Isosorbide Dinitrate

Coronary Disease, Chest Pain, Congestive Heart Failure + 1 more
Treatment
20 Active Studies for Isosorbide Dinitrate

What is Isosorbide Dinitrate

Isosorbide dinitrateThe Generic name of this drug
Treatment SummaryIsosorbide dinitrate is a drug used to relax and widen blood vessels, helping to reduce chest pain caused by angina. Its effects are similar to nitroglycerin, but it takes longer to produce relief.
Isordilis the brand name
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Isosorbide Dinitrate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Isordil
Isosorbide dinitrate
1968
157

Effectiveness

How Isosorbide Dinitrate Affects PatientsIsosorbide Dinitrate is a drug taken orally to reduce chest pain (angina pectoris) and to prevent it from happening again. It works by relaxing the muscles that line blood vessels, which allows the vessels to widen and increases the amount of blood flowing to the heart. It also reduces the pressure in the heart and decreases the pressure in the lungs. This decreases overall blood pressure.
How Isosorbide Dinitrate works in the bodyIsosorbide dinitrate works by increasing the production of nitric oxide, which then activates an enzyme called guanylate cyclase. This enzyme increases levels of a molecule known as cGMP, which then triggers a series of reactions that relax the smooth muscle fibers and cause blood vessels to widen (vasodilation).

When to interrupt dosage

The proposed dosage of Isosorbide Dinitrate is contingent upon the diagnosed condition, including Coronary Artery Disease (CAD), Congestive Heart Failure and self-identified black. The sum of dosage can be found in the table below, relative to the mode of administration (e.g. Tablet, extended release - Oral or Tablet - Oral).
Condition
Dosage
Administration
Coronary Disease
, 5.0 mg, 2.5 mg, 30.0 mg, 40.0 mg, 10.0 mg, 20.0 mg
, Sublingual, Tablet, Tablet - Sublingual, Oral, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral
Chest Pain
, 5.0 mg, 2.5 mg, 30.0 mg, 40.0 mg, 10.0 mg, 20.0 mg
, Sublingual, Tablet, Tablet - Sublingual, Oral, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral
self-identified black
, 5.0 mg, 2.5 mg, 30.0 mg, 40.0 mg, 10.0 mg, 20.0 mg
, Sublingual, Tablet, Tablet - Sublingual, Oral, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral
Congestive Heart Failure
, 5.0 mg, 2.5 mg, 30.0 mg, 40.0 mg, 10.0 mg, 20.0 mg
, Sublingual, Tablet, Tablet - Sublingual, Oral, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral

Warnings

Isosorbide Dinitrate Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Isosorbide Dinitrate.
Common Isosorbide Dinitrate Drug Interactions
Drug Name
Risk Level
Description
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Isosorbide dinitrate.
Phenobarbital
Major
The metabolism of Phenobarbital can be decreased when combined with Isosorbide dinitrate.
Riociguat
Major
Isosorbide dinitrate may increase the hypotensive activities of Riociguat.
Rosiglitazone
Major
The risk or severity of adverse effects can be increased when Isosorbide dinitrate is combined with Rosiglitazone.
Sildenafil
Major
The risk or severity of hypotension can be increased when Isosorbide dinitrate is combined with Sildenafil.
Isosorbide Dinitrate Toxicity & Overdose RiskOverdosing on a drug can cause reduced blood flow and low blood pressure.
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Isosorbide Dinitrate Novel Uses: Which Conditions Have a Clinical Trial Featuring Isosorbide Dinitrate?

Currently, 317 active clinical trials are assessing the efficacy of Isosorbide Dinitrate in providing relief to those self-identifying as Black, suffering from Congestive Heart Failure and Chest Pain.
Condition
Clinical Trials
Trial Phases
Congestive Heart Failure
173 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Phase 3, Early Phase 1
Coronary Disease
1 Actively Recruiting
Not Applicable
Chest Pain
2 Actively Recruiting
Not Applicable, Phase 2, Phase 3
self-identified black
0 Actively Recruiting

Isosorbide Dinitrate Reviews: What are patients saying about Isosorbide Dinitrate?

5Patient Review
6/10/2009
Isosorbide Dinitrate for Angina Pectoris Prevention
I was given this medication for my chronic high blood pressure. I don't have chest pain or any other heart-related pains. I'm a disabled veteran, and my primary care physician gave me this prescription. Along with a variety of other medications, is it safe for me to take this one?
4.7Patient Review
2/27/2008
Isosorbide Dinitrate for Angina
4.3Patient Review
5/11/2012
Isosorbide Dinitrate for Angina Pectoris Prevention
I had some really unpleasant side effects while taking this medication. It gave me a headache, nausea, low blood pressure, and hallucinations. I was hospitalized for a week because we didn't know what was causing the hallucinations at first. The medicine made me act violently, which is not something I would normally do.
3.7Patient Review
12/25/2010
Isosorbide Dinitrate for Angina
The medicine worked well for my chest pain, but the migraines it caused were so severe that I had to stop taking it.
3.7Patient Review
8/11/2008
Isosorbide Dinitrate for Angina Pectoris Prevention
I've been taking this for two months and it's helped me a lot. Before I started the medication, I was having multiple angina attacks every day. Now, I very rarely have any problems with angina.
View All Reviews
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Patient Q&A Section about isosorbide dinitrate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

When should I take isosorbide dinitrate?

"Schedule a drug-free time each day when you will not take the medicine. This will allow the medicine to work more effectively."

Answered by AI

Does isosorbide affect blood pressure?

"Sublingual isosorbide has been shown to be a safe and effective way to lower systolic and diastolic blood pressure levels in patients who have uncontrolled arterial hypertension."

Answered by AI

What is isosorbide dinitrate used for?

"Isosorbide dinitrate is used to prevent chest pain caused by coronary artery disease. It does not work fast enough to relieve pain from an angina attack that has already started."

Answered by AI

What is isosorbide dinitrate side effects?

"headache, weakness, mild dizziness, and skin changes such as redness, tingling, or warmth."

Answered by AI

Clinical Trials for Isosorbide Dinitrate

Have you considered Isosorbide Dinitrate clinical trials? We made a collection of clinical trials featuring Isosorbide Dinitrate, we think they might fit your search criteria.
Have you considered Isosorbide Dinitrate clinical trials? We made a collection of clinical trials featuring Isosorbide Dinitrate, we think they might fit your search criteria.
Have you considered Isosorbide Dinitrate clinical trials? We made a collection of clinical trials featuring Isosorbide Dinitrate, we think they might fit your search criteria.
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