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Hormone Therapy

Healthy Young Women for E-Cigarette Use

Q: Are individuals of any age eligible for this research trial?

Participants who meet the age requirements of 18 years and below 24 can be enrolled in this clinical trial.

Q: What criteria must be met in order to join this experiment?

This research initiative requires that enrollees are between 18 and 24 years of age, have a history of e-cigarette use, and is looking to recruit approximately 80 people.

Q: What is the current recruitment count for this experiment?

Affirmative. The information on clinicaltrials.gov confirms that this research is currently enrolling participants, which it first did in November of 2024 and was most recently updated in December 2023. 80 candidates must be sourced from one medical site for the study to commence.

Q: Are there any vacancies available for individuals to join this clinical trial?

Affirmative. According to information provided on clinicaltrials.gov, this experiment is actively seeking participants. Initially posted in November 1st 2024 and recently updated in December 4th 2023, the study needs to enrol 80 individuals from one medical centre.

Phase < 1

Recruiting

Research Sponsored by Anna Stanhewicz, PhD

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Either have no history of e-cigarette use or be a current e-cigarette user who has been using e-cigarettes for 6 months or longer

Aged 18-24 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 1 month

Awards & highlights

Study Summary

This trial will explore the effects of e-cigarette use on mechanisms which could lead to CVD in young adults.

Who is the study for?

This trial is for healthy young adults aged 18-24 who either have never used e-cigarettes or have been vaping regularly for at least 6 months. Participants should not have any cardiovascular, metabolic, skin diseases, obesity, high blood pressure, a history of smoking tobacco cigarettes or using illegal substances. Pregnant or breastfeeding individuals and those with allergies to latex or study drugs are also excluded.Check my eligibility

What is being tested?

The study investigates how chronic e-cigarette use affects the blood vessels in young adults by comparing non-users to regular users. It involves local heating of the skin and administering L-NAME via microdialysis to test vascular function. Blood and urine samples will be collected from participants to analyze cardiovascular health markers and inflammation.See study design

What are the potential side effects?

Potential side effects may include reactions at the site where drugs are administered into the skin (like redness or swelling), changes in blood pressure due to L-NAME which inhibits nitric oxide production affecting vessel dilation, and discomfort from heat application.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I either have never used e-cigarettes or have been using them for over 6 months.

Select...

I am between 18 and 24 years old.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 1 month

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~1 month

This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 month for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in microvascular endothelium-dependent dilation response measured by laser-Doppler flowmetry

monthly estrogen exposure

Trial Design

4Treatment groups

Experimental Treatment

Group I: Young Women using E-cigarettesExperimental Treatment2 Interventions

Young women chronically use e-cigarettes

Group II: Young Men using E-cigarettesExperimental Treatment1 Intervention

Young men chronically use e-cigarettes

Group III: Healthy Young WomenExperimental Treatment2 Interventions

Young women who do not use e-cigarettes

Group IV: Healthy Young MenExperimental Treatment1 Intervention

Young men who do not use e-cigarettes

0 / 2Eligibility criteria met

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Who is running the clinical trial?

Anna Stanhewicz, PhDLead Sponsor

9 Previous Clinical Trials

300 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are individuals of any age eligible for this research trial?

"Participants who meet the age requirements of 18 years and below 24 can be enrolled in this clinical trial."

Answered by AI

What criteria must be met in order to join this experiment?

"This research initiative requires that enrollees are between 18 and 24 years of age, have a history of e-cigarette use, and is looking to recruit approximately 80 people."

Answered by AI

What is the current recruitment count for this experiment?

"Affirmative. The information on clinicaltrials.gov confirms that this research is currently enrolling participants, which it first did in November of 2024 and was most recently updated in December 2023. 80 candidates must be sourced from one medical site for the study to commence."

Answered by AI

Are there any vacancies available for individuals to join this clinical trial?

"Affirmative. According to information provided on clinicaltrials.gov, this experiment is actively seeking participants. Initially posted in November 1st 2024 and recently updated in December 4th 2023, the study needs to enrol 80 individuals from one medical centre."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Sex Differences in the Vascular Effects of E-cigarette Use

Anna Stanhewicz, PhD 2024. "Sex Differences in the Vascular Effects of E-cigarette Use". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06159608.