Jadenu

Blood Transfusions, Non-transfusion Dependent Thalassemia, Iron Overload

Treatment

2 Active Studies for Jadenu

Treatment for

Blood Transfusions

What is Jadenu

Deferasirox

The Generic name of this drug

Treatment Summary

Deferasirox is a prescription drug used to help reduce the amount of excess iron in the body. It is the first oral medication approved by the FDA for treating people who receive long-term blood transfusions.

Exjade

is the brand name

image of different drug pills on a surface

Jadenu Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Exjade

Deferasirox

2005

112

Effectiveness

How Jadenu Affects Patients

Deferasirox is a pill that binds to iron in the body. It is highly effective at grabbing onto iron, and also has some effect on zinc and copper. However, it is unclear if these decreases in trace metals have any important effects on the body.

How Jadenu works in the body

Deferasirox is effective at treating iron toxicity. It works by binding to iron atoms and forming a stable complex. This complex is then removed from the body via the kidneys.

When to interrupt dosage

The portion of Jadenu is contingent upon the perceived affliction, including Iron Overload, Blood Transfusions and Non-transfusion Dependent Thalassemia. The measure of dosage additionally differs as indicated by the method of administration (e.g. Granule or Tablet, film coated) featured in the table underneath.

Condition

Dosage

Administration

Iron Overload

125.0 mg, , 250.0 mg, 500.0 mg, 90.0 mg, 180.0 mg, 360.0 mg

Oral, , Tablet, for suspension - Oral, Tablet, for suspension, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Granule, Granule - Oral, Tablet, coated, Tablet, coated - Oral

Blood Transfusions

125.0 mg, , 250.0 mg, 500.0 mg, 90.0 mg, 180.0 mg, 360.0 mg

Oral, , Tablet, for suspension - Oral, Tablet, for suspension, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Granule, Granule - Oral, Tablet, coated, Tablet, coated - Oral

Non-transfusion Dependent Thalassemia

125.0 mg, , 250.0 mg, 500.0 mg, 90.0 mg, 180.0 mg, 360.0 mg

Oral, , Tablet, for suspension - Oral, Tablet, for suspension, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Granule, Granule - Oral, Tablet, coated, Tablet, coated - Oral

Warnings

Jadenu has four contraindications. When encountering any of the conditions in the given table, Jadenu should not be administered.

Jadenu Contraindications

Condition

Risk Level

Notes

Advanced Malignancies

Do Not Combine

Myelodysplastic Syndromes

Do Not Combine

Poor Performance Status

Do Not Combine

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Jadenu.

Common Jadenu Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be increased when combined with Deferasirox.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be increased when combined with Deferasirox.

Alectinib

Major

The metabolism of Alectinib can be increased when combined with Deferasirox.

Alpelisib

Major

The metabolism of Alpelisib can be increased when combined with Deferasirox.

Amiodarone

Major

The metabolism of Amiodarone can be increased when combined with Deferasirox.

image of a doctor in a lab doing drug, clinical research

Jadenu Novel Uses: Which Conditions Have a Clinical Trial Featuring Jadenu?

Currently, there are no active studies assessing the effectiveness of Jadenu in providing Blood Transfusions, Non-transfusion Dependent Thalassemia and Iron Overload relief.

Condition

Clinical Trials

Trial Phases

Blood Transfusions

3 Actively Recruiting

Not Applicable

Iron Overload

0 Actively Recruiting

Non-transfusion Dependent Thalassemia

0 Actively Recruiting

Jadenu Reviews: What are patients saying about Jadenu?

Patient Review

11/19/2019

Jadenu for excess iron due to repeated blood transfusions

I've been taking this drug for over a year now and it has helped me immensely. There have been a few times when my Ferritin level has increased, but it always goes back down eventually.

3.7

Patient Review

5/15/2016

Jadenu for Too Much Iron in the Blood for a Long Period of Time

I was prescribed Jadenu in order to lower my ferritin level, which had been gradually increasing. The medication did successfully achieve this, however I had to stop taking it because of severe gut issues and extreme fatigue/muscle weakness caused by skyrocketing liver functions. Now that I've been taken off the drug, I'm not sure what my next treatment option will be, as the anemia prevents me from being phlebotomized.

Patient Review

10/12/2018

Jadenu for excess iron in person with non-transfusion-dependent thalassemia (NTDT)

My daughter takes this for her Hemaglobin H Disease/Thalassemia disorder. Her Iron stores were through the roof and, since starting this medication, she is now iron deficient and her bilirubin level is now high. The pills are quite large and she can not swallow them, so we have to crush them. Unfortunately, they have a bitter taste that she doesn't enjoy.

Patient Review

8/5/2016

Jadenu for Too Much Iron in the Blood for a Long Period of Time

I unfortunately had to discontinue use after just ten days due to developing an extreme rash all over my body. My iron levels did decrease while taking the medication, however.

Patient Q&A Section about jadenu

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What type of drug is JADENU?

"Jadenu is a prescription medicine used to treat the symptoms of iron overload caused by Transfusional Hemosiderosis and Nontransfusion-Dependent Thalassemia. Jadenu may be used alone or with other medications. Jadenu helps to remove excess iron from the body by binding to it and allowing it to be passed out of the body in urine or stool. Jadenu belongs to a class of drugs called Chelators."

Answered by AI

What is JADENU prescribed for?

"JADENU is a prescription medication used to treat chronic iron buildup in people aged 2 and up who have received multiple blood transfusions."

Answered by AI

How long does it take JADENU to work?

"The treatment usually takes several months, during which time JADENU will help remove excess iron from your body to protect your heart and liver."

Answered by AI

Is there a generic for JADENU?

"The drug Deferasirox is available in various forms, including tablets and granules of different strengths, as well as a generic form for oral suspension."

Answered by AI