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What is Incivek
TelaprevirThe Generic name of this drug
Treatment SummaryTelaprevir is a medication used to treat chronic Hepatitis C, an infection caused by the Hepatitis C virus. It is recommended to use telaprevir with other medications like [DB00811], [DB00008], and [DB00022] which can help cure the virus. The combination therapy needs to be taken for 12 weeks followed by 12 or 36 weeks of taking the other medications. If successful, the treatment can reduce liver-related damage, improve quality of life, reduce the risk of certain cancer, and lower mortality rate. Telaprevir was available as a product called Incivek,
Incivekis the brand name
Incivek Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Incivek
Telaprevir
2011
1
Approved as Treatment by the FDA
Telaprevir, also called Incivek, is approved by the FDA for 6 uses which include compensated liver disease and Chronic Hepatitis C Genotype 1 .compensated liver disease
Used to treat compensated liver disease in combination with Peginterferon alfa-2b
Chronic Hepatitis C Genotype 1
Used to treat Chronic Hepatitis C Genotype 1 in combination with Peginterferon alfa-2b
Liver Diseases
Used to treat compensated liver disease in combination with Peginterferon alfa-2b
Treatment Naive
Used to treat Treatment Naive in combination with Peginterferon alfa-2b
Interferon Treatment
Used to treat Interferon Treatment in combination with Peginterferon alfa-2b
Hepatitis C
Used to treat Chronic Hepatitis C Genotype 1 in combination with Peginterferon alfa-2b
Effectiveness
How Incivek Affects PatientsTelaprevir is a medicine that stops the hepatitis C virus genotype 1 from spreading in the body.
How Incivek works in the bodyTelaprevir is a drug used to fight the hepatitis C virus. It works by blocking an enzyme called NS3/4a protease, which helps the virus replicate. By inhibiting this enzyme, telaprevir can stop the virus from spreading and reproducing.
When to interrupt dosage
The proposed dosage of Incivek is contingent upon the diagnosed state, including compensated liver disease, Hepatitis C and Treatment Naive. The quantity of dosage fluctuates as per the technique of delivery (e.g. Tablet - Oral or Tablet, film coated - Oral) featured in the table underneath.Condition
Dosage
Administration
Treatment Naive
375.0 mg,
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Liver Diseases
375.0 mg,
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Hepatitis C
375.0 mg,
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Interferon Treatment
375.0 mg,
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Warnings
There are 20 known major drug interactions with Incivek.Common Incivek Drug Interactions
Drug Name
Risk Level
Description
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be decreased when combined with Telaprevir.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Telaprevir.
5-androstenedione
Major
The metabolism of 5-androstenedione can be decreased when combined with Telaprevir.
6-O-benzylguanine
Major
The metabolism of 6-O-benzylguanine can be decreased when combined with Telaprevir.
7-ethyl-10-hydroxycamptothecin
Major
The metabolism of 7-ethyl-10-hydroxycamptothecin can be decreased when combined with Telaprevir.
Incivek Toxicity & Overdose RiskTelaprevir combination treatment has been linked to severe skin reactions such as Stevens Johnson Syndrome, Drug Reaction with Eosinophilia and Systemic Symptoms, and Toxic Epidermal Necrolysis. Taking telaprevir with other drugs can increase the risk of anemia.
Incivek Novel Uses: Which Conditions Have a Clinical Trial Featuring Incivek?
Currently, there are 2 active clinical trials examining the potential of Incivek in providing Treatment Naive, Interferon Treatment and alleviating Compensated Liver Disease.Condition
Clinical Trials
Trial Phases
Interferon Treatment
0 Actively Recruiting
Hepatitis C
0 Actively Recruiting
Liver Diseases
0 Actively Recruiting
Treatment Naive
0 Actively Recruiting
Incivek Reviews: What are patients saying about Incivek?
4.3Patient Review
1/14/2013 I took this treatment for hep-c a second time and found it much better than the last. I didn't feel as sick, but it did take longer to recover.
3.7Patient Review
5/23/2013 I had to stop taking this medication after only nine weeks due to some serious side effects. I went from feeling fine to having a high fever, rash all over my body, and shortness of breath in just one week. So far the virus has been undetectable in follow-up testing, so hopefully this will continue and the three-month recovery process will have been worth it in the end.
3.7Patient Review
4/15/2013 This treatment is tough, but it really works. My viral count went from 500 million to undetectable in just two months. I had to have blood transfusions because of the severe anemia, and it was hard to eat that much fat. But I'm glad I did it!
3.7Patient Review
5/13/2013 I'm nearing the end of my treatment and there's been no sign of hep c according to recent tests. I was hesitant to start this, but am glad that I did.
3.7Patient Review
5/24/2013 I was unfortunately unable to complete the full treatment due to some nasty side effects. However, in the short term it seemed to be working well. I'm hopeful that the one year check-in will show that the virus is still undetectable.
Patient Q&A Section about incivek
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Incivek used for?
"Incivek is an antiviral medicine that prevents multiplying virus cells in your body, used in combination with peginterferon alfa and ribavirin to treat hepatitis c in adults."
Answered by AI
Why was telaprevir discontinued?
"As of October 2014, Vertex Pharmaceuticals is no longer selling or distributing the drug telaprevir in the United States. The main reason for this is that there are now other available treatments and the demand for this drug has decreased. Telaprevir was originally developed by Vertex Pharmaceuticals and Johnson & Johnson under the name VX-950."
Answered by AI
Is telaprevir FDA approved?
"On May 23, 2011, the United States Food and Drug Administration approved INCIVEK™ (telaprevir) for the treatment of hepatitis c.INCIVEK is a protease inhibitor that works by blocking a protein that the hepatitis C virus needs to multiply. It is used in combination with two other drugs, peginterferon alfa and ribavirin.
The FDA has approved INCIVEK™ (telaprevir), a protease inhibitor, for the treatment of hepatitis C. INCIVEK works by blocking a protein that the hepatitis C virus needs to multiply. It is used in combination with two other drugs, peginterferon alfa and ribavirin."
Answered by AI
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