Luteal phase ovarian stimulation (LPOS) for Infertility

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Infertility+2 MoreTiming of injectable gonadotropins - Procedure
Eligibility
20 - 45
Female
What conditions do you have?
Select

Study Summary

This trial will compare the two different protocols for controlled ovarian stimulation in patients with diminished ovarian reserve.

Eligible Conditions
  • Infertility
  • In Vitro Fertilization
  • Diminished Ovarian Reserve

Treatment Effectiveness

Study Objectives

1 Primary · 6 Secondary · Reporting Duration: 40 weeks post embryo transfer

Week 40
Live birth rate
Day 5
Blastocyst development rate
First day after oocyte retrieval
Number of mature (Metaphase II) oocytes retrieved
Number of oocytes cumulus complexes retrieved
Oocyte fertilization rate
Five to seven weeks post embryo transfer
Clinical pregnancy rate
From the first day of injections, through the day of oocyte retrieval
Duration of stimulation (days)
Total FSH dosage (IU) used
Two weeks post embryo transfer
Implantation rate
When biopsy results return, usually within four weeks after oocyte retrieval
Embryo ploidy status
Within two weeks of cycle start
Cycle cancellation rate

Trial Safety

Trial Design

2 Treatment Groups

Luteal phase ovarian stimulation (LPOS)
1 of 2
Luteal estradiol priming protocol
1 of 2

Active Control

142 Total Participants · 2 Treatment Groups

Primary Treatment: Luteal phase ovarian stimulation (LPOS) · No Placebo Group · N/A

Luteal phase ovarian stimulation (LPOS)
Procedure
ActiveComparator Group · 1 Intervention: Timing of injectable gonadotropins · Intervention Types: Procedure
Luteal estradiol priming protocol
Procedure
ActiveComparator Group · 1 Intervention: Timing of injectable gonadotropins · Intervention Types: Procedure

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 40 weeks post embryo transfer

Who is running the clinical trial?

Northwell HealthLead Sponsor
425 Previous Clinical Trials
493,388 Total Patients Enrolled
3 Trials studying Infertility
465 Patients Enrolled for Infertility

Eligibility Criteria

Age 20 - 45 · Female Participants · 9 Total Inclusion Criteria

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Who else is applying?

What state do they live in?
Pennsylvania50.0%
Florida50.0%
How old are they?
18 - 65100.0%
What site did they apply to?
Northwell Fertility100.0%
What portion of applicants met pre-screening criteria?
Met criteria50.0%
Did not meet criteria50.0%