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What is Janumet
SitagliptinThe Generic name of this drug
Treatment SummarySitagliptin is a diabetes medication that works by lowering blood sugar levels. It is usually taken in combination with diet and exercise, and was approved by the FDA in 2006. The drug works by blocking an enzyme called dipeptidyl peptidase-4 (DPP-4) that breaks down a hormone called incretin, which helps the body produce insulin and reduces glucagon production. This helps to regulate blood sugar levels in patients with type 2 diabetes.
Januviais the brand name
Janumet Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Januvia
Sitagliptin
2006
52
Effectiveness
How Janumet Affects PatientsSitagliptin stops an enzyme (DPP-4) from working, leading to higher levels of two hormones (GLP-1 and GIP), lower levels of another hormone (glucagon), and stronger insulin production when exposed to glucose.
How Janumet works in the bodySitagliptin works by slowing down the activity of an enzyme called DPP-4. This enzyme breaks down a type of hormone called incretins, which help control blood sugar levels. When DPP-4 is inhibited, more incretins are available, which causes the body to produce more insulin and less glucagon. The result is better control of blood glucose levels, as demonstrated by reduced levels of glycosylated hemoglobin (HbA1c).
When to interrupt dosage
The prescribed dosage of Janumet is contingent upon the diagnosed condition. The amount of dosage also changes, based on the administration technique featured in the table beneath.Condition
Dosage
Administration
Type 2 Diabetes
, 100.0 mg, 50.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Diet
, 100.0 mg, 50.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Physical Activity
, 100.0 mg, 50.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Warnings
Janumet has one contraindication and should not be taken if you are experiencing any of the conditions in the table below.Janumet ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Sitagliptin may interact with Pulse Frequency
Common Janumet Drug Interactions
Drug Name
Risk Level
Description
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Sitagliptin.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Sitagliptin.
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Sitagliptin.
Erlotinib
Major
The metabolism of Erlotinib can be decreased when combined with Sitagliptin.
Fluorouracil
Major
The metabolism of Fluorouracil can be decreased when combined with Sitagliptin.
Janumet Toxicity & Overdose RiskStudies have not found any negative effects on mothers or babies when taking Sitagliptin at normal doses. However, high doses of the drug have been linked to malformations in ribs in animals. It is not known if Sitagliptin would be expressed in human breast milk. Prescribing the drug should be done cautiously, considering both the benefits and risks. Currently, there is not enough data to determine the safety and effectiveness of Sitagliptin in children. Elderly patients may respond differently than younger patients, so caution should be used when prescribing it to this group. Additionally, Sitagliptin has been linked to an
Janumet Novel Uses: Which Conditions Have a Clinical Trial Featuring Janumet?
162 active trials are currently in progress to study the potential of Janumet in treating Type 2 Diabetes.Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
192 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 1, Phase 4, Phase 3
Physical Activity
39 Actively Recruiting
Not Applicable, Phase 2, Phase 1, Early Phase 1
Diet
5 Actively Recruiting
Not Applicable
Janumet Reviews: What are patients saying about Janumet?
5Patient Review
6/5/2015 I've been on this medication for a year and a half now and I absolutely love it. It's helped me lose weight and my blood sugar levels are now perfectly normal.
5Patient Review
4/21/2018 I got a urinary tract infection in 2012. My A1C was over 13 at the time, so my doctor put me on Janumet 50/500 2x/day. I'm happy to report that my A1C has been stable at 5.7-5.9 ever since, and I no longer have to check my blood sugar levels.
5Patient Review
12/25/2021 Janumet has been a game-changer for me. For over 30 years, it's helped keep my blood sugar levels in check.
5Patient Review
7/10/20145Patient Review
3/23/2015 I'm really pleased with how this medication turned out.
4.7Patient Review
6/17/2015 Janumet has been an absolute lifesaver for me. I was stuck on metformin for years with little to no results, but as soon as I switched over to this medication I started seeing results almost immediately. In just six months I lost 40lbs, and it's because this drug completely curbed my cravings for unhealthy foods. If you're struggling with weight loss, give this a try!
4.3Patient Review
8/17/2014 I tried this medication and while it did lower my blood sugar to a good range, I started having really severe leg cramps. I had to stop taking it because the cramps were so bad that I could hardly walk. Now I'm just back on Metformin.
4.3Patient Review
9/11/2014 I've been taking this medication for four years now with no side effects. My sugar levels have decreased significantly, which is great.
3.3Patient Review
7/30/2014 Janumet 50/500 has been a great help for me. I started with one pill at bedtime, and increased to twice a day after six days. My blood sugar levels have dropped significantly, and I've lost 32 pounds without feeling hungry.
3.3Patient Review
8/15/2014 I am feeling more comfortable with this treatment.
3Patient Review
3/14/2018 It's been about a month since I started taking JANUMET, and within the first week I developed itchy hives. I spoke to my doctor and she said to give it some time; 33 days later, they're still here. So, I've gone back to using METFORMIN. If you have a choice in medication, avoid JANUMET.
3Patient Review
5/11/2016 The Janumet did lower my blood sugar levels, but the side effects were far too much for me to handle. I lost my appetite, had diarrhea, and experienced extremely blurry vision.
2.3Patient Review
1/28/2020 Janumet was unfortunately not the right medication for me. I experienced a lot of stomach pain while taking it.
2Patient Review
11/9/2016 I was put on Janumet when my previous medication wasn't doing the trick. I think the red dye caused me to throw up if I didn't eat before taking the pill, which made it difficult to keep up with the recommended dosage.
2Patient Review
6/28/2016 This treatment has been okay, but it only works if I'm careful about what I eat.
1Patient Review
7/20/2018 I had an incredibly negative reaction to this medication, developing painful blisters within a week of taking it. I reported my experience to the FDA.
1Patient Review
10/26/2017 I'm writing this review in case someone else has experienced blurred vision while taking Janumet. I woke up with blurred vision after the 7th day on Janumet XR 100/1000mg and it's still bothering me two months later. Hopefully, it will improve over time but it's been frustrating so far.
1Patient Review
6/5/2022 I had a really terrible experience with this medication. I felt dizzy, jittery, and anxious the entire time I was on it, and ended up having to go to the emergency room.
Patient Q&A Section about janumet
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the side effect of JANUMET?
"The most common side effects when taking JANUMET or JANUMET XR are a stuffy or runny nose and sore throat, gas, upset stomach, indigestion, headache, upper respiratory tract infection, weakness, diarrhea, and low blood sugar (hypoglycemia). When used in combination with certain medicines such as sulfonylurea or insulin, there is also a risk of nausea and..."
Answered by AI
Is JANUMET and metformin the same thing?
"If you have any of the symptoms of lactic acidosis, call your doctor right away.
Janumet contains metformin which on rare occasions can cause lactic acidosis. Lactic acidosis is a condition where there is too much lactic acid in the blood. This can lead to other health problems that can be deadly. If you experience any of the symptoms of lactic acidosis, you should call your doctor immediately."
Answered by AI
What is the drug JANUMET used for?
"JANUMET XR tablets are a once-daily prescription medication that contains sitagliptin (the medicine in JANUVIA®) and extended-release metformin. JANUMET or JANUMET XR can be used in combination with diet and exercise to lower blood sugar in adults with type 2 diabetes."
Answered by AI
Is JANUMET considered insulin?
"Janumet, a combination of two anti-diabetic medicines, is available only as a brand name medication. It is one of the few medications in its class that does not require a prescription, but it is expensive. Janumet lowers blood sugar levels."
Answered by AI