Ismelin
Treatment
0 Active Studies for Ismelin
What is Ismelin
Guanethidine
The Generic name of this drug
Treatment Summary
A medication used to treat high blood pressure, this drug works by blocking the transmission of nerve signals in post-ganglionic nerves. It is thought to prevent the release of a certain chemical (norepinephrine) from nerve endings and reduces the amount of norepinephrine in the peripheral sympathetic nerves and tissues.
Ismelin
is the brand name
Ismelin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ismelin
Guanethidine
1960
2
Effectiveness
How Ismelin Affects Patients
High blood pressure can cause serious problems like stroke, heart failure, and kidney failure. Guanethidine helps lower the risk of these issues by slowing down the heartbeat and making it easier for blood to move through the body. It works by blocking the release of a hormone (norepinephrine) from nerve endings in the body.
How Ismelin works in the body
Guanethidine works by blocking norepinephrine from leaving the nerve endings. Norepinephrine is a neurotransmitter that usually causes an increase in blood pressure. By preventing it from leaving the nerve endings, Guanethidine helps to reduce blood pressure in both the supine and upright positions. This is because it decreases the amount of sympathetic nerve activity, which is responsible for tightening the blood vessels.
Warnings
There are 20 known major drug interactions with Ismelin.
Common Ismelin Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Guanethidine may increase the hypotensive activities of Amifostine.
4-Bromo-2,5-dimethoxyphenethylamine
Minor
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyphenethylamine can be decreased when used in combination with Guanethidine.
Aclidinium
Minor
Guanethidine may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine
Minor
Guanethidine may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Albutrepenonacog alfa
Minor
Guanethidine may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Ismelin Toxicity & Overdose Risk
Side effects of taking this drug can be drowsiness, dizziness, fatigue, or confusion. The lowest toxic dose in mice was found to be 1000mg/kg when taken orally.
Patient Q&A Section about ismelin
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What is the mechanism of action of guanethidine?
"Guanethidine slows the heart rate and relaxes blood vessels so that blood can flow more easily, reducing the risks. It blocks norepinephrine from being released from nerve terminals, preventing it from working."
Answered by AI
What is a Guanethidine used for?
"Guanethidine is an antihypertensive medication used to treat high blood pressure."
Answered by AI
What is Phenoxybenzamine used for?
"Phenoxybenzamine is used to treat hypertension caused by pheochromocytoma by blocking the effects of chemicals in the body that cause high blood pressure when present in high amounts."
Answered by AI
What Is the brand Name for guanethidine?
"Ismelin (guanethidine monosulfate) is used to treat hypertension (high blood pressure) and high blood pressure in the kidneys. The brand name Ismelin is discontinued, but generic versions may be available."
Answered by AI