Infed

Iron deficiency
Treatment
2 FDA approvals
7 Active Studies for Infed

What is Infed

Iron DextranThe Generic name of this drug
Treatment SummaryIron dextran is an injectable medication made up of iron and a complex sugar used to treat iron deficiency. It is administered either intravenously or intramuscularly and is used when oral administration of iron is not possible or not effective.
INFeDis the brand name
image of different drug pills on a surface
Infed Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
INFeD
Iron Dextran
1974
8

Approved as Treatment by the FDA

Iron Dextran, otherwise known as INFeD, is approved by the FDA for 2 uses including Iron Deficiency (ID) and Iron deficiency .
Iron Deficiency (ID)
Iron deficiency

Effectiveness

How Infed Affects PatientsIron dextran is a dark brown liquid given through a vein or muscle for people who do not have enough iron in their body. Iron is necessary for the body to produce hemoglobin and other compounds, and a lack of iron can cause iron deficiency anemia. Iron dextran helps to replenish iron stores in the body.
How Infed works in the bodyWhen iron dextran is injected, it enters the bloodstream and is picked up by cells that make up the reticuloendothelial system. These cells break down the complex into its components, iron and dextran. The iron attaches to proteins like hemosiderin and ferritin, which are the ways the body normally stores iron. This iron helps replenish hemoglobin and other iron stores.

When to interrupt dosage

The prescribed dosage of Infed is contingent upon the diagnostically determined condition. The amount of dosage is contingent upon the technique of administration (e.g. Kit; Tablet; Tablet, film coated or Capsule, gelatin coated - Oral) outlined in the table beneath.
Condition
Dosage
Administration
Iron deficiency
22.0 mg, , 50.0 mg/mL, 100.0 mg, 65.0 mg, 15.0 mg, 29.0 mg, 53.0 mg, 28.0 mg, 115.2 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Solution, Liquid, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous

Warnings

Infed Contraindications
Condition
Risk Level
Notes
Iron Deficiency Anemia
Do Not Combine
There are 20 known major drug interactions with Infed.
Common Infed Drug Interactions
Drug Name
Risk Level
Description
Technetium Tc-99m oxidronate
Major
Iron Dextran can cause a decrease in the absorption of Technetium Tc-99m oxidronate resulting in a reduced serum concentration and potentially a decrease in efficacy.
3-Aza-2,3-Dihydrogeranyl Diphosphate
Minor
Iron Dextran can cause a decrease in the absorption of 3-Aza-2,3-Dihydrogeranyl Diphosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium Phosphate
Minor
Iron Dextran can cause a decrease in the absorption of Calcium Phosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium phosphate dihydrate
Minor
Iron Dextran can cause a decrease in the absorption of Calcium phosphate dihydrate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dipotassium phosphate
Minor
Iron Dextran can cause a decrease in the absorption of Dipotassium phosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Infed Toxicity & Overdose RiskThe toxic dose of iron dextran in mice is 500mg/kg. Taking too much iron dextran can cause a buildup of iron in the body, known as hemosiderosis. Severe allergic reactions, including loss of consciousness, breathing difficulties, hives, swelling, and seizures have also been reported, as well as a drop in blood pressure.
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Infed Novel Uses: Which Conditions Have a Clinical Trial Featuring Infed?

Condition
Clinical Trials
Trial Phases
Iron deficiency
7 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Early Phase 1, Phase 3

Infed Reviews: What are patients saying about Infed?

5Patient Review
11/21/2009
Infed for Anemia from Inadequate Iron
Thanks to other reviewers for preparing me mentally and emotionally for this treatment. I was given a lot of medication beforehand, including steroids, Benedryl, and an anti-nausea drug. Then I did a test bag (no reaction) and finally got the full dosage of iron. It was rough but I'm glad I survived it!
4Patient Review
7/7/2012
Infed for Anemia from Inadequate Iron
So far, I've had two iron infusions and am scheduled for weekly 200ml treatments. I had gastric bypass surgery in 2009 which now prevents me from being able to tolerate or absorb oral iron. These infusions have helped with my extreme exhaustion, headaches and feelings of shakiness.
3.7Patient Review
1/28/2009
Infed for Anemia from Inadequate Iron
I didn't have any bad reactions while getting the treatment, but the day after I got it I had a headache, felt awful, and was shaking from cold.
3.7Patient Review
11/16/2012
Infed for Anemia from Inadequate Iron
I've had two Infed infusions within six weeks of each other and haven't experienced any side effects.
3Patient Review
1/28/2011
Infed for Anemia from Inadequate Iron
I've been using this treatment for a few years now and have definitely noticed some of the listed side effects. One in particular that I'm curious about is if other users have experienced extreme drying of skin, especially on the face?
3Patient Review
3/16/2010
Infed for Osteoporosis
This treatment really helped me. I'm grateful for modern medicine.
1.3Patient Review
10/1/2009
Infed for Anemia from Inadequate Iron
The first two doses went without a hitch, but the third caused some serious back pain. Then, about 30 minutes after the injection, I had an extreme allergic reaction. Welts and uncontrollable itching all over my body. Thankfully, they were able to give me steroids and Benedryl to reverse it.
1.3Patient Review
3/26/2022
Infed for Anemia from Inadequate Iron
I had a very bad reaction to this infusion, even though I was told that reactions are very rare. I felt faint and had stars in my eyes, and my blood pressure fell to 84/43. I had to be given supplemental oxygen and fluids until it resolved.
1Patient Review
10/15/2009
Infed for Anemia from Inadequate Iron
I was 8 months pregnant when I had a very bad reaction to this treatment. Only 2ml of the test dose was given before my baby's heart rate dropped and I went into shock. We both could have died if I hadn't been rushed into emergency surgery. Please don't take this medication if you are pregnant!
1Patient Review
1/26/2010
Infed for Anemia from Inadequate Iron
Infed caused me to have a seizure that lasted two minutes. I woke up to find EMS surrounding me and was then taken to the ER. Prior to the seizure, I told the nurse at the doctor's office that my back was in pain and my legs were numb.
1Patient Review
7/12/2016
Infed for Anemia from Inadequate Iron
Allergic reactions are unfortunately quite common with this treatment, as I found out the hard way. My blood pressure spiked and I started coughing and wheezing uncontrollably. Thankfully, I didn't have to go to the ER; however, I would not recommend this product to anyone.
1Patient Review
2/12/2009
Infed for Anemia from Inadequate Iron
I'm only four days into this treatment, and I am already experiencing a lot of pain in my lower back and legs. I have to continue the treatment for nine more days, and I am really dreading it. So far, I haven't seen any benefits from this treatment.
1Patient Review
9/3/2015
Infed for Anemia from Inadequate Iron
I had an incredibly severe reaction to this test dose and had to be rushed to the ER via ambulance. Definitely not worth it.
1Patient Review
3/13/2009
Infed for Anemia from Inadequate Iron
I nearly died from anaphalactic shock after only receiving a fraction of the first dose.
1Patient Review
4/22/2010
Infed for Anemia from Inadequate Iron
The pain I felt was unbearable and it spread throughout my chest and back. My blood pressure dropped dangerously low and I lost consciousness.
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Patient Q&A Section about infed

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are side effects of INFeD infusions?

"The side effects of the influenza vaccine can include flushing, tingling of the hands and feet, shivering, dizziness, injection site reactions, nausea, vomiting, and diarrhea."

Answered by AI

How do you administer an INFeD IV?

"The INFeD medication should only be injected into the large muscle mass in the upper outer section of the buttock. It should never be injected into the arm or any other exposed area of the body. The needle used should be 2-3 inches long and of 19 or 20 gauge width."

Answered by AI

What is INFeD used for?

"INFeD is a prescription drug used to relieve the symptoms of iron deficiency anemia. It may be used singly or in combination with other drugs. INFeD is one of a group of drugs called iron products and its safety and effectiveness have not been established in children under four months old."

Answered by AI

How long does it take INFeD to work?

"The symptoms of an Infed reaction usually start 24 to 48 hours after taking the medication, and they usually go away within 3 to 4 days. The cause of these reactions is unknown. Do not take more than 2 mL of Infed per day."

Answered by AI

Clinical Trials for Infed

Image of Columbia University Irving Medical Center in New York, United States.

Intravenous Iron for Iron Deficiency in Scoliosis

10 - 19
All Sexes
New York, NY
Adolescents and young adults undergoing spinal fusion surgery for the correction of scoliosis and other spinal deformity are at high risk of perioperative iron deficiency and anemia, yet the means and evidence for optimizing iron status have not been described in this setting. The proposed study is a randomized controlled trial of preoperative intravenous iron supplementation, to identify whether iron deficiency is a modifiable risk factor for adverse surgical outcomes such as red blood cell transfusion and diminished postoperative cognitive and physical capacity in this vulnerable population. Building evidence for patient blood management interventions such as iron supplementation is vital to ensuring high quality care of surgical patients and may reduce unnecessary transfusions amid recent blood shortages.
Phase 2 & 3
Waitlist Available
Columbia University Irving Medical Center
Image of University of Calgary in Calgary, Canada.

Iron Supplementation for Iron Deficiency

18 - 40
Female
Calgary, Canada
The goal of this clinical trial is to learn whether oral iron supplementation will increase skeletal muscle iron storage and its effects on exercise capacity in females with suboptimal iron status. The study will include healthy females, ages 18-40, who either have suboptimal or optimal iron stores. The main questions it aims to answer are: * Does iron supplementation increase skeletal muscle iron storage and alter the expression of iron-related and mitochondrial proteins? * Does iron supplementation improve single-leg exercise performance? * Is serum ferritin correlated with the abundance of iron-related proteins in skeletal muscle? Researchers will compare outcomes from females with suboptimal iron status who receive oral iron supplementation to those who receive a placebo to see if supplementation improves muscle iron storage, protein expression, and exercise performance. Additionally, a non-intervention control group with optimal iron status will be included to assess baseline differences. Participants will: \- Be randomly assigned to receive 150 mg elemental iron or placebo (maltodextrin) every other day for 12 weeks Complete pre- and post-supplementation testing, including: * Blood draws to assess iron status * Skeletal muscle biopsies to analyze protein content * Whole-body and single-leg exercise tests to assess performance * Controls will undergo baseline-only testing to compare physiological and biochemical markers
Phase < 1
Waitlist Available
University of CalgaryMartin J MacInnis
Image of The Medical Center in Bowling Green, United States.

Iron Supplementation for Heart Failure

18 - 100
All Sexes
Bowling Green, KY
The goal of this clinical trial is to learn which iron treatment works better for adults with congestive heart failure and low iron levels: intravenous (IV) iron given through a vein or oral (PO) iron taken by mouth. Participants must have heart failure with reduced ejection fraction (HFrEF) or preserved ejection fraction (HFpEF) and a transferrin-saturation (TSAT) level below 20 percent. The main questions the study will answer are: 1. Does IV iron raise walking distance on a 6-minute walk test more than oral iron after 24 weeks? 2. Does IV iron improve symptoms and quality of life more than oral iron? 3. How do the two treatments compare for safety, side effects, and hospital readmissions/ mortality? Researchers will compare IV ferric carboxymaltose with oral ferrous sulfate to see which option helps people feel and function better. What participants will do * Be randomly assigned by (like flipping a coin) to IV iron or oral iron. * Receive either a one-time IV iron infusion (with possible repeat at 12 weeks) or take iron pills twice each day for 24 weeks. * Visit the infusion clinic at 6 weeks for second dose of IV iron if needed. * Visit the clinic at 12 weeks for a follow-up to gather follow-up data including 1. A 6-minute walk test 2. Brief symptom and quality-of-life surveys 3. Blood tests to measure serum iron, ferritin, and transferrin saturation This study will help doctors decide whether IV or oral iron is the safer, more effective way to treat iron deficiency in people with heart failure in our local community.
Phase 4
Recruiting
The Medical CenterAmerican Regent, Inc.
Image of University of Calgary in Calgary, Canada.

Iron Supplements for Iron Deficiency

16 - 35
Female
Calgary, Canada
The goal of this clinical trial is to learn if different types and doses of oral iron supplements can improve iron levels, athletic performance, and gut health in young female athletes with low iron stores. The main questions it aims to answer are: * Does a low dose of yeast-bound iron improve iron status better than traditional iron supplements? * Do the different iron supplements cause fewer or more gastrointestinal (stomach) symptoms? * How do iron supplements affect exercise performance and gut bacteria? Researchers will compare three types of iron supplements: * A low-dose iron supplement (40 mg) * A low-dose yeast-bound iron supplement (40 mg) * A high-dose iron supplement (150 mg) This will help researchers find out which type of supplement is most effective and easiest on the stomach. Participants will: * Take one of the three assigned iron supplements every other day for 12 weeks * Complete fitness tests before and after the study, including cycling and jumping tests * Give blood samples to measure iron levels * Provide stool and intestinal samples to study gut bacteria * Swallow a SIMBA capsule before and after the study to collect a sample from the small intestine * Complete regular online surveys about sleep, stress, menstrual cycles, and gut symptoms
Waitlist Available
Has No Placebo
University of CalgaryJane ShearerMitacs
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Iron Supplements for Iron Deficiency in Pregnancy

19 - 42
Female
Vancouver, Canada
This two-arm, double-blind randomized clinical trial will recruit 172 generally healthy, low-risk pregnant individuals aged 19-42 years living in Vancouver, Canada. Participants will be randomized to receive one of two forms of iron (ferrous fumarate or ferrous bisglycinate) in addition to a prenatal multivitamin (without iron) daily during their pregnancy until delivery, with optional continuation until \~4 weeks postpartum for breastmilk sample collection. Blood samples will be taken at baseline (13-25 weeks gestation) and follow-up (35-37 weeks gestation) to assess how different forms of iron impact body iron stores. Stool samples will be obtained within 1 week of both baseline and follow-up visits to assess changes in gut microbiome composition. This research will inform more specific guidelines for optimal iron supplementation practices for the prevention and treatment of iron deficiency for both mother and baby.
Recruiting
Has No Placebo
University of British Columbia, Food, Nutrition and Health Building (+1 Sites)Crystal Karakochuk, PhD
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