Loestrin Fe 1/20

Endometriosis, Low Testosterone, Osteoporosis + 16 more

Treatment

20 Active Studies for Loestrin Fe 1/20

Treatment for

Endometriosis

What is Loestrin Fe 1/20

Norethisterone

The Generic name of this drug

Treatment Summary

Norethisterone (also known as norethindrone) is a synthetic hormone that mimics the natural hormone progesterone. It is a second-generation progestin, which means it is more powerful than other progestins. It is used in birth control pills and in hormone replacement therapy to regulate menstruation and treat endometriosis. It was first developed in 1951 and was first marketed as an oral contraceptive in 1962.

Necon

is the brand name

Loestrin Fe 1/20 Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Necon

Norethisterone

1967

347

Effectiveness

How Loestrin Fe 1/20 Affects Patients

Norethisterone is a medication taken orally for contraception or to treat other hormone-related conditions. It is much stronger than the natural progesterone our bodies produce and works by altering the cervical and endometrial function, as well as blocking certain hormones released by the pituitary gland. Taking this medication may slightly increase the risk of developing breast cancer, so patients should be aware and practice regular self-exams.

How Loestrin Fe 1/20 works in the body

Norethisterone works in a few different ways to prevent pregnancy. It thickens cervical mucus to stop sperm from entering the uterus. It also changes the endometrium, making it difficult for a fertilized egg to implant. Norethisterone also suppresses hormones that help with ovulation, so eggs cannot be released. For menopausal women, norethisterone is used to prevent endometrial cancer. It does this by blocking the growth of the endometrium. Norethisterone has low activity at other hormone receptors, like the androgen receptor and glucocorticoid receptor. This

When to interrupt dosage

The prescribed measure of Loestrin Fe 1/20 is contingent upon the determined affliction, including Atrophic, Fracture and Hormone Replacement Therapy. The dose also differs depending on the method of delivery (e.g. Oral or Tablet) outlined in the table below.

Condition

Dosage

Administration

Fracture

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical

Osteoporosis

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

Atrophic

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

hypoestrogenism

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

Hot flashes

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

Birth Control

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

Therapeutic procedure

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

Endometriosis

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

Menopause

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

Estrogen Deprivation Symptoms

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

Oral Contraceptives

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

Low Testosterone

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

Osteoporosis, Postmenopausal

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

Endometriosis

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

Primary Ovarian Insufficiency

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

Hormonal Contraception

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

female castration

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

Hormone Replacement Therapy

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

Vasomotor System

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

Warnings

Loestrin Fe 1/20 has eight contraindications, thus it should not be employed while enduring any of the ailments listed in the following table.

Loestrin Fe 1/20 Contraindications

Condition

Risk Level

Notes

Liver Diseases

Do Not Combine

Thrombophilia

Do Not Combine

Vaginal Hemorrhage

Do Not Combine

Malignant Neoplasms

Do Not Combine

Benign hepatic neoplasm

Do Not Combine

Breast Cancer

Do Not Combine

Thromboembolism

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Norethisterone may interact with Pulse Frequency

There are 20 known major drug interactions with Loestrin Fe 1/20.

Common Loestrin Fe 1/20 Drug Interactions

Drug Name

Risk Level

Description

Astemizole

Major

The metabolism of Astemizole can be decreased when combined with Norethisterone.

Axitinib

Major

The metabolism of Axitinib can be decreased when combined with Norethisterone.

Cabazitaxel

Major

The metabolism of Cabazitaxel can be decreased when combined with Norethisterone.

Clomipramine

Major

The metabolism of Clomipramine can be increased when combined with Norethisterone.

Copanlisib

Major

The metabolism of Copanlisib can be decreased when combined with Norethisterone.

Loestrin Fe 1/20 Toxicity & Overdose Risk

The lowest toxic dose of oral contraceptives in mice has been found to be 6 g/kg and in women is 42 mg/kg. There have been no reports of major harm caused by taking too many oral contraceptives, including in children. Common symptoms of an overdose may include nausea and vomiting.

image of a doctor in a lab doing drug, clinical research

Loestrin Fe 1/20 Novel Uses: Which Conditions Have a Clinical Trial Featuring Loestrin Fe 1/20?

160 active studies are being conducted to assess the potential of Loestrin Fe 1/20 in providing Birth Control, Atrophy prevention and Low Testosterone alleviation.

Condition

Clinical Trials

Trial Phases

Birth Control

19 Actively Recruiting

Not Applicable, Phase 3, Phase 4, Early Phase 1, Phase 2

Oral Contraceptives

1 Actively Recruiting

Not Applicable

Endometriosis

30 Actively Recruiting

Early Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4

Osteoporosis

28 Actively Recruiting

Not Applicable, Phase 4, Phase 1, Phase 3, Phase 2

Low Testosterone

5 Actively Recruiting

Phase 4, Phase 2, Phase 1

Endometriosis

2 Actively Recruiting

Phase 4, Not Applicable

Hot flashes

19 Actively Recruiting

Not Applicable, Phase 2, Phase 4, Early Phase 1, Phase 3

Estrogen Deprivation Symptoms

0 Actively Recruiting

Osteoporosis, Postmenopausal

0 Actively Recruiting

female castration

0 Actively Recruiting

Atrophic

5 Actively Recruiting

Phase 4, Not Applicable

Hormone Replacement Therapy

0 Actively Recruiting

Hormonal Contraception

0 Actively Recruiting

hypoestrogenism

1 Actively Recruiting

Phase 4

Fracture

0 Actively Recruiting

Vasomotor System

0 Actively Recruiting

Primary Ovarian Insufficiency

0 Actively Recruiting

Therapeutic procedure

0 Actively Recruiting

Menopause

0 Actively Recruiting

Loestrin Fe 1/20 Reviews: What are patients saying about Loestrin Fe 1/20?

Patient Review

9/18/2022

Loestrin Fe 1/20 for Painful Periods

I've been on this pill for six years, and I have absolutely no complaints. It took me four tries to get put on the right pill, but Lolofe has been perfect for me. I highly recommend it to others.

Patient Review

10/31/2022

Loestrin Fe 1/20 for Birth Control

I've been taking Lo Loestrin Fe for a decade now, and it has effectively prevented pregnancy the entire time. I didn't have any major side effects when I started, and still don't really experience them except for some occasional spotting. My doctors have reassured me that this is normal and won't impact my fertility down the line. Overall, I highly recommend this oral contraceptive!

Patient Review

11/8/2022

Loestrin Fe 1/20 for Abnormally Long or Heavy Periods

I've been using this birth control for five years and have had no more abnormal bleeding or painful periods. I do remember in the beginning I lost an appetite and lost weight but when my body got used to it, it regulated out.

Patient Review

9/18/2022

Loestrin Fe 1/20 for Painful Periods

I've been on this pill for six years now, and I have zero complaints. It took me four tries of switching pills to finally get put on lolofe, but ever since then it's been perfect. I highly recommend it to anyone in a similar situation as me.

Patient Review

10/31/2022

Loestrin Fe 1/20 for Birth Control

I've been taking Lo Loestrin Fe for a decade now, and it has done wonders for me. No major side effects when I started, and it's kept me from getting pregnant all this time. My periods have basically stopped entirely (just some spotting a couple times a year), but my doctors assure me that this is normal and won't affect my fertility down the road. If you're considering an oral contraceptive, I would highly recommend this one!

Patient Review

11/8/2022

Loestrin Fe 1/20 for Abnormally Long or Heavy Periods

I've been using this birth control for five years and it's been amazing. I used to have really heavy, painful periods, but since starting this treatment they've become much lighter and less frequent. I would highly recommend it to anyone looking for a good birth control option.

Patient Review

10/31/2022

Loestrin Fe 1/20 for Birth Control

I've been using Lo Loestrin for a decade now, and it has really worked well for me. When I started, I didn't experience any major side effects. It's prevented pregnancy the whole time I've taken it, to the point where I don't get periods anymore (just a little spotting a couple times a year). My doctors have reassured me that this is normal and won't affect my fertility, so I would recommend this oral contraceptive option!

Patient Review

11/8/2022

Loestrin Fe 1/20 for Abnormally Long or Heavy Periods

I've been using this birth control for five years and it's really changed my life for the better. No more abnormal bleeding or painful periods! I will say that when I first started taking it, I lost my appetite and some weight, but those side effects evened out after a little while.

Patient Review

9/18/2022

Loestrin Fe 1/20 for Painful Periods

I've been on this pill for six years with no complaints. I had to switch pills a few times before landing on lolofe, but it was well worth it. I would highly recommend it to anyone else in a similar situation.

Patient Review

11/8/2022

Loestrin Fe 1/20 for Abnormally Long or Heavy Periods

I've been using this birth control for five years now and it's really helped with my abnormal bleeding and painful periods. In the beginning, I did lose weight and have a decreased appetite but that regulated itself eventually. Now, I rarely have periods and when I do, they're short with little to no bleeding or pain. This has been an all-around great experience for me.

Patient Review

9/18/2022

Loestrin Fe 1/20 for Painful Periods

I've been on this pill for six years now with zero complaints. It took me four times of switching my pill to finally get put on lolofe, but ever since then I have had no problems. I would highly recommend it to others.

Patient Review

10/31/2022

Loestrin Fe 1/20 for Birth Control

I've been taking Lo Loestrin Fe for a decade now, and it has been incredibly effective. I didn't experience any major side effects when I first started taking it, and it has prevented pregnancy throughout the entire time I've taken it. Now, I don't get periods at all except for maybe some spotting a couple times a year. My doctors have reassured me that this is normal and won't affect my fertility. Overall, I would highly recommend this oral contraceptive option!

4.7

Patient Review

6/22/2022

Loestrin Fe 1/20 for Birth Control

I was on this birth control for just over three years, and it became very expensive (it tripled in price). I noticed that if I took it a few hours late, it would make me feel more anxious. The only other side effect was that I never had my period while on this pill - which some people like and others do not, so I thought it was worth mentioning.

4.7

Patient Review

6/22/2022

Loestrin Fe 1/20 for Birth Control

I was on this birth control for just over three years, until it became way too expensive. It's worth mentioning that if I took it a couple hours late, it would make me feel more anxious. The only other side effect was that I never had my period on this pill - which might be a pro or con depending on the person.

4.7

Patient Review

6/22/2022

Loestrin Fe 1/20 for Birth Control

I was on this birth control for just over three years, until the price spiked (went from $25/3 packs to $118/3 packs to $430/3 packs). I noticed that if I took it a couple hours late, it would make me feel more anxious. The only other side effect was that I never had my period on this pill - I know that some people like that and others do not, so it’s worth mentioning.

4.7

Patient Review

6/22/2022

Loestrin Fe 1/20 for Birth Control

I was on this birth control for just over three years, until the price became prohibitive. I found that if I took it a couple hours late, I would feel more anxious. The only other side effect was that I never had my period on this pill - which some people might like and others might not.

4.3

Patient Review

8/29/2022

Loestrin Fe 1/20 for Birth Control

Lo Loestrin Fe has been much more effective for me than Nexoplanon. I haven't had any problems with it so far, and it's nice to finally have a normal cycle again after years of non-stop bleeding. However, my breasts have been tender since starting the medication.

4.3

Patient Review

7/12/2022

Loestrin Fe 1/20 for Birth Control

I liked that this medication lightened my periods and made my boobs grow; however, it also increased my mood swings to the point where I couldn't take it anymore.

4.3

Patient Review

7/12/2022

Loestrin Fe 1/20 for Birth Control

I liked that this medication lightened my periods and made my boobs grow, but I didn't love the way it made my mood swings all over the place. I found myself crying over minor things during the placebo pills especially. In the end, I couldn't take not being myself and switched medications.

4.3

Patient Review

8/29/2022

Loestrin Fe 1/20 for Birth Control

I've been using Lo Loestrin Fe for a couple months now, and it's been much better than my previous form of birth control (Nexoplanon). I haven't had any of the same problems.

4.3

Patient Review

7/12/2022

Loestrin Fe 1/20 for Birth Control

I liked that this medication lightened my period, and I didn't mind the increased breast size; however, the downside was that it made my mood swings worse. I would find myself crying over minor things, especially during the placebo pills. In the end, I couldn't take it anymore and had to switch medications.

4.3

Patient Review

8/29/2022

Loestrin Fe 1/20 for Birth Control

Lo Loestrin Fe has been working well for me these past few months. It's a relief not to have to worry about my period anymore, and the PMS symptoms are manageable. The only downside is that my breasts have been sore since I started taking the medication.

4.3

Patient Review

8/29/2022

Loestrin Fe 1/20 for Birth Control

I've been using Lo Loestrin Fe for a few months now, and no complaints so far. I was previously on Nexoplanon, but switched because of the terrible reviews I saw (my experience reflected those sentiments exactly). With this new birth control, my periods are normal again and PMS symptoms only show up right before my period starts. The only downside is that my breasts have been sore since I started taking it.

4.3

Patient Review

7/12/2022

Loestrin Fe 1/20 for Birth Control

I liked that this medication lightened my periods and made my boobs grow; however, it also increased my mood swings to the point where I felt like I couldn't control myself. The crying spells were especially bad during the placebo pills.

Patient Review

7/27/2022

Loestrin Fe 1/20 for Birth Control

This birth control made me extremely emotional. I would get mad over the smallest of things, and my confidence took a nose-dive. My periods became twice monthly, and my acne got worse. The cramps were also unbearable. I took it for five months before switching to something else.

Patient Review

7/27/2022

Loestrin Fe 1/20 for Birth Control

This birth control made me extremely emotional. I would get mad over small things, and my confidence decreased a lot. I also started getting my period twice a month and had worse acne. The cramps were also really bad. I took it for five months and then switched to something else.

Patient Review

7/27/2022

Loestrin Fe 1/20 for Birth Control

This birth control messed with my emotions. I was getting mad over small things, my confidence decreased, I got acne, and my cramps were really bad.

Patient Review

7/27/2022

Loestrin Fe 1/20 for Birth Control

This birth control made me incredibly emotional, to the point where I would get mad over small things. My confidence decreased significantly and my acne got worse. Additionally, I started getting my period twice a month and my cramps became unbearable. I took it for five months before switching to something else.

1.7

Patient Review

7/15/2022

Loestrin Fe 1/20 for Absence of Menstrual Periods

I would not recommend this birth control to anyone. In the five months that I took it, I experienced an increase in appetite, weight gain, worsening acne, anxiety, and blurred vision. Additionally, my libido decreased significantly.

1.7

Patient Review

7/15/2022

Loestrin Fe 1/20 for Absence of Menstrual Periods

I have been on this medication for five months and, in that time, I have gained 10lbs, had worsening acne, felt more anxious, and experienced low libido and blurred vision. Do not take this birth control pill!

1.7

Patient Review

7/15/2022

Loestrin Fe 1/20 for Absence of Menstrual Periods

I would not recommend this birth control to anyone. I've been on it for five months and have only experienced negative side effects, such as weight gain, anxiety, blurred vision, and low libido.

1.7

Patient Review

7/15/2022

Loestrin Fe 1/20 for Absence of Menstrual Periods

I would not recommend this birth control to anyone. I've been on it for five months and have seen zero benefits. If anything, it's made my acne worse, caused me to gain weight, and given me anxiety and blurred vision.

Patient Review

8/18/2022

Loestrin Fe 1/20 for Acne

I took this pill for three months and, 11 months later, yesterday I had a partial mastectomy at 20 years old for a fibroadenoma lump that was over four inches big. Yes, I do blame this pill. Ladies, there are other options; don't put extra hormones in your body that it doesn't need.

Patient Review

8/18/2022

Loestrin Fe 1/20 for Acne

I took this pill for three months and, 11 months later, I had to have a partial mastectomy due to a fibroadenoma lump that was over four inches big. I firmly believe that this pill is to blame and would caution other women against taking it. There are other options available that don't involve pumping extra hormones into your body.

Patient Review

8/18/2022

Loestrin Fe 1/20 for Acne

I took this pill for three months and, eleven months later, I had to get a partial mastectomy yesterday. I firmly believe that this medication is at fault and would caution other women against taking it. There are other options available that don't involve pumping extra hormones into your body.

Patient Review

8/18/2022

Loestrin Fe 1/20 for Acne

I took this pill for three months and, 11 months later, I had to get a partial mastectomy because of a fibroadenoma lump. I'm only 20 years old. Ladies, there are other options out there. Don't pump your body full of unnecessary hormones.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about loestrin fe 1/20

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What kind of birth control is loestrin 1 20?

"This medication prevents pregnancy by containing two hormones: norethindrone (a progestin) and ethinyl estradiol (an estrogen)."

Answered by AI

Is Loestrin Fe 1/20 Discontinued?

"is the date that this will be last updated. This text will no longer be updated after Aug 10, 2022."

Answered by AI

Does loestrin 1/20 cause weight gain?

"I wanted to start taking birth control pills for two reasons: to help with my hormonal acne and to contraception. My doctor prescribed Loestrin Fe 1/20 and my experience with it was okay. I didn't have any bad side effects like weight gain, nausea, headaches, bloating, or mood changes."

Answered by AI

What is loestrin 1/20 used for?

"This hormone medication, which is a combination of a progestin and an estrogen, is used to prevent pregnancy. In addition to preventing pregnancy, birth control pills can make your periods more regular, decrease blood loss and painful periods, decrease the risk of ovarian cysts, and also treat acne."

Answered by AI