Infed

Iron deficiency

Treatment

2 FDA approvals

4 Active Studies for Infed

Treatment for

Iron deficiency

What is Infed

Iron DextranThe Generic name of this drug

Treatment SummaryIron dextran is an injectable medication made up of iron and a complex sugar used to treat iron deficiency. It is administered either intravenously or intramuscularly and is used when oral administration of iron is not possible or not effective.

INFeDis the brand name

image of different drug pills on a surface

Infed Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

INFeD

Iron Dextran

1974

Approved as Treatment by the FDA

Iron Dextran, otherwise known as INFeD, is approved by the FDA for 2 uses including Iron Deficiency (ID) and Iron deficiency .

Iron Deficiency (ID)

Iron deficiency

Effectiveness

How Infed Affects PatientsIron dextran is a dark brown liquid given through a vein or muscle for people who do not have enough iron in their body. Iron is necessary for the body to produce hemoglobin and other compounds, and a lack of iron can cause iron deficiency anemia. Iron dextran helps to replenish iron stores in the body.

How Infed works in the bodyWhen iron dextran is injected, it enters the bloodstream and is picked up by cells that make up the reticuloendothelial system. These cells break down the complex into its components, iron and dextran. The iron attaches to proteins like hemosiderin and ferritin, which are the ways the body normally stores iron. This iron helps replenish hemoglobin and other iron stores.

When to interrupt dosage

The prescribed dosage of Infed is contingent upon the diagnostically determined condition. The amount of dosage is contingent upon the technique of administration (e.g. Kit; Tablet; Tablet, film coated or Capsule, gelatin coated - Oral) outlined in the table beneath.

Condition

Dosage

Administration

Iron deficiency

22.0 mg, , 50.0 mg/mL, 100.0 mg, 65.0 mg, 15.0 mg, 29.0 mg, 53.0 mg, 28.0 mg, 115.2 mg

, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Solution, Liquid, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous

Warnings

Infed Contraindications

Condition

Risk Level

Notes

Iron Deficiency Anemia

Do Not Combine

There are 20 known major drug interactions with Infed.

Common Infed Drug Interactions

Drug Name

Risk Level

Description

Technetium Tc-99m oxidronate

Major

Iron Dextran can cause a decrease in the absorption of Technetium Tc-99m oxidronate resulting in a reduced serum concentration and potentially a decrease in efficacy.

3-Aza-2,3-Dihydrogeranyl Diphosphate

Minor

Iron Dextran can cause a decrease in the absorption of 3-Aza-2,3-Dihydrogeranyl Diphosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.

Calcium Phosphate

Minor

Iron Dextran can cause a decrease in the absorption of Calcium Phosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.

Calcium phosphate dihydrate

Minor

Iron Dextran can cause a decrease in the absorption of Calcium phosphate dihydrate resulting in a reduced serum concentration and potentially a decrease in efficacy.

Dipotassium phosphate

Minor

Iron Dextran can cause a decrease in the absorption of Dipotassium phosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.

Infed Toxicity & Overdose RiskThe toxic dose of iron dextran in mice is 500mg/kg. Taking too much iron dextran can cause a buildup of iron in the body, known as hemosiderosis. Severe allergic reactions, including loss of consciousness, breathing difficulties, hives, swelling, and seizures have also been reported, as well as a drop in blood pressure.

image of a doctor in a lab doing drug, clinical research

Infed Novel Uses: Which Conditions Have a Clinical Trial Featuring Infed?

Condition

Clinical Trials

Trial Phases

Iron deficiency

4 Actively Recruiting

Phase 2, Not Applicable