Cooling Flavors for Electronic Cigarette Use
Trial Summary
What is the purpose of this trial?
This pilot sensory experiment will examine cooling from comparable concentrations of WS-3 and menthol to determine appropriate concentrations to use in the main study.
Do I need to stop taking my current medications to join the trial?
The trial information does not specify whether you need to stop taking your current medications.
Is it safe to use cooling flavors in e-cigarettes?
Research indicates that while some cooling agents like menthol and WS-23 are used in e-cigarettes, their safety when inhaled is not well understood. High concentrations of flavor chemicals, including menthol, can be harmful, and the potential health risks from inhaling these substances need further study.12345
What makes this e-liquid coolant treatment unique compared to other treatments?
This e-liquid coolant treatment is unique because it uses different concentrations of menthol and other cooling agents (WS-23 and WS-3) to provide a cooling sensation, which may enhance the vaping experience. Unlike traditional treatments, this approach focuses on the sensory effects of vaping rather than addressing a medical condition.678910
Research Team
Suchitra Krishnan-Sarin, PhD
Principal Investigator
Yale University
Eligibility Criteria
Adults who have used nicotine e-cigarettes, can read and write, and have vaped in the past month. Not for those allergic to propylene glycol or nut/e-liquid flavors, pregnant or breastfeeding women, people with uncontrolled asthma, marijuana vapers, or anyone showing symptoms of lung injury from vaping.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants are exposed to e-liquids containing five different concentrations of two different cooling flavors without nicotine and rate 'coolness' using the generalized Labeled Magnitude Scale (gLMS)
Follow-up
Participants are monitored for any adverse reactions and effectiveness of the cooling sensation
Treatment Details
Interventions
- E-liquid coolant (menthol, 0.05%)
- E-liquid coolant (menthol, 0.1%)
- E-liquid coolant (menthol, 0.5%)
- E-liquid coolant (menthol, 1.0%)
- E-liquid coolant (menthol, 2.0%)
- E-liquid coolant (WS-23, 0.05%)
- E-liquid coolant (WS-23, 0.1%)
- E-liquid coolant (WS-23, 0.5%)
- E-liquid coolant (WS-23, 1.0%)
- E-liquid coolant (WS-23, 2.0%)
- E-liquid coolant (WS-23, 4.0%)
- E-liquid coolant (WS-3, 0.05%)
- E-liquid coolant (WS-3, 0.1%)
- E-liquid coolant (WS-3, 0.5%)
- E-liquid coolant (WS-3, 1.0%)
- E-liquid coolant (WS-3, 2.0%)
E-liquid coolant (menthol, 0.05%) is already approved in European Union, United States for the following indications:
- General use as a flavoring agent in food and tobacco products
- General use as a flavoring agent in food and tobacco products
Find a Clinic Near You
Who Is Running the Clinical Trial?
Yale University
Lead Sponsor
National Institute on Drug Abuse (NIDA)
Collaborator