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What is Isordil
Isosorbide dinitrateThe Generic name of this drug
Treatment SummaryIsosorbide dinitrate is a medication used to treat chest pain caused by angina. It works in a similar way to nitroglycerin, but takes longer to take effect.
Isordilis the brand name
Isordil Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Isordil
Isosorbide dinitrate
1968
157
Effectiveness
How Isordil Affects PatientsIsosorbide Dinitrate is a medication used to treat angina pectoris. It opens up the blood vessels, making it easier for blood to flow. This reduces pressure on the heart and lowers the blood pressure in the body. It is taken orally and takes a moderate to long time to take effect.
How Isordil works in the bodyIsosorbide dinitrate works by increasing levels of a molecule called nitric oxide, which triggers a series of reactions in the body. These reactions lead to dephosphorylation of smooth muscle fibers and a release of calcium ions. The end result is the relaxation of the smooth muscle and widening of the blood vessels.
When to interrupt dosage
The suggested dose of Isordil is contingent upon the determined condition, such as Coronary Artery Disease (CAD), Congestive Heart Failure and self-proclaimed black. The amount of dosage is subject to the technique of delivery (e.g. Tablet, extended release - Oral or Tablet - Oral) specified in the subsequent table.Condition
Dosage
Administration
Coronary Artery Disease (CAD)
, 5.0 mg, 2.5 mg, 30.0 mg, 40.0 mg, 10.0 mg, 20.0 mg
, Sublingual, Tablet, Tablet - Sublingual, Oral, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral
self-identified black
, 5.0 mg, 2.5 mg, 30.0 mg, 40.0 mg, 10.0 mg, 20.0 mg
, Sublingual, Tablet, Tablet - Sublingual, Oral, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral
Chest Pain
, 5.0 mg, 2.5 mg, 30.0 mg, 40.0 mg, 10.0 mg, 20.0 mg
, Sublingual, Tablet, Tablet - Sublingual, Oral, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral
Congestive Heart Failure
, 5.0 mg, 2.5 mg, 30.0 mg, 40.0 mg, 10.0 mg, 20.0 mg
, Sublingual, Tablet, Tablet - Sublingual, Oral, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral
Warnings
Isordil ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Common Isordil Drug Interactions
Drug Name
Risk Level
Description
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Isosorbide dinitrate.
Phenobarbital
Major
The metabolism of Phenobarbital can be decreased when combined with Isosorbide dinitrate.
Riociguat
Major
Isosorbide dinitrate may increase the hypotensive activities of Riociguat.
Rosiglitazone
Major
The risk or severity of adverse effects can be increased when Isosorbide dinitrate is combined with Rosiglitazone.
Sildenafil
Major
The risk or severity of hypotension can be increased when Isosorbide dinitrate is combined with Sildenafil.
Isordil Toxicity & Overdose RiskOverdosing on this drug can result in a decrease in heart output and low blood pressure.
Isordil Novel Uses: Which Conditions Have a Clinical Trial Featuring Isordil?
317 clinical trials are currently in progress to determine the potential of Isordil to reduce symptoms associated with self-identified black patients, Congestive Heart Failure and Chest Pain.Condition
Clinical Trials
Trial Phases
Chest Pain
6 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 4
Coronary Artery Disease (CAD)
1 Actively Recruiting
Not Applicable
Congestive Heart Failure
312 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1, Phase 4
self-identified black
0 Actively Recruiting
Isordil Reviews: What are patients saying about Isordil?
5Patient Review
12/23/2010 I had some severe headaches when I started taking this medication, but they fortunately subsided after the first week. I still get mild to moderate chest pain when walking short distances, though.
5Patient Review
2/28/2013 This medication has been a big help to me, especially with my heart condition.
4.3Patient Review
7/15/2011 Isordil has always been reliable for me in terms of providing relief from chest pain. I'm truly grateful to have this medication available to me.
4Patient Review
11/15/20073.3Patient Review
6/4/2010 This medication has done a lot to reduce the chest pain I was experiencing. However, my blood pressure remains high.
Patient Q&A Section about isordil
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.When should you take Isordil?
"You should take this medicine first thing in the morning, at the same time each day. It will work best if you have a period of time every day when you do not take the medicine, so that the medicine has a chance to work. Your doctor will schedule your doses during the day to allow for a drug-free time."
Answered by AI
What is the medication Isordil used for?
"Isosorbide dinitrate is a nitrate that widens blood vessels and is used to prevent chest pain in those with coronary artery disease."
Answered by AI
What is the side effect of Isordil?
"People frequently report headaches as a side effect, which can be severe. Headaches may come back each time you take the medication, especially if you take high doses. You may also feel lightheadedness occasionally, which may be related to changes in your blood pressure."
Answered by AI
Does Isordil lower blood pressure?
"When used together with alcohol or other blood pressure-lowering drugs, Isosorbide dinitrate (Isordil) may cause your blood pressure to drop too low.
Isosorbide dinitrate (Isordil) may lower blood pressure. If alcohol or other blood pressure-lowering drugs are consumed while taking Isosorbide dinitrate (Isordil), it may cause blood pressure to drop too low."
Answered by AI