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What is Isosorbide Dinitrate
Isosorbide dinitrateThe Generic name of this drug
Treatment SummaryIsosorbide dinitrate is a drug used to relax and widen blood vessels, helping to reduce chest pain caused by angina. Its effects are similar to nitroglycerin, but it takes longer to produce relief.
Isordilis the brand name
Isosorbide Dinitrate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Isordil
Isosorbide dinitrate
1968
157
Effectiveness
How Isosorbide Dinitrate Affects PatientsIsosorbide Dinitrate is a drug taken orally to reduce chest pain (angina pectoris) and to prevent it from happening again. It works by relaxing the muscles that line blood vessels, which allows the vessels to widen and increases the amount of blood flowing to the heart. It also reduces the pressure in the heart and decreases the pressure in the lungs. This decreases overall blood pressure.
How Isosorbide Dinitrate works in the bodyIsosorbide dinitrate works by increasing the production of nitric oxide, which then activates an enzyme called guanylate cyclase. This enzyme increases levels of a molecule known as cGMP, which then triggers a series of reactions that relax the smooth muscle fibers and cause blood vessels to widen (vasodilation).
When to interrupt dosage
The proposed dosage of Isosorbide Dinitrate is contingent upon the diagnosed condition, including Coronary Artery Disease (CAD), Congestive Heart Failure and self-identified black. The sum of dosage can be found in the table below, relative to the mode of administration (e.g. Tablet, extended release - Oral or Tablet - Oral).Condition
Dosage
Administration
Coronary Artery Disease (CAD)
, 5.0 mg, 2.5 mg, 30.0 mg, 40.0 mg, 10.0 mg, 20.0 mg
, Sublingual, Tablet, Tablet - Sublingual, Oral, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral
self-identified black
, 5.0 mg, 2.5 mg, 30.0 mg, 40.0 mg, 10.0 mg, 20.0 mg
, Sublingual, Tablet, Tablet - Sublingual, Oral, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral
Chest Pain
, 5.0 mg, 2.5 mg, 30.0 mg, 40.0 mg, 10.0 mg, 20.0 mg
, Sublingual, Tablet, Tablet - Sublingual, Oral, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral
Congestive Heart Failure
, 5.0 mg, 2.5 mg, 30.0 mg, 40.0 mg, 10.0 mg, 20.0 mg
, Sublingual, Tablet, Tablet - Sublingual, Oral, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral
Warnings
Isosorbide Dinitrate ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Common Isosorbide Dinitrate Drug Interactions
Drug Name
Risk Level
Description
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Isosorbide dinitrate.
Phenobarbital
Major
The metabolism of Phenobarbital can be decreased when combined with Isosorbide dinitrate.
Riociguat
Major
Isosorbide dinitrate may increase the hypotensive activities of Riociguat.
Rosiglitazone
Major
The risk or severity of adverse effects can be increased when Isosorbide dinitrate is combined with Rosiglitazone.
Sildenafil
Major
The risk or severity of hypotension can be increased when Isosorbide dinitrate is combined with Sildenafil.
Isosorbide Dinitrate Toxicity & Overdose RiskOverdosing on a drug can cause reduced blood flow and low blood pressure.
Isosorbide Dinitrate Novel Uses: Which Conditions Have a Clinical Trial Featuring Isosorbide Dinitrate?
Currently, 317 active clinical trials are assessing the efficacy of Isosorbide Dinitrate in providing relief to those self-identifying as Black, suffering from Congestive Heart Failure and Chest Pain.Condition
Clinical Trials
Trial Phases
Chest Pain
6 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 4
Coronary Artery Disease (CAD)
1 Actively Recruiting
Not Applicable
Congestive Heart Failure
312 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1, Phase 4
self-identified black
0 Actively Recruiting
Isosorbide Dinitrate Reviews: What are patients saying about Isosorbide Dinitrate?
5Patient Review
6/10/2009 I was given this medication for my chronic high blood pressure. I don't have chest pain or any other heart-related pains. I'm a disabled veteran, and my primary care physician gave me this prescription. Along with a variety of other medications, is it safe for me to take this one?
4.7Patient Review
2/27/20084.3Patient Review
5/11/2012 I had some really unpleasant side effects while taking this medication. It gave me a headache, nausea, low blood pressure, and hallucinations. I was hospitalized for a week because we didn't know what was causing the hallucinations at first. The medicine made me act violently, which is not something I would normally do.
3.7Patient Review
12/25/2010 The medicine worked well for my chest pain, but the migraines it caused were so severe that I had to stop taking it.
3.7Patient Review
8/11/2008 I've been taking this for two months and it's helped me a lot. Before I started the medication, I was having multiple angina attacks every day. Now, I very rarely have any problems with angina.
3.7Patient Review
3/26/2008 I felt a burning sensation in my face and neck, like I was choking. I also started to feel faint.
3.7Patient Review
7/30/2012 I took this for several years with only minor problems like low blood pressure. It really helped keep my angina under control until recently.
3.7Patient Review
10/15/2021 I've been using this medication in conjunction with blood pressure and antidepressant medications, and it's worked great. I only take one pill when needed.
3.3Patient Review
4/16/2009 So far, this medication has been helpful.
3Patient Review
3/13/2010 I sometimes feel discomfort in the morning before taking this medication, but it always provides relief afterwards.
2.3Patient Review
2/7/2010 I have severe headaches, nausea, and blurred vision.
1.7Patient Review
1/20/20081.7Patient Review
12/29/2013 Stomach cramps, nausea, burping constantly, flatulance.Stomach full of gas, swollen stomach.Worse on lying down. Taking 10mg x 2 per day for Angina. Had 2 heart attacks, l 6 years ago, l Sept. 20ll. ~Used spray too much, blood pressure dropped too low. Ambulance called. GP put me on isosorbide monotrate 3 days ago--this medication has caused a litany of gastric issues including but not limited to bloating and intestinal upset..
1.3Patient Review
4/17/2009 This has helped to ease the constant chest pain I was experiencing.
1Patient Review
5/31/2009 I've only been taking this medication for two weeks, but I'm already experiencing some serious gastrointestinal issues like heartburn and a burning sensation on my tongue and in my esophagus. Is this common?
1Patient Review
11/11/2022 I had a really terrible experience with this medication. I took it for two days and my headache actually got worse. It was the worst headache I've ever had.
Patient Q&A Section about isosorbide dinitrate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.When should I take isosorbide dinitrate?
"Schedule a drug-free time each day when you will not take the medicine. This will allow the medicine to work more effectively."
Answered by AI
Does isosorbide affect blood pressure?
"Sublingual isosorbide has been shown to be a safe and effective way to lower systolic and diastolic blood pressure levels in patients who have uncontrolled arterial hypertension."
Answered by AI
What is isosorbide dinitrate used for?
"Isosorbide dinitrate is used to prevent chest pain caused by coronary artery disease. It does not work fast enough to relieve pain from an angina attack that has already started."
Answered by AI
What is isosorbide dinitrate side effects?
"headache, weakness, mild dizziness, and skin changes such as redness, tingling, or warmth."
Answered by AI