Frovatriptan Succinate

Migraine without Aura, Migraine with Aura, Menstruation
Treatment
4 FDA approvals
5 Active Studies for Frovatriptan Succinate

What is Frovatriptan Succinate

FrovatriptanThe Generic name of this drug
Treatment SummaryFrovatriptan is a medication used to treat migraine headaches, especially those linked to menstruation. It works by constricting the blood vessels in the head and reducing the amount of blood flowing in the area.
Frovais the brand name
Frovatriptan Succinate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Frova
Frovatriptan
2001
9

Approved as Treatment by the FDA

Frovatriptan, commonly known as Frova, is approved by the FDA for 4 uses like Migraine Without Aura and Migraine With Aura .
Migraine Without Aura
Migraine With Aura
Migraine without Aura
Migraine with Aura

Effectiveness

How Frovatriptan Succinate Affects PatientsFrovatriptan is a medication used to treat migraine headaches. It works by targeting certain receptors in the brain and reducing the swelling of blood vessels near the brain that can cause migraine. Frovatriptan has a strong connection to these receptors and is one of the most effective medications for treating migraines.
How Frovatriptan Succinate works in the bodyThe triptans are used to treat migraines, and they work in three ways. First, they stimulate serotonin receptors in the brain, which helps to reduce inflammation. Second, they inhibit the excitability of cells in the brainstem, and third, they cause constriction of blood vessels in the head, which can help reduce pain.

When to interrupt dosage

The portion of Frovatriptan Succinate is contingent upon the diagnosed state, including Menstruation, Migraine Without Aura and Migraine With Aura. The quantity of dosage is contingent upon the approach of administration (e.g. Tablet or Tablet, film coated) noted in the table beneath.
Condition
Dosage
Administration
Menstruation
, 2.5 mg
, Tablet, film coated - Oral, Tablet, film coated, Oral, Tablet, Tablet - Oral
Migraine without Aura
, 2.5 mg
, Tablet, film coated - Oral, Tablet, film coated, Oral, Tablet, Tablet - Oral
Migraine with Aura
, 2.5 mg
, Tablet, film coated - Oral, Tablet, film coated, Oral, Tablet, Tablet - Oral

Warnings

Frovatriptan Succinate Contraindications
Condition
Risk Level
Notes
Stroke
Do Not Combine
Migraine Disorders
Do Not Combine
Pulse Frequency
Do Not Combine
Atrioventricular Block
Do Not Combine
Pulse Frequency
Do Not Combine
Vasospastic Angina
Do Not Combine
Transient Ischemic Attack
Do Not Combine
Pulse Frequency
Do Not Combine
Coronary Vasospasm
Do Not Combine
Coronary Artery Disease
Do Not Combine
intestinal ischemia
Do Not Combine
Peripheral Vascular Disease
Do Not Combine
Atrial Fibrillation
Do Not Combine
Hypertensive disease
Do Not Combine
Basilar-Type Migraine
Do Not Combine
There are 20 known major drug interactions with Frovatriptan Succinate.
Common Frovatriptan Succinate Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Frovatriptan may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Ethanol
Major
Frovatriptan may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Methylene blue
Major
Frovatriptan may increase the serotonergic activities of Methylene blue.
Mirtazapine
Major
Frovatriptan may increase the serotonergic activities of Mirtazapine.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Frovatriptan is combined with Oliceridine.
Frovatriptan Succinate Toxicity & Overdose RiskTaking an overdose of Frovatriptan has not been reported. The highest single dose given to migraine patients was 40mg (16 times the standard dose) for both men and women, and 100mg (40 times the standard dose) for male test subjects without any major side effects.

Frovatriptan Succinate Novel Uses: Which Conditions Have a Clinical Trial Featuring Frovatriptan Succinate?

4 active studies are presently assessing the potential of Frovatriptan Succinate in alleviating symptoms of Migraine Without Aura, Migraine With Aura and Menstrual Migraines.
Condition
Clinical Trials
Trial Phases
Menstruation
2 Actively Recruiting
Phase 4, Phase 3
Migraine with Aura
0 Actively Recruiting
Migraine without Aura
3 Actively Recruiting
Not Applicable

Frovatriptan Succinate Reviews: What are patients saying about Frovatriptan Succinate?

5Patient Review
12/8/2007
Frovatriptan Succinate for Migraine Headache
Frova has been an incredible help for me. I get debilitating migraines every month around my period, and this medication takes care of the pain in less than two hours so that I can carry on with my day-to-day activities without issue. Other medications I've tried in the past would either take forever to start working (if they worked at all), or they would knock me out completely so that I couldn't function.
5Patient Review
2/23/2008
Frovatriptan Succinate for Migraine Headache
I've been struggling with migraines since I was a child. This is the first medication that has worked for me without causing terrible side effects. It's a lifesaver, and I only hope that a generic version will be made soon because it's quite expensive ($25 for 9 pills).
5Patient Review
12/3/2009
Frovatriptan Succinate for Migraine Headache
After three days of Fiorinol and no relief, I tried Frovatriptan. Within two hours, the pain was completely gone and it's been 12 hours now with no recurrence. I highly recommend this to anyone else suffering from migraines.
5Patient Review
4/21/2009
Frovatriptan Succinate for Migraine Headache
Frova has been a game-changer for me, and I've been taking it for four years now. It's the only medication that has alleviated my menstrual migraines in such a short amount of time (usually 2-3 hours). Even though it's quite expensive ($20/pill), it's worth every penny to me.
5Patient Review
8/10/2009
Frovatriptan Succinate for Migraine Headache
Frova is excellent at preventing migraines triggered by common migraine triggers like travel, exams, or social events. I take it as soon as I notice any hint of a headache and it usually lasts for the duration of whatever event I'm taking it for.
View All Reviews
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about frovatriptan succinate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is a common side effects of frovatriptan?

"The side effects of the drug include dizziness, headache, dry mouth, indigestion, drowsiness, excessive tiredness, flushing, hot or cold feeling."

Answered by AI

How long does it take for frovatriptan to work?

"Although frovatriptan has the lowest efficacy of the triptans in terms of 2-hour response and 2-hour pain free, 25% of patients who take it experience headache relief within 1.3 to 1.7 hours."

Answered by AI

What is frovatriptan succinate used for?

"Frovatriptan is used to treat acute migraine headaches in adults. Frovatriptan works by agonizing serotonin 5-HT1B/1D receptors, which are found on the blood vessels and nerve endings in the brain. This causes the blood vessels to constrict and blocks the release of pain-causing chemicals from the nerve endings. Many people find that their headaches go away completely after they take frovatriptan."

Answered by AI

Is frovatriptan better than sumatriptan?

"A large RCT comparing sumatriptan 100 mg to frovatriptan 2.5 mg found that the headache relief rates were 47% and 37% respectively, with similar recurrence rates for both drugs."

Answered by AI

Clinical Trials for Frovatriptan Succinate

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