Halaven

RNA-Binding Protein FUS, Breast, Liposarcoma

Treatment

5 FDA approvals

0 Active Studies for Halaven

What is Halaven

Eribulin

The Generic name of this drug

Treatment Summary

Eribulin is a medication used to treat metastatic breast cancer that has not responded to previous chemotherapy treatments. It was derived from a type of marine sponge and is also being studied for its potential to treat other advanced solid tumors.

Halaven

is the brand name

image of different drug pills on a surface

Halaven Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Halaven

Eribulin

2010

2

Approved as Treatment by the FDA

Eribulin, also known as Halaven, is approved by the FDA for 5 uses which include Metastatic Liposarcoma and refractory, metastatic Breast cancer .

Metastatic Liposarcoma

refractory, metastatic Breast cancer

Breast

Liposarcoma

RNA-Binding Protein FUS

Effectiveness

How Halaven Affects Patients

This drug has a predictable effect that remains the same when increased doses are taken.

How Halaven works in the body

Eribulin stops cells from dividing by blocking the growth of microtubules. This blockage disrupts the mitotic spindles, which are essential for cell division, and eventually leads to cell death.

When to interrupt dosage

The prescribed measure of Halaven depends upon the diagnosed disorder, including Metastatic Liposarcoma, Breast and RNA-Binding Protein FUS. The dosage amount is contingent upon the procedure of delivery (e.g. Injection, solution or Solution - Intravenous) as shown in the table beneath.

Condition

Dosage

Administration

RNA-Binding Protein FUS

, 0.44 mg/mL, 0.5 mg/mL

, Solution, Intravenous, Solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous

Breast

, 0.44 mg/mL, 0.5 mg/mL

, Solution, Intravenous, Solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous

Liposarcoma

, 0.44 mg/mL, 0.5 mg/mL

, Solution, Intravenous, Solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous

Warnings

Halaven has one contraindication, so it ought not to be taken while encountering the conditions outlined in the table below.

Halaven Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Halaven.

Common Halaven Drug Interactions

Drug Name

Risk Level

Description

9-(N-methyl-L-isoleucine)-cyclosporin A

Major

The risk or severity of adverse effects can be increased when Eribulin is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.

Acteoside

Major

The risk or severity of adverse effects can be increased when Eribulin is combined with Acteoside.

Antilymphocyte immunoglobulin (horse)

Major

The risk or severity of adverse effects can be increased when Eribulin is combined with Antilymphocyte immunoglobulin (horse).

Bacillus calmette-guerin substrain russian BCG-I live antigen

Major

The therapeutic efficacy of Bacillus calmette-guerin substrain russian BCG-I live antigen can be decreased when used in combination with Eribulin.

Baricitinib

Major

The risk or severity of adverse effects can be increased when Eribulin is combined with Baricitinib.

Halaven Toxicity & Overdose Risk

Eribulin can cause damage to the peripheral nerves, which is the most common side effect that leads to people stopping the medication. In animal testing, a single dose of 0.75 mg/kg was fatal for rats, and two doses of 0.075 mg/kg was fatal for dogs. The amount of eribulin that caused no harm in rats and dogs was 0.015 and 0.0045 mg/kg per day, respectively.

image of a doctor in a lab doing drug, clinical research

Halaven Novel Uses: Which Conditions Have a Clinical Trial Featuring Halaven?

Two active trials are currently investigating the potential of Halaven to treat Breast Cancer, RNA-Binding Protein FUS and Metastatic Liposarcoma.

Condition

Clinical Trials

Trial Phases

Breast

0 Actively Recruiting

Liposarcoma

0 Actively Recruiting

RNA-Binding Protein FUS

0 Actively Recruiting

Halaven Reviews: What are patients saying about Halaven?

5

Patient Review

2/10/2011

Halaven for Breast Cancer that has Spread to Another Part of the Body

I was one of the first people in my state to try this new medication, and it's going really well so far. I'm feeling much better.

4.7

Patient Review

10/31/2011

Halaven for Breast Cancer that has Spread to Another Part of the Body

So far, this medication is doing exactly what it's supposed to. My tumors have remained stable since starting treatment. However, I am experiencing more and worse "cold symptom" side effects the longer I stay on the medication.

4.3

Patient Review

11/13/2011

Halaven for Breast Cancer that has Spread to Another Part of the Body

This chemotherapy is working wonders for my skin cancer. I've tried other chemo's, 40 rounds of radiation, and all sorts of hormone treatments, but this is the first one that's actually had an effect.

4

Patient Review

6/7/2011

Halaven for Breast Cancer that has Spread to Another Part of the Body

I've had over seventy chemo treatments in the past ten years, including ten times of Halavan. The side effects are tolerable; I lost my hair but it grew back, though thinner. I also experienced nausea, itching, and some depression, which aren't typical for me.

4

Patient Review

2/2/2016

Halaven for Breast Cancer that has Spread to Another Part of the Body

Halaven has, on the whole, been an effective treatment for me. Some of the common side effects like hair loss, neuropathy and fatigue were a bit tough to deal with but, ultimately, worth it because my PET scan showed that the tumor had shrunken in size. Recently, my ANC levels have become low which resulted in having to miss some doses.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about halaven

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is HALAVEN chemotherapy?

"Eribulin mesylate, also known by its brand name Halaven, is a chemotherapy drug."

Answered by AI

What is HALAVEN used for?

"HALAVEN is prescribed to adults with breast cancer that has metastasized to other parts of the body. It is usually given after the patient has received other types of anticancer medicines."

Answered by AI

How effective is HALAVEN?

"Patients with advanced liposarcoma who were treated with HALAVEN lived an average of 15.6 months compared with patients treated with the other chemotherapy, who lived an average of 8.4 months. This means that patients who received HALAVEN chemotherapy lived 86% longer, on average, than patients who received the other chemotherapy."

Answered by AI

Does HALAVEN cause hair loss?

"The most common side effects of HALAVEN in adults with breast cancer include neutropenia, anemia, weakness or tiredness, alopecia, nausea, and constipation."

Answered by AI