Labetalol Hydrochloride

Hypertension, Subarachnoid Hemorrhage, Hypertensive disease + 3 more
Treatment
1 FDA approval
20 Active Studies for Labetalol Hydrochloride

What is Labetalol Hydrochloride

LabetalolThe Generic name of this drug
Treatment SummaryLabetalol is a medication used to treat high blood pressure. It is made up of two chemical components taken as an injection or in tablet form. Labetalol was approved by the FDA in 1984.
Trandateis the brand name
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Labetalol Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Trandate
Labetalol
1984
261

Approved as Treatment by the FDA

Labetalol, commonly known as Trandate, is approved by the FDA for 1 uses including Hypertensive disease .
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)

Effectiveness

How Labetalol Hydrochloride Affects PatientsLabetalol helps lower blood pressure by blocking certain hormones in the body. It lasts for a long time, and is usually taken twice daily in doses of 200-400mg. People with asthma should not take labetalol unless other medications have not worked for them.
How Labetalol Hydrochloride works in the bodyLabetalol works by blocking certain hormones that cause your blood vessels to narrow and your heart rate to increase. This causes your blood vessels to widen and your heart rate to slow down, leading to a decrease in blood pressure, especially when standing. Labetalol also produces some side effects, such as bronchospasms, but these are reduced by the widening of the blood vessels. Over time, labetalol produces sustained widening of the blood vessels and only a small decrease in heart rate and stroke volume.

When to interrupt dosage

The proposed dose of Labetalol Hydrochloride is contingent upon the diagnosed affliction, including Subarachnoid Hemorrhage, Hypertensive Emergency and Chronic Stable Angina Pectoris. The magnitude of dosage is based on the technique of administration (e.g. Oral or Tablet, film coated - Oral) provided in the below table.
Condition
Dosage
Administration
Angina, Stable
, 100.0 mg, 200.0 mg, 300.0 mg, 5.0 mg/mL, 400.0 mg, 50.0 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Tablet, coated, Tablet, coated - Oral
Hypertension
, 100.0 mg, 200.0 mg, 300.0 mg, 5.0 mg/mL, 400.0 mg, 50.0 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Tablet, coated, Tablet, coated - Oral
Subarachnoid Hemorrhage
, 100.0 mg, 200.0 mg, 300.0 mg, 5.0 mg/mL, 400.0 mg, 50.0 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
, 100.0 mg, 200.0 mg, 300.0 mg, 5.0 mg/mL, 400.0 mg, 50.0 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Tablet, coated, Tablet, coated - Oral
Pheochromocytoma
, 100.0 mg, 200.0 mg, 300.0 mg, 5.0 mg/mL, 400.0 mg, 50.0 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Tablet, coated, Tablet, coated - Oral
Hypertensive Emergency
, 100.0 mg, 200.0 mg, 300.0 mg, 5.0 mg/mL, 400.0 mg, 50.0 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Tablet, coated, Tablet, coated - Oral

Warnings

Labetalol Hydrochloride Contraindications
Condition
Risk Level
Notes
Asthma
Do Not Combine
severe bradycardia
Do Not Combine
Hypotension
Do Not Combine
Shock, Cardiogenic
Do Not Combine
Heart Failure
Do Not Combine
Hypotension
Do Not Combine
Heart Block
Do Not Combine
Lung Diseases, Obstructive
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Labetalol may interact with Pulse Frequency
There are 20 known major drug interactions with Labetalol Hydrochloride.
Common Labetalol Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyphenethylamine can be decreased when used in combination with Labetalol.
4-Methoxyamphetamine
Major
The therapeutic efficacy of 4-Methoxyamphetamine can be decreased when used in combination with Labetalol.
Abediterol
Major
The therapeutic efficacy of Abediterol can be decreased when used in combination with Labetalol.
Acepromazine
Major
Labetalol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Adrafinil
Major
The therapeutic efficacy of Adrafinil can be decreased when used in combination with Labetalol.
Labetalol Hydrochloride Toxicity & Overdose RiskThe toxic dose of this drug in mice is 600mg/kg, and in rats is more than 2g/kg. Those who overdose may experience low blood pressure and slow heart rate. Treatment includes gastric lavage or vomiting, atropine or epinephrine for slow heart rate, digitalis and a diuretic for heart failure, vasopressors for low blood pressure, epinephrine or a beta2 agonist for bronchospasms, and diazepam for seizures. Patients should be placed on their back with their legs raised to keep the brain supplied with oxygen.
image of a doctor in a lab doing drug, clinical research

Labetalol Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Labetalol Hydrochloride?

Presently, 81 active trials are being conducted to examine the potential of Labetalol Hydrochloride for Hypertensive disease, Hypertensive crisis and Chronic Stable Angina Pectoris management.
Condition
Clinical Trials
Trial Phases
Hypertension
0 Actively Recruiting
Pheochromocytoma
0 Actively Recruiting
Angina, Stable
1 Actively Recruiting
Not Applicable
Hypertensive Emergency
1 Actively Recruiting
Phase 4
Subarachnoid Hemorrhage
8 Actively Recruiting
Not Applicable, Phase 1
Hypertensive disease
23 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3

Labetalol Hydrochloride Reviews: What are patients saying about Labetalol Hydrochloride?

5Patient Review
12/20/2019
Labetalol Hydrochloride for High Blood Pressure
I've been on this medication for over six years with no significant adverse effects. I have tried other medications (metoprolol and lisinopril) but they gave me bad side effects. This one has been good to me, though I can't drink alcohol while taking it or else I'll get anxiety attacks.
5Patient Review
2/13/2019
Labetalol Hydrochloride for High Blood Pressure
I've been taking this medication for 25 years and it's been working great in keeping my blood pressure stable.
3Patient Review
4/23/2021
Labetalol Hydrochloride for High Blood Pressure
On 200 mg three times a day, my blood pressure has lowered; however, I have been feeling extremely tired and uninterested in activities.
2.7Patient Review
12/31/2019
Labetalol Hydrochloride for High Blood Pressure
I've been taking this for four months now. It's effective when I'm not under stress, but it sometimes gives me unwanted side effects like high blood pressure and depression.
2.3Patient Review
8/9/2019
Labetalol Hydrochloride for High Blood Pressure
I was really tired after taking this medication, and my blood pressure wasn't any lower.
View All Reviews
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Patient Q&A Section about labetalol hydrochloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is labetalol used for in pregnancy?

"Labetalol can help to control high blood pressure, which in turn reduces the risk of pregnancy complications."

Answered by AI

What is labetalol hydrochloride used for?

"Labetalol is a medication used to treat high blood pressure. When used alone or with other medications, it can help to reduce the workload on the heart and arteries. If high blood pressure is left untreated for a long period of time, it can lead to serious health problems."

Answered by AI

Does labetalol make you sleep?

"Labetalol may cause drowsiness when taken as an oral tablet. It can also cause other side effects."

Answered by AI

What are the most common side effects of labetalol?

"Labatelol may cause drowsiness, dizziness, or weakness. If this occurs, stop what you are doing and rest until you feel better. ...Headaches may also occur. Make sure to rest and drink plenty of fluids. ...You may also experience cold fingers or toes. ...Nausea or vomiting may also occur. ...Diarrhea may also occur. ...Stomach pain may also occur."

Answered by AI

Clinical Trials for Labetalol Hydrochloride

Have you considered Labetalol Hydrochloride clinical trials? We made a collection of clinical trials featuring Labetalol Hydrochloride, we think they might fit your search criteria.
Have you considered Labetalol Hydrochloride clinical trials? We made a collection of clinical trials featuring Labetalol Hydrochloride, we think they might fit your search criteria.
Have you considered Labetalol Hydrochloride clinical trials? We made a collection of clinical trials featuring Labetalol Hydrochloride, we think they might fit your search criteria.
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