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What is Glynase
GlyburideThe Generic name of this drug
Treatment SummaryGlyburide is a type of drug used to treat people with type 2 diabetes. It is usually given to people who cannot control their diabetes with the usual first-line therapy, which is metformin. Glyburide works by increasing the amount of insulin in the body, which helps to regulate blood sugar levels. It was FDA approved in 1984 and a combination of glyburide and metformin was approved in 2000.
Micronaseis the brand name
Glynase Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Micronase
Glyburide
1984
341
Approved as Treatment by the FDA
Glyburide, also known as Micronase, is approved by the FDA for 2 uses which include Type 2 Diabetes and Glycemic Control .Type 2 Diabetes
Helps manage Type 2 Diabetes Mellitus
Glycemic Control
Used to treat Glycemic Control in combination with Metformin
Effectiveness
How Glynase Affects PatientsGlyburide is a drug that helps the body produce insulin. It is taken once daily and the dose is usually started low (0.75mg) and can increase up to 10mg or more as needed. It is important to note that taking glyburide may increase the risk of cardiovascular death, similar to the drug tolbutamide.
How Glynase works in the bodyGlyburide is a type of drug that helps the body make and release more insulin. It does this by blocking potassium channels, which normally open in response to high glucose concentrations and cause the body to make insulin. By forcing them to stay closed, glyburide boosts insulin production.
When to interrupt dosage
The suggested dose of Glynase is contingent upon the determined condition, including Glycemic Control, Type 2 Diabetes and Gestational Diabetes. The measure of dosage fluctuates as per the technique of delivery (e.g. Oral or Tablet) specified in the table below.Condition
Dosage
Administration
Glycemic Control
, 1.25 mg, 2.5 mg, 1.5 mg, 3.0 mg, 6.0 mg, 5.0 mg, 6.0 mg/mL, 0.6 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral
Type 2 Diabetes
, 1.25 mg, 2.5 mg, 1.5 mg, 3.0 mg, 6.0 mg, 5.0 mg, 6.0 mg/mL, 0.6 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral
Gestational Diabetes Mellitus
, 1.25 mg, 2.5 mg, 1.5 mg, 3.0 mg, 6.0 mg, 5.0 mg, 6.0 mg/mL, 0.6 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral
Warnings
Glynase has six recognized contraindications and should not be taken with any of the conditions given in the below table.Glynase ContraindicationsCondition
Risk Level
Notes
Type 1 Diabetes
Do Not Combine
Metabolic Acidosis
Do Not Combine
Comatose
Do Not Combine
Diabetic ketoacidosis with coma
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Glyburide may interact with Pulse Frequency
Common Glynase Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Glyburide.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Glyburide.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Glyburide.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Glyburide.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Glyburide.
Glynase Toxicity & Overdose RiskThe lowest toxic dose of the drug in rats has been found to be greater than 3200mg/kg, in mice greater than 1500mg/kg, in rabbits greater than 10,000mg/kg, and in guinea pigs greater than 1500mg/kg. An overdose of this drug can cause low blood sugar levels. Mild hypoglycemia should be treated with sugar and changes to the drug dosage or meal schedule. Severe hypoglycemia can cause coma, seizures, and brain damage and should be treated immediately in a hospital with intravenous sugar and monitored for 24-48 hours.
Glynase Novel Uses: Which Conditions Have a Clinical Trial Featuring Glynase?
An array of 196 active trials are being conducted to assess the potential of Glynase in providing Gestational Diabetes, Glycemic Control and Type 2 Diabetes relief.Condition
Clinical Trials
Trial Phases
Gestational Diabetes Mellitus
37 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Phase 2, Early Phase 1
Type 2 Diabetes
192 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 1, Phase 4, Phase 3
Glycemic Control
3 Actively Recruiting
Not Applicable
Glynase Reviews: What are patients saying about Glynase?
5Patient Review
9/16/2009 Glynase has been by far the most effective medication I've tried for my hyperglycemia. Not only did it show results immediately, but over time as I lost weight and exercised more, I was able to reduce my dosage with no loss in efficacy. Additionally, it's very easy to take and I experienced no negative side effects whatsoever.
4Patient Review
2/4/20084Patient Review
1/28/20093.3Patient Review
10/18/2010 I've been using this medication for about ten years now and it's always been pretty straightforward for me.
3Patient Review
3/16/2010 This treatment really helped me. I'm grateful for modern medicine.
Patient Q&A Section about glynase
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the generic name for glynase?
"It works by stimulating the release of insulin from the pancreas, leading to better blood sugar control.
Glipizide is a generic drug prescribed to people with type 2 diabetes in order to help control their blood sugar levels. It works by stimulating the release of insulin from the pancreas, which helps to regulate blood sugar levels in the body."
Answered by AI
What is glynase-MF?
"This medicine is a combination of two medicines, Glipizide and Metformin, which is used to treat type 2 diabetes mellitus (DM). It improves blood glucose levels in adults when taken along with a proper diet and regular exercise."
Answered by AI
When should glynase be taken?
"You should take Glynase Tablet before meals, or exactly as your doctor tells you to. There is evidence suggesting that taking Glynase Tablet 30 minutes before breakfast helps control post-meal high blood sugar levels."
Answered by AI
What is the use of glynase?
"Glyburide is a medication used to help control high blood sugar. It is typically used in conjunction with a proper diet and exercise program, and may also be used with other diabetes medications. Managing blood sugar levels can help to prevent a range of complications associated with diabetes, such as kidney damage, blindness, nerve problems, and loss of limb function."
Answered by AI