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Psychedelic

DMT for Depression

Phase 1
Waitlist Available
Research Sponsored by Yale University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up -60 minutes before dmt administration; 0, +30, and +60 minutes after dmt administration
Awards & highlights

Study Summary

This trial is testing the safety and effectiveness of DMT, a psychedelic drug, in humans.

Who is the study for?
This trial is for people who are mentally and physically healthy, without any major depressive disorder or other psychiatric conditions. It's designed to see if DMT can be safe and effective for those not currently experiencing depression.Check my eligibility
What is being tested?
The study is testing two different doses of Dimethyltryptamine (DMT), a psychedelic compound: one lower dose at 0.1 mg/kg and a higher dose at 0.3 mg/kg, to understand its effects on humans in a controlled setting.See study design
What are the potential side effects?
Possible side effects of DMT may include altered sense of time, visual hallucinations, euphoria, increased heart rate, rapid eye movement, dizziness, and anxiety during the period it's active in the body.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~-60 minutes before dmt administration; 0, +30, and +60 minutes after dmt administration
This trial's timeline: 3 weeks for screening, Varies for treatment, and -60 minutes before dmt administration; 0, +30, and +60 minutes after dmt administration for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Anxiety
Change in Blood Pressure
Change in Heart Rate
+3 more

Trial Design

2Treatment groups
Active Control
Group I: 0.1 mg/kg DMTActive Control1 Intervention
0.1 mg/kg DMT administered intravenously
Group II: 0.3 mg/kg DMTActive Control1 Intervention
0.3 mg/kg DMT administered intravenously

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

Yale UniversityLead Sponsor
1,847 Previous Clinical Trials
2,736,498 Total Patients Enrolled
63 Trials studying Depression
20,616 Patients Enrolled for Depression

Media Library

Dimethyltryptamine (DMT) (Psychedelic) Clinical Trial Eligibility Overview. Trial Name: NCT04711915 — Phase 1
Depression Research Study Groups: 0.1 mg/kg DMT, 0.3 mg/kg DMT
Depression Clinical Trial 2023: Dimethyltryptamine (DMT) Highlights & Side Effects. Trial Name: NCT04711915 — Phase 1
Dimethyltryptamine (DMT) (Psychedelic) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04711915 — Phase 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does the Federal Drug Administration recognize 0.1 mg/kg of DMT as an authorized dosage?

"Due to the limited clinical data available on 0.1 mg/kg DMT, our team rated its safety as a 1 out of 3. This early stage trial is providing insights into efficacy and safety profiles."

Answered by AI

Who is allowed to enlist in this clinical experiment?

"This mental health research is recruiting 30 volunteers suffering from depression and aged 21 to 65. The only medical precondition for enrollment is general wellness."

Answered by AI

Is this a groundbreaking research initiative?

"Presently, two experiments with 0.1 mg/kg of DMT are operational in one city and two countries. This research initially began in 2021 under the auspices of Small Pharma Ltd., involving 66 individuals who completed their Phase 1 & 2 examinations successfully. Since then, five additional researches have been concluded as well."

Answered by AI

What is the number of participants being treated in this research endeavor?

"Unfortunately, this trial is not presently accepting candidates. Initially posted on March 17th 2021 and last modified on February 9th 2022, it has concluded recruiting for the moment. If you are looking to join another study related to depression, 1295 trials are open while two clinical studies involving 0.1 mg/kg of DMT are actively admitting patients."

Answered by AI

Are participants aged twenty or younger admissible to this research?

"This trial seeks out participants aged between 21 and 65. There are 192 studies for minors, while there is room in 970 studies for patients over the age of 65."

Answered by AI

What prior studies have been conducted to assess the effects of 0.1 mg/kg DMT?

"Currently, 2 trials are being conducted to research the effects of 0.1 mg/kg DMT with none reaching Phase 3 yet. While most studies reside in West Haven, Connecticut there is also a presence of this trial at three other sites."

Answered by AI

Is this research endeavor currently seeking participants?

"According to the latest update on clinicaltrials.gov, this trial is no longer enrolling participants - though it was initially published on March 17th 2021 and edited lastly in February 9th 2022. But don't worry: there are currently 1297 other medical trials actively searching for eligible patients!"

Answered by AI

Who else is applying?

What state do they live in?
Wisconsin
Connecticut
How old are they?
18 - 65
What site did they apply to?
Biological Studies Unit at the VA Connecticut Healthcare System, Yale School of Medicine
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
0
3+
Recent research and studies
clinicaltrials.govStudy
Fixed Order, Open-Label, Dose-Escalation Study of DMT in Humans
Deepak C. D'Souza 2021. "Fixed Order, Open-Label, Dose-Escalation Study of DMT in Humans". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04711915.
All > Depression New York
~5 spots leftby Dec 2024
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