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What is Glucotrol
GlipizideThe Generic name of this drug
Treatment SummaryGlipizide is a medication used to control blood sugar levels in people with type 2 diabetes. It was first introduced in 1984 and is used in many countries. Glipizide is part of a group of drugs called sulfonylureas and is usually prescribed when type 2 diabetes is in the early stages and the pancreas is still functioning properly. Glipizide has a short half-life and duration of action compared to other sulfonylureas, which means it is less likely to cause long-lasting low blood sugar levels. Glipizide was approved by the FDA in 1994 and is available on its
Glipizideis the brand name
Glucotrol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Glipizide
Glipizide
1984
471
Approved as Treatment by the FDA
Glipizide, also called Glipizide, is approved by the FDA for 1 uses such as Type 2 Diabetes .Type 2 Diabetes
Helps manage Type 2 Diabetes Mellitus
Effectiveness
How Glucotrol Affects PatientsGlipizide is a medicine used to lower blood sugar levels. It usually starts working within 30 minutes after taking it and can last up to 24 hours. Over time, taking glipizide does not result in higher fasting insulin levels, but it does increase the insulin response to food. It works primarily on the pancreas to release insulin, but it can also affect other body cells. It can cause hypoglycemia and weight gain in some people, and may lead to the pancreas becoming less responsive over time. Other effects of glipizide include increased glucose uptake in the muscles, decreased lipolysis in
How Glucotrol works in the bodyGlipizide is a drug used to treat type 2 diabetes. It encourages the body to produce more insulin, which helps to keep blood glucose levels in check. Glipizide works by binding to special receptors on the surface of pancreatic beta cells in the pancreas. This causes potassium channels to close and calcium channels to open, which triggers the release of insulin from the cells. Additionally, glipizide increases the number and sensitivity of insulin receptors, which helps the body use glucose more effectively.
When to interrupt dosage
The quantity of Glucotrol is contingent upon the identified condition. The dosage is subject to the technique of delivery (e.g. Tablet - Oral or Tablet, film coated - Oral) detailed in the table below.Condition
Dosage
Administration
Type 2 Diabetes
2.5 mg, , 5.0 mg, 10.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
Glucotrol ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Acute Coryza
Do Not Combine
Metabolic acidosis
Do Not Combine
Comatose
Do Not Combine
Comatose
Do Not Combine
Diabetic ketoacidosis with coma
Do Not Combine
Comatose
Do Not Combine
Common Glucotrol Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Minor
Glipizide may increase the anticoagulant activities of (R)-warfarin.
(S)-Warfarin
Minor
Glipizide may increase the anticoagulant activities of (S)-Warfarin.
Abrocitinib
Minor
The metabolism of Abrocitinib can be decreased when combined with Glipizide.
Aclidinium
Minor
Glipizide may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine
Minor
Glipizide may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Glucotrol Toxicity & Overdose RiskThe lowest amount of glipizide that has been found to be toxic in rats is greater than 4000 mg/kg when taken orally and 1200 mg/kg when taken intraperitoneally. In children, the lowest toxic dose is 379 μg/kg. Signs of an overdose may include coma, seizures, or other neurological problems caused by dangerously low blood sugar levels. These symptoms require immediate treatment with glucagon or intravenous glucose and close monitoring for at least 24 to 48 hours, since hypoglycemia may come back after initial recovery. Milder symptoms with no loss of consciousness or neurologic changes can be treated with oral glucose.
Glucotrol Novel Uses: Which Conditions Have a Clinical Trial Featuring Glucotrol?
162 ongoing studies are assessing the potential of Glucotrol to treat Type 2 Diabetes.Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
192 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 1, Phase 4, Phase 3
Glucotrol Reviews: What are patients saying about Glucotrol?
5Patient Review
2/17/2010 This, combined with 1000mg of metformin, helped me to lower my blood sugar from the mid 200's to a 99 on a morning fast test. I also didn't experience any unpleasant side effects, like I did with the metformin.
5Patient Review
8/14/2017 I've found that this treatment really lowers my blood sugar levels. Within a few hours, it's usually down to around 50.
5Patient Review
4/10/2012 Glucotrol has been an extremely effective treatment for me. Along with taking a cinnamon supplement, it has helped control my blood sugar levels and diabetes.
4.7Patient Review
7/20/2008 This medication has been a big help in managing my type 2 diabetes. My blood sugar levels have dropped to where my doctor wants them to be (lower than 150). I've also made some diet changes and started exercising, which has helped occasional loose stools. I get regular check-ups for nerve damage, checking my toes, and an eye exam yearly.
4.7Patient Review
6/5/2012 I was originally prescribed Metformin, but I had an allergic reaction in the form of a rash. So, my doctor switched me to Glipizide. This worked well for a while, but my blood sugar started climbing again for no reason. I was then upped to 10mg, which has caused some irregularity and low blood sugar readings. Has anyone else experienced this issue?
4.3Patient Review
6/29/2009 I just started taking this medication and it seems to be working great with no negative side effects. I had been taking Metformin previously, but stopped because of the adverse reactions I experienced.
3.3Patient Review
4/28/2014 The glipizide was effective in lowering my blood sugar, but the side effects were really unpleasant. I experienced headaches, stomach pains, nausea, and a throbbing/racing pulse. I also take Metformin, 1,000 mg in the morning and at night.
3Patient Review
5/8/2015 I was originally taking 10mg, but that has been reduced to 5mg. I continue to have low blood sugar levels unless I eat several times over the course of four or five hours after taking my medication. I'm currently trying to convince my doctor to discontinue this treatment, or else I'll stop taking it on my own. Maintaining a healthy weight and paying attention to diet are important for everyone, not just diabetics.
2.7Patient Review
6/14/2008 I'm only using this medicine because I've run out of my regular one, Glucovance. So far, it's been keeping my blood sugar in the 200-300 range.
2.3Patient Review
4/20/2013 I was taking metformin with 5 grams of glipizide. My blood sugar was under control but the doctor decided that metformin was affecting my liver, so he took me off of it. I am now taking 40 grams of glipizide every day, but it seems to be having no effect whatsoever. My blood sugar usually stays in the 190s.
1Patient Review
8/31/2010 I'm starting this medication today, so I can't speak to its efficacy yet. However, I am replacing Glimepiride 8 mg with it and will also continue to take Metformin ER 500 mg twice daily.
1Patient Review
8/22/2013 My mother has experienced extremely high blood sugar levels since she started taking this medication about a year ago, to the point where she had a t.i.a (mini-stroke).
Patient Q&A Section about glucotrol
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Glucotrol an insulin?
"Glipizide works by making the pancreas produce insulin, which helps the body to break down sugar. It also helps the body to use insulin effectively."
Answered by AI
What is the drug Glucotrol used for?
"Glipizide is used in conjunction with diet and exercise to help control high blood sugar levels in people with type 2 diabetes. It may also be used in combination with other diabetes medications. By controlling high blood sugar levels, it helps to prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems."
Answered by AI
What kind of drug is Glucotrol?
"A prescription medication called Glucotrol is used to treat the symptoms of type 2 diabetes mellitus. Glucotrol can be used alone or with other medications. It belongs to a class of antidiabetic drugs called sulfonylureas."
Answered by AI
Is Glucotrol the same as metformin?
"Metformin is a medication used to treat polycystic ovaries and weight gain due to medications used for treating psychoses. Metformin is sold under the brand names Glumetza, Glucophage, and Fortamet. Glipizide is another medication used to treat these conditions and it is sold under the brand names Glucotrol and Glucotrol XL."
Answered by AI