarrhea .
Diarrhea
Traveler's Diarrhea
Inflammatory Bowel Diseases (IBD)
Gastroenteritis
Intestinal stoma leak
Diarrhea
Chronic Functional Diarrhea
Crohn's Disease

Effectiveness

How Loperamide Hydrochloride Affects PatientsLoperamide is an anti-diarrheal medication that helps relieve diarrhea. It helps reduce the speed of digestion and encourages the body to absorb more fluid and electrolytes from the digestive system. It also tightens the anal sphincter, which helps reduce incontinence and sudden urges to go to the bathroom. The effects of loperamide usually start within an hour and can last up to three days. Although it is a potent mu-opioid receptor agonist, it does not usually provide pain relief. Taking large amounts of loperamide can interfere with how the heart works, which can cause irregular heartbe
How Loperamide Hydrochloride works in the bodyLoperamide is a drug that helps manage gastrointestinal issues. It works by binding to opioids receptors on the circular and longitudinal muscles of the intestine. This binding activates certain pathways which reduce nerve activity in the gut, decreasing the release of neurotransmitters and other molecules. This leads to decreased peristalsis, which slows down the movement of food through the gut. Loperamide also helps with the absorption of water and electrolytes, and can lead to firmer stools.

When to interrupt dosage

The prescribed dose of Loperamide Hydrochloride is contingent upon the diagnosed disorder, including Diarrhea, Crohn's Disease and Ulcerative Colitis and Intestinal stoma leak. The quantity of dosage fluctuates, in accordance with the administration technique featured in the table underneath.
Condition
Dosage
Administration
Gastroenteritis
, 2.0 mg, 1.0 mg/mL, 0.2 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Suspension, Suspension - Oral, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, chewable, Tablet, chewable - Oral, Kit, Kit - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating
Intestinal stoma leak
, 2.0 mg, 1.0 mg/mL, 0.2 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Suspension, Suspension - Oral, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, chewable, Tablet, chewable - Oral, Kit, Kit - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating
Diarrhea
, 2.0 mg, 1.0 mg/mL, 0.2 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Suspension, Suspension - Oral, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, chewable, Tablet, chewable - Oral, Kit, Kit - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating
Crohn's Disease
, 2.0 mg, 1.0 mg/mL, 0.2 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Suspension, Suspension - Oral, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, chewable, Tablet, chewable - Oral, Kit, Kit - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating
Chronic Functional Diarrhea
, 2.0 mg, 1.0 mg/mL, 0.2 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Suspension, Suspension - Oral, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, chewable, Tablet, chewable - Oral, Kit, Kit - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating

Warnings

Loperamide Hydrochloride Contraindications
Condition
Risk Level
Notes
Abdominal Pain
Do Not Combine
Therapeutic procedure
Do Not Combine
Pulse Frequency
Do Not Combine
Dysentery
Do Not Combine
Enterocolitis
Do Not Combine
Ulcerative Colitis
Do Not Combine
There are 20 known major drug interactions with Loperamide Hydrochloride.
Common Loperamide Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Major
The metabolism of (R)-warfarin can be decreased when combined with Loperamide.
(S)-Warfarin
Major
The metabolism of (S)-Warfarin can be decreased when combined with Loperamide.
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be decreased when combined with Loperamide.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Loperamide.
5-androstenedione
Major
The metabolism of 5-androstenedione can be decreased when combined with Loperamide.
Loperamide Hydrochloride Toxicity & Overdose RiskThe toxic dose of loperamide in rats is 185 mg/kg. Taking too much loperamide can cause serious heart problems, such as an irregular heartbeat, or sudden death. It can also lead to symptoms of opioid toxicity, like confusion, sleepiness, pinpoint pupils, stiff muscles, shallow breathing, and a blocked intestine. If you suspect an overdose, medical treatment may include naloxone to reverse the toxic effects.
image of a doctor in a lab doing drug, clinical research

Loperamide Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Loperamide Hydrochloride?

Currently, 52 active trials are assessing the potential of Loperamide Hydrochloride to manage Chronic Functional Diarrhea, Intestinal stoma leak and Gastroenteritis.
Condition
Clinical Trials
Trial Phases
Diarrhea
0 Actively Recruiting
Crohn's Disease
26 Actively Recruiting
Phase 1, Not Applicable, Early Phase 1, Phase 2, Phase 4
Chronic Functional Diarrhea
0 Actively Recruiting
Intestinal stoma leak
0 Actively Recruiting
Gastroenteritis
12 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1

Loperamide Hydrochloride Reviews: What are patients saying about Loperamide Hydrochloride?

5Patient Review
7/29/2010
Loperamide Hydrochloride for Diarrhea
Get a prescription from your doctor so you can buy it in bulk; 100 count bottles. Insurance companies will cover the cost this way. The drug is effective at masking symptoms, but I want to get to the root of the issue and eliminate it altogether. This might be connected to the surgery I had in California over three years ago, but nobody seems to know for sure.
5Patient Review
2/15/2014
Loperamide Hydrochloride for Diarrhea due to Inflammatory Bowel Disease
I've been struggling with IBS for six years now and have tried every medical treatment possible to no avail. This is my last resort, and so far it's working! I haven't had any reoccurrences in the nine weeks that I've been taking this medication.
5Patient Review
7/7/2017
Loperamide Hydrochloride for Diarrhea due to Inflammatory Bowel Disease
I'm not sure if it's more effective to take this once or twice a week as a preventative measure, or only after you've been exposed to the risk of bowel explosion.
5Patient Review
6/22/2011
Loperamide Hydrochloride for Diarrhea due to Inflammatory Bowel Disease
After my gallbladder surgery, I had nonstop diarrhea. This medication was the only thing that finally helped me get some relief.
5Patient Review
3/19/2013
Loperamide Hydrochloride for Diarrhea
Loperamide has been a total life-saver for me. I was really suffering from some stomach issues, but this medication stopped the diarrhea almost immediately. Whenever I have a flare-up now, I take Loperamide and it goes away quickly.
5Patient Review
12/25/2013
Loperamide Hydrochloride for Diarrhea due to Inflammatory Bowel Disease
This treatment caused me to have several days of diarrhea.
5Patient Review
2/2/2012
Loperamide Hydrochloride for Diarrhea
I have colitis, and this medication really helps to lessen the severity of my symptoms. I've tried other oral powders before, but this one seems to work the best.
5Patient Review
12/13/2017
Loperamide Hydrochloride for Diarrhea
This drug is a lifesaver. Whenever I get the stomach flu, it's the only thing that helps me feel better quickly.
5Patient Review
2/22/2021
Loperamide Hydrochloride for Diarrhea due to Inflammatory Bowel Disease
My doctor recommended this for my IBS and it has helped me a lot. I don't have as many sudden urges to go to the bathroom, and it's really improved my quality of life.
5Patient Review
2/27/2017
Loperamide Hydrochloride for Diarrhea caused by Chemotherapy
Follow the directions and this will help you out a lot!
5Patient Review
6/19/2016
Loperamide Hydrochloride for Diarrhea
This medication is incredibly effective at treating my IBS-D. Whenever I start to feel the cramping and burning, I take a dose of this and it always does the trick.
4.7Patient Review
5/9/2010
Loperamide Hydrochloride for Diarrhea
4Patient Review
7/29/2011
Loperamide Hydrochloride for Diarrhea
I've been struggling with IBS for years, but this medication has helped me immensely. Eating smaller meals more frequently in conjunction with taking a 2mg tablet of loperamide hydrochloride has really regulated my digestive system.
2.3Patient Review
3/27/2017
Loperamide Hydrochloride for Diarrhea due to Inflammatory Bowel Disease
Easy to use and very effective. I like that it was easy to adjust the dosage.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about loperamide hydrochloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are side effects of loperamide?

"The following are symptoms of a bad reaction to a medication: blistering, peeling, or loosening of skin; chest pain or discomfort; decrease in urine volume; decrease in frequency of urination; difficulty in passing urine; fast, pounding, or irregular heartbeat or pulse; hives or welts; itching; rash; or irregular or slow heartbeat."

Answered by AI

What does loperamide hydrochloride do?

"Loperamide is a medicine used to treat diarrhoea by making the stool firmer. It can help with short-term diarrhoea or irritable bowel syndrome (IBS) by decreasing the number of bowel movements and making the stool less watery. Loperamide is also used for recurring or longer lasting diarrhoea from bowel conditions such as Crohn's disease, ulcerative colitis and short bowel syndrome. It works by slowing down the movement of the intestine so that the body can absorb more water from the stool."

Answered by AI

Why is loperamide not recommended?

"This medicine could lead to heart rhythm problems, such as torsades de pointes, ventricular arrhythmias. If you or your child have chest pain or discomfort, a fast, slow, or irregular heartbeat, fainting, or trouble breathing, check with your doctor right away. Loperamide may raise your chances for stomach or bowel problems."

Answered by AI

When is the best time to take loperamide?

"Adults and teenagers should take 4 mg (2 tablets) after the first loose bowel movement, and 2 mg (1 tablet) after each loose bowel movement after the first dose has been taken. No more than 8 mg (4 tablets) should be taken in any 24-hour period."

Answered by AI

Clinical Trials for Loperamide Hydrochloride

Image of Humana Healthcare Research, Inc. in Louisville, United States.

Academic Detailing for Rheumatoid Arthritis

Any Age
All Sexes
Louisville, KY
The goal of this trial is to learn if an interactive evidence-based educational outreach visits to clinicians who prescribe biologics change prescribing of biosimilar medications. The main questions it aims to answer are: 1. Do educational outreach visits lead to a higher number of prescriptions for biosimilar versions of adalimumab? 2. Do in-person or virtual visits work better? Researchers will compare clinicians offered the educational outreach visit to those who are not offered the visit to see if there is a difference in prescribing of biosimilar versions of adalimumab instead of the original brand-name version. Participants will be offered the chance to meet with a trained clinician who will provide educational information tailored to their knowledge and attitudes on the topic. They will also be provided an educational brochure and patient educational materials.
Waitlist Available
Has No Placebo
Humana Healthcare Research, Inc. (+1 Sites)
Image of Atlanta VA Medical and Rehab Center, Decatur, GA in Decatur, United States.

Measurement-Based Care for Inflammatory Bowel Disease

18+
All Sexes
Decatur, GA
This research study is addressing issues related to Inflammatory bowel disease (IBD), which is a chronic autoimmune disorder that affects over 60,000 Veterans. With close monitoring and timely treatment adjustment, the investigators can stop the natural progression of IBD, improving health-related quality of life (HRQOL) and reducing flares and hospitalizations. However, it is difficult to closely monitor Veterans with IBD between clinic visits. There is a critical need for solutions that support close between visit monitoring of Veterans with IBD. The Measurement-Based Care (MBC) for IBD study will take a systematic approach to collect, share, and act on patient reported outcome (PRO) data that can be used to achieve close monitoring. MBC supports patients' in managing their condition and boosting their confidence in their ability to handle their symptoms and disease, and also supports care teams in early recognition of health issues. The investigators will work with both Veterans and their care teams to understand and assess this program so it can be a model for future initiatives.
Waitlist Available
Has No Placebo
Atlanta VA Medical and Rehab Center, Decatur, GA (+3 Sites)Shirley Cohen-Mekelburg, MD MS
Image of Mount Sinai Hospital in New York, United States.

Morning Light Therapy for Inflammatory Bowel Disease

18+
All Sexes
New York, NY
The pilot study will focus on the effects of morning light therapy (MLT) in adult patients with ulcerative colitis (UC) who have evidence of poor sleep quality and active inflammation. The specific population is at risk for circadian rhythm sleep-wake disorders and has significant potential benefit from circadian realignment, which may lead to improved sleep quality and, ultimately, UC-related inflammatory activity. During an initial one-week lead-in period, participants will obtain baseline circadian-related labs, complete symptom-related surveys, and use a wearable device continuously to obtain baseline sleep-wake data. After the lead-in week, patients will undergo one hour of MLT while wearing wearable devices continuously and completing daily symptom surveys. At the end of four weeks of MLT, patients will obtain post-intervention circadian and inflammatory assessments in addition to completing the same symptom-related surveys.
Waitlist Available
Has No Placebo
Mount Sinai HospitalHyder Said
Have you considered Loperamide Hydrochloride clinical trials? We made a collection of clinical trials featuring Loperamide Hydrochloride, we think they might fit your search criteria.Go to Trials
Image of Victoria Hospital - London Health Sciences Centre in London, Canada.

Vitamin D for Inflammatory Bowel Disease

18 - 85
All Sexes
London, Canada
The aim of this clinical trial is to gain a better understanding of the effect of Vitamin D supplementation on disease activity and overall health. The main questions it aims to answer are: 1. What proportion of IBD patients adhere to Vitamin D supplement recommendations over a 12-month period? 2. Is the ASK-12 Questionnaire valid in measuring adherence among IBD patients? 3. Does the severity of a patient's Crohn's disease effect overall adherence, over a 12-month period? 4. Does the severity of a patient's Ulcerative Colitis disease effect overall adherence, over a 12-month period? 5. Does Vitamin D supplementation affect the health-related Quality of Life for IBD patients? 6. Is 2,000 IU/Day an effective dose to sustain appropriate blood Vitamin D levels among previously Vitamin deficient IBD patients? Participants will: * Take 2000 IU of Vitamin D every day for the next 12 months * Complete 2 surveys, bloodwork and a fecal calprotectin test at the initial, visit, 6 month follow up and 12 month follow up
Phase 1
Waitlist Available
Victoria Hospital - London Health Sciences CentreTerry Ponich, MD
Image of Massachusetts General Hospital in Boston, United States.

Diet and Stress Management for Inflammatory Bowel Disease

18+
All Sexes
Boston, MA
Inflammatory Bowel Disease (IBD), which includes Crohn's Disease (CD) and Ulcerative Colitis (UC), is a chronic, immune-mediated disease characterized by recurrent episodes of relapse. The goal of this single site, pragmatic, randomized trial is to answer if combining lifestyle modifications (mindfulness/stress management + nutrition support) with advanced therapies for induction and maintenance of clinical remission in CD and UC as evaluated by disease activity scores in patients with active CD and UC. Researchers will compare 4 study arms (Group 1, Group 2, Group 3, and Group 4) to see if combining lifestyle modifications with advanced therapies for induction and maintenance will show improvement in condition as evaluated by disease activity scores. Groups: 1. Group A - Subjects will receive a visit with an IBD dietician and a visit with an IBD GI psychologist within the first month of advanced therapy initiation and another visit with both parties 4+/-2 weeks after the first intervention visit. 2. Group B - Subjects will receive a visit with an IBD dietician within the first month of advanced therapy initiation and another visit 4+/-2 weeks after the first intervention visit. They will later be offered a visit with an IBD GI psychologist after 3 months (after assessment of our primary outcomes). 3. Group C - Subjects will receive a visit with an IBD psychologist within the first month of advanced therapy initiation and another visit with the IBD GI psychologist 4+/-2 weeks after the first intervention visit. They will later be offered a visit with an IBD dietician after 2 months (after assessment of our primary outcomes). 4. Group D - Subjects will be offered a visit with an IBD GI psychologist and IBD dietician after 3 months (after assessment of our primary outcomes). All subjects will be asked to complete a set of questionnaires and have the option to give blood and stool samples throughout the life of their participation in the study at certain visits.
Recruiting
Has No Placebo
Massachusetts General HospitalAshwin Ananthakrishnan, MD, MPH
Image of Wake Forest University Health Sciences in Winston-Salem, United States.

Elemental Diet for Inflammatory Bowel Disease

18+
All Sexes
Winston-Salem, NC
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic inflammatory conditions of the gastrointestinal tract that affect millions of people in the United States of America. Among patients with IBD, symptomatic flares are quite common; up to 40-50% of patients in some populations report having a flare at least once per month. For most patients with IBD flares, the typical outpatient treatment consists of corticosteroids and, in some instances, initiation of or switching between 5-aminosalicylic acid-acid preparations, immunomodulators, or biologics. These treatments, while often effective, can have harmful side effects, especially when used for long durations of time. Therefore, alternative treatments are highly sought after by both patients and providers.
Waitlist Available
Has No Placebo
Wake Forest University Health SciencesRichard B Weinberg, MD
Image of University of Texas at Arlington in Arlington, United States.

Confocal Laser Endomicroscopy for IBD

2 - 21
All Sexes
Arlington, TX
This study aims to test the overall hypothesis that the membrane tissue binding capacity of cytokines in the biopsied tissue of patients with Inflammatory Bowel Disease (IBD) is predictive of/strongly correlated to clinical response/outcomes observed. The key questions under investigation are: Aim 1: To assess the fluorescent signal intensity at baseline (control antibody with control biopsy and control antibody with IBD biopsy). Aim 2: To characterize the cellular landscape by surveying surface markers using bar-coded antibodies and performing gene expression profiling on every cell within inflamed tissue of patients with IBD. Aim 3: Develop algorithm using artificial intelligence to predict responders versus non-responders and to further subclassify IBD patients using phenotype data.
Waitlist Available
Has No Placebo
University of Texas at Arlington (+1 Sites)Clifton Huang, MD
Have you considered Loperamide Hydrochloride clinical trials? We made a collection of clinical trials featuring Loperamide Hydrochloride, we think they might fit your search criteria.Go to Trials
Image of Toronto Immune and Digestive Health Institute in North York, Canada.

Healing Circuits™ for Inflammatory Bowel Disease

18 - 75
All Sexes
North York, Canada
The purpose of this study is to test the impact of Healing Circuits™; a structured mental health support model on IBD patients. The eligible study participants will be randomly divided into two groups: 1. the group receiving structured mental health support with a social worker and 2. the group receiving structured mental health support via a self-directed online curriculum. Both groups will be receiving the same type of therapy, Healing Circuits™, but the group receiving the therapy via the online self-directed curriculum will be receiving the therapy mostly by web-based video instruction. The two groups will be evaluated over a period of 12 months.
Recruiting
Has No Placebo
Toronto Immune and Digestive Health InstituteMarci Reiss, DSWAmgen
Have you considered Loperamide Hydrochloride clinical trials? We made a collection of clinical trials featuring Loperamide Hydrochloride, we think they might fit your search criteria.Go to Trials
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