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What is Halaven
EribulinThe Generic name of this drug
Treatment SummaryEribulin is a medication used to treat metastatic breast cancer that has not responded to previous chemotherapy treatments. It was derived from a type of marine sponge and is also being studied for its potential to treat other advanced solid tumors.
Halavenis the brand name
Halaven Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Halaven
Eribulin
2010
2
Approved as Treatment by the FDA
Eribulin, also known as Halaven, is approved by the FDA for 3 uses which include RNA-Binding Protein FUS and Breast .RNA-Binding Protein FUS
Breast
Metastatic Liposarcoma
Effectiveness
How Halaven Affects PatientsThis drug has a predictable effect that remains the same when increased doses are taken.
How Halaven works in the bodyEribulin stops cells from dividing by blocking the growth of microtubules. This blockage disrupts the mitotic spindles, which are essential for cell division, and eventually leads to cell death.
When to interrupt dosage
The prescribed measure of Halaven depends upon the diagnosed disorder, including Metastatic Liposarcoma, Breast and RNA-Binding Protein FUS. The dosage amount is contingent upon the procedure of delivery (e.g. Injection, solution or Solution - Intravenous) as shown in the table beneath.Condition
Dosage
Administration
Metastatic Liposarcoma
, 0.44 mg/mL, 0.5 mg/mL
, Intravenous, Solution, Solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection - Intravenous, Injection
RNA-Binding Protein FUS
, 0.44 mg/mL, 0.5 mg/mL
, Intravenous, Solution, Solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection - Intravenous, Injection
Breast
, 0.44 mg/mL, 0.5 mg/mL
, Intravenous, Solution, Solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection - Intravenous, Injection
Warnings
Halaven has one contraindication, so it ought not to be taken while encountering the conditions outlined in the table below.Halaven ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Common Halaven Drug Interactions
Drug Name
Risk Level
Description
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Eribulin is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Acteoside
Major
The risk or severity of adverse effects can be increased when Eribulin is combined with Acteoside.
Antilymphocyte immunoglobulin (horse)
Major
The risk or severity of adverse effects can be increased when Eribulin is combined with Antilymphocyte immunoglobulin (horse).
Bacillus calmette-guerin substrain russian BCG-I live antigen
Major
The therapeutic efficacy of Bacillus calmette-guerin substrain russian BCG-I live antigen can be decreased when used in combination with Eribulin.
Baricitinib
Major
The risk or severity of adverse effects can be increased when Eribulin is combined with Baricitinib.
Halaven Toxicity & Overdose RiskEribulin can cause damage to the peripheral nerves, which is the most common side effect that leads to people stopping the medication. In animal testing, a single dose of 0.75 mg/kg was fatal for rats, and two doses of 0.075 mg/kg was fatal for dogs. The amount of eribulin that caused no harm in rats and dogs was 0.015 and 0.0045 mg/kg per day, respectively.
Halaven Novel Uses: Which Conditions Have a Clinical Trial Featuring Halaven?
Two active trials are currently investigating the potential of Halaven to treat Breast Cancer, RNA-Binding Protein FUS and Metastatic Liposarcoma.Condition
Clinical Trials
Trial Phases
RNA-Binding Protein FUS
0 Actively Recruiting
Breast
0 Actively Recruiting
Metastatic Liposarcoma
0 Actively Recruiting
Halaven Reviews: What are patients saying about Halaven?
5Patient Review
2/10/2011 I was one of the first people in my state to try this new medication, and it's going really well so far. I'm feeling much better.
4.7Patient Review
10/31/2011 So far, this medication is doing exactly what it's supposed to. My tumors have remained stable since starting treatment. However, I am experiencing more and worse "cold symptom" side effects the longer I stay on the medication.
4.3Patient Review
11/13/2011 This chemotherapy is working wonders for my skin cancer. I've tried other chemo's, 40 rounds of radiation, and all sorts of hormone treatments, but this is the first one that's actually had an effect.
4Patient Review
6/7/2011 I've had over seventy chemo treatments in the past ten years, including ten times of Halavan. The side effects are tolerable; I lost my hair but it grew back, though thinner. I also experienced nausea, itching, and some depression, which aren't typical for me.
4Patient Review
2/2/2016 Halaven has, on the whole, been an effective treatment for me. Some of the common side effects like hair loss, neuropathy and fatigue were a bit tough to deal with but, ultimately, worth it because my PET scan showed that the tumor had shrunken in size. Recently, my ANC levels have become low which resulted in having to miss some doses.
Patient Q&A Section about halaven
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is HALAVEN chemotherapy?
"Eribulin mesylate, also known by its brand name Halaven, is a chemotherapy drug."
Answered by AI
What is HALAVEN used for?
"HALAVEN is prescribed to adults with breast cancer that has metastasized to other parts of the body. It is usually given after the patient has received other types of anticancer medicines."
Answered by AI
How effective is HALAVEN?
"Patients with advanced liposarcoma who were treated with HALAVEN lived an average of 15.6 months compared with patients treated with the other chemotherapy, who lived an average of 8.4 months. This means that patients who received HALAVEN chemotherapy lived 86% longer, on average, than patients who received the other chemotherapy."
Answered by AI
Does HALAVEN cause hair loss?
"The most common side effects of HALAVEN in adults with breast cancer include neutropenia, anemia, weakness or tiredness, alopecia, nausea, and constipation."
Answered by AI