What is Labetalol Hydrochloride
LabetalolThe Generic name of this drug
Treatment SummaryLabetalol is a medication used to treat high blood pressure. It is made up of two chemical components taken as an injection or in tablet form. Labetalol was approved by the FDA in 1984.
Trandateis the brand name
Labetalol Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Trandate
Labetalol
1984
260
Approved as Treatment by the FDA
Labetalol, commonly known as Trandate, is approved by the FDA for 1 uses including Hypertensive disease .Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Effectiveness
How Labetalol Hydrochloride Affects PatientsLabetalol helps lower blood pressure by blocking certain hormones in the body. It lasts for a long time, and is usually taken twice daily in doses of 200-400mg. People with asthma should not take labetalol unless other medications have not worked for them.
How Labetalol Hydrochloride works in the bodyLabetalol works by blocking certain hormones that cause your blood vessels to narrow and your heart rate to increase. This causes your blood vessels to widen and your heart rate to slow down, leading to a decrease in blood pressure, especially when standing. Labetalol also produces some side effects, such as bronchospasms, but these are reduced by the widening of the blood vessels. Over time, labetalol produces sustained widening of the blood vessels and only a small decrease in heart rate and stroke volume.
When to interrupt dosage
The proposed dose of Labetalol Hydrochloride is contingent upon the diagnosed affliction, including Subarachnoid Hemorrhage, Hypertensive Emergency and Chronic Stable Angina Pectoris. The magnitude of dosage is based on the technique of administration (e.g. Oral or Tablet, film coated - Oral) provided in the below table.Condition
Dosage
Administration
Subarachnoid Hemorrhage
100.0 mg, 200.0 mg, 300.0 mg, , 5.0 mg/mL, 1.0 mg/mL, 50.0 mg, 400.0 mg
Oral, Tablet, film coated - Oral, Tablet, film coated, Injection - Intravenous, Tablet, Tablet, coated - Oral, , Intravenous, Liquid, Tablet - Oral, Injection, Solution, Tablet, coated, Liquid - Intravenous, Injection, solution - Intravenous, Solution - Intravenous, Injection, solution
Hypertensive Emergency
100.0 mg, 200.0 mg, 300.0 mg, , 5.0 mg/mL, 1.0 mg/mL, 50.0 mg, 400.0 mg
Oral, Tablet, film coated - Oral, Tablet, film coated, Injection - Intravenous, Tablet, Tablet, coated - Oral, , Intravenous, Liquid, Tablet - Oral, Injection, Solution, Tablet, coated, Liquid - Intravenous, Injection, solution - Intravenous, Solution - Intravenous, Injection, solution
Chronic Stable Angina Pectoris
100.0 mg, 200.0 mg, 300.0 mg, , 5.0 mg/mL, 1.0 mg/mL, 50.0 mg, 400.0 mg
Oral, Tablet, film coated - Oral, Tablet, film coated, Injection - Intravenous, Tablet, Tablet, coated - Oral, , Intravenous, Liquid, Tablet - Oral, Injection, Solution, Tablet, coated, Liquid - Intravenous, Injection, solution - Intravenous, Solution - Intravenous, Injection, solution
Pregnancy
100.0 mg, 200.0 mg, 300.0 mg, , 5.0 mg/mL, 1.0 mg/mL, 50.0 mg, 400.0 mg
Oral, Tablet, film coated - Oral, Tablet, film coated, Injection - Intravenous, Tablet, Tablet, coated - Oral, , Intravenous, Liquid, Tablet - Oral, Injection, Solution, Tablet, coated, Liquid - Intravenous, Injection, solution - Intravenous, Solution - Intravenous, Injection, solution
Pheochromocytomas
100.0 mg, 200.0 mg, 300.0 mg, , 5.0 mg/mL, 1.0 mg/mL, 50.0 mg, 400.0 mg
Oral, Tablet, film coated - Oral, Tablet, film coated, Injection - Intravenous, Tablet, Tablet, coated - Oral, , Intravenous, Liquid, Tablet - Oral, Injection, Solution, Tablet, coated, Liquid - Intravenous, Injection, solution - Intravenous, Solution - Intravenous, Injection, solution
Hypertensive disease
100.0 mg, 200.0 mg, 300.0 mg, , 5.0 mg/mL, 1.0 mg/mL, 50.0 mg, 400.0 mg
Oral, Tablet, film coated - Oral, Tablet, film coated, Injection - Intravenous, Tablet, Tablet, coated - Oral, , Intravenous, Liquid, Tablet - Oral, Injection, Solution, Tablet, coated, Liquid - Intravenous, Injection, solution - Intravenous, Solution - Intravenous, Injection, solution
Hypertensive crisis
100.0 mg, 200.0 mg, 300.0 mg, , 5.0 mg/mL, 1.0 mg/mL, 50.0 mg, 400.0 mg
Oral, Tablet, film coated - Oral, Tablet, film coated, Injection - Intravenous, Tablet, Tablet, coated - Oral, , Intravenous, Liquid, Tablet - Oral, Injection, Solution, Tablet, coated, Liquid - Intravenous, Injection, solution - Intravenous, Solution - Intravenous, Injection, solution
Warnings
Labetalol Hydrochloride ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Labetalol may interact with Toxoplasma Infections
Heart Block
Do Not Combine
Shock, Cardiogenic
Do Not Combine
severe bradycardia
Do Not Combine
Bronchial Asthma
Do Not Combine
Hypotension
Do Not Combine
overt cardiac failure
Do Not Combine
Lung Diseases, Obstructive
Do Not Combine
Hypotension
Do Not Combine
Common Labetalol Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyphenethylamine can be decreased when used in combination with Labetalol.
4-Methoxyamphetamine
Major
The therapeutic efficacy of 4-Methoxyamphetamine can be decreased when used in combination with Labetalol.
Abediterol
Major
The therapeutic efficacy of Abediterol can be decreased when used in combination with Labetalol.
Acepromazine
Major
Labetalol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Adrafinil
Major
The therapeutic efficacy of Adrafinil can be decreased when used in combination with Labetalol.
Labetalol Hydrochloride Toxicity & Overdose RiskThe toxic dose of this drug in mice is 600mg/kg, and in rats is more than 2g/kg. Those who overdose may experience low blood pressure and slow heart rate. Treatment includes gastric lavage or vomiting, atropine or epinephrine for slow heart rate, digitalis and a diuretic for heart failure, vasopressors for low blood pressure, epinephrine or a beta2 agonist for bronchospasms, and diazepam for seizures. Patients should be placed on their back with their legs raised to keep the brain supplied with oxygen.
Labetalol Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Labetalol Hydrochloride?
Presently, 81 active trials are being conducted to examine the potential of Labetalol Hydrochloride for Hypertensive disease, Hypertensive crisis and Chronic Stable Angina Pectoris management.Condition
Clinical Trials
Trial Phases
Subarachnoid Hemorrhage
19 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2, Phase 4, Early Phase 1
Pheochromocytomas
0 Actively Recruiting
Chronic Stable Angina Pectoris
3 Actively Recruiting
Phase 3, Not Applicable
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4
Hypertensive crisis
0 Actively Recruiting
Pregnancy
45 Actively Recruiting
Phase 3, Phase 4, Not Applicable, Phase 2, Phase 1
Hypertensive Emergency
1 Actively Recruiting
Phase 4
Labetalol Hydrochloride Reviews: What are patients saying about Labetalol Hydrochloride?
5Patient Review
12/20/2019 I've been on this medication for over six years with no significant adverse effects. I have tried other medications (metoprolol and lisinopril) but they gave me bad side effects. This one has been good to me, though I can't drink alcohol while taking it or else I'll get anxiety attacks.
5Patient Review
2/13/2019 I've been taking this medication for 25 years and it's been working great in keeping my blood pressure stable.
3Patient Review
4/23/2021 On 200 mg three times a day, my blood pressure has lowered; however, I have been feeling extremely tired and uninterested in activities.
2.7Patient Review
12/31/2019 I've been taking this for four months now. It's effective when I'm not under stress, but it sometimes gives me unwanted side effects like high blood pressure and depression.
2.3Patient Review
8/9/2019 I was really tired after taking this medication, and my blood pressure wasn't any lower.
2Patient Review
5/1/2019 I experienced some negative side effects in the form of bad dreams and vivid dreams. My physician didn't mention this as a possibility, so be warned.
2Patient Review
3/24/2021 I never had high blood pressure before I started taking this medication, and it hasn't changed since. This just isn't the right treatment for me.
1.7Patient Review
5/26/2019 Though this medication did lower my blood pressure from 150 to 120, the severe side effects were not worth it. These included a dry mouth, weight loss, low appetite, increased urination, and itchy skin.
1.7Patient Review
7/6/2017 I took Labetalol 100 MG twice daily for one year and nine months. While it was effective in controlling my BP at first, I needed to increase the dosage over time. Additionally, I developed a number of negative side effects including decreased libido, fatigue, weight gain, and leg cramps. Finally, I stopped taking the drug and all of those symptoms went away.
1.7Patient Review
7/31/2018 I started with a low dose, 100mg twice a day, but quickly had to increase it to 600mg with little decrease in my blood pressure. Not only that, but I think I'm experiencing some side effects like an itchy scalp and tingling.
1.3Patient Review
10/4/2021 Worked for the first few weeks but has since lost its efficacy. I've been experiencing an irregular heartbeat as a side effect of the higher dosage, so now I'm not sure what to do.
1Patient Review
1/18/2017 I had really terrible experiences with this blood pressure medication. My BP was constantly high, and I even had to be hospitalized because it got so bad. The side effects were also really horrible - dizziness, fatigue, shortness of breath. I'm glad I'm off of it now and taking something that actually works.
1Patient Review
5/29/2019 I started taking this medication again a few weeks ago and have been experiencing chest pain, dizziness, and pain in my left shoulder. I had to go to the ER and they took me off the medication. My blood pressure is still high.
1Patient Review
2/25/2021 Do not take this medication. It made me feel dizzy and tired, my scalp itched, and my blood pressure would go up and down too quickly. My heart rate would race and then stop. I felt like I was going to fall even though I only took 100mg. This medication also made me look pale. Talk to your doctor before taking this medication.
1Patient Review
6/29/2020 There are so many negative side effects to this medication that it's not worth taking. I've been on it for 300mg twice a day and have experienced dizziness, fatigue, itching, and blood pressure fluctuations, among other things. I'm seeing my doctor today to get off of this stuff.
1Patient Review
1/29/2022 My friend has been taking this medication for a while and I have advised people not to take it. He was taking labetalol 100 mg a day.. he has passed out, feels weak, light headed, no appetite. This does more harm than good.. they need to discontinue this medication now his heart rate drops.
1Patient Review
1/13/2021 I cannot believe that this drug is legal. It made me feel incredibly ill and I would urge you to stay away from it if at all possible.
Patient Q&A Section about labetalol hydrochloride
What is labetalol used for in pregnancy?
"Labetalol can help to control high blood pressure, which in turn reduces the risk of pregnancy complications." - Anonymous Online Contributor
Unverified Answer
What is labetalol hydrochloride used for?
"Labetalol is a medication used to treat high blood pressure. When used alone or with other medications, it can help to reduce the workload on the heart and arteries. If high blood pressure is left untreated for a long period of time, it can lead to serious health problems." - Anonymous Online Contributor
Unverified Answer
Does labetalol make you sleep?
"Labetalol may cause drowsiness when taken as an oral tablet. It can also cause other side effects." - Anonymous Online Contributor
Unverified Answer
What are the most common side effects of labetalol?
"Labatelol may cause drowsiness, dizziness, or weakness. If this occurs, stop what you are doing and rest until you feel better. ...Headaches may also occur. Make sure to rest and drink plenty of fluids. ...You may also experience cold fingers or toes. ...Nausea or vomiting may also occur. ...Diarrhea may also occur. ...Stomach pain may also occur." - Anonymous Online Contributor
Unverified Answer