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What is Haloperidol Decanoate
HaloperidolThe Generic name of this drug
Treatment SummaryHaloperidol is a medication used to treat symptoms of mental disorders such as schizophrenia, Tourette syndrome, and severe behavioural states. It works by blocking dopamine receptors in the brain, reducing the overproduction of dopamine associated with these disorders. Haloperidol is usually effective and well-tolerated, although it can cause side effects such as movement disorders, sedation, weight gain, and prolactin changes. It is less likely to cause these side effects than other first-generation antipsychotic drugs, such as chlorpromazine and thioridazine. While haloperidol is still widely used, it has been
Haldolis the brand name
Haloperidol Decanoate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Haldol
Haloperidol
1971
300
Approved as Treatment by the FDA
Haloperidol, otherwise known as Haldol, is approved by the FDA for 1 uses which include Gilles de la Tourette's Syndrome .Gilles de la Tourette's Syndrome
Helps manage Gilles de la Tourette's Syndrome
Effectiveness
How Haloperidol Decanoate Affects PatientsHaloperidol is an antipsychotic medication that is used to treat the positive symptoms of schizophrenia, such as hallucinations, aggression, disorganized speech, and psychomotor agitation. It can cause side effects such as movement disorders, sedation, weight gain, and changes in prolactin levels. Compared to other first-generation antipsychotics, haloperidol usually has fewer side effects. However, it can still cause serious health issues including QT-prolongation and torsade de pointes (heart rhythm issues), Neuroleptic Malignant Syndrome (NMS), and a syndrome with potentially irreversible involuntary movement disorders
How Haloperidol Decanoate works in the bodyHaloperidol works by blocking dopamine receptors in the brain, which helps reduce symptoms of psychosis. The drug binds tightly to dopamine D2 receptors, which can lead to the development of side effects like extrapyramidal symptoms. Haloperidol has some effect on other receptors, including 5-HT2 and alpha-1 receptors, and it also works on the chemoreceptive trigger zone to provide antiemetic effects. Newer medications have been developed that work in a similar way but have a lower affinity for dopamine D2 receptors, which decreases the risk of extrapyramidal symptoms. Haloperidol should only be used
When to interrupt dosage
The suggested dosage of Haloperidol Decanoate is contingent upon the diagnosed condition, including Palliative Care, aggressive reaction and phencyclidine. The amount of dosage is subject to the technique of delivery listed in the table beneath.Condition
Dosage
Administration
Obsessive-Compulsive Disorder
5.0 mg/mL, , 2.0 mg/mL, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 0.5 mg, 20.0 mg, 50.0 mg/mL, 100.0 mg/mL, 1.5 mg, 500.0 mg/mL, 70.52 mg/mL, 141.04 mg/mL
, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Oral, Solution, concentrate, Solution, concentrate - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Injection, Liquid - Intramuscular, Liquid, Solution - Intramuscular
Delirium
5.0 mg/mL, , 2.0 mg/mL, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 0.5 mg, 20.0 mg, 50.0 mg/mL, 100.0 mg/mL, 1.5 mg, 500.0 mg/mL, 70.52 mg/mL, 141.04 mg/mL
, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Oral, Solution, concentrate, Solution, concentrate - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Injection, Liquid - Intramuscular, Liquid, Solution - Intramuscular
Nausea
5.0 mg/mL, , 2.0 mg/mL, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 0.5 mg, 20.0 mg, 50.0 mg/mL, 100.0 mg/mL, 1.5 mg, 500.0 mg/mL, 70.52 mg/mL, 141.04 mg/mL
, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Oral, Solution, concentrate, Solution, concentrate - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Injection, Liquid - Intramuscular, Liquid, Solution - Intramuscular
severe Hyperactivity
5.0 mg/mL, , 2.0 mg/mL, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 0.5 mg, 20.0 mg, 50.0 mg/mL, 100.0 mg/mL, 1.5 mg, 500.0 mg/mL, 70.52 mg/mL, 141.04 mg/mL
, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Oral, Solution, concentrate, Solution, concentrate - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Injection, Liquid - Intramuscular, Liquid, Solution - Intramuscular
Palliative Treatment
5.0 mg/mL, , 2.0 mg/mL, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 0.5 mg, 20.0 mg, 50.0 mg/mL, 100.0 mg/mL, 1.5 mg, 500.0 mg/mL, 70.52 mg/mL, 141.04 mg/mL
, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Oral, Solution, concentrate, Solution, concentrate - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Injection, Liquid - Intramuscular, Liquid, Solution - Intramuscular
Severe Disruptive Behaviour Disorders
5.0 mg/mL, , 2.0 mg/mL, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 0.5 mg, 20.0 mg, 50.0 mg/mL, 100.0 mg/mL, 1.5 mg, 500.0 mg/mL, 70.52 mg/mL, 141.04 mg/mL
, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Oral, Solution, concentrate, Solution, concentrate - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Injection, Liquid - Intramuscular, Liquid, Solution - Intramuscular
Schizophrenia
5.0 mg/mL, , 2.0 mg/mL, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 0.5 mg, 20.0 mg, 50.0 mg/mL, 100.0 mg/mL, 1.5 mg, 500.0 mg/mL, 70.52 mg/mL, 141.04 mg/mL
, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Oral, Solution, concentrate, Solution, concentrate - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Injection, Liquid - Intramuscular, Liquid, Solution - Intramuscular
Schizophrenia
5.0 mg/mL, , 2.0 mg/mL, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 0.5 mg, 20.0 mg, 50.0 mg/mL, 100.0 mg/mL, 1.5 mg, 500.0 mg/mL, 70.52 mg/mL, 141.04 mg/mL
, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Oral, Solution, concentrate, Solution, concentrate - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Injection, Liquid - Intramuscular, Liquid, Solution - Intramuscular
Gilles de la Tourette's Syndrome
5.0 mg/mL, , 2.0 mg/mL, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 0.5 mg, 20.0 mg, 50.0 mg/mL, 100.0 mg/mL, 1.5 mg, 500.0 mg/mL, 70.52 mg/mL, 141.04 mg/mL
, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Oral, Solution, concentrate, Solution, concentrate - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Injection, Liquid - Intramuscular, Liquid, Solution - Intramuscular
phencyclidine
5.0 mg/mL, , 2.0 mg/mL, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 0.5 mg, 20.0 mg, 50.0 mg/mL, 100.0 mg/mL, 1.5 mg, 500.0 mg/mL, 70.52 mg/mL, 141.04 mg/mL
, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Oral, Solution, concentrate, Solution, concentrate - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Injection, Liquid - Intramuscular, Liquid, Solution - Intramuscular
Huntington Disease
5.0 mg/mL, , 2.0 mg/mL, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 0.5 mg, 20.0 mg, 50.0 mg/mL, 100.0 mg/mL, 1.5 mg, 500.0 mg/mL, 70.52 mg/mL, 141.04 mg/mL
, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Oral, Solution, concentrate, Solution, concentrate - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Injection, Liquid - Intramuscular, Liquid, Solution - Intramuscular
aggressive reaction
5.0 mg/mL, , 2.0 mg/mL, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 0.5 mg, 20.0 mg, 50.0 mg/mL, 100.0 mg/mL, 1.5 mg, 500.0 mg/mL, 70.52 mg/mL, 141.04 mg/mL
, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Oral, Solution, concentrate, Solution, concentrate - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Injection, Liquid - Intramuscular, Liquid, Solution - Intramuscular
Warnings
Haloperidol Decanoate ContraindicationsCondition
Risk Level
Notes
Comatose
Do Not Combine
Asthma
Do Not Combine
Parkinson's Disease
Do Not Combine
Mental Depression
Do Not Combine
Basal Ganglia Lesions
Do Not Combine
Mental Depression
Do Not Combine
Common Haloperidol Decanoate Drug Interactions
Drug Name
Risk Level
Description
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Haloperidol.
Amisulpride
Major
Haloperidol may increase the antipsychotic activities of Amisulpride.
Azelastine
Major
Haloperidol may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Cariprazine
Major
The metabolism of Cariprazine can be decreased when combined with Haloperidol.
Eliglustat
Major
The metabolism of Eliglustat can be decreased when combined with Haloperidol.
Haloperidol Decanoate Toxicity & Overdose RiskThe highest amount of the drug that has been tested on rats without causing death has been found to be 71mg/kg.
Haloperidol Decanoate Novel Uses: Which Conditions Have a Clinical Trial Featuring Haloperidol Decanoate?
285 active clinical trials are being conducted to evaluate the potential of Haloperidol Decanoate in treating Obsessive-Compulsive Disorder, Palliative Care and Phencyclidine-based disorders.Condition
Clinical Trials
Trial Phases
Nausea
0 Actively Recruiting
Schizophrenia
34 Actively Recruiting
Early Phase 1, Not Applicable, Phase 4
Delirium
50 Actively Recruiting
Phase 2, Not Applicable, Phase 3, Phase 4, Phase 1, Early Phase 1
Schizophrenia
174 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Early Phase 1, Phase 4, Phase 1
Palliative Treatment
0 Actively Recruiting
Huntington Disease
4 Actively Recruiting
Phase 1, Phase 2, Phase 3
Obsessive-Compulsive Disorder
17 Actively Recruiting
Not Applicable, Phase 3, Phase 2
severe Hyperactivity
0 Actively Recruiting
aggressive reaction
0 Actively Recruiting
Severe Disruptive Behaviour Disorders
0 Actively Recruiting
phencyclidine
0 Actively Recruiting
Gilles de la Tourette's Syndrome
0 Actively Recruiting
Haloperidol Decanoate Reviews: What are patients saying about Haloperidol Decanoate?
4.7Patient Review
3/15/2018 Haloperidol has been a lifesaver for me. It helps me sleep and keeps my delusions at bay.
2.7Patient Review
9/26/2009 While this drug is helpful in some ways, it cannot address negative symptoms such as a loss of motivation or enjoyment.
Patient Q&A Section about haloperidol decanoate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is haloperidol decanoate used for?
"Haloperidol decanoate is used for treating schizophrenia over the long term. It may be used in people who have trouble remembering to take their medication every day. This medicine helps people to think more clearly, feel less nervous, and take part in everyday life."
Answered by AI
Why is HALDOL given in decanoate form?
"It also reduces aggression and the desire to hurt others. It can decrease negative thoughts and hallucinations. Haloperidol decanoate is a long-acting form of psychiatric medication (antipsychotic-type) that works by helping to restore the balance of certain natural substances (neurotransmitters) in the brain."
Answered by AI
Is haloperidol decanoate long-acting?
"The long-acting forms of HALDOL are used to treat schizophrenia, though the mechanism of action is unclear."
Answered by AI
What is the difference between haloperidol and haloperidol decanoate?
"The long-acting forms of HALDOL are HALDOL Decanoate 50 and HALDOL Decanoate 100. The only difference between the long-acting and regular forms of HALDOL is the duration of action."
Answered by AI