Incivek

Liver Diseases, Interferon Treatment, Hepatitis C + 1 more

Treatment

6 FDA approvals

0 Active Studies for Incivek

What is Incivek

Telaprevir

The Generic name of this drug

Treatment Summary

Telaprevir is a medication used to treat chronic Hepatitis C, an infection caused by the Hepatitis C virus. It is recommended to use telaprevir with other medications like [DB00811], [DB00008], and [DB00022] which can help cure the virus. The combination therapy needs to be taken for 12 weeks followed by 12 or 36 weeks of taking the other medications. If successful, the treatment can reduce liver-related damage, improve quality of life, reduce the risk of certain cancer, and lower mortality rate. Telaprevir was available as a product called Incivek,

Incivek

is the brand name

image of different drug pills on a surface

Incivek Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Incivek

Telaprevir

2011

1

Approved as Treatment by the FDA

Telaprevir, also called Incivek, is approved by the FDA for 6 uses which include compensated liver disease and Chronic Hepatitis C Genotype 1 .

compensated liver disease

Used to treat compensated liver disease in combination with Peginterferon alfa-2b

Chronic Hepatitis C Genotype 1

Used to treat Chronic Hepatitis C Genotype 1 in combination with Peginterferon alfa-2b

Liver Diseases

Used to treat compensated liver disease in combination with Peginterferon alfa-2b

Treatment Naive

Used to treat Treatment Naive in combination with Peginterferon alfa-2b

Interferon Treatment

Used to treat Interferon Treatment in combination with Peginterferon alfa-2b

Hepatitis C

Used to treat Chronic Hepatitis C Genotype 1 in combination with Peginterferon alfa-2b

Effectiveness

How Incivek Affects Patients

Telaprevir is a medicine that stops the hepatitis C virus genotype 1 from spreading in the body.

How Incivek works in the body

Telaprevir is a drug used to fight the hepatitis C virus. It works by blocking an enzyme called NS3/4a protease, which helps the virus replicate. By inhibiting this enzyme, telaprevir can stop the virus from spreading and reproducing.

When to interrupt dosage

The proposed dosage of Incivek is contingent upon the diagnosed state, including compensated liver disease, Hepatitis C and Treatment Naive. The quantity of dosage fluctuates as per the technique of delivery (e.g. Tablet - Oral or Tablet, film coated - Oral) featured in the table underneath.

Condition

Dosage

Administration

Treatment Naive

375.0 mg,

, Tablet - Oral, Tablet, Oral, Tablet, film coated - Oral, Tablet, film coated

Liver Diseases

375.0 mg,

, Tablet - Oral, Tablet, Oral, Tablet, film coated - Oral, Tablet, film coated

Hepatitis C

375.0 mg,

, Tablet - Oral, Tablet, Oral, Tablet, film coated - Oral, Tablet, film coated

Interferon Treatment

375.0 mg,

, Tablet - Oral, Tablet, Oral, Tablet, film coated - Oral, Tablet, film coated

Warnings

There are 20 known major drug interactions with Incivek.

Common Incivek Drug Interactions

Drug Name

Risk Level

Description

1,2-Benzodiazepine

Major

The metabolism of 1,2-Benzodiazepine can be decreased when combined with Telaprevir.

3,5-diiodothyropropionic acid

Major

The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Telaprevir.

5-androstenedione

Major

The metabolism of 5-androstenedione can be decreased when combined with Telaprevir.

6-O-benzylguanine

Major

The metabolism of 6-O-benzylguanine can be decreased when combined with Telaprevir.

7-ethyl-10-hydroxycamptothecin

Major

The metabolism of 7-ethyl-10-hydroxycamptothecin can be decreased when combined with Telaprevir.

Incivek Toxicity & Overdose Risk

Telaprevir combination treatment has been linked to severe skin reactions such as Stevens Johnson Syndrome, Drug Reaction with Eosinophilia and Systemic Symptoms, and Toxic Epidermal Necrolysis. Taking telaprevir with other drugs can increase the risk of anemia.

image of a doctor in a lab doing drug, clinical research

Incivek Novel Uses: Which Conditions Have a Clinical Trial Featuring Incivek?

Currently, there are 2 active clinical trials examining the potential of Incivek in providing Treatment Naive, Interferon Treatment and alleviating Compensated Liver Disease.

Condition

Clinical Trials

Trial Phases

Interferon Treatment

0 Actively Recruiting

Hepatitis C

0 Actively Recruiting

Liver Diseases

0 Actively Recruiting

Treatment Naive

0 Actively Recruiting

Incivek Reviews: What are patients saying about Incivek?

4.3

Patient Review

1/14/2013

Incivek for Chronic Hepatitis C

I took this treatment for hep-c a second time and found it much better than the last. I didn't feel as sick, but it did take longer to recover.

3.7

Patient Review

5/23/2013

Incivek for Chronic Hepatitis C

I had to stop taking this medication after only nine weeks due to some serious side effects. I went from feeling fine to having a high fever, rash all over my body, and shortness of breath in just one week. So far the virus has been undetectable in follow-up testing, so hopefully this will continue and the three-month recovery process will have been worth it in the end.

3.7

Patient Review

4/15/2013

Incivek for Chronic Hepatitis C

This treatment is tough, but it really works. My viral count went from 500 million to undetectable in just two months. I had to have blood transfusions because of the severe anemia, and it was hard to eat that much fat. But I'm glad I did it!

3.7

Patient Review

5/13/2013

Incivek for Chronic Hepatitis C

I'm nearing the end of my treatment and there's been no sign of hep c according to recent tests. I was hesitant to start this, but am glad that I did.

3.7

Patient Review

5/24/2013

Incivek for Chronic Hepatitis C

I was unfortunately unable to complete the full treatment due to some nasty side effects. However, in the short term it seemed to be working well. I'm hopeful that the one year check-in will show that the virus is still undetectable.

3.3

Patient Review

6/5/2012

Incivek for Chronic Hepatitis C

I experienced some tough side effects while taking this medication, including hives and flu-like symptoms.

3.3

Patient Review

10/5/2012

Incivek for Chronic Hepatitis C

I experienced forgetfulness, stuttering, tremors, and hyperthyroidism as a result of this treatment.

2.7

Patient Review

1/12/2013

Incivek for Chronic Hepatitis C

I found it hard to take large amounts of fat, and I had an embolism as a result. I was taken off the medication because of this side effect.

2.3

Patient Review

12/18/2012

Incivek for Chronic Hepatitis C

I developed an unfortunate and uncomfortable rash about two months into the treatment. Otherwise, I was able to tolerate it well.

1

Patient Review

7/9/2013

Incivek for Chronic Hepatitis C

I had an awful experience with this treatment. I developed a rash all over my body within two months of starting it, and ended up having to go to the ER. I was out of work for three weeks as a result.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about incivek

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Incivek used for?

"Incivek is an antiviral medicine that prevents multiplying virus cells in your body, used in combination with peginterferon alfa and ribavirin to treat hepatitis c in adults."

Answered by AI

Why was telaprevir discontinued?

"As of October 2014, Vertex Pharmaceuticals is no longer selling or distributing the drug telaprevir in the United States. The main reason for this is that there are now other available treatments and the demand for this drug has decreased. Telaprevir was originally developed by Vertex Pharmaceuticals and Johnson & Johnson under the name VX-950."

Answered by AI

Is telaprevir FDA approved?

"On May 23, 2011, the United States Food and Drug Administration approved INCIVEK™ (telaprevir) for the treatment of hepatitis c.INCIVEK is a protease inhibitor that works by blocking a protein that the hepatitis C virus needs to multiply. It is used in combination with two other drugs, peginterferon alfa and ribavirin.

The FDA has approved INCIVEK™ (telaprevir), a protease inhibitor, for the treatment of hepatitis C. INCIVEK works by blocking a protein that the hepatitis C virus needs to multiply. It is used in combination with two other drugs, peginterferon alfa and ribavirin."

Answered by AI