Tranexamic Acid for Fractures, Bone

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Fractures, Bone+1 More
Tranexamic Acid - Drug
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

This trial will evaluate whether the use of tranexamic acid can reduce blood loss in patients undergoing surgery to repair a fracture in their hip socket.

Eligible Conditions
  • Fractures, Bone
  • Bone structure of acetabulum

Treatment Effectiveness

Effectiveness Progress

1 of 3

Other trials for Fractures, Bone

Study Objectives

2 Primary · 0 Secondary · Reporting Duration: Postoperative Day 2

Postoperative Day 2
Hematocrit (Hct)
Hemoglobin (Hb)

Trial Safety

Safety Progress

1 of 3

Other trials for Fractures, Bone

Side Effects for

Tranexamic Acid
8%Myocardial infaction
8%Postoperative wound infection
8%Postoperative wound infection after release from hospital
This histogram enumerates side effects from a completed 2015 Phase 4 trial (NCT02063035) in the Tranexamic Acid ARM group. Side effects include: Myocardial infaction with 8%, Postoperative wound infection with 8%, Postoperative wound infection after release from hospital with 8%.

Trial Design

2 Treatment Groups

Topical TXA Treatment
1 of 2
No Topical Treatment
1 of 2
Experimental Treatment
Non-Treatment Group

98 Total Participants · 2 Treatment Groups

Primary Treatment: Tranexamic Acid · Has Placebo Group · Phase < 1

Topical TXA Treatment
Drug
Experimental Group · 1 Intervention: Tranexamic Acid · Intervention Types: Drug
No Topical Treatment
Drug
PlaceboComparator Group · 1 Intervention: Normal saline · Intervention Types: Drug
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Tranexamic Acid
2011
Completed Phase 4
~2630

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: postoperative day 2

Who is running the clinical trial?

Foundation for Orthopedic TraumaUNKNOWN
1 Previous Clinical Trials
60 Total Patients Enrolled
1 Trials studying Fractures, Bone
60 Patients Enrolled for Fractures, Bone
University of CincinnatiLead Sponsor
385 Previous Clinical Trials
630,400 Total Patients Enrolled
5 Trials studying Fractures, Bone
297 Patients Enrolled for Fractures, Bone

Eligibility Criteria

Age 18+ · All Participants · 2 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
Patients with an isolated, closed, posterior wall acetabular fracture managed surgically within 7 days of injury

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 23rd, 2021

Last Reviewed: October 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.

References