Kovanaze
Nasal Intubation, Rhinorrhea, Rhinitis, Allergic + 10 more
Treatment
3 FDA approvals
20 Active Studies for Kovanaze
Treatment for
Nasal Intubation
What is Kovanaze
Oxymetazoline
The Generic name of this drug
Treatment Summary
Tetracaine is a topical anesthetic used to numb the skin. It is most often combined with lidocaine and applied as a cream or patch.
Afrin Original Pump Mist
is the brand name
Kovanaze Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Afrin Original Pump Mist
Oxymetazoline
1975
7
Approved as Treatment by the FDA
Oxymetazoline, commonly known as Afrin Original Pump Mist, is approved by the FDA for 3 uses including Anesthesia, Conduction and Obesity .
Anesthesia, Conduction
Used to treat induction of Regional Anesthesia in combination with Tetracaine
Obesity
Used to treat weight 40 kg or more in combination with Tetracaine
Anesthesia, Conduction
Used to treat Regional Anesthesia therapy in combination with Tetracaine
Effectiveness
How Kovanaze works in the body
Tetracaine is a drug used to numb a specific area of the body. It works by blocking the electrical signals that cause nerves to fire.
When to interrupt dosage
The prescribed dose of Kovanaze is contingent upon the determined affliction, including Sunburn, Insect Bites and Dermabrasion. The magnitude of dosage can be found in the table below, relative to the method of delivery (e.g. Spray - Topical or Cream - Topical).
Condition
Dosage
Administration
Sinus Congestion
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Solution / drops - Ophthalmic, Kit - Topical, Jelly, Jelly - Nasal
Postoperative Hemorrhage
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Solution / drops - Ophthalmic, Kit - Topical, Jelly, Jelly - Nasal
Nasal Intubation
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Solution / drops - Ophthalmic, Kit - Topical, Jelly, Jelly - Nasal
Rhinorrhea
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Solution / drops - Ophthalmic, Kit - Topical, Jelly, Jelly - Nasal
Rhinitis, Allergic
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Solution / drops - Ophthalmic, Kit - Topical, Jelly, Jelly - Nasal
Obesity
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Solution / drops - Ophthalmic, Kit - Topical, Jelly, Jelly - Nasal
Nasal Congestion
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Solution / drops - Ophthalmic, Kit - Topical, Jelly, Jelly - Nasal
Acquired Blepharoptosis
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Solution / drops - Ophthalmic, Kit - Topical, Jelly, Jelly - Nasal
Anesthesia, Conduction
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Solution / drops - Ophthalmic, Kit - Topical, Jelly, Jelly - Nasal
Rosacea
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Solution / drops - Ophthalmic, Kit - Topical, Jelly, Jelly - Nasal
Anesthesia, Conduction
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Solution / drops - Ophthalmic, Kit - Topical, Jelly, Jelly - Nasal
Airway visualization
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Solution / drops - Ophthalmic, Kit - Topical, Jelly, Jelly - Nasal
persistent facial erythema
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Solution / drops - Ophthalmic, Kit - Topical, Jelly, Jelly - Nasal
Warnings
Kovanaze Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Oxymetazoline may interact with Pulse Frequency
There are 20 known major drug interactions with Kovanaze.
Common Kovanaze Drug Interactions
Drug Name
Risk Level
Description
Antazoline
Major
The absorption of Antazoline can be decreased when combined with Oxymetazoline.
Azelastine
Major
The absorption of Azelastine can be decreased when combined with Oxymetazoline.
Beclomethasone dipropionate
Major
The absorption of Beclomethasone dipropionate can be decreased when combined with Oxymetazoline.
Betamethasone
Major
The absorption of Betamethasone can be decreased when combined with Oxymetazoline.
Budesonide
Major
The absorption of Budesonide can be decreased when combined with Oxymetazoline.
Kovanaze Toxicity & Overdose Risk
Common side effects of the combination cream include redness (47%), skin discoloration (16%), and swelling (14%). Less common side effects (occurring in less than 1% of patients) include vomiting, headache, dizziness, and fever. The cream may also cause central nervous system stimulation or depression. It is not known at what level of concentration systemic toxicity occurs with tetracaine, but it is thought to be much lower than with lidocaine, which is 1000 ng/mL.
Kovanaze Novel Uses: Which Conditions Have a Clinical Trial Featuring Kovanaze?
Currently, there are 6 active trials evaluating the potential of Kovanaze to provide Dermabrasion, Sunburn Relief and Local Anesthesia.
Condition
Clinical Trials
Trial Phases
Postoperative Hemorrhage
7 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
persistent facial erythema
0 Actively Recruiting
Rhinorrhea
0 Actively Recruiting
Anesthesia, Conduction
0 Actively Recruiting
Rosacea
0 Actively Recruiting
Acquired Blepharoptosis
0 Actively Recruiting
Anesthesia, Conduction
0 Actively Recruiting
Airway visualization
0 Actively Recruiting
Nasal Congestion
0 Actively Recruiting
Rhinitis, Allergic
0 Actively Recruiting
Nasal Intubation
0 Actively Recruiting
Obesity
638 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Early Phase 1, Phase 3
Sinus Congestion
0 Actively Recruiting
Kovanaze Reviews: What are patients saying about Kovanaze?
5
Patient Review
3/17/2019
Kovanaze for Administration of Local Anesthetic Drug
Patient Q&A Section about kovanaze
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
How does oxymetazoline work?
"Oxymetazoline is a medication used to treat congestion by narrowing the blood vessels in the nasal passages."
Answered by AI
What is anesthetic nasal Spray?
"Oxymetazoline is a decongestant that works by narrowing the blood vessels in your nose, which decreases swelling
The medication used in this instance is a nasal spray that contains two ingredients - tetracaine and oxymetazoline. Tetracaine is a local anesthetic that numbs the area by blocking nerves whilst oxymetazoline is a decongestant that works by reducing swelling by narrowing the blood vessels in your nose."
Answered by AI
Can a dentist prescribe nasal spray?
"A dentist will give you or your child this medicine in a dental clinic. This medicine is given as a spray into your nose on the same side of the maxillary tooth on which the dental procedure will be done."
Answered by AI
What is Kovanaze?
"Kovanaze is a prescription medicine used as Dental Anesthesia. Kovanaze may be used alone or with other medications. Kovanaze belongs to a class of drugs called Anesthetics, Inhaled, Dental. It is not known if Kovanaze is safe and effective in children."
Answered by AI