Janumet

Physical Activity, Type 2 Diabetes, Diet
Treatment
20 Active Studies for Janumet

What is Janumet

SitagliptinThe Generic name of this drug
Treatment SummarySitagliptin is a diabetes medication that works by lowering blood sugar levels. It is usually taken in combination with diet and exercise, and was approved by the FDA in 2006. The drug works by blocking an enzyme called dipeptidyl peptidase-4 (DPP-4) that breaks down a hormone called incretin, which helps the body produce insulin and reduces glucagon production. This helps to regulate blood sugar levels in patients with type 2 diabetes.
Januviais the brand name
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Janumet Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Januvia
Sitagliptin
2006
52

Effectiveness

How Janumet Affects PatientsSitagliptin stops an enzyme (DPP-4) from working, leading to higher levels of two hormones (GLP-1 and GIP), lower levels of another hormone (glucagon), and stronger insulin production when exposed to glucose.
How Janumet works in the bodySitagliptin works by slowing down the activity of an enzyme called DPP-4. This enzyme breaks down a type of hormone called incretins, which help control blood sugar levels. When DPP-4 is inhibited, more incretins are available, which causes the body to produce more insulin and less glucagon. The result is better control of blood glucose levels, as demonstrated by reduced levels of glycosylated hemoglobin (HbA1c).

When to interrupt dosage

The prescribed dosage of Janumet is contingent upon the diagnosed condition. The amount of dosage also changes, based on the administration technique featured in the table beneath.
Condition
Dosage
Administration
Physical Activity
, 100.0 mg, 50.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Type 2 Diabetes
, 100.0 mg, 50.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Diet
, 100.0 mg, 50.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral

Warnings

Janumet has one contraindication and should not be taken if you are experiencing any of the conditions in the table below.Janumet Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Sitagliptin may interact with Pulse Frequency
There are 20 known major drug interactions with Janumet.
Common Janumet Drug Interactions
Drug Name
Risk Level
Description
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Sitagliptin.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Sitagliptin.
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Sitagliptin.
Erlotinib
Major
The metabolism of Erlotinib can be decreased when combined with Sitagliptin.
Fluorouracil
Major
The metabolism of Fluorouracil can be decreased when combined with Sitagliptin.
Janumet Toxicity & Overdose RiskStudies have not found any negative effects on mothers or babies when taking Sitagliptin at normal doses. However, high doses of the drug have been linked to malformations in ribs in animals. It is not known if Sitagliptin would be expressed in human breast milk. Prescribing the drug should be done cautiously, considering both the benefits and risks. Currently, there is not enough data to determine the safety and effectiveness of Sitagliptin in children. Elderly patients may respond differently than younger patients, so caution should be used when prescribing it to this group. Additionally, Sitagliptin has been linked to an
image of a doctor in a lab doing drug, clinical research

Janumet Novel Uses: Which Conditions Have a Clinical Trial Featuring Janumet?

162 active trials are currently in progress to study the potential of Janumet in treating Type 2 Diabetes.
Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
177 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Physical Activity
35 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Early Phase 1
Diet
5 Actively Recruiting
Not Applicable, Phase 1

Janumet Reviews: What are patients saying about Janumet?

5Patient Review
6/5/2015
Janumet for Type 2 Diabetes Mellitus
I've been on this medication for a year and a half now and I absolutely love it. It's helped me lose weight and my blood sugar levels are now perfectly normal.
5Patient Review
4/21/2018
Janumet for Type 2 Diabetes Mellitus
I got a urinary tract infection in 2012. My A1C was over 13 at the time, so my doctor put me on Janumet 50/500 2x/day. I'm happy to report that my A1C has been stable at 5.7-5.9 ever since, and I no longer have to check my blood sugar levels.
5Patient Review
12/25/2021
Janumet for Type 2 Diabetes Mellitus
Janumet has been a game-changer for me. For over 30 years, it's helped keep my blood sugar levels in check.
5Patient Review
7/10/2014
Janumet for Type 2 Diabetes Mellitus
5Patient Review
3/23/2015
Janumet for Type 2 Diabetes Mellitus
I'm really pleased with how this medication turned out.
View All Reviews
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Patient Q&A Section about janumet

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the side effect of JANUMET?

"The most common side effects when taking JANUMET or JANUMET XR are a stuffy or runny nose and sore throat, gas, upset stomach, indigestion, headache, upper respiratory tract infection, weakness, diarrhea, and low blood sugar (hypoglycemia). When used in combination with certain medicines such as sulfonylurea or insulin, there is also a risk of nausea and..."

Answered by AI

Is JANUMET and metformin the same thing?

"If you have any of the symptoms of lactic acidosis, call your doctor right away.

Janumet contains metformin which on rare occasions can cause lactic acidosis. Lactic acidosis is a condition where there is too much lactic acid in the blood. This can lead to other health problems that can be deadly. If you experience any of the symptoms of lactic acidosis, you should call your doctor immediately."

Answered by AI

What is the drug JANUMET used for?

"JANUMET XR tablets are a once-daily prescription medication that contains sitagliptin (the medicine in JANUVIA®) and extended-release metformin. JANUMET or JANUMET XR can be used in combination with diet and exercise to lower blood sugar in adults with type 2 diabetes."

Answered by AI

Is JANUMET considered insulin?

"Janumet, a combination of two anti-diabetic medicines, is available only as a brand name medication. It is one of the few medications in its class that does not require a prescription, but it is expensive. Janumet lowers blood sugar levels."

Answered by AI

Clinical Trials for Janumet

Have you considered Janumet clinical trials? We made a collection of clinical trials featuring Janumet, we think they might fit your search criteria.
Have you considered Janumet clinical trials? We made a collection of clinical trials featuring Janumet, we think they might fit your search criteria.
Have you considered Janumet clinical trials? We made a collection of clinical trials featuring Janumet, we think they might fit your search criteria.
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