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What is Isradipine
IsradipineThe Generic name of this drug
Treatment SummaryIsradipine is a medication used to lower blood pressure in patients with mild to moderate essential hypertension. It belongs to a class of drugs called calcium channel blockers (CCBs) and is specifically a dihydropyridine (DHP). This drug works by blocking the calcium channels in both cardiac and arterial smooth muscle cells and preventing calcium from entering the cells, which helps to relax the muscles and reduce blood pressure. Isradipine is the most potent DHP CCB and is more selective towards arterial smooth muscle cells than other drugs in its class.
DynaCircis the brand name
Isradipine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
DynaCirc
Isradipine
1998
24
Approved as Treatment by the FDA
Isradipine, also known as DynaCirc, is approved by the FDA for 1 uses including Hypertensive disease .Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Effectiveness
How Isradipine Affects PatientsIsradipine helps relax the walls of your blood vessels, which can lower your blood pressure. This drug works by preventing calcium from entering your cells, which stops the muscles in your arteries from contracting. When the muscles don't contract, your arteries open wider, allowing more blood to flow through them and helping to reduce your blood pressure.
How Isradipine works in the bodyIsradipine is a type of calcium channel blocker. It works by targeting L-type calcium channels that are responsible for muscle contraction, particularly in the smooth muscles of the arteries. The drug binds to these inactive channels and keeps them inactive, preventing the stimulation of muscle cells. Isradipine also has additional properties that make it more suitable for targeting the arteries specifically, while having little effect on the cardiac muscle cells.
When to interrupt dosage
The measure of Isradipine is contingent upon the diagnosed affliction. The quantity of dosage fluctuates as per the technique of delivery mentioned in the table below.Condition
Dosage
Administration
Hypertensive disease
, 2.5 mg, 5.0 mg, 10.0 mg
, Oral, Capsule, Capsule - Oral, Tablet - Oral, Tablet, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release
Warnings
There are 20 known major drug interactions with Isradipine.Common Isradipine Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Isradipine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Isradipine.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Isradipine.
Alpelisib
Major
The metabolism of Alpelisib can be decreased when combined with Isradipine.
Amifostine
Major
Isradipine may increase the hypotensive activities of Amifostine.
Isradipine Toxicity & Overdose RiskOverdosing on Isradipine can cause fatigue, rapid heartbeat, and low blood pressure. A high dose of over 200 mg/kg can be lethal in mice, and 50 mg/kg can be lethal in rabbits. Rats, however, can tolerate doses of up to 2000 mg/kg without any negative effects.
Isradipine Novel Uses: Which Conditions Have a Clinical Trial Featuring Isradipine?
18 active studies are examining the potential of Isradipine to provide relief from Hypertensive disease.Condition
Clinical Trials
Trial Phases
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Isradipine Reviews: What are patients saying about Isradipine?
4Patient Review
12/26/2009 This treatment is good. It helped me a lot.
3Patient Review
4/23/2012 I switched from the brand name to the generic version because my insurance wouldn't cover the cost of the brand name. The generic doesn't work as well, unfortunately.
2.3Patient Review
2/17/2012 not very effective
Patient Q&A Section about isradipine
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of isradipine?
"The side effects of the medication include headache, dizziness, lightheadedness, flushing, fast heartbeat, excessive tiredness, upset stomach, vomiting, and diarrhea."
Answered by AI
How quickly does isradipine work?
"It takes 2 to 3 hours for isradipine to start lowering blood pressure, though it may work a little slower if taken with food. The full effects of isradipine can take 2 to 4 weeks to see."
Answered by AI
What is the generic of isradipine?
"The ideal dosage of DynaCirc® (isradipine) varies from person to person. The recommended starting dose is 2.5 mg twice a day, either on its own or combined with a thiazide diuretic. The drug usually starts working to lower blood pressure within 2-3 hours. However, it may take up to 2-4 weeks for the full effect to be seen."
Answered by AI
What is isradipine used for?
"Isradipine is used to lower blood pressure. It is used either alone or with other medications like hydrochlorothiazide. High blood pressure can damage the heart and arteries if it is not treated."
Answered by AI